-
1
-
-
33344462540
-
Mutation of the PIK3CA oncogene in human cancers
-
DOI 10.1038/sj.bjc.6602970
-
Karakas B, Bachman KE, Park BH. Mutation of the PIK3CA oncogene in human cancers. Br J Cancer 2006;94:455-459. (Pubitemid 43289745)
-
(2006)
British Journal of Cancer
, vol.94
, Issue.4
, pp. 455-459
-
-
Karakas, B.1
Bachman, K.E.2
Park, B.H.3
-
2
-
-
79952198405
-
The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer
-
Castaneda CA, Cortes-Funes H, Gomez HL, et al. The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer. Cancer Metastasis Rev 2010;29: 751-759.
-
(2010)
Cancer Metastasis Rev
, vol.29
, pp. 751-759
-
-
Castaneda, C.A.1
Cortes-Funes, H.2
Gomez, H.L.3
-
3
-
-
51849128358
-
Class i PI3K in oncogenic cellular transformation
-
Zhao L, Vogt PK. Class I PI3K in oncogenic cellular transformation. Oncogene 2008;27:5486-5496.
-
(2008)
Oncogene
, vol.27
, pp. 5486-5496
-
-
Zhao, L.1
Vogt, P.K.2
-
4
-
-
33746257209
-
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
-
DOI 10.1038/nrg1879, PII NRG1879
-
Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 2006;7:606-619. (Pubitemid 44100518)
-
(2006)
Nature Reviews Genetics
, vol.7
, Issue.8
, pp. 606-619
-
-
Engelman, J.A.1
Luo, J.2
Cantley, L.C.3
-
5
-
-
15044338824
-
Phosphoinositide 3-kinase in disease: Timing, location, and scaffolding
-
DOI 10.1016/j.ceb.2005.02.011, Cell Regulation
-
Wymann MP, Marone R. Phosphoinositide 3-kinase in disease: timing, location, and scaffolding. Curr Opin Cell Biol 2005;17:141-149. (Pubitemid 40380937)
-
(2005)
Current Opinion in Cell Biology
, vol.17
, Issue.2
, pp. 141-149
-
-
Wymann, M.P.1
Marone, R.2
-
6
-
-
78649706942
-
Deciphering the role of PI3K/Akt/mTOR pathway in breast cancer biology and pathogenesis
-
McAuliffe PF, Meric-Bernstam F, Mills GB, et al. Deciphering the role of PI3K/Akt/mTOR pathway in breast cancer biology and pathogenesis. Clin Breast Cancer 2010;10(Suppl 3):S59-S65.
-
(2010)
Clin Breast Cancer
, vol.10
, Issue.SUPPL. 3
-
-
McAuliffe, P.F.1
Meric-Bernstam, F.2
Mills, G.B.3
-
7
-
-
67749122122
-
Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
-
Engelman JA. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer 2009;9:550-562.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 550-562
-
-
Engelman, J.A.1
-
8
-
-
11144358645
-
High frequency of mutations of the pik3ca gene in human cancers
-
DOI 10.1126/science.1096502
-
Samuels Y,Wang Z, Bardelli A, et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 2004;304:554. (Pubitemid 38541907)
-
(2004)
Science
, vol.304
, Issue.5670
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
Silliman, N.4
Ptak, J.5
Szabo, S.6
Yan, H.7
Gazdar, A.8
Powell, S.M.9
Riggins, G.J.10
Willson, J.K.V.11
Markowitz, S.12
Kinzler, K.W.13
Vogelstein, B.14
Velculescu, V.E.15
-
9
-
-
16644393213
-
The PIK3CA gene is mutated with high frequency in human breast cancers
-
Bachman KE, Argani P, Samuels Y, et al. The PIK3CA gene is mutated with high frequency in human breast cancers. Cancer Biol Ther 2004;3:772-775. (Pubitemid 41351083)
-
(2004)
Cancer Biology and Therapy
, vol.3
, Issue.8
, pp. 772-775
-
-
Bachman, K.E.1
Argani, P.2
Samuels, Y.3
Silliman, N.4
Ptak, J.5
Szabo, S.6
Konishi, H.7
Karakas, B.8
Blair, B.G.9
Lin, C.10
Peters, B.A.11
Velculescu, V.E.12
Park, B.H.13
-
10
-
-
84863447451
-
PIK3CA/AKT1 mutations in breast carcinoma: A comprehensive review of experimental and clinical studies
-
doi: 10.4172/2161-0681.S1-002
-
Troxell ML. PIK3CA/AKT1 mutations in breast carcinoma: a comprehensive review of experimental and clinical studies. J Clin Exp Pathol 2012; doi: 10.4172/2161-0681.S1-002.
-
(2012)
J Clin Exp Pathol
-
-
Troxell, M.L.1
-
11
-
-
34547172596
-
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
-
DOI 10.1038/nature05933, PII NATURE05933
-
Carpten JD, Faber AL, Horn C, et al. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 2007;448:439-444. (Pubitemid 47123510)
-
(2007)
Nature
, vol.448
, Issue.7152
, pp. 439-444
-
-
Carpten, J.D.1
Faber, A.L.2
Horn, C.3
Donoho, G.P.4
Briggs, S.L.5
Robbins, C.M.6
Hostetter, G.7
Boguslawski, S.8
Moses, T.Y.9
Savage, S.10
Uhlik, M.11
Lin, A.12
Du, J.13
Qian, Y.-W.14
Zeckner, D.J.15
Tucker-Kellogg, G.16
Touchman, J.17
Patel, K.18
Mousses, S.19
Bittner, M.20
Schevitz, R.21
Lai, M.-H.T.22
Blanchard, K.L.23
Thomas, J.E.24
more..
-
12
-
-
77950691967
-
Phosphatidylinositol-3-kinase and AKT1 mutations occur early in breast carcinoma
-
Dunlap J, Le C, Shukla A, et al. Phosphatidylinositol-3-kinase and AKT1 mutations occur early in breast carcinoma. Breast Cancer Res Treat 2010;120:409-418.
-
(2010)
Breast Cancer Res Treat
, vol.120
, pp. 409-418
-
-
Dunlap, J.1
Le Shukla C, A.2
-
13
-
-
74749101634
-
PIK3CA mutations mostly begin to develop in ductal carcinoma of the breast
-
Li H, Zhu R, Wang L, et al. PIK3CA mutations mostly begin to develop in ductal carcinoma of the breast. Exp Mol Pathol 2010;88:150-155.
-
(2010)
Exp Mol Pathol
, vol.88
, pp. 150-155
-
-
Li, H.1
Zhu, R.2
Wang, L.3
-
14
-
-
77955043615
-
PIK3CA mutations in in situ and invasive breast carcinomas
-
Miron A, Varadi M, Carrasco D, et al. PIK3CA mutations in in situ and invasive breast carcinomas. Cancer Res 2010;70:5674-5678.
-
(2010)
Cancer Res
, vol.70
, pp. 5674-5678
-
-
Miron, A.1
Varadi, M.2
Carrasco, D.3
-
15
-
-
80955181019
-
PIK3CA mutations rarely demonstrate genotypic intratumoral heterogeneity and are selected for in breast cancer progression
-
Kalinsky K, Heguy A, Bhanot UK, et al. PIK3CA mutations rarely demonstrate genotypic intratumoral heterogeneity and are selected for in breast cancer progression. Breast Cancer Res Treat 2011;129:635-643.
-
(2011)
Breast Cancer Res Treat
, vol.129
, pp. 635-643
-
-
Kalinsky, K.1
Heguy, A.2
Bhanot, U.K.3
-
16
-
-
73949156234
-
High prevalence of PIK3CA/AKT pathway mutations in papillary neoplasms of the breast
-
Troxell ML, Levine J, Beadling C, et al. High prevalence of PIK3CA/AKT pathway mutations in papillary neoplasms of the breast. Mod Pathol 2010;23: 27-37.
-
(2010)
Mod Pathol
, vol.23
, pp. 27-37
-
-
Troxell, M.L.1
Levine, J.2
Beadling, C.3
-
18
-
-
34247604611
-
High frequency of coexistence of columnar cell lesions, lobular neoplasia, and low grade ductal carcinoma in situ with invasive tubular carcinoma and invasive lobular carcinoma
-
DOI 10.1097/01.pas.0000213368.41251.b9, PII 0000047820070300000011
-
Abdel-Fatah TM, Powe DG, Hodi Z, et al. High frequency of coexistence of columnar cell lesions, lobular neoplasia, and low grade ductal carcinoma in situ with invasive tubular carcinoma and invasive lobular carcinoma. Am J Surg Pathol 2007;31: 417-426. (Pubitemid 46673116)
-
(2007)
American Journal of Surgical Pathology
, vol.31
, Issue.3
, pp. 417-426
-
-
Abdel-Fatah, T.M.A.1
Powe, D.G.2
Hodi, Z.3
Lee, A.H.S.4
Reis-Filho, J.S.5
Ellis, I.O.6
-
19
-
-
67049155832
-
Flat ductal intraepithelial neoplasia of the breast: A review of diagnostic criteria, differential diagnoses, molecular-genetic findings, and clinical relevance-it is time to appreciate the Azzopardi concept!
-
Moinfar F. Flat ductal intraepithelial neoplasia of the breast: a review of diagnostic criteria, differential diagnoses, molecular-genetic findings, and clinical relevance-it is time to appreciate the Azzopardi concept!. Arch Pathol Lab Med 2009;133:879-892.
-
(2009)
Arch Pathol Lab Med
, vol.133
, pp. 879-892
-
-
Moinfar, F.1
-
21
-
-
1842509066
-
Flat epithelial atypia
-
Tavassoli F, Devilee P (eds) Vol. IARC Press: Lyon
-
Tavassoli F, Hoefler H, Rosai J, et al. Flat epithelial atypia. In: Tavassoli F, Devilee P (eds). Tumous of the Breast and Female Genital Organs Vol. IARC Press: Lyon, 2003, pp 65-66.
-
(2003)
Tumous of the Breast and Female Genital Organs
, pp. 65-66
-
-
Tavassoli, F.1
Hoefler, H.2
Rosai, J.3
-
22
-
-
0034192211
-
Genetic abnormalities in mammary ductal intraepithelial neoplasia-flat type ('clinging ductal carcinoma in situ'): A simulator of normal mammary epithelium
-
DOI 10.1002/(SICI)1097-0142 (20000501)88:9<2072::AID-CNCR13>3.0. CO;2-H
-
Moinfar F, Man YG, Bratthauer GL, et al. Genetic abnormalities in mammary ductal intraepithelial neoplasia-flat type (00clinging ductal carcinoma in situ00): a simulator of normal mammary epithelium. Cancer 2000;88:2072-2081. (Pubitemid 30233209)
-
(2000)
Cancer
, vol.88
, Issue.9
, pp. 2072-2081
-
-
Moinfar, F.1
Man, Y.-G.2
Bratthauer, G.L.3
Ratschek, M.4
Tavassoli, F.A.5
-
23
-
-
0043155851
-
The diagnosis and management of pre-invasive breast disease: Genetic alterations in pre-invasive lesions
-
Reis-Filho JS, Lakhani SR. The diagnosis and management of pre-invasive breast disease: genetic alterations in pre-invasive lesions. Breast Cancer Res 2003;5:313-319.
