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Volumn 27, Issue 18, 2013, Pages 2039-2048

Mechanistic insights into CED-4-mediated activation of CED-3

Author keywords

Apoptosis; Caspase activation; CED 3; CED 4; Programmed cell death (PCD)

Indexed keywords

APOPTOSOME; CASPASE; CED 3 PROTEIN; CED 4 PROTEIN; ENZYME PRECURSOR; UNCLASSIFIED DRUG;

EID: 84884572146     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.224428.113     Document Type: Article
Times cited : (29)

References (46)
  • 4
    • 0035798361 scopus 로고    scopus 로고
    • Crystal structure of a procaspase-7 zymogen: Mechanisms of activation and substrate binding
    • Chai J, Wu Q, Shiozaki E, Srinivasula SM, Alnemri ES, Shi Y. 2001. Crystal structure of a procaspase-7 zymogen: Mechanisms of activation and substrate binding. Cell 107: 399-407.
    • (2001) Cell , vol.107 , pp. 399-407
    • Chai, J.1    Wu, Q.2    Shiozaki, E.3    Srinivasula, S.M.4    Alnemri, E.S.5    Shi, Y.6
  • 5
  • 6
    • 0031034997 scopus 로고    scopus 로고
    • Interaction of CED-4 with CED-3 and CED-9: A molecular framework for cell death
    • Chinnaiyan AM, O'Rourke K, Lane BR, Dixit VM. 1997. Interaction of CED-4 with CED-3 and CED-9: A molecular framework for cell death. Science 275: 1122-1126.
    • (1997) Science , vol.275 , pp. 1122-1126
    • Chinnaiyan, A.M.1    O'Rourke, K.2    Lane, B.R.3    Dixit, V.M.4
  • 7
    • 0028103275 scopus 로고
    • The CCP4 suite: Programs for protein crystallography
    • Collaborative Computational Project, Number 4
    • Collaborative Computational Project, Number 4. 1994. The CCP4 suite: Programs for protein crystallography. Acta Crystallogr D Biol Crystallogr 50: 760-763.
    • (1994) Acta Crystallogr D Biol Crystallogr , vol.50 , pp. 760-763
  • 8
    • 0032524885 scopus 로고    scopus 로고
    • The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9
    • Conradt B, Horvitz HR. 1998. The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9. Cell 93: 519-529.
    • (1998) Cell , vol.93 , pp. 519-529
    • Conradt, B.1    Horvitz, H.R.2
  • 9
    • 0032509238 scopus 로고    scopus 로고
    • Caenorhabditis elegans EGL-1 disrupts the interaction of CED-9 with CED-4 and promotes CED-3 activation
    • del Peso L, González VM, Nuñez G. 1998. Caenorhabditis elegans EGL-1 disrupts the interaction of CED-9 with CED-4 and promotes CED-3 activation. J Biol Chem 273: 33495-33500.
    • (1998) J Biol Chem , vol.273 , pp. 33495-33500
    • del Peso, L.1    González, V.M.2    Nuñez, G.3
  • 10
    • 0034282926 scopus 로고    scopus 로고
    • Disruption of the CED-9. CED-4 complex by EGL-1 is a critical step for programmed cell death in Caenorhabditis elegans
    • del Peso L, Gonzalez VM, Inohara N, Ellis RE, Nunez G. 2000. Disruption of the CED-9. CED-4 complex by EGL-1 is a critical step for programmed cell death in Caenorhabditis elegans. J Biol Chem 275: 27205-27211.
    • (2000) J Biol Chem , vol.275 , pp. 27205-27211
    • del Peso, L.1    Gonzalez, V.M.2    Inohara, N.3    Ellis, R.E.4    Nunez, G.5
  • 11
    • 13244281317 scopus 로고    scopus 로고
    • Coot: Model-building tools for molecular graphics
    • Emsley P, Cowtan K. 2004. Coot: Model-building tools for molecular graphics. Acta Crystallogr 60: 2126-2132.
    • (2004) Acta Crystallogr , vol.60 , pp. 2126-2132
    • Emsley, P.1    Cowtan, K.2
  • 12
    • 0028288277 scopus 로고
    • C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
    • Hengartner MO, Horvitz HR. 1994. C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell 76: 665-676.
    • (1994) Cell , vol.76 , pp. 665-676
    • Hengartner, M.O.1    Horvitz, H.R.2
  • 13
    • 0042469295 scopus 로고    scopus 로고
    • Worms, life, and death (Nobel lecture)
    • Horvitz HR. 2003. Worms, life, and death (Nobel lecture). ChemBioChem 4: 697-711.
    • (2003) ChemBioChem , vol.4 , pp. 697-711
    • Horvitz, H.R.1
  • 14
  • 15
    • 0030951345 scopus 로고    scopus 로고
    • Direct physical interaction between the Caenorhabditis elegans 'death proteins' CED-3 and CED-4
    • Irmler M, Hofmann K, Vaux D, Tschopp J. 1997. Direct physical interaction between the Caenorhabditis elegans 'death proteins' CED-3 and CED-4. FEBS Lett 406: 189-190.
    • (1997) FEBS Lett , vol.406 , pp. 189-190
