AKT1E17K mutation profiling in breast cancer: Prevalence, concurrent oncogenic alterations, and blood-based detection

BMC Cancer

Volumn 16, Issue 1, 2016, Pages

  Rudolph, Marion ^a   Anzeneder, Tobias ^b   Schulz, Anke ^a   Beckmann, Georg ^a   Byrne, Annette T ^c,d   Jeffers, Michael ^d   Pena, Carol ^d   Politz, Oliver ^a   Köchert, Karl ^a   Vonk, Richardus ^a   Reischl, Joachim ^a,e  

^a BAYER PHARMA AG   (Germany)

^b Patients' Tumor Bank of Hope (PATH)   (Germany)

^c ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^d BAYER CORPORATION   (United States)

^e ASTRAZENECA R AND D   (Sweden)

Author keywords

AKT1E17K mutation; Blood based mutation detection; Breast cancer

Indexed keywords

ESTROGEN RECEPTOR; AKT1 PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PIK3CA PROTEIN, HUMAN; PROTEIN KINASE B;

ADULT; AGED; AKT1 GENE; ARTICLE; BREAST CANCER; CANCER GRADING; CANCER INCIDENCE; CANCER MORTALITY; CANCER STAGING; EXOME; FEMALE; GENE; GENE AMPLIFICATION; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCUS; GENE MUTATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; PERSONALIZED MEDICINE; POLYMERASE CHAIN REACTION; PREVALENCE; QUANTITATIVE ANALYSIS; SEQUENCE ANALYSIS; SURVIVAL TIME; BLOOD; BREAST NEOPLASMS; CARCINOGENESIS; CARCINOMA, DUCTAL, BREAST; DNA MUTATIONAL ANALYSIS; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETICS; KAPLAN MEIER METHOD; MISSENSE MUTATION; MORTALITY; PROPORTIONAL HAZARDS MODEL;

BREAST NEOPLASMS; CARCINOGENESIS; CARCINOMA, DUCTAL, BREAST; CLASS I PHOSPHATIDYLINOSITOL 3-KINASES; DNA MUTATIONAL ANALYSIS; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; KAPLAN-MEIER ESTIMATE; MUTATION, MISSENSE; PREVALENCE; PROPORTIONAL HAZARDS MODELS; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 84991666714     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/s12885-016-2626-1     Document Type: Article

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