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Volumn , Issue , 2016, Pages 1171-1179

New perspectives on the use of mTOR inhibitors in allogeneic haematopoietic stem cell transplantation and graft-versus-host disease

Author keywords

allogeneic haematopoietic stem cell transplantation; everolimus; graft versus host disease; mTOR inhibitors; sirolimus

Indexed keywords

BORTEZOMIB; CALCINEURIN INHIBITOR; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; EVEROLIMUS; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; METHOTREXATE; MYCOPHENOLATE MOFETIL; RAPAMYCIN; STEROID; TACROLIMUS; THYMOCYTE ANTIBODY;

EID: 84991267968     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/bcp.13022     Document Type: Review
Times cited : (25)

References (74)
  • 1
    • 78650510609 scopus 로고    scopus 로고
    • mTOR: from growth signal integration to cancer, diabetes and ageing
    • Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011; 12: 21–35.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 3
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin DA, Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell 2007; 12: 9–22.
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 4
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006; 124: 471–84.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 6
    • 84954309969 scopus 로고    scopus 로고
    • PI3K/Akt/mTOR inhibitors in breast cancer
    • Lee JJ, Loh K, Yap YS. PI3K/Akt/mTOR inhibitors in breast cancer. Cancer Biol Med 2015; 12: 342–54.
    • (2015) Cancer Biol Med , vol.12 , pp. 342-354
    • Lee, J.J.1    Loh, K.2    Yap, Y.S.3
  • 7
    • 84871926128 scopus 로고    scopus 로고
    • Medical treatment of neuroendocrine tumours
    • Weber HC. Medical treatment of neuroendocrine tumours. Curr Opin Endocrinol Diabetes Obes 2013; 20: 27–31.
    • (2013) Curr Opin Endocrinol Diabetes Obes , vol.20 , pp. 27-31
    • Weber, H.C.1
  • 8
    • 85027953660 scopus 로고    scopus 로고
    • Targeting the mTOR signaling pathway in neuroendocrine tumors
    • Chan J, Kulke M. Targeting the mTOR signaling pathway in neuroendocrine tumors. Curr Treat Options Oncol 2014; 15: 365–79.
    • (2014) Curr Treat Options Oncol , vol.15 , pp. 365-379
    • Chan, J.1    Kulke, M.2
  • 9
    • 84924755289 scopus 로고    scopus 로고
    • Future perspectives for mTOR inhibitors in renal cell cancer treatment
    • Czarnecka AM, Kornakiewicz A, Lian F, Szczylik C. Future perspectives for mTOR inhibitors in renal cell cancer treatment. Future Oncol 2015; 11: 801–17.
    • (2015) Future Oncol , vol.11 , pp. 801-817
    • Czarnecka, A.M.1    Kornakiewicz, A.2    Lian, F.3    Szczylik, C.4
  • 11
    • 84879195658 scopus 로고    scopus 로고
    • mTOR and lymphocyte metabolism
    • Zeng H, Chi H. mTOR and lymphocyte metabolism. Curr Opin Immunol 2013; 25: 347–55.
    • (2013) Curr Opin Immunol , vol.25 , pp. 347-355
    • Zeng, H.1    Chi, H.2
  • 12
    • 84865301337 scopus 로고    scopus 로고
    • mTOR, metabolism, and the regulation of T-cell differentiation and function
    • Waickman AT, Powell JD. mTOR, metabolism, and the regulation of T-cell differentiation and function. Immunol Rev 2012; 249: 43–58.
    • (2012) Immunol Rev , vol.249 , pp. 43-58
    • Waickman, A.T.1    Powell, J.D.2
  • 13
    • 84904705879 scopus 로고    scopus 로고
    • Everolimus initiation and early calcineurin inhibitor withdrawal in heart transplant recipients: a randomized trial
    • Andreassen AK, Andersson B, Gustafsson F, Eiskjaer H, Radegran G, Gude E, et al. Everolimus initiation and early calcineurin inhibitor withdrawal in heart transplant recipients: a randomized trial. Am J Transplant 2014; 14: 1828–38.
    • (2014) Am J Transplant , vol.14 , pp. 1828-1838
    • Andreassen, A.K.1    Andersson, B.2    Gustafsson, F.3    Eiskjaer, H.4    Radegran, G.5    Gude, E.6
  • 15
    • 84907277321 scopus 로고    scopus 로고
    • The role of mTOR inhibitors in liver transplantation: Reviewing the evidence
    • Klintmalm GB, Nashan B. The role of mTOR inhibitors in liver transplantation: Reviewing the evidence. J Transplant 2014; 2014: 845438.