-
(2003)
Breast Cancer Res
, vol.5
, pp. 313-319
-
-
Reis-Filho, J.S.1
Lakhani, S.R.2
-
24
-
-
21144447899
-
Columnar cell lesions of the breast: The missing link in breast cancer progression? A morphological and molecular analysis
-
DOI 10.1097/01.pas.0000157295.93914.3b
-
Simpson PT, Gale T, Reis-Filho JS, et al. Columnar cell lesions of the breast: the missing link in breast cancer progression? A morphological and molecular analysis. Am J Surg Pathol 2005;29:734-746. (Pubitemid 40734423)
-
(2005)
American Journal of Surgical Pathology
, vol.29
, Issue.6
, pp. 734-746
-
-
Simpson, P.T.1
Gale, T.2
Reis-Filho, J.S.3
Jones, C.4
Parry, S.5
Sloane, J.P.6
Hanby, A.7
Pinder, S.E.8
Lee, A.H.S.9
Humphreys, S.10
Ellis, I.O.11
Lakhani, S.R.12
-
25
-
-
33244461701
-
Molecular alterations in columnar cell lesions of the breast
-
DOI 10.1038/modpathol.3800538, PII 3800538
-
Dabbs DJ, Carter G, Fudge M, et al. Molecular alterations in columnar cell lesions of the breast. Mod Pathol 2006;19:344-349. (Pubitemid 43276987)
-
(2006)
Modern Pathology
, vol.19
, Issue.3
, pp. 344-349
-
-
Dabbs, D.J.1
Carter, G.2
Fudge, M.3
Peng, Y.4
Swalsky, P.5
Finkelstein, S.6
-
26
-
-
41449084759
-
Morphologic and molecular evolutionary pathways of low nuclear grade invasive breast cancers and their putative precursor lesions: Further evidence to support the concept of low nuclear grade breast neoplasia family
-
DOI 10.1097/PAS.0b013e318161d1a5, PII 0000047820080400000003
-
Abdel-Fatah TM, Powe DG, Hodi Z, et al. Morphologic and molecular evolutionary pathways of low nuclear grade invasive breast cancers and their putative precursor lesions: further evidence to support the concept of low nuclear grade breast neoplasia family. Am J Surg Pathol 2008;32:513-523. (Pubitemid 351458293)
-
(2008)
American Journal of Surgical Pathology
, vol.32
, Issue.4
, pp. 513-523
-
-
Abdel-Fatah, T.M.A.1
Powe, D.G.2
Hodi, Z.3
Reis-Filho, J.S.4
Lee, A.H.S.5
Ellis, I.O.6
-
27
-
-
77954819026
-
Chromosomal alterations in pure nonneoplastic breast lesions: Implications for breast cancer progression
-
Ellsworth RE, Ellsworth DL, Weyandt JD, et al. Chromosomal alterations in pure nonneoplastic breast lesions: implications for breast cancer progression. Ann Surg Oncol 2010;17:1688-1694.
-
(2010)
Ann Surg Oncol
, vol.17
, pp. 1688-1694
-
-
Ellsworth, R.E.1
Ellsworth, D.L.2
Weyandt, J.D.3
-
28
-
-
80053307108
-
Chromosomal aberrations as detected by array comparative genomic hybridization in early low-grade intraepithelial neoplasias of the breast
-
Stacher E, Boldt V, Leibl S, et al. Chromosomal aberrations as detected by array comparative genomic hybridization in early low-grade intraepithelial neoplasias of the breast. Histopathology 2011;59:549-555.
-
(2011)
Histopathology
, vol.59
, pp. 549-555
-
-
Stacher, E.1
Boldt, V.2
Leibl, S.3
-
29
-
-
82655176916
-
Multiplex mutation screening by mass spectrometry evaluation of 820 cases from a personalized cancer medicine registry
-
Beadling C, Heinrich MC, Warrick A, et al. Multiplex mutation screening by mass spectrometry evaluation of 820 cases from a personalized cancer medicine registry. J Mol Diagn 2011;13:504-513.
-
(2011)
J Mol Diagn
, vol.13
, pp. 504-513
-
-
Beadling, C.1
Heinrich, M.C.2
Warrick, A.3
-
30
-
-
7444250290
-
Mutation of the PIK3CA gene in ovarian and breast cancer
-
DOI 10.1158/0008-5472.CAN-04-2933
-
Campbell IG, Russell SE, Choong DY, et al. Mutation of the PIK3CA gene in ovarian and breast cancer. Cancer Res 2004;64:7678-7681. (Pubitemid 39446895)
-
(2004)
Cancer Research
, vol.64
, Issue.21
, pp. 7678-7681
-
-
Campbell, I.G.1
Russell, S.E.2
Choong, D.Y.H.3
Montgomery, K.G.4
Ciavarella, M.L.5
Hooi, C.S.F.6
Cristiano, B.E.7
Pearson, R.B.8
Phillips, W.A.9
-
31
-
-
33645224005
-
PIK3CA mutations in breast cancer are associated with poor outcome
-
Li SY, Rong M, Grieu F, et al. PIK3CA mutations in breast cancer are associated with poor outcome. Breast Cancer Res Treat 2006;96:91-95.
