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Volumn 20, Issue 11, 2014, Pages 1828-1834

Calcineurin inhibitor-free graft-versus-host disease prophylaxis with post-transplantation cyclophosphamide and brief-course sirolimus following reduced-intensity peripheral blood stem cell transplantation

Author keywords

Allogeneic; Graft versus host disease; Peripheral blood stem cell transplantation; Post transplantation cyclophosphamide; Reduced intensity conditioning; Sirolimus

Indexed keywords

CALCINEURIN INHIBITOR; CYCLOPHOSPHAMIDE; RAPAMYCIN; IMMUNOSUPPRESSIVE AGENT;

EID: 84908046608     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2014.07.020     Document Type: Article
Times cited : (51)

References (71)
  • 2
    • 0021167047 scopus 로고
    • How does bone-marrow transplantation cure leukaemia?
    • Gale R.P., Champlin R.E. How does bone-marrow transplantation cure leukaemia?. Lancet 1984, 324:28-30.
    • (1984) Lancet , vol.324 , pp. 28-30
    • Gale, R.P.1    Champlin, R.E.2
  • 3
    • 0033768662 scopus 로고    scopus 로고
    • Harnessing graft-versus-malignancy: non-myeloablative preparative regimens for allogeneic haematopoietic transplantation, an evolving strategy for adoptive immunotherapy
    • Champlin R., Khouri I., Shimoni A., et al. Harnessing graft-versus-malignancy: non-myeloablative preparative regimens for allogeneic haematopoietic transplantation, an evolving strategy for adoptive immunotherapy. Br J Haematol 2000, 111:18-29.
    • (2000) Br J Haematol , vol.111 , pp. 18-29
    • Champlin, R.1    Khouri, I.2    Shimoni, A.3
  • 4
    • 4644307254 scopus 로고    scopus 로고
    • Nonmyeloablative stem cell transplantation: lessons from the first decade of clinical experience
    • Shimoni A., Nagler A. Nonmyeloablative stem cell transplantation: lessons from the first decade of clinical experience. Curr Hematol Rep 2004, 3:242-248.
    • (2004) Curr Hematol Rep , vol.3 , pp. 242-248
    • Shimoni, A.1    Nagler, A.2
  • 5
    • 13544257121 scopus 로고    scopus 로고
    • Comparative outcome of nonmyeloablative and myeloablative allogeneic hematopoietic cell transplantation for patients older than 50 years of age
    • Alyea E.P., Kim H.T., Ho V., et al. Comparative outcome of nonmyeloablative and myeloablative allogeneic hematopoietic cell transplantation for patients older than 50 years of age. Blood 2005, 105:1810-1814.
    • (2005) Blood , vol.105 , pp. 1810-1814
    • Alyea, E.P.1    Kim, H.T.2    Ho, V.3
  • 6
    • 0036225351 scopus 로고    scopus 로고
    • Allogeneic hematopoetic stem-cell transplantation for patients with relapsed or refractory lymphomas: comparison of high-dose conventional conditioning versus fludarabine-based reduced-intensity regimens
    • Bertz H., Illerhaus G., Veelken H., Finke J. Allogeneic hematopoetic stem-cell transplantation for patients with relapsed or refractory lymphomas: comparison of high-dose conventional conditioning versus fludarabine-based reduced-intensity regimens. Ann Oncol 2002, 13:135-139.
    • (2002) Ann Oncol , vol.13 , pp. 135-139
    • Bertz, H.1    Illerhaus, G.2    Veelken, H.3    Finke, J.4
  • 7
    • 31444444950 scopus 로고    scopus 로고
    • Allogeneic hematopoietic stem-cell transplantation in AML and MDS using myeloablative versus reduced-intensity conditioning: the role of dose intensity
    • Shimoni A., Hardan I., Shem-Tov N., et al. Allogeneic hematopoietic stem-cell transplantation in AML and MDