메뉴 건너뛰기




Volumn 25, Issue 7, 2012, Pages 930-937

Phosphatidylinositol-3-kinase pathway mutations are common in breast columnar cell lesions

Author keywords

breast cancer; columnar cell lesion; PIK3CA

Indexed keywords

DNA; FORMALDEHYDE; PARAFFIN; PHOSPHATIDYLINOSITOL 3 KINASE;

EID: 84863441069     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2012.55     Document Type: Article
Times cited : (38)

References (58)
  • 1
    • 33344462540 scopus 로고    scopus 로고
    • Mutation of the PIK3CA oncogene in human cancers
    • DOI 10.1038/sj.bjc.6602970
    • Karakas B, Bachman KE, Park BH. Mutation of the PIK3CA oncogene in human cancers. Br J Cancer 2006;94:455-459. (Pubitemid 43289745)
    • (2006) British Journal of Cancer , vol.94 , Issue.4 , pp. 455-459
    • Karakas, B.1    Bachman, K.E.2    Park, B.H.3
  • 2
    • 79952198405 scopus 로고    scopus 로고
    • The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer
    • Castaneda CA, Cortes-Funes H, Gomez HL, et al. The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer. Cancer Metastasis Rev 2010;29: 751-759.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 751-759
    • Castaneda, C.A.1    Cortes-Funes, H.2    Gomez, H.L.3
  • 3
    • 51849128358 scopus 로고    scopus 로고
    • Class i PI3K in oncogenic cellular transformation
    • Zhao L, Vogt PK. Class I PI3K in oncogenic cellular transformation. Oncogene 2008;27:5486-5496.
    • (2008) Oncogene , vol.27 , pp. 5486-5496
    • Zhao, L.1    Vogt, P.K.2
  • 4
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • DOI 10.1038/nrg1879, PII NRG1879
    • Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 2006;7:606-619. (Pubitemid 44100518)
    • (2006) Nature Reviews Genetics , vol.7 , Issue.8 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 5
    • 15044338824 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase in disease: Timing, location, and scaffolding
    • DOI 10.1016/j.ceb.2005.02.011, Cell Regulation
    • Wymann MP, Marone R. Phosphoinositide 3-kinase in disease: timing, location, and scaffolding. Curr Opin Cell Biol 2005;17:141-149. (Pubitemid 40380937)
    • (2005) Current Opinion in Cell Biology , vol.17 , Issue.2 , pp. 141-149
    • Wymann, M.P.1    Marone, R.2
  • 6
    • 78649706942 scopus 로고    scopus 로고
    • Deciphering the role of PI3K/Akt/mTOR pathway in breast cancer biology and pathogenesis
    • McAuliffe PF, Meric-Bernstam F, Mills GB, et al. Deciphering the role of PI3K/Akt/mTOR pathway in breast cancer biology and pathogenesis. Clin Breast Cancer 2010;10(Suppl 3):S59-S65.
    • (2010) Clin Breast Cancer , vol.10 , Issue.SUPPL. 3
    • McAuliffe, P.F.1    Meric-Bernstam, F.2    Mills, G.B.3
  • 7
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
    • Engelman JA. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer 2009;9:550-562.
    • (2009) Nat Rev Cancer , vol.9 , pp. 550-562
    • Engelman, J.A.1
  • 10
    • 84863447451 scopus 로고    scopus 로고
    • PIK3CA/AKT1 mutations in breast carcinoma: A comprehensive review of experimental and clinical studies
    • doi: 10.4172/2161-0681.S1-002
    • Troxell ML. PIK3CA/AKT1 mutations in breast carcinoma: a comprehensive review of experimental and clinical studies. J Clin Exp Pathol 2012; doi: 10.4172/2161-0681.S1-002.
    • (2012) J Clin Exp Pathol
    • Troxell, M.L.1
  • 12
    • 77950691967 scopus 로고    scopus 로고
    • Phosphatidylinositol-3-kinase and AKT1 mutations occur early in breast carcinoma
    • Dunlap J, Le C, Shukla A, et al. Phosphatidylinositol-3-kinase and AKT1 mutations occur early in breast carcinoma. Breast Cancer Res Treat 2010;120:409-418.
    • (2010) Breast Cancer Res Treat , vol.120 , pp. 409-418
    • Dunlap, J.1    Le Shukla C, A.2
  • 13
    • 74749101634 scopus 로고    scopus 로고
    • PIK3CA mutations mostly begin to develop in ductal carcinoma of the breast
    • Li H, Zhu R, Wang L, et al. PIK3CA mutations mostly begin to develop in ductal carcinoma of the breast. Exp Mol Pathol 2010;88:150-155.
    • (2010) Exp Mol Pathol , vol.88 , pp. 150-155
    • Li, H.1    Zhu, R.2    Wang, L.3
  • 14
    • 77955043615 scopus 로고    scopus 로고
    • PIK3CA mutations in in situ and invasive breast carcinomas
    • Miron A, Varadi M, Carrasco D, et al. PIK3CA mutations in in situ and invasive breast carcinomas. Cancer Res 2010;70:5674-5678.
    • (2010) Cancer Res , vol.70 , pp. 5674-5678
    • Miron, A.1    Varadi, M.2    Carrasco, D.3
  • 15
    • 80955181019 scopus 로고    scopus 로고
    • PIK3CA mutations rarely demonstrate genotypic intratumoral heterogeneity and are selected for in breast cancer progression
    • Kalinsky K, Heguy A, Bhanot UK, et al. PIK3CA mutations rarely demonstrate genotypic intratumoral heterogeneity and are selected for in breast cancer progression. Breast Cancer Res Treat 2011;129:635-643.
    • (2011) Breast Cancer Res Treat , vol.129 , pp. 635-643
    • Kalinsky, K.1    Heguy, A.2    Bhanot, U.K.3
  • 16
    • 73949156234 scopus 로고    scopus 로고
    • High prevalence of PIK3CA/AKT pathway mutations in papillary neoplasms of the breast
    • Troxell ML, Levine J, Beadling C, et al. High prevalence of PIK3CA/AKT pathway mutations in papillary neoplasms of the breast. Mod Pathol 2010;23: 27-37.
    • (2010) Mod Pathol , vol.23 , pp. 27-37
    • Troxell, M.L.1    Levine, J.2    Beadling, C.3
  • 18
    • 34247604611 scopus 로고    scopus 로고
    • High frequency of coexistence of columnar cell lesions, lobular neoplasia, and low grade ductal carcinoma in situ with invasive tubular carcinoma and invasive lobular carcinoma
    • DOI 10.1097/01.pas.0000213368.41251.b9, PII 0000047820070300000011
    • Abdel-Fatah TM, Powe DG, Hodi Z, et al. High frequency of coexistence of columnar cell lesions, lobular neoplasia, and low grade ductal carcinoma in situ with invasive tubular carcinoma and invasive lobular carcinoma. Am J Surg Pathol 2007;31: 417-426. (Pubitemid 46673116)
    • (2007) American Journal of Surgical Pathology , vol.31 , Issue.3 , pp. 417-426
    • Abdel-Fatah, T.M.A.1    Powe, D.G.2    Hodi, Z.3    Lee, A.H.S.4    Reis-Filho, J.S.5    Ellis, I.O.6
  • 19
    • 67049155832 scopus 로고    scopus 로고
    • Flat ductal intraepithelial neoplasia of the breast: A review of diagnostic criteria, differential diagnoses, molecular-genetic findings, and clinical relevance-it is time to appreciate the Azzopardi concept!
    • Moinfar F. Flat ductal intraepithelial neoplasia of the breast: a review of diagnostic criteria, differential diagnoses, molecular-genetic findings, and clinical relevance-it is time to appreciate the Azzopardi concept!. Arch Pathol Lab Med 2009;133:879-892.
    • (2009) Arch Pathol Lab Med , vol.133 , pp. 879-892
    • Moinfar, F.1
  • 22
    • 0034192211 scopus 로고    scopus 로고
    • Genetic abnormalities in mammary ductal intraepithelial neoplasia-flat type ('clinging ductal carcinoma in situ'): A simulator of normal mammary epithelium
    • DOI 10.1002/(SICI)1097-0142 (20000501)88:9<2072::AID-CNCR13>3.0. CO;2-H
    • Moinfar F, Man YG, Bratthauer GL, et al. Genetic abnormalities in mammary ductal intraepithelial neoplasia-flat type (00clinging ductal carcinoma in situ00): a simulator of normal mammary epithelium. Cancer 2000;88:2072-2081. (Pubitemid 30233209)
    • (2000) Cancer , vol.88 , Issue.9 , pp. 2072-2081
    • Moinfar, F.1    Man, Y.-G.2    Bratthauer, G.L.3    Ratschek, M.4    Tavassoli, F.A.5
  • 23
    • 0043155851 scopus 로고    scopus 로고
    • The diagnosis and management of pre-invasive breast disease: Genetic alterations in pre-invasive lesions
    • Reis-Filho JS, Lakhani SR. The diagnosis and management of pre-invasive breast disease: genetic alterations in pre-invasive lesions. Breast Cancer Res 2003;5:313-319.
    • (2003) Breast Cancer Res , vol.5 , pp. 313-319
    • Reis-Filho, J.S.1    Lakhani, S.R.2
  • 26
    • 41449084759 scopus 로고    scopus 로고
    • Morphologic and molecular evolutionary pathways of low nuclear grade invasive breast cancers and their putative precursor lesions: Further evidence to support the concept of low nuclear grade breast neoplasia family
    • DOI 10.1097/PAS.0b013e318161d1a5, PII 0000047820080400000003
    • Abdel-Fatah TM, Powe DG, Hodi Z, et al. Morphologic and molecular evolutionary pathways of low nuclear grade invasive breast cancers and their putative precursor lesions: further evidence to support the concept of low nuclear grade breast neoplasia family. Am J Surg Pathol 2008;32:513-523. (Pubitemid 351458293)
    • (2008) American Journal of Surgical Pathology , vol.32 , Issue.4 , pp. 513-523
    • Abdel-Fatah, T.M.A.1    Powe, D.G.2    Hodi, Z.3    Reis-Filho, J.S.4    Lee, A.H.S.5    Ellis, I.O.6
  • 27
    • 77954819026 scopus 로고    scopus 로고
    • Chromosomal alterations in pure nonneoplastic breast lesions: Implications for breast cancer progression
    • Ellsworth RE, Ellsworth DL, Weyandt JD, et al. Chromosomal alterations in pure nonneoplastic breast lesions: implications for breast cancer progression. Ann Surg Oncol 2010;17:1688-1694.
    • (2010) Ann Surg Oncol , vol.17 , pp. 1688-1694
    • Ellsworth, R.E.1    Ellsworth, D.L.2    Weyandt, J.D.3
  • 28
    • 80053307108 scopus 로고    scopus 로고
    • Chromosomal aberrations as detected by array comparative genomic hybridization in early low-grade intraepithelial neoplasias of the breast
    • Stacher E, Boldt V, Leibl S, et al. Chromosomal aberrations as detected by array comparative genomic hybridization in early low-grade intraepithelial neoplasias of the breast. Histopathology 2011;59:549-555.
    • (2011) Histopathology , vol.59 , pp. 549-555
    • Stacher, E.1    Boldt, V.2    Leibl, S.3
  • 29
    • 82655176916 scopus 로고    scopus 로고
    • Multiplex mutation screening by mass spectrometry evaluation of 820 cases from a personalized cancer medicine registry
    • Beadling C, Heinrich MC, Warrick A, et al. Multiplex mutation screening by mass spectrometry evaluation of 820 cases from a personalized cancer medicine registry. J Mol Diagn 2011;13:504-513.
    • (2011) J Mol Diagn , vol.13 , pp. 504-513
    • Beadling, C.1    Heinrich, M.C.2    Warrick, A.3
  • 31
    • 33645224005 scopus 로고    scopus 로고
    • PIK3CA mutations in breast cancer are associated with poor outcome
    • Li SY, Rong M, Grieu F, et al. PIK3CA mutations in breast cancer are associated with poor outcome. Breast Cancer Res Treat 2006;96:91-95.
    • (2006) Breast Cancer Res Treat , vol.96 , pp. 91-95
    • Li, S.Y.1    Rong, M.2    Grieu, F.3
  • 32
    • 51049118140 scopus 로고    scopus 로고
    • An integrative genomic and proteomic analysis of PIK3CA PTEN, and AKT mutations in breast cancer
    • Stemke-Hale K, Gonzalez-Angulo AM, Lluch A, et al. An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Res 2008;68:6084-6091.
    • (2008) Cancer Res , vol.68 , pp. 6084-6091
    • Stemke-Hale, K.1    Gonzalez-Angulo, A.M.2    Lluch, A.3
  • 33
    • 66249109653 scopus 로고    scopus 로고
    • Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics
    • Hennessy BT, Gonzalez-Angulo AM, Stemke-Hale K, et al. Characterization of a naturally occurring breast cancer subset enriched in epithelial-to- mesenchymal transition and stem cell characteristics. Cancer Res 2009;69:4116-4124.