-
(2006)
Breast Cancer Res Treat
, vol.96
, pp. 91-95
-
-
Li, S.Y.1
Rong, M.2
Grieu, F.3
-
32
-
-
51049118140
-
An integrative genomic and proteomic analysis of PIK3CA PTEN, and AKT mutations in breast cancer
-
Stemke-Hale K, Gonzalez-Angulo AM, Lluch A, et al. An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Res 2008;68:6084-6091.
-
(2008)
Cancer Res
, vol.68
, pp. 6084-6091
-
-
Stemke-Hale, K.1
Gonzalez-Angulo, A.M.2
Lluch, A.3
-
33
-
-
66249109653
-
Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics
-
Hennessy BT, Gonzalez-Angulo AM, Stemke-Hale K, et al. Characterization of a naturally occurring breast cancer subset enriched in epithelial-to- mesenchymal transition and stem cell characteristics. Cancer Res 2009;69:4116-4124.
-
(2009)
Cancer Res
, vol.69
, pp. 4116-4124
-
-
Hennessy, B.T.1
Gonzalez-Angulo, A.M.2
Stemke-Hale, K.3
-
34
-
-
32244445352
-
PIK3CA mutation and histological type in breast carcinoma: High frequency of mutations in lobular carcinoma
-
DOI 10.1002/path.1908
-
Buttitta F, Felicioni L, Barassi F, et al. PIK3CA mutation and histological type in breast carcinoma: high frequency of mutations in lobular carcinoma. J Pathol 2006;208:350-355. (Pubitemid 43210521)
-
(2006)
Journal of Pathology
, vol.208
, Issue.3
, pp. 350-355
-
-
Buttitta, F.1
Felicioni, L.2
Barassi, F.3
Martella, C.4
Paolizzi, D.5
Fresu, G.6
Salvatore, S.7
Cuccurullo, F.8
Mezzetti, A.9
Campani, D.10
Marchetti, A.11
-
35
-
-
33646814055
-
Mutational hotspot in exon 20 of PIK3CA in breast cancer among Singapore Chinese
-
Liang X, Lau QC, Salto-Tellez M, et al. Mutational hotspot in exon 20 of PIK3CA in breast cancer among Singapore Chinese. Cancer Biol Ther 2006;5:544-548. (Pubitemid 43765291)
-
(2006)
Cancer Biology and Therapy
, vol.5
, Issue.5
, pp. 544-548
-
-
Liang, X.1
Quek, C.L.2
Salto-Tellez, M.3
Putti, T.C.4
Loh, M.5
Sukumar, S.6
-
36
-
-
33846854921
-
Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women
-
DOI 10.1158/1078-0432.CCR-06-0267
-
Maruyama N, Miyoshi Y, Taguchi T, et al. Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women. Clin Cancer Res 2007;13:408-414. (Pubitemid 46225343)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.2
, pp. 408-414
-
-
Maruyama, N.1
Miyoshi, Y.2
Taguchi, T.3
Tamaki, Y.4
Monden, M.5
Noguchi, S.6
-
37
-
-
34250749822
-
PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer
-
DOI 10.1158/1078-0432.CCR-06-1609
-
Perez-Tenorio G, Alkhori L, Olsson B, et al. PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer. Clin Cancer Res 2007;13:3577-3584. (Pubitemid 46955118)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.12
, pp. 3577-3584
-
-
Perez-Tenorio, G.1
Alkhori, L.2
Olsson, B.3
Waltersson, M.A.4
Nordenskjold, B.5
Rutqvist, L.E.6
Skoog, L.7
Stal, O.8
-
38
-
-
38949133202
-