    • (2014) J Transplant , vol.2014 , pp. 845438
    • Klintmalm, G.B.1    Nashan, B.2
  • 16
    • 84915827759 scopus 로고    scopus 로고
    • Graft-versus-host disease prophylaxis after transplantation: a network meta-analysis
    • Ziakas PD, Zervou FN, Zacharioudakis IM, Mylonakis E. Graft-versus-host disease prophylaxis after transplantation: a network meta-analysis. PLoS One 2014; 9: e114735.
    • (2014) PLoS One , vol.9
    • Ziakas, P.D.1    Zervou, F.N.2    Zacharioudakis, I.M.3    Mylonakis, E.4
  • 17
    • 84871923117 scopus 로고    scopus 로고
    • Defining the role of sirolimus in the management of graft-versus-host disease: from prophylaxis to treatment
    • Abouelnasr A, Roy J, Cohen S, Kiss T, Lachance S. Defining the role of sirolimus in the management of graft-versus-host disease: from prophylaxis to treatment. Biol Blood Marrow Transplant 2013; 19: 12–21.
    • (2013) Biol Blood Marrow Transplant , vol.19 , pp. 12-21
    • Abouelnasr, A.1    Roy, J.2    Cohen, S.3    Kiss, T.4    Lachance, S.5
  • 20
    • 0029872662 scopus 로고    scopus 로고
    • In vivo inhibition of cytokine responsiveness and graft-versus-host disease mortality by rapamycin leads to a clinical-pathological syndrome discrete from that observed with cyclosporin A
    • Blazar BR, Taylor PA, Panoskaltsis-Mortari A, Sehgal S, Vallera DA. In vivo inhibition of cytokine responsiveness and graft-versus-host disease mortality by rapamycin leads to a clinical-pathological syndrome discrete from that observed with cyclosporin A. Blood 1996; 87: 4001–9.
    • (1996) Blood , vol.87 , pp. 4001-4009
    • Blazar, B.R.1    Taylor, P.A.2    Panoskaltsis-Mortari, A.3    Sehgal, S.4    Vallera, D.A.5
  • 21
    • 0041941520 scopus 로고    scopus 로고
    • Sirolimus, tacrolimus, and low-dose methotrexate for graft-versus-host disease prophylaxis in mismatched related donor or unrelated donor transplantation
    • Antin JH, Kim HT, Cutler C, Ho VT, Lee SJ, Miklos DB, et al. Sirolimus, tacrolimus, and low-dose methotrexate for graft-versus-host disease prophylaxis in mismatched related donor or unrelated donor transplantation. Blood 2003; 102: 1601–5.
    • (2003) Blood , vol.102 , pp. 1601-1605
    • Antin, J.H.1    Kim, H.T.2    Cutler, C.3    Ho, V.T.4    Lee, S.J.5    Miklos, D.B.6
  • 22
    • 84870455529 scopus 로고    scopus 로고
    • A randomized phase II study to evaluate tacrolimus in combination with sirolimus or methotrexate after allogeneic hematopoietic cell transplantation
    • Pidala J, Kim J, Jim H, Kharfan-Dabaja MA, Nishihori T, Fernandez HF, et al. A randomized phase II study to evaluate tacrolimus in combination with sirolimus or methotrexate after allogeneic hematopoietic cell transplantation. Haematologica 2012; 97: 1882–9.
    • (2012) Haematologica , vol.97 , pp. 1882-1889
    • Pidala, J.1    Kim, J.2    Jim, H.3    Kharfan-Dabaja, M.A.4    Nishihori, T.5    Fernandez, H.F.6
  • 23
    • 84936150654 scopus 로고    scopus 로고
    • Prolonged sirolimus administration after allogeneic hematopoietic cell transplantation is associated with decreased risk for moderate-severe chronic graft-versus-host disease
    • Pidala J, Kim J, Alsina M, Ayala E, Betts BC, Fernandez HF, et al. Prolonged sirolimus administration after allogeneic hematopoietic cell transplantation is associated with decreased risk for moderate-severe chronic graft-versus-host disease. Haematologica 2015; 100: 970–7.
    • (2015) Haematologica , vol.100 , pp. 970-977
    • Pidala, J.1    Kim, J.2    Alsina, M.3    Ayala, E.4    Betts, B.C.5    Fernandez, H.F.6
  • 24
    • 84895751788 scopus 로고    scopus 로고
    • Quality of life associated with sirolimus for prevention of graft-versus-host disease: results from a randomized trial
    • Jim HS, Barata A, Small BJ, Jacobsen PB, Pidala J. Quality of life associated with sirolimus for prevention of graft-versus-host disease: results from a randomized trial. Haematologica 2014; 99: 548–53.