    • (2009) Cancer Res , vol.69 , pp. 4116-4124
    • Hennessy, B.T.1    Gonzalez-Angulo, A.M.2    Stemke-Hale, K.3
  • 36
    • 33846854921 scopus 로고    scopus 로고
    • Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women
    • DOI 10.1158/1078-0432.CCR-06-0267
    • Maruyama N, Miyoshi Y, Taguchi T, et al. Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women. Clin Cancer Res 2007;13:408-414. (Pubitemid 46225343)
    • (2007) Clinical Cancer Research , vol.13 , Issue.2 , pp. 408-414
    • Maruyama, N.1    Miyoshi, Y.2    Taguchi, T.3    Tamaki, Y.4    Monden, M.5    Noguchi, S.6
  • 39
    • 77953422867 scopus 로고    scopus 로고
    • PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptorpositive breast cancer
    • Loi S, Haibe-Kains B, Majjaj S, et al. PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptorpositive breast cancer. Proc Natl Acad Sci USA 2010;107:10208-10213.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 10208-10213
    • Loi, S.1    Haibe-Kains, B.2    Majjaj, S.3
  • 40
    • 74849112055 scopus 로고    scopus 로고
    • Phosphatidylinositol-3-kinase alpha catalytic subunit mutation and response to neoadjuvant endocrine therapy for estrogen receptor positive breast cancer
    • Ellis MJ, Lin L, Crowder R, et al. Phosphatidylinositol-3-kinase alpha catalytic subunit mutation and response to neoadjuvant endocrine therapy for estrogen receptor positive breast cancer. Breast Cancer Res Treat 2010;119:379-390.
    • (2010) Breast Cancer Res Treat , vol.119 , pp. 379-390
    • Ellis, M.J.1    Lin, L.2    Crowder, R.3
  • 41
    • 77957603427 scopus 로고    scopus 로고
    • Alterations in p53, BRCA1, ATM, PIK3CA, and HER2 genes and their effect in modifying clinicopathological characteristics and overall survival of Bulgarian patients with breast cancer
    • Bozhanov SS, Angelova SG, Krasteva ME, et al. Alterations in p53, BRCA1, ATM, PIK3CA, and HER2 genes and their effect in modifying clinicopathological characteristics and overall survival of Bulgarian patients with breast cancer. J Cancer Res Clin Oncol 2010;136:1657-1669.
    • (2010) J Cancer Res Clin Oncol , vol.136 , pp. 1657-1669
    • Bozhanov, S.S.1    Angelova, S.G.2    Krasteva, M.E.3
  • 42
    • 84857921336 scopus 로고    scopus 로고
    • Mutational characterization of individual breast tumors: TP53 and PI3K pathway genes are frequently and distinctively mutated in different subtypes
    • Boyault S, Drouet Y, Navarro C, et al. Mutational characterization of individual breast tumors: TP53 and PI3K pathway genes are frequently and distinctively mutated in different subtypes. Breast Cancer Res Treat 2011;132:29-39.
    • (2011) Breast Cancer Res Treat , vol.132 , pp. 29-39
    • Boyault, S.1    Drouet, Y.2    Navarro, C.3
  • 43
    • 78651233471 scopus 로고    scopus 로고
    • Gene expression profiling reveals new aspects of PIK3CA mutation in ERalpha-positive breast cancer: Major implication of the Wnt signaling pathway
    • Cizkova M, Cizeron-Clairac G, Vacher S, et al. Gene expression profiling reveals new aspects of PIK3CA mutation in ERalpha-positive breast cancer: major implication of the Wnt signaling pathway. PLoS One 2010;5:e15647.
    • (2010) PLoS One , vol.5
    • Cizkova, M.1    Cizeron-Clairac, G.2    Vacher, S.3
  • 44
    • 69349105634 scopus 로고    scopus 로고
    • PIK3CA mutation associates with improved outcome in breast cancer
    • Kalinsky K, Jacks LM, Heguy A, et al. PIK3CA mutation associates with improved outcome in breast cancer. Clin Cancer Res 2009;15:5049-5059.
    • (2009) Clin Cancer Res , vol.15 , pp. 5049-5059
    • Kalinsky, K.1    Jacks, L.M.2    Heguy, A.3
  • 45
    • 79951834210 scopus 로고    scopus 로고
    • PIK3CA mutations may be discordant between primary and corresponding metastatic disease in breast cancer
    • Dupont Jensen J, Laenkholm AV, Knoop A, et al. PIK3CA mutations may be discordant between primary and corresponding metastatic disease in breast cancer. Clin Cancer Res 2011;17:667-677.
    • (2011) Clin Cancer Res , vol.17 , pp. 667-677
    • Dupont Jensen, J.1    Laenkholm, A.V.2    Knoop, A.3
  • 46
    • 77956839940 scopus 로고    scopus 로고
    • PIK3CA hotspot mutation scanning by a novel and highly sensitive high-resolution small amplicon melting analysis method
    • Vorkas PA, Poumpouridou N, Agelaki S, et al. PIK3CA hotspot mutation scanning by a novel and highly sensitive high-resolution small amplicon melting analysis method. J Mol Diagn 2010;12: 697-704.