PIK3CA cancer mutations display gender and tissue specificity patterns
-
DOI 10.1002/humu.20648
-
Benvenuti S, Frattini M, Arena S, et al. PIK3CA cancer mutations display gender and tissue specificity patterns. Hum Mutat 2008;29:284-288. (Pubitemid 351240601)
-
(2008)
Human Mutation
, vol.29
, Issue.2
, pp. 284-288
-
-
Benvenuti, S.1
Frattini, M.2
Arena, S.3
Zanon, C.4
Cappelletti, V.5
Coradini, D.6
Daidone, M.G.7
Pilotti, S.8
Pierotti, M.A.9
Bardelli, A.10
-
39
-
-
77953422867
-
PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptorpositive breast cancer
-
Loi S, Haibe-Kains B, Majjaj S, et al. PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptorpositive breast cancer. Proc Natl Acad Sci USA 2010;107:10208-10213.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 10208-10213
-
-
Loi, S.1
Haibe-Kains, B.2
Majjaj, S.3
-
40
-
-
74849112055
-
Phosphatidylinositol-3-kinase alpha catalytic subunit mutation and response to neoadjuvant endocrine therapy for estrogen receptor positive breast cancer
-
Ellis MJ, Lin L, Crowder R, et al. Phosphatidylinositol-3-kinase alpha catalytic subunit mutation and response to neoadjuvant endocrine therapy for estrogen receptor positive breast cancer. Breast Cancer Res Treat 2010;119:379-390.
-
(2010)
Breast Cancer Res Treat
, vol.119
, pp. 379-390
-
-
Ellis, M.J.1
Lin, L.2
Crowder, R.3
-
41
-
-
77957603427
-
Alterations in p53, BRCA1, ATM, PIK3CA, and HER2 genes and their effect in modifying clinicopathological characteristics and overall survival of Bulgarian patients with breast cancer
-
Bozhanov SS, Angelova SG, Krasteva ME, et al. Alterations in p53, BRCA1, ATM, PIK3CA, and HER2 genes and their effect in modifying clinicopathological characteristics and overall survival of Bulgarian patients with breast cancer. J Cancer Res Clin Oncol 2010;136:1657-1669.
-
(2010)
J Cancer Res Clin Oncol
, vol.136
, pp. 1657-1669
-
-
Bozhanov, S.S.1
Angelova, S.G.2
Krasteva, M.E.3
-
42
-
-
84857921336
-
Mutational characterization of individual breast tumors: TP53 and PI3K pathway genes are frequently and distinctively mutated in different subtypes
-
Boyault S, Drouet Y, Navarro C, et al. Mutational characterization of individual breast tumors: TP53 and PI3K pathway genes are frequently and distinctively mutated in different subtypes. Breast Cancer Res Treat 2011;132:29-39.
-
(2011)
Breast Cancer Res Treat
, vol.132
, pp. 29-39
-
-
Boyault, S.1
Drouet, Y.2
Navarro, C.3
-
43
-
-
78651233471
-
Gene expression profiling reveals new aspects of PIK3CA mutation in ERalpha-positive breast cancer: Major implication of the Wnt signaling pathway
-
Cizkova M, Cizeron-Clairac G, Vacher S, et al. Gene expression profiling reveals new aspects of PIK3CA mutation in ERalpha-positive breast cancer: major implication of the Wnt signaling pathway. PLoS One 2010;5:e15647.