    • (2014) Haematologica , vol.99 , pp. 548-553
    • Jim, H.S.1    Barata, A.2    Small, B.J.3    Jacobsen, P.B.4    Pidala, J.5
  • 25
    • 84907357105 scopus 로고    scopus 로고
    • Tacrolimus/sirolimus vs. tacrolimus/methotrexate as GVHD prophylaxis after matched, related donor allogeneic HCT
    • Cutler C, Logan B, Nakamura R, Johnston L, Choi S, Porter D, et al. Tacrolimus/sirolimus vs. tacrolimus/methotrexate as GVHD prophylaxis after matched, related donor allogeneic HCT. Blood 2014; 124: 1372–7.
    • (2014) Blood , vol.124 , pp. 1372-1377
    • Cutler, C.1    Logan, B.2    Nakamura, R.3    Johnston, L.4    Choi, S.5    Porter, D.6
  • 26
    • 84897494651 scopus 로고    scopus 로고
    • The addition of sirolimus to tacrolimus/methotrexate GVHD prophylaxis in children with ALL: a phase 3 Children's Oncology Group/Pediatric Blood and Marrow Transplant Consortium trial
    • Pulsipher MA, Langholz B, Wall DA, Schultz KR, Bunin N, Carroll WL, et al. The addition of sirolimus to tacrolimus/methotrexate GVHD prophylaxis in children with ALL: a phase 3 Children's Oncology Group/Pediatric Blood and Marrow Transplant Consortium trial. Blood 2014; 123: 2017–25.
    • (2014) Blood , vol.123 , pp. 2017-2025
    • Pulsipher, M.A.1    Langholz, B.2    Wall, D.A.3    Schultz, K.R.4    Bunin, N.5    Carroll, W.L.6
  • 27
    • 84907495257 scopus 로고    scopus 로고
    • A randomized phase II trial of tacrolimus, mycophenolate mofetil and sirolimus after non-myeloablative unrelated donor transplantation
    • Kornblit B, Maloney DG, Storer BE, Maris MB, Vindelov L, Hari P, et al. A randomized phase II trial of tacrolimus, mycophenolate mofetil and sirolimus after non-myeloablative unrelated donor transplantation. Haematologica 2014; 99: 1624–31.
    • (2014) Haematologica , vol.99 , pp. 1624-1631
    • Kornblit, B.1    Maloney, D.G.2    Storer, B.E.3    Maris, M.B.4    Vindelov, L.5    Hari, P.6
  • 28
    • 34547123123 scopus 로고    scopus 로고
    • Sirolimus-based graft-versus-host disease prophylaxis protects against cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation: a cohort analysis
    • Marty FM, Bryar J, Browne SK, Schwarzberg T, Ho VT, Bassett IV, et al. Sirolimus-based graft-versus-host disease prophylaxis protects against cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation: a cohort analysis. Blood 2007; 110: 490–500.
    • (2007) Blood , vol.110 , pp. 490-500
    • Marty, F.M.1    Bryar, J.2    Browne, S.K.3    Schwarzberg, T.4    Ho, V.T.5    Bassett, I.V.6
  • 29
    • 34548632281 scopus 로고    scopus 로고
    • The use of sirolimus in ganciclovir-resistant cytomegalovirus infections in renal transplant recipients
    • Ozaki KS, Camara NO, Nogueira E, Pereira MG, Granato C, Melaragno C, et al. The use of sirolimus in ganciclovir-resistant cytomegalovirus infections in renal transplant recipients. Clin Transplant 2007; 21: 675–80.
    • (2007) Clin Transplant , vol.21 , pp. 675-680
    • Ozaki, K.S.1    Camara, N.O.2    Nogueira, E.3    Pereira, M.G.4    Granato, C.5    Melaragno, C.6
  • 30
    • 84953308839 scopus 로고    scopus 로고
    • The addition of sirolimus to the graft-versus-host disease prophylaxis regimen in reduced intensity allogeneic stem cell transplantation for lymphoma: a multicentre randomized trial
    • Armand P, Kim HT, Sainvil MM, Lange PB, Giardino AA, Bachanova V, et al. The addition of sirolimus to the graft-versus-host disease prophylaxis regimen in reduced intensity allogeneic stem cell transplantation for lymphoma: a multicentre randomized trial. Br J Haematol 2016; 173: 96–104.
