SOCS1 protects protein tyrosine phosphatases by thioredoxin upregulation and attenuates Jaks to suppress ROS-mediated apoptosis

Oncogene

Volumn 28, Issue 35, 2009, Pages 3145-3156

  Oh, J ^a   Hur, M W ^b   Lee, C E ^a  

^a Sungkyunkwan University   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

Apoptosis; Jaks thioredoxin; PTPs; ROS; SOCS1

Indexed keywords

CD45 ANTIGEN; HYDROGEN PEROXIDE; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; REACTIVE OXYGEN METABOLITE; SUPPRESSOR OF CYTOKINE SIGNALING 1; THIOREDOXIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; IMMUNOPRECIPITATION; LEUKEMIA CELL LINE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SPLEEN CELL; T LYMPHOCYTE; UPREGULATION;

APOPTOSIS; CELL LINE; DEXAMETHASONE; HUMANS; HYDROGEN PEROXIDE; INTERFERON-GAMMA; JURKAT CELLS; OXIDATIVE STRESS; PROTEIN METHYLTRANSFERASES; PROTEIN TYROSINE PHOSPHATASES; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; RNA, SMALL INTERFERING; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; T-LYMPHOCYTES; THIOREDOXINS; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 69849091121     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.169     Document Type: Article

References (38)