-
(2010)
PLoS One
, vol.5
-
-
Cizkova, M.1
Cizeron-Clairac, G.2
Vacher, S.3
-
44
-
-
69349105634
-
PIK3CA mutation associates with improved outcome in breast cancer
-
Kalinsky K, Jacks LM, Heguy A, et al. PIK3CA mutation associates with improved outcome in breast cancer. Clin Cancer Res 2009;15:5049-5059.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5049-5059
-
-
Kalinsky, K.1
Jacks, L.M.2
Heguy, A.3
-
45
-
-
79951834210
-
PIK3CA mutations may be discordant between primary and corresponding metastatic disease in breast cancer
-
Dupont Jensen J, Laenkholm AV, Knoop A, et al. PIK3CA mutations may be discordant between primary and corresponding metastatic disease in breast cancer. Clin Cancer Res 2011;17:667-677.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 667-677
-
-
Dupont Jensen, J.1
Laenkholm, A.V.2
Knoop, A.3
-
46
-
-
77956839940
-
PIK3CA hotspot mutation scanning by a novel and highly sensitive high-resolution small amplicon melting analysis method
-
Vorkas PA, Poumpouridou N, Agelaki S, et al. PIK3CA hotspot mutation scanning by a novel and highly sensitive high-resolution small amplicon melting analysis method. J Mol Diagn 2010;12: 697-704.
-
(2010)
J Mol Diagn
, vol.12
, pp. 697-704
-
-
Vorkas, P.A.1
Poumpouridou, N.2
Agelaki, S.3
-
47
-
-
79952259564
-
Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay
-
Arcila ME, Oxnard GR, Nafa K, et al. Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay. Clin Cancer Res 2011;17:1169-1180.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 1169-1180
-
-
Arcila, M.E.1
Oxnard, G.R.2
Nafa, K.3
-
48
-
-
79958728268
-
PI3K pathway mutations and PTEN levels in primary and metastatic breast cancer
-
Gonzalez-Angulo AM, Ferrer-Lozano J, Stemke-Hale K, et al. PI3K pathway mutations and PTEN levels in primary and metastatic breast cancer. Mol Cancer Ther 2011;10:1093-1101.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 1093-1101
-
-
Gonzalez-Angulo, A.M.1
Ferrer-Lozano, J.2
Stemke-Hale, K.3
-
49
-
-
0023748414
-
Genetic alterations during colorectal-tumor development
-
Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988;319:525-532.
-
(1988)
N Engl J Med
, vol.319
, pp. 525-532
-
-
Vogelstein, B.1
Fearon, E.R.2
Hamilton, S.R.3
-
50
-
-
36248962105
-
The genomic landscapes of human breast and colorectal cancers
-
DOI 10.1126/science.1145720
-
Wood LD, Parsons DW, Jones S, et al. The genomic landscapes of human breast and colorectal cancers. Science 2007;318:1108-1113. (Pubitemid 350134889)
-
(2007)
Science
, vol.318
, Issue.5853
, pp. 1108-1113
-
-
Wood, L.D.1
Parsons, D.W.2
Jones, S.3
Lin, J.4
Sjoblom, T.5
Leary, R.J.6
Shen, D.7
Boca, S.M.8
Barber, T.9
Ptak, J.10
Silliman, N.11
Szabo, S.12
Dezso, Z.13
Ustyanksky, V.14
Nikolskaya, T.15
Nikolsky, Y.16
Karchin, R.17
Wilson, P.A.18
Kaminker, J.S.19
Zhang, Z.20
Croshaw, R.21
Willis, J.22
Dawson, D.23
Shipitsin, M.24
Willson, J.K.V.25
Sukumar, S.26
Polyak, K.27
Ben, H.P.28
Pethiyagoda, C.L.29
Pant, P.V.K.30
Ballinger, D.G.31
Sparks, A.B.32
Hartigan, J.33
Smith, D.R.34
Suh, E.35
Papadopoulos, N.36
Buckhaults, P.37
Markowitz, S.D.38
Parmigiani, G.39
Kinzler, K.W.40
Velculescu, V.E.41
Vogelstein, B.42
more..