    • (2016) Br J Haematol , vol.173 , pp. 96-104
    • Armand, P.1    Kim, H.T.2    Sainvil, M.M.3    Lange, P.B.4    Giardino, A.A.5    Bachanova, V.6
  • 31
    • 84924666861 scopus 로고    scopus 로고
    • Sirolimus, tacrolimus and low-dose methotrexate based graft-versus-host disease prophylaxis after non-ablative or reduced intensity conditioning in related and unrelated donor allogeneic hematopoietic cell transplant
    • Ceberio I, Devlin SM, Sauter C, Barker JN, Castro-Malaspina H, Giralt S, et al. Sirolimus, tacrolimus and low-dose methotrexate based graft-versus-host disease prophylaxis after non-ablative or reduced intensity conditioning in related and unrelated donor allogeneic hematopoietic cell transplant. Leuk Lymphoma 2015; 56: 663–70.
    • (2015) Leuk Lymphoma , vol.56 , pp. 663-670
    • Ceberio, I.1    Devlin, S.M.2    Sauter, C.3    Barker, J.N.4    Castro-Malaspina, H.5    Giralt, S.6
  • 32
    • 84920628434 scopus 로고    scopus 로고
    • GVHD prophylaxis with sirolimus-tacrolimus may overcome the deleterious effect on survival of HLA mismatch after reduced-intensity conditioning allo-SCT
    • Parody R, Lopez-Corral L, Godino OL, Cadenas IG, Martinez AP, Vazquez L, et al. GVHD prophylaxis with sirolimus-tacrolimus may overcome the deleterious effect on survival of HLA mismatch after reduced-intensity conditioning allo-SCT. Bone Marrow Transplant 2015; 50: 121–6.
    • (2015) Bone Marrow Transplant , vol.50 , pp. 121-126
    • Parody, R.1    Lopez-Corral, L.2    Godino, O.L.3    Cadenas, I.G.4    Martinez, A.P.5    Vazquez, L.6
  • 33
    • 67349198571 scopus 로고    scopus 로고
    • Calcineurin inhibitor-free GVHD prophylaxis with sirolimus, mycophenolate mofetil and ATG in Allo-SCT for leukemia patients with high relapse risk: an observational cohort study
    • Schleuning M, Judith D, Jedlickova Z, Stubig T, Heshmat M, Baurmann H, et al. Calcineurin inhibitor-free GVHD prophylaxis with sirolimus, mycophenolate mofetil and ATG in Allo-SCT for leukemia patients with high relapse risk: an observational cohort study. Bone Marrow Transplant 2009; 43: 717–23.
    • (2009) Bone Marrow Transplant , vol.43 , pp. 717-723
    • Schleuning, M.1    Judith, D.2    Jedlickova, Z.3    Stubig, T.4    Heshmat, M.5    Baurmann, H.6
  • 34
    • 84859465951 scopus 로고    scopus 로고
    • Sirolimus and mycophenolate mofetil as GVHD prophylaxis in myeloablative, matched-related donor hematopoietic cell transplantation
    • Johnston L, Florek M, Armstrong R, McCune JS, Arai S, Brown J, et al. Sirolimus and mycophenolate mofetil as GVHD prophylaxis in myeloablative, matched-related donor hematopoietic cell transplantation. Bone Marrow Transplant 2012; 47: 581–8.
    • (2012) Bone Marrow Transplant , vol.47 , pp. 581-588
    • Johnston, L.1    Florek, M.2    Armstrong, R.3    McCune, J.S.4    Arai, S.5    Brown, J.6
  • 35
    • 84908046608 scopus 로고    scopus 로고
    • Calcineurin inhibitor–free graft-versus-host disease prophylaxis with post-transplantation cyclophosphamide and brief-course sirolimus following reduced-intensity peripheral blood stem cell transplantation
    • Solomon SR, Sanacore M, Zhang X, Brown S, Holland K, Morris LE, et al. Calcineurin inhibitor–free graft-versus-host disease prophylaxis with post-transplantation cyclophosphamide and brief-course sirolimus following reduced-intensity peripheral blood stem cell transplantation. Biol Blood Marrow Transplant 2014; 20: 1828–34.
    • (2014) Biol Blood Marrow Transplant , vol.20 , pp. 1828-1834
    • Solomon, S.R.1    Sanacore, M.2    Zhang, X.3    Brown, S.4    Holland, K.5    Morris, L.E.6
  • 36
    • 84937726953 scopus 로고    scopus 로고
    • Post-transplantation Cyclophosphamide and sirolimus after haploidentical hematopoietic stem cell transplantation using a treosulfan-based myeloablative conditioning and peripheral blood stem cells
    • Cieri N, Greco R, Crucitti L, Morelli M, Giglio F, Levati G, et al. Post-transplantation Cyclophosphamide and sirolimus after haploidentical hematopoietic stem cell transplantation using a treosulfan-based myeloablative conditioning and peripheral blood stem cells. Biol Blood Marrow Transplant 2015; 21: 1506–14.
