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Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth
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This study establishes the role of ROS in downregulation of Sp transcription factors and Spregulated genes important in cancer cell proliferation, growth, and survival in bladder cancer and several other cancer cell types
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Jutooru I et al. Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth. Exp Cell Res. 2010;316(13):2174-88. This study establishes the role of ROS in downregulation of Sp transcription factors and Spregulated genes important in cancer cell proliferation, growth, and survival in bladder cancer and several other cancer cell types.
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Identification of oncogenic microRNA-17-92/ ZBTB4/specificity protein axis in breast cancer
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The authors demonstrate a novel mechanism of Sp regulation by microRNAs derived from the miR-17-92 cluster, which suppresses the expression of an Sp repressor, ZBTB4
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Kim K et al. Identification of oncogenic microRNA-17-92/ ZBTB4/specificity protein axis in breast cancer. Oncogene. 2012;31(8):1034-44. The authors demonstrate a novel mechanism of Sp regulation by microRNAs derived from the miR-17-92 cluster, which suppresses the expression of an Sp repressor, ZBTB4.
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Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG islands
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The authors demonstrate that oxidative damage can cause recruiting of silencing complexes containingDNA methyltransferases from the non-GC-rich or transcriptionally poor regions of the genome to GC-rich regions of the genome, which explains global hypomethylation that is commonly observed in cancer
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O'Hagan HM et al. Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG islands. Cancer Cell. 2011;20(5):606-19. The authors demonstrate that oxidative damage can cause recruiting of silencing complexes containingDNA methyltransferases from the non-GC-rich or transcriptionally poor regions of the genome to GC-rich regions of the genome, which explains global hypomethylation that is commonly observed in cancer.
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