    • Irmler, M.1    Hofmann, K.2    Vaux, D.3    Tschopp, J.4
  • 16
    • 0031127578 scopus 로고    scopus 로고
    • CED-4 induces chromatin condensation in Schizosaccharomyces pombe and is inhibited by direct physical association with CED-9
    • James C, Gschmeissner S, Fraser A, Evan GI. 1997. CED-4 induces chromatin condensation in Schizosaccharomyces pombe and is inhibited by direct physical association with CED-9. Curr Biol 7: 246-252.
    • (1997) Curr Biol , vol.7 , pp. 246-252
    • James, C.1    Gschmeissner, S.2    Fraser, A.3    Evan, G.I.4
  • 17
    • 84889120137 scopus 로고
    • Improved methods for building protein models in electron density maps and the location of errors in these models
    • Jones TA, Zou J-Y, Cowan SW, Kjeldgaard M. 1991. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A 47: 110-119.
    • (1991) Acta Crystallogr A , vol.47 , pp. 110-119
    • Jones, T.A.1    Zou, J.-Y.2    Cowan, S.W.3    Kjeldgaard, M.4
  • 20
    • 0031059866 scopus 로고    scopus 로고
    • Processing of X-ray diffraction data collected in oscillation mode
    • Otwinowski Z, Minor W. 1997. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol 276: 307-326.
    • (1997) Methods Enzymol , vol.276 , pp. 307-326
    • Otwinowski, Z.1    Minor, W.2
  • 21
    • 0034710971 scopus 로고    scopus 로고
    • Demonstration of the in vivo interaction of key cell death regulators by structurebased design of second-site suppressors
    • Parrish J, Metters H, Chen L, Xue D. 2000. Demonstration of the in vivo interaction of key cell death regulators by structurebased design of second-site suppressors. Proc Natl Acad Sci 97: 11916-11921.
    • (2000) Proc Natl Acad Sci , vol.97 , pp. 11916-11921
    • Parrish, J.1    Metters, H.2    Chen, L.3    Xue, D.4
  • 22
    • 77951881456 scopus 로고    scopus 로고
    • Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4
    • Qi S, Pang Y, Hu Q, Liu Q, Li H, Zhou Y, He T, Liang Q, Liu Y, Yuan X, et al. 2010. Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4. Cell 141: 446-457.
    • (2010) Cell , vol.141 , pp. 446-457
    • Qi, S.1    Pang, Y.2    Hu, Q.3    Liu, Q.4    Li, H.5    Zhou, Y.6    He, T.7    Liang, Q.8    Liu, Y.9    Yuan, X.10
  • 23
    • 0033542482 scopus 로고    scopus 로고
    • Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1
    • Qin H, Srinivasula SM, Wu G, Fernandes-Alnemri T, Alnemri ES, Shi Y. 1999. Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1. Nature 399: 549-557.
    • (1999) Nature , vol.399 , pp. 549-557
    • Qin, H.1    Srinivasula, S.M.2    Wu, G.3    Fernandes-Alnemri, T.4    Alnemri, E.S.5    Shi, Y.6
  • 26
    • 0033613143 scopus 로고    scopus 로고
    • Caspase activation: The induced-proximity model
    • Salvesen GS, Dixit VM. 1999. Caspase activation: The induced-proximity model. Proc Natl Acad Sci 96: 10964-10967.
    • (1999) Proc Natl Acad Sci , vol.96 , pp. 10964-10967
    • Salvesen, G.S.1    Dixit, V.M.2
  • 28
    • 0031194404 scopus 로고    scopus 로고
    • Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced apoptosis
    • Seshagiri S, Miller LK. 1997. Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced apoptosis. Curr Biol 7: 455-460.
    • (1997) Curr Biol , vol.7 , pp. 455-460
    • Seshagiri, S.1    Miller, L.K.2
  • 29
    • 0032728443 scopus 로고    scopus 로고
    • Mutational analysis of the Caenorhabditis elegans cell-death gene ced-3
    • Shaham S, Reddien PW, Davies B, Horvitz HR. 1999. Mutational analysis of the Caenorhabditis elegans cell-death gene ced-3. Genetics 153: 1655-1671.
    • (1999) Genetics , vol.153 , pp. 1655-1671
    • Shaham, S.1    Reddien, P.W.2    Davies, B.3    Horvitz, H.R.4
  • 30
    • 0036121272 scopus 로고    scopus 로고
    • Apoptosome: The cellular engine for the activation of caspase-9
    • Shi Y. 2002a. Apoptosome: The cellular engine for the activation of caspase-9. Structure 10: 285-288.
    • (2002) Structure , vol.10 , pp. 285-288
    • Shi, Y.1
  • 31
    • 0036205587 scopus 로고    scopus 로고
    • Mechanisms of caspase activation and inhibition during apoptosis
    • Shi Y. 2002b. Mechanisms of caspase activation and inhibition during apoptosis. Mol Cell 9: 459-470.
    • (2002) Mol Cell , vol.9 , pp. 459-470