    • (2015) Biol Blood Marrow Transplant , vol.21 , pp. 1506-1514
    • Cieri, N.1    Greco, R.2    Crucitti, L.3    Morelli, M.4    Giglio, F.5    Levati, G.6
  • 37
    • 84865979985 scopus 로고    scopus 로고
    • The novel combination of sirolimus and bortezomib prevents graft-versus-host disease but maintains the graft-versus-leukemia effect after allogeneic transplantation
    • Caballero-Velazquez T, Sanchez-Abarca LI, Gutierrez-Cosio S, Blanco B, Calderon C, Herrero C, et al. The novel combination of sirolimus and bortezomib prevents graft-versus-host disease but maintains the graft-versus-leukemia effect after allogeneic transplantation. Haematologica 2012; 97: 1329–37.
    • (2012) Haematologica , vol.97 , pp. 1329-1337
    • Caballero-Velazquez, T.1    Sanchez-Abarca, L.I.2    Gutierrez-Cosio, S.3    Blanco, B.4    Calderon, C.5    Herrero, C.6
  • 38
    • 58149182699 scopus 로고    scopus 로고
    • Graft-versus-host disease prophylaxis with everolimus and tacrolimus is associated with a high incidence of sinusoidal obstruction syndrome and microangiopathy: results of the EVTAC trial
    • Platzbecker U, von Bonin M, Goekkurt E, Radke J, Binder M, Kiani A, et al. Graft-versus-host disease prophylaxis with everolimus and tacrolimus is associated with a high incidence of sinusoidal obstruction syndrome and microangiopathy: results of the EVTAC trial. Biol Blood Marrow Transplant 2009; 15: 101–8.
    • (2009) Biol Blood Marrow Transplant , vol.15 , pp. 101-108
    • Platzbecker, U.1    von Bonin, M.2    Goekkurt, E.3    Radke, J.4    Binder, M.5    Kiani, A.6
  • 39
    • 84862122358 scopus 로고    scopus 로고
    • Everolimus in combination with cyclosporin a as pre- and post-transplantation immunosuppressive therapy in nonmyeloablative allogeneic hematopoietic stem cell transplantation
    • Junghanss C, Rathsack S, Wacke R, Weirich V, Vogel H, Drewelow B, et al. Everolimus in combination with cyclosporin a as pre- and post-transplantation immunosuppressive therapy in nonmyeloablative allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2012; 18: 1061–8.
    • (2012) Biol Blood Marrow Transplant , vol.18 , pp. 1061-1068
    • Junghanss, C.1    Rathsack, S.2    Wacke, R.3    Weirich, V.4    Vogel, H.5    Drewelow, B.6
  • 40
    • 84905569746 scopus 로고    scopus 로고
    • Everolimus in combination with mycophenolate mofetil as pre- and post-transplantation immunosuppression after nonmyeloablative hematopoietic stem cell transplantation in canine littermates
    • Machka C, Lange S, Werner J, Wacke R, Killian D, Knueppel A, et al. Everolimus in combination with mycophenolate mofetil as pre- and post-transplantation immunosuppression after nonmyeloablative hematopoietic stem cell transplantation in canine littermates. Biol Blood Marrow Transplant 2014; 20: 1301–6.
    • (2014) Biol Blood Marrow Transplant , vol.20 , pp. 1301-1306
    • Machka, C.1    Lange, S.2    Werner, J.3    Wacke, R.4    Killian, D.5    Knueppel, A.6
  • 41
    • 77955301448 scopus 로고    scopus 로고
    • Tacrolimus-associated posterior reversible encephalopathy syndrome after solid organ transplantation
    • Wu Q, Marescaux C, Wolff V, Jeung MY, Kessler R, Lauer V, et al. Tacrolimus-associated posterior reversible encephalopathy syndrome after solid organ transplantation. Eur Neurol 2010; 64: 169–77.
    • (2010) Eur Neurol , vol.64 , pp. 169-177
    • Wu, Q.1    Marescaux, C.2    Wolff, V.3    Jeung, M.Y.4    Kessler, R.5    Lauer, V.6
  • 42
    • 84949312808 scopus 로고    scopus 로고
    • Clinical Management of Posterior Reversible Encephalopathy Syndrome after Allogeneic Hematopoietic Stem Cell Transplantation: A Case Series and Review of the Literature
    • Schmidt V, Prell T, Treschl A, Klink A, Hochhaus A, Sayer HG. Clinical Management of Posterior Reversible Encephalopathy Syndrome after Allogeneic Hematopoietic Stem Cell Transplantation: A Case Series and Review of the Literature. Acta Haematol 2016; 135: 1–10.