1. Alexander WS. (2002). Suppressors of cytokine signaling (SOCS) in the immune system. Nat Rev Immunol 2: 410-416.
2. Baetz A, Koelsche C, Strebovsky J, Heeg K, Dalpke AH. (2008). Identification of a nuclear localization signal in suppressor of cytokine signaling 1. FASEB J 22: 4296-4305.
3. Barrett DM, Black SM, Todor H, Schmidt-Ullrich RK, Dawson KS, Mikkelsen RB. (2005). Inhibition of protein-tyrosine phosphatases by mild oxidative stresses is dependent on S-nitrosylation. J Biol Chem 280: 14453-14461.
4. 2-dependant MAPK pathways. J Biol Chem 279: 4292-4304.
5. Chong MM, Thomas HE, Kay TW. (2002). Suppressor of cytokine signaling-1 regulates the sensitivity of pancreatic beta cells to tumor necrosis factor. J Biol Chem 277: 27945-27952.
6. Cuncic C, Detich N, Ethier D, Tracey AS, Gresser MJ, Ramachandran C. (1999). Vanadate inhibition of protein tyrosine phosphatases in Jurkat cells: modulation by redox state. J Biol Inorg Chem 4: 354-359.
7. Dang PM, Stensballe A, Boussetta T, Raad H, Dewas C, Kroviarski Y et al. (2006). A specific p47phox-serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites. J Clin Invest 116: 2033-2043.
8. Denu JM, Tanner KG. (1998). Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: evidence for a sulfenic acid intermediate and implications for redox regulation. Biochemistry 37: 5633-5642.
9. Devadas S, Zaritskaya L, Rhee SG, Oberley L, Williams MS. (2002). Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression. J Exp Med 195: 59-70.
10. Didier C, Kerblat I, Drouet C, Favier A, Beani JC, Richard MJ. (2001). Induction of thioredoxin by ultraviolet-A radiation prevents oxidative-mediated cell death in human skin fibroblasts. Free Radic Biol Med 31: 585-598. (Pubitemid 32777859)
11. Endo TA, Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K et al. (1997). A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387: 921-924.
12. Fialkow L, Chan CK, Grinstein S, Downey GP. (1993). Regulation of tyrosine phosphorylation in neutrophils by the NADPH oxidase. Role of reactive oxygen intermediates. J Biol Chem 268: 17131-17137.
13. Han SI, Kim YS, Kim TH. (2008). Role of apoptotic and necrotic cell death under physiological conditions. J Biochem Mol Biol 41: 1-10.
14. He Y, Zhang W, Zhang R, Zhang H, Min W. (2006). SOCS1 inhibits tumor necrosis factor-induced activation of ASK1-JNK inflammatory signaling by mediating ASK1 degradation. J Biol Chem 281: 5559-5566.
15. Hsieh CC, Papaconstantinou J. (2006). Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice. FASEB J 20: 259-268.
16. Irie-Sasaki J, Sasaki T, Matsumoto W, Opavsky A, Cheng M, Welstead G et al. (2001). CD45 is a JAK phosphatase and negatively regulates cytokine receptor signaling. Nature 409: 349-354.
17. Jang JY, Lee CE. (2006). IL-4-induced upregulation of adenine nucleotide translocase 3 and its role in Th cell survival from apoptosis. Cell Immunol 241: 14-25.
18. Jeon BN, Yoo JY, Choi WI, Lee CE, Yoon HG, Hur MW. (2008). Proto-oncogene FBI-1(Pokemon/ZBTB7A) represses transcription of tumor suppressor Rb gene via binding competition with SP1 and recruitment of corepressors. J Biol Chem 283: 33199-323210.
19. Jeong SY, Seol DW. (2008). The role of mitochondria in apoptosis. J Biochem Mol Biol 41: 11-22.
20. Kim BJ, Ryu SW, Song BJ. (2006). JNK-and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells. J Biol Chem 281: 21256-21265.
21. Kim SH, Oh J, Choi JY, Jang JY, Kang MW, Lee CE. (2008). Identification of human thioredoxin as a novel IFN-gamma-induced factor: mechanism of induction and its role in cytokine production. BMC Immunol 9: 64.
22. Kimura A, Naka T, Nagata S, Kawase I, Kishimoto T. (2004). SOCS-1 suppresses TNF-alpha-induced apoptosis through the regulation of Jak activation. Int Immunol 16: 991-999.
23. Kinjyo I, Hanada T, Inagaki-Ohara K, Mori H, Aki D, Ohishi M et al. (2002). SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity 17: 583-591.
24. Kubo M, Hanada T, Yoshimura A. (2003). Suppressors of cytokine signaling and immunity. Nat Immunol 4: 1169-1176.
25. 2 regulates the activation of distinct MAPK pathways. Free Radic Biol Med 33: 1121-1132.
26. Masuhiro Y, Kayama K, Fukushima A, Baba K, Soutsu M, Kamiya Y et al. (2008). SOCS-3 inhibits E2F/DP-1 transcriptional activity and cell cycle progression via interaction with DP-1. J Biol Chem 283: 31575-31583.
27. Morita Y, Naka T, Kawazoe Y, Fujimoto M, Narazaki M, Nakagawa R et al. (2000). Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts. Proc Natl Acad Sci USA 97: 5405-5410.
28. Nakamura H, Nakamura K, Yodoi J. (1997). Redox regulation of cellular activation. Annu Rev Immunol 15: 351-369.
29. Nordberg J, Arner ES. (2001). Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. Free Radic Biol Med 31: 1287-1312.
30. Odaka C, Mizuochi T, Yang J, Ding A. (2003). Murine macrophages produce secretory leukocyte protease inhibitor during clearance of apoptotic cells: implications for resolution of the inflammatory response. J Immunol 171: 1507-1514.
31. Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K et al. (2001). Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 22: 153-183.
32. Penninger JM, Irie-Sasaki J, Sasaki T, Oliveira-dos-Santos AJ. (2001). CD45: new jobs for an old acquaintance. Nat Immunol 2: 389-396.
33. Reth M. (2002). Hydrogen peroxide as second messenger in lymphocyte activation. Nat Immunol 3: 1129-1134.
34. Rusanescu G, Yang W, Bai A, Neel BG, Feig LA. (2005). Tyrosine phosphatase SHP-2 is a mediator of activity-dependent neuronal excitotoxicity. EMBO J 24: 305-314.
35. Sparwasser T, Miethke T, Lipford G, Erdmann A, Hacker H, Heeg K et al. (1997). Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-alpha-mediated shock. Eur J Immunol 27: 1671-1679.
36. To KF, Chan MW, Leung WK, Ng EK, Yu J, Bai AH et al. (2004). Constitutional activation of IL-6-mediated JAK/STAT pathway through hypermethylation of SOCS-1 in human gastric cancer cell line. Br J Cancer 91: 1335-1341.
37. Yasukawa H, Misawa H, Sakamoto H, Masuhara M, Sasaki A, Wakioka T et al. (1999). The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J 18: 1309-1320.
38. Yoshida T, Ogata H, Kamio M, Joo A, Shiraishi H, Tokunaga Y et al. (2004). SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis. J Exp Med 199: 1701-1707.