Understanding the complex-I-ty of metformin action: Limiting mitochondrial respiration to improve cancer therapy

BMC Biology

Volumn 12, Issue 1, 2014, Pages

  Luengo, Alba ^a   Sullivan, Lucas B ^a   Heiden, Vander G ^a,b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84924326053     PISSN: None     EISSN: 17417007     Source Type: Journal    
DOI: 10.1186/s12915-014-0082-4     Document Type: Article

References (13)

1. Gandini S, Puntoni M, Heckman-Stoddard BM, Dunn BK, Ford L, DeCensi A, Szabo E: Metformin and cancer risk and mortality: a systematic review and meta-analysis taking into account biases and confounders. Cancer Prev Res (Phila) 2014, 7:867-885.
2. Mihaylova MM, Shaw RJ: The AMPKsignalling pathway coordinates cell growth, autophagy, and metabolism. Nat Cell Bio 2011, 13:1016-1023.
3. Hardie DG, Alessi DR: LKB1 and AMPK and the cancer-metabolism link - ten years after. BMC Biol 2013, 11:36.
4. Foretz M, Hébrard S, Leclerc J, Zarrinpashneh E, Soty M, Mithieux G, Sakamoto K, Andreelli F, Viollet B: Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J Clin Invest 2010, 120:2355-2369.
5. Miller RA, Chu Q, Xie J, Foretz M, Viollet B, Birnbaum MJ: Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP. Nature 2013, 494:256-260.
6. Madiraju AK, Erion DM, Rahimi Y, Zhang XM, Braddock DT, Albright RA, Prigaro BJ, Wood JL, Bhanot S, MacDonald MJ, Jurczak MJ, Camporez JP, Lee HY, Cline GW, Samuel VT, Kibbey RG, Shulman GI: Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature 2014, 510:542-546.
7. Pollak MN: Investigating metformin for cancer prevention and treatment: the end of the beginning. Cancer Discov 2012, 2:778-790.
8. Shackelford DB, Abt E, Gerken L, Vasquez DS, Seki A, Leblanc M, Wei L, Fishbein MC, Czernin J, Mischel PS, Shaw RJ: LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. Cancer Cell 2013, 23:143-158.
9. Andrzejewski S, Gravel SP, Pollak M, St-Pierre J: Metformin directly acts on mitochondria to alter cellular bioenergetics. Cancer Metab 2014, 2:12.
10. Marin-Valencia I, Yang C, Mashimo T, Cho S, Baek H, Yang XL, Rajagopalan KN, Maddie M, Vemireddy V, Zhao Z, Cai L, Good L, Tu BP, Hatanpaa KJ, Mickey BE, Matés JM, Pascual JM, Maher EA, Malloy CR, Deberardinis RJ, Bachoo RM: Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo. Cell Metab 2012, 15:827-837.
11. Semenza GL: HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. J Clin Invest 2013, 123:3664-3671.
12. Wheaton WW, Weinberg SE, Hamanaka RB, Soberanes S, Sullivan LB, Anso E, Glasauer A, Dufour E, Mutlu GM, Budinger GS, Chandel NS: Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. eLife 2014, 3:e02242.
13. Tomimoto A, Endo H, Sugiyama M, Fujisawa T, Hosono K, Takahashi H, Nakajima N, Nagashima Y, Wada K, Nakagama H, Nakajima A: Metformin suppresses intestinal polyp growth in ApcMin/+mice. Cancer Sci 2008, 99:2136-2141.