    • (2016) Acta Haematol , vol.135 , pp. 1-10
    • Schmidt, V.1    Prell, T.2    Treschl, A.3    Klink, A.4    Hochhaus, A.5    Sayer, H.G.6
  • 43
    • 66949170651 scopus 로고    scopus 로고
    • Sirolimus as primary treatment of acute graft-versus-host disease following allogeneic hematopoietic cell transplantation
    • Pidala J, Kim J, Anasetti C. Sirolimus as primary treatment of acute graft-versus-host disease following allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 2009; 15: 881–5.
    • (2009) Biol Blood Marrow Transplant , vol.15 , pp. 881-885
    • Pidala, J.1    Kim, J.2    Anasetti, C.3
  • 44
    • 80052369626 scopus 로고    scopus 로고
    • Sirolimus demonstrates activity in the primary therapy of acute graft-versus-host disease without systemic glucocorticoids
    • Pidala J, Tomblyn M, Nishihori T, Field T, Ayala E, Perkins J, et al. Sirolimus demonstrates activity in the primary therapy of acute graft-versus-host disease without systemic glucocorticoids. Haematologica 2011; 96: 1351–6.
    • (2011) Haematologica , vol.96 , pp. 1351-1356
    • Pidala, J.1    Tomblyn, M.2    Nishihori, T.3    Field, T.4    Ayala, E.5    Perkins, J.6
  • 45
    • 0035660613 scopus 로고    scopus 로고
    • Sirolimus (rapamycin) for the treatment of steroid-refractory acute graft-versus-host disease
    • Benito AI, Furlong T, Martin PJ, Anasetti C, Appelbaum FR, Doney K, et al. Sirolimus (rapamycin) for the treatment of steroid-refractory acute graft-versus-host disease. Transplantation 2001; 72: 1924–9.
    • (2001) Transplantation , vol.72 , pp. 1924-1929
    • Benito, A.I.1    Furlong, T.2    Martin, P.J.3    Anasetti, C.4    Appelbaum, F.R.5    Doney, K.6
  • 48
    • 0030061045 scopus 로고    scopus 로고
    • Inhibition by rapamycin of PDGF- and bFGF-induced human tenon fibroblast proliferation in vitro
    • Salas-Prato M, Assalian A, Mehdi AZ, Duperre J, Thompson P, Brazeau P. Inhibition by rapamycin of PDGF- and bFGF-induced human tenon fibroblast proliferation in vitro. J Glaucoma 1996; 5: 54–9.
    • (1996) J Glaucoma , vol.5 , pp. 54-59
    • Salas-Prato, M.1    Assalian, A.2    Mehdi, A.Z.3    Duperre, J.4    Thompson, P.5    Brazeau, P.6
  • 49
    • 84930686643 scopus 로고    scopus 로고
    • Rapamycin inhibits human laryngotracheal stenosis-derived fibroblast proliferation, metabolism, and function in vitro
    • Namba DR, Ma G, Samad I, Ding D, Pandian V, Powell JD, et al. Rapamycin inhibits human laryngotracheal stenosis-derived fibroblast proliferation, metabolism, and function in vitro. Otolaryngol Head Neck Surg 2015; 152: 881–8.
    • (2015) Otolaryngol Head Neck Surg , vol.152 , pp. 881-888
    • Namba, D.R.1    Ma, G.2    Samad, I.3    Ding, D.4    Pandian, V.5    Powell, J.D.6
  • 51
    • 84938743616 scopus 로고    scopus 로고
    • Aberrant germinal center formation, follicular T-helper cells, and germinal center B-cells were involved in chronic graft-versus-host disease
    • Shao L, Lie AK, Zhang Y, Wong CH, Kwong YL. Aberrant germinal center formation, follicular T-helper cells, and germinal center B-cells were involved in chronic graft-versus-host disease. Ann Hematol 2015; 94: 1493–504.
    • (2015) Ann Hematol , vol.94 , pp. 1493-1504
    • Shao, L.1    Lie, A.K.2    Zhang, Y.3    Wong, C.H.4    Kwong, Y.L.5
  • 53
    • 24944570255 scopus 로고    scopus 로고
    • Sirolimus in combination with tacrolimus and corticosteroids for the treatment of resistant chronic graft-versus-host disease
    • Couriel DR, Saliba R, Escalon MP, Hsu Y, Ghosh S, Ippoliti C, et al. Sirolimus in combination with tacrolimus and corticosteroids for the treatment of resistant chronic graft-versus-host disease. Br J Haematol 2005; 130: 409–17.
