Rapid Method to Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells

Drug Metabolism and Disposition

Volumn 44, Issue 3, 2016, Pages 356-364

  Chien, Huan Chieh ^a   Zur, Arik A ^a   Maurer, Tristan S ^b   Yee, Sook Wah ^a   Tolsma, John ^c   Jasper, Paul ^c   Scott, Dennis O ^b   Giacomini, Kathleen M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b PFIZER INC   (United States)

^c RES Group   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METFORMIN; ORGANIC CATION TRANSPORTER 1;

ARTICLE; BIOASSAY; CELL COMPARTMENTALIZATION; CELL CULTURE; CELLULAR DISTRIBUTION; CELLULAR UPTAKE ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG UPTAKE; EMBRYO; ENDOPLASMIC RETICULUM; EXTRACELLULAR SPACE; GENE OVEREXPRESSION; HEK293 CELL LINE; HUMAN; HUMAN CELL; INTRACELLULAR SPACE; MATHEMATICAL MODEL; MITOCHONDRION; PRIORITY JOURNAL; CELL LINE; GENETIC TRANSFECTION; METABOLISM; PHYSIOLOGY; PROCEDURES; TRANSPORT AT THE CELLULAR LEVEL;

BIOLOGICAL TRANSPORT; CELL LINE; ENDOPLASMIC RETICULUM; HEK293 CELLS; HUMANS; METFORMIN; MITOCHONDRIA; ORGANIC CATION TRANSPORTER 1; TRANSFECTION;

EID: 84959019045     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.115.066647     Document Type: Article

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