-
51
-
-
0038137601
-
Gene expression profiles of human breast cancer progression
-
DOI 10.1073/pnas.0931261100
-
Ma XJ, Salunga R, Tuggle JT, et al. Gene expression profiles of human breast cancer progression. Proc Natl Acad Sci USA 2003;100:5974-5979. (Pubitemid 36576916)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.10
, pp. 5974-5979
-
-
Ma, X.-J.1
Salunga, R.2
Tuggle, J.T.3
Gaudet, J.4
Enright, E.5
McQuary, P.6
Payette, T.7
Pistone, M.8
Stecker, K.9
Zhang, B.M.10
Zhou, Y.-X.11
Varnholt, H.12
Smith, B.13
Gadd, M.14
Chatfield, E.15
Kessler, J.16
Baer, T.M.17
Erlander, M.G.18
Sgroi, D.C.19
-
52
-
-
24944505221
-
Premalignant and in situ breast disease: Biology and clinical implications
-
Arpino G, Laucirica R, Elledge RM. Premalignant and in situ breast disease: biology and clinical implications. Ann Intern Med 2005;143:446-457. (Pubitemid 41338942)
-
(2005)
Annals of Internal Medicine
, vol.143
, Issue.6
, pp. 446-457
-
-
Arpino, G.1
Laucirica, R.2
Elledge, R.M.3
-
53
-
-
35148885729
-
A Functional Genetic Approach Identifies the PI3K Pathway as a Major Determinant of Trastuzumab Resistance in Breast Cancer
-
DOI 10.1016/j.ccr.2007.08.030, PII S1535610807002620
-
Berns K, Horlings HM, Hennessy BT, et al. A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell 2007;12:395-402. (Pubitemid 47539306)
-
(2007)
Cancer Cell
, vol.12
, Issue.4
, pp. 395-402
-
-
Berns, K.1
Horlings, H.M.2
Hennessy, B.T.3
Madiredjo, M.4
Hijmans, E.M.5
Beelen, K.6
Linn, S.C.7
Gonzalez-Angulo, A.M.8
Stemke-Hale, K.9
Hauptmann, M.10
Beijersbergen, R.L.11
Mills, G.B.12
Van de Vijver, M.J.13
Bernards, R.14
-
54
-
-
35148854641
-
PI3 Kinase Activation and Response to Trastuzumab Therapy: What's neu with Herceptin Resistance?
-
DOI 10.1016/j.ccr.2007.10.004, PII S1535610807002735
-
Park BH, Davidson NE. PI3 kinase activation and response to Trastuzumab Therapy: what0s neu with herceptin resistance? Cancer Cell 2007;12:297-299. (Pubitemid 47539315)
-
(2007)
Cancer Cell
, vol.12
, Issue.4
, pp. 297-299
-
-
Park, B.H.1
Davidson, N.E.2
-
55
-
-
33646712747
-
Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer
-
DOI 10.1038/ncponc0509, PII N0509
-
Nahta R, Yu D, Hung MC, et al. Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol 2006;3: 269-280. (Pubitemid 43731112)
-
(2006)
Nature Clinical Practice Oncology
, vol.3
, Issue.5
, pp. 269-280
-
-
Nahta, R.1
Yu, D.2
Hung, M.-C.3
Hortobagyi, G.N.4
Esteva, F.J.5
-
56
-
-
77953411708
-
Activated phosphoinositide 3-kinase/AKT signaling confers resistance to trastuzumab but not lapatinib
-
O0Brien NA, Browne BC, Chow L, et al. Activated phosphoinositide 3-kinase/AKT signaling confers resistance to trastuzumab but not lapatinib. Mol Cancer Ther 2010;9:1489-1502.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 1489-1502
-
-
Brien, N.A.1
Browne, B.C.2
Chow, L.3
-
57
-
-
69349093749
-
Phosphoinositide 3-kinase mutations in breast cancer: A 00good00 activating mutation?
-
Di Cosimo S, Baselga J. Phosphoinositide 3-kinase mutations in breast cancer: a 00good00 activating mutation? Clin Cancer Res 2009;15:5017-5019.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5017-5019
-
-
Di Cosimo, S.1
Baselga, J.2
-
58
-
-
80052490834
-
Oncogenic PIK3CAdriven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms
-
Liu P, Cheng H, Santiago S, et al. Oncogenic PIK3CAdriven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms. Nat Med 2011;17:1116-1120.
-
(2011)
Nat Med
, vol.17
, pp. 1116-1120
-
-
Liu, P.1
Cheng, H.2
Santiago, S.3
|