    • (2005) Br J Haematol , vol.130 , pp. 409-417
    • Couriel, D.R.1    Saliba, R.2    Escalon, M.P.3    Hsu, Y.4    Ghosh, S.5    Ippoliti, C.6
  • 56
    • 84940206690 scopus 로고    scopus 로고
    • Transplantation-associated thrombotic microangiopathy in patients treated with sirolimus and cyclosporine as salvage therapy for graft-versus-host disease
    • Garcia-Martin P, Alarcon-Payer C, Lopez-Fernandez E, Moratalla L, Romero A, Sainz J, et al. Transplantation-associated thrombotic microangiopathy in patients treated with sirolimus and cyclosporine as salvage therapy for graft-versus-host disease. Ann Pharmacother 2015; 49: 986–94.
    • (2015) Ann Pharmacother , vol.49 , pp. 986-994
    • Garcia-Martin, P.1    Alarcon-Payer, C.2    Lopez-Fernandez, E.3    Moratalla, L.4    Romero, A.5    Sainz, J.6
  • 57
    • 79955632748 scopus 로고    scopus 로고
    • Consensus Conference on Clinical Practice in Chronic GVHD: Second-line treatment of chronic graft-versus-host disease
    • Wolff D, Schleuning M, von Harsdorf S, Bacher U, Gerbitz A, Stadler M, et al. Consensus Conference on Clinical Practice in Chronic GVHD: Second-line treatment of chronic graft-versus-host disease. Biol Blood Marrow Transplant 2011; 17: 1–17.
    • (2011) Biol Blood Marrow Transplant , vol.17 , pp. 1-17
    • Wolff, D.1    Schleuning, M.2    von Harsdorf, S.3    Bacher, U.4    Gerbitz, A.5    Stadler, M.6
  • 58
    • 84856874363 scopus 로고    scopus 로고
    • Systemic treatment of chronic GVHD
    • Schleuning M. Systemic treatment of chronic GVHD. Cell Ther Transplant 2009; 2: e.000050.01. doi:10.3205/ctt-2009-en-000050.01.
    • (2009) Cell Ther Transplant , vol.2
    • Schleuning, M.1
  • 59
    • 84856867312 scopus 로고    scopus 로고
    • High overall response rate in calcineurin inhibitor-free treatment with the mTOR inhibitor everolimus in advanced extensive chronic GvHD after allogeneic stem cell transplantation
    • (ASH Annual Meeting Abstracts)
    • Klink A, Schilling K, Rapp K, Höffken K, Sayer HG. High overall response rate in calcineurin inhibitor-free treatment with the mTOR inhibitor everolimus in advanced extensive chronic GvHD after allogeneic stem cell transplantation. Blood (ASH Annual Meeting Abstracts) 2008; 112: 2210.
    • (2008) Blood , vol.112 , pp. 2210
    • Klink, A.1    Schilling, K.2    Rapp, K.3    Höffken, K.4    Sayer, H.G.5
  • 60
    • 84902272883 scopus 로고    scopus 로고
    • [Delayed wound healing during therapy of cutaneous graft-versus-host disease with everolimus]
    • Brown A, Neumayer D, Rafiee-Tari Z, Krieg T, Eming SA. [Delayed wound healing during therapy of cutaneous graft-versus-host disease with everolimus]. Hautarzt 2014; 65: 553–5.
    • (2014) Hautarzt , vol.65 , pp. 553-555
    • Brown, A.1    Neumayer, D.2    Rafiee-Tari, Z.3    Krieg, T.4    Eming, S.A.5
  • 61
    • 80053377953 scopus 로고    scopus 로고
    • Natural history, management and pharmacokinetics of everolimus-induced-oral ulcers: insights into compliance issues
    • Ferte C, Paci A, Zizi M, Gonzales DB, Goubar A, Gomez-Roca C, et al. Natural history, management and pharmacokinetics of everolimus-induced-oral ulcers: insights into compliance issues. Eur J Cancer 2011; 47: 2249–55.
    • (2011) Eur J Cancer , vol.47 , pp. 2249-2255
    • Ferte, C.1    Paci, A.2    Zizi, M.3    Gonzales, D.B.4    Goubar, A.5    Gomez-Roca, C.6
  • 62
    • 84909954469 scopus 로고    scopus 로고
    • Salvage therapy with everolimus reduces the severity of treatment-refractory chronic GVHD without impairing disease control: a dual center retrospective analysis
    • Mielke S, Lutz M, Schmidhuber J, Kapp M, Ditz D, Ammer J, et al. Salvage therapy with everolimus reduces the severity of treatment-refractory chronic GVHD without impairing disease control: a dual center retrospective analysis. Bone Marrow Transplant 2014; 49: 1412–8.