    • Shi, Y.1
  • 33
    • 0031019739 scopus 로고    scopus 로고
    • Interaction between the C. elegans cell-death regulators CED-9 and CED-4
    • Spector MS, Desnoyers S, Hoeppner DJ, Hengartner MO. 1997. Interaction between the C. elegans cell-death regulators CED-9 and CED-4. Nature 385: 653-656.
    • (1997) Nature , vol.385 , pp. 653-656
    • Spector, M.S.1    Desnoyers, S.2    Hoeppner, D.J.3    Hengartner, M.O.4
  • 37
    • 0031020227 scopus 로고    scopus 로고
    • Interaction and regulation of subcellular localization of CED-4 by CED-9
    • Wu D, Wallen HD, Nunez G. 1997. Interaction and regulation of subcellular localization of CED-4 by CED-9. Science 275: 1126-1129.
    • (1997) Science , vol.275 , pp. 1126-1129
    • Wu, D.1    Wallen, H.D.2    Nunez, G.3
  • 38
    • 0029880987 scopus 로고    scopus 로고
    • The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease
    • Xue D, Shaham S, Horvitz HR. 1996. The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease. Genes Dev 10: 1073-1083.
    • (1996) Genes Dev , vol.10 , pp. 1073-1083
    • Xue, D.1    Shaham, S.2    Horvitz, H.R.3
  • 39
    • 4644249309 scopus 로고    scopus 로고
    • Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4
    • Yan N, Gu L, Kokel D, Chai J, Li W, Han A, Chen L, Xue D, Shi Y. 2004. Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4. Mol Cell 15: 999-1006.
    • (2004) Mol Cell , vol.15 , pp. 999-1006
    • Yan, N.1    Gu, L.2    Kokel, D.3    Chai, J.4    Li, W.5    Han, A.6    Chen, L.7    Xue, D.8    Shi, Y.9
  • 40
    • 26844485563 scopus 로고    scopus 로고
    • Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans
    • Yan N, Chai J, Lee ES, Gu L, Liu Q, He J, Wu JW, Kokel D, Li H, Hao Q, et al. 2005. Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans. Nature 437: 831-837.
    • (2005) Nature , vol.437 , pp. 831-837
    • Yan, N.1    Chai, J.2    Lee, E.S.3    Gu, L.4    Liu, Q.5    He, J.6    Wu, J.W.7    Kokel, D.8    Li, H.9    Hao, Q.10
  • 41
    • 33646839270 scopus 로고    scopus 로고
    • Structure and activation mechanism of the Drosophila initiator caspase Dronc
    • Yan N, Huh JR, Schirf V, Demeler B, Hay BA, Shi Y. 2006a. Structure and activation mechanism of the Drosophila initiator caspase Dronc. J Biol Chem 281: 8667-8674.
    • (2006) J Biol Chem , vol.281 , pp. 8667-8674
    • Yan, N.1    Huh, J.R.2    Schirf, V.3    Demeler, B.4    Hay, B.A.5    Shi, Y.6
  • 42
    • 33645366156 scopus 로고    scopus 로고
    • 2:1 Stoichiometry of the CED-4-CED-9 complex and the tetrameric CED-4: Insights into the regulation of CED-3 activation
    • Yan N, Xu Y, Shi Y. 2006b. 2:1 Stoichiometry of the CED-4-CED-9 complex and the tetrameric CED-4: Insights into the regulation of CED-3 activation. Cell cycle 5: 31-34.
    • (2006) Cell cycle , vol.5 , pp. 31-34
    • Yan, N.1    Xu, Y.2    Shi, Y.3
  • 43
    • 0032575723 scopus 로고    scopus 로고
    • Essential role of CED-4 oligomerization in CED-3 activation and apoptosis
    • Yang X, Chang HY, Baltimore D. 1998. Essential role of CED-4 oligomerization in CED-3 activation and apoptosis. Science 281: 1355-1357.
    • (1998) Science , vol.281 , pp. 1355-1357
    • Yang, X.1    Chang, H.Y.2    Baltimore, D.3
  • 44
    • 0025255636 scopus 로고
    • The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death
    • Yuan JY, Horvitz HR. 1990. The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death. Dev Biol 138: 33-41.
    • (1990) Dev Biol , vol.138 , pp. 33-41
    • Yuan, J.Y.1    Horvitz, H.R.2
  • 45
    • 0026448963 scopus 로고
    • The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death
    • Yuan J, Horvitz HR. 1992. The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death. Development 116: 309-320.
    • (1992) Development , vol.116 , pp. 309-320
    • Yuan, J.1    Horvitz, H.R.2
  • 46
    • 0027525104 scopus 로고
    • The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme
    • Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR. 1993. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell 75: 641-652.
    • (1993) Cell , vol.75 , pp. 641-652
    • Yuan, J.1    Shaham, S.2    Ledoux, S.3    Ellis, H.M.4    Horvitz, H.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.