    • (2010) J Mol Diagn , vol.12 , pp. 697-704
    • Vorkas, P.A.1    Poumpouridou, N.2    Agelaki, S.3
  • 47
    • 79952259564 scopus 로고    scopus 로고
    • Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay
    • Arcila ME, Oxnard GR, Nafa K, et al. Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay. Clin Cancer Res 2011;17:1169-1180.
    • (2011) Clin Cancer Res , vol.17 , pp. 1169-1180
    • Arcila, M.E.1    Oxnard, G.R.2    Nafa, K.3
  • 48
    • 79958728268 scopus 로고    scopus 로고
    • PI3K pathway mutations and PTEN levels in primary and metastatic breast cancer
    • Gonzalez-Angulo AM, Ferrer-Lozano J, Stemke-Hale K, et al. PI3K pathway mutations and PTEN levels in primary and metastatic breast cancer. Mol Cancer Ther 2011;10:1093-1101.
    • (2011) Mol Cancer Ther , vol.10 , pp. 1093-1101
    • Gonzalez-Angulo, A.M.1    Ferrer-Lozano, J.2    Stemke-Hale, K.3
  • 49
    • 0023748414 scopus 로고
    • Genetic alterations during colorectal-tumor development
    • Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988;319:525-532.
    • (1988) N Engl J Med , vol.319 , pp. 525-532
    • Vogelstein, B.1    Fearon, E.R.2    Hamilton, S.R.3
  • 52
    • 24944505221 scopus 로고    scopus 로고
    • Premalignant and in situ breast disease: Biology and clinical implications
    • Arpino G, Laucirica R, Elledge RM. Premalignant and in situ breast disease: biology and clinical implications. Ann Intern Med 2005;143:446-457. (Pubitemid 41338942)
    • (2005) Annals of Internal Medicine , vol.143 , Issue.6 , pp. 446-457
    • Arpino, G.1    Laucirica, R.2    Elledge, R.M.3
  • 54
    • 35148854641 scopus 로고    scopus 로고
    • PI3 Kinase Activation and Response to Trastuzumab Therapy: What's neu with Herceptin Resistance?
    • DOI 10.1016/j.ccr.2007.10.004, PII S1535610807002735
    • Park BH, Davidson NE. PI3 kinase activation and response to Trastuzumab Therapy: what0s neu with herceptin resistance? Cancer Cell 2007;12:297-299. (Pubitemid 47539315)
    • (2007) Cancer Cell , vol.12 , Issue.4 , pp. 297-299
    • Park, B.H.1    Davidson, N.E.2
  • 55
    • 33646712747 scopus 로고    scopus 로고
    • Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer
    • DOI 10.1038/ncponc0509, PII N0509
    • Nahta R, Yu D, Hung MC, et al. Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol 2006;3: 269-280. (Pubitemid 43731112)
    • (2006) Nature Clinical Practice Oncology , vol.3 , Issue.5 , pp. 269-280
    • Nahta, R.1    Yu, D.2    Hung, M.-C.3    Hortobagyi, G.N.4    Esteva, F.J.5
  • 56
    • 77953411708 scopus 로고    scopus 로고
    • Activated phosphoinositide 3-kinase/AKT signaling confers resistance to trastuzumab but not lapatinib
    • O0Brien NA, Browne BC, Chow L, et al. Activated phosphoinositide 3-kinase/AKT signaling confers resistance to trastuzumab but not lapatinib. Mol Cancer Ther 2010;9:1489-1502.
    • (2010) Mol Cancer Ther , vol.9 , pp. 1489-1502
    • Brien, N.A.1    Browne, B.C.2    Chow, L.3
  • 57
    • 69349093749 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase mutations in breast cancer: A 00good00 activating mutation?
    • Di Cosimo S, Baselga J. Phosphoinositide 3-kinase mutations in breast cancer: a 00good00 activating mutation? Clin Cancer Res 2009;15:5017-5019.
    • (2009) Clin Cancer Res , vol.15 , pp. 5017-5019
    • Di Cosimo, S.1    Baselga, J.2
  • 58
    • 80052490834 scopus 로고    scopus 로고
    • Oncogenic PIK3CAdriven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms
    • Liu P, Cheng H, Santiago S, et al. Oncogenic PIK3CAdriven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms. Nat Med 2011;17:1116-1120.
    • (2011) Nat Med , vol.17 , pp. 1116-1120
    • Liu, P.1    Cheng, H.2    Santiago, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.