    • (2014) Bone Marrow Transplant , vol.49 , pp. 1412-1418
    • Mielke, S.1    Lutz, M.2    Schmidhuber, J.3    Kapp, M.4    Ditz, D.5    Ammer, J.6
  • 63
    • 57449092086 scopus 로고    scopus 로고
    • Improved survival in lymphoma patients receiving sirolimus for graft-versus-host disease prophylaxis after allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning
    • Armand P, Gannamaneni S, Kim HT, Cutler CS, Ho VT, Koreth J, et al. Improved survival in lymphoma patients receiving sirolimus for graft-versus-host disease prophylaxis after allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning. J Clin Oncol 2008; 26: 5767–74.
    • (2008) J Clin Oncol , vol.26 , pp. 5767-5774
    • Armand, P.1    Gannamaneni, S.2    Kim, H.T.3    Cutler, C.S.4    Ho, V.T.5    Koreth, J.6
  • 65
    • 84918828951 scopus 로고    scopus 로고
    • Improvement of quality of life in patients with steroid-refractory chronic graft-versus-host disease treated with the mTOR inhibitor everolimus
    • Lutz M, Kapp M, Einsele H, Grigoleit GU, Mielke S. Improvement of quality of life in patients with steroid-refractory chronic graft-versus-host disease treated with the mTOR inhibitor everolimus. Clin Transplant 2014; 28: 1410–5.
    • (2014) Clin Transplant , vol.28 , pp. 1410-1415
    • Lutz, M.1    Kapp, M.2    Einsele, H.3    Grigoleit, G.U.4    Mielke, S.5
  • 66
    • 84897554850 scopus 로고    scopus 로고
    • High prevalence of distress in patients after allogeneic hematopoietic SCT: fear of progression is associated with a younger age
    • Hefner J, Kapp M, Drebinger K, Dannenmann A, Einsele H, Grigoleit GU, et al. High prevalence of distress in patients after allogeneic hematopoietic SCT: fear of progression is associated with a younger age. Bone Marrow Transplant 2014; 49: 581–4.
    • (2014) Bone Marrow Transplant , vol.49 , pp. 581-584
    • Hefner, J.1    Kapp, M.2    Drebinger, K.3    Dannenmann, A.4    Einsele, H.5    Grigoleit, G.U.6
  • 67
    • 84873095231 scopus 로고    scopus 로고
    • A dedicated GvHD clinic may improve the quality of life for allogeneic stem cell transplant survivors
    • Dignan FL, Manwani R, Potter MN, Ethell ME, Leonard H, Brennan J, et al. A dedicated GvHD clinic may improve the quality of life for allogeneic stem cell transplant survivors. Clin Transplant 2013; 27: E1–2.
    • (2013) Clin Transplant , vol.27 , pp. E1-2
    • Dignan, F.L.1    Manwani, R.2    Potter, M.N.3    Ethell, M.E.4    Leonard, H.5    Brennan, J.6
  • 70
    • 84943582032 scopus 로고    scopus 로고
    • Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey
    • Zeiser R, Burchert A, Lengerke C, Verbeek M, Maas-Bauer K, Metzelder SK, et al. Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey. Leukemia 2015; 29: 2062–8.
    • (2015) Leukemia , vol.29 , pp. 2062-2068
    • Zeiser, R.1    Burchert, A.2    Lengerke, C.3    Verbeek, M.4    Maas-Bauer, K.5    Metzelder, S.K.6
  • 71
    • 84957439242 scopus 로고    scopus 로고
    • The impact of CYP3A5*3 polymorphism on sirolimus pharmacokinetics: insights from predictions with a physiologically-based pharmacokinetic model
    • Emoto C, Fukuda T, Venkatasubramanian R, Vinks AA. The impact of CYP3A5*3 polymorphism on sirolimus pharmacokinetics: insights from predictions with a physiologically-based pharmacokinetic model. Br J Clin Pharmacol 2015; 80: 1438–46.
    • (2015) Br J Clin Pharmacol , vol.80 , pp. 1438-1446
    • Emoto, C.1    Fukuda, T.2    Venkatasubramanian, R.3    Vinks, A.A.4
  • 72
    • 84931843832 scopus 로고    scopus 로고
    • Everolimus and sirolimus in transplantation-related but different
    • Klawitter J, Nashan B, Christians U. Everolimus and sirolimus in transplantation-related but different. Expert Opin Drug Saf 2015; 14: 1055–70.
    • (2015) Expert Opin Drug Saf , vol.14 , pp. 1055-1070
    • Klawitter, J.1    Nashan, B.2    Christians, U.3
  • 73
    • 84880051527 scopus 로고    scopus 로고
    • Drug interactions and the pharmacist: focus on everolimus
    • Grabowsky JA. Drug interactions and the pharmacist: focus on everolimus. Ann Pharmacother 2013; 47: 1055–63.
    • (2013) Ann Pharmacother , vol.47 , pp. 1055-1063
    • Grabowsky, J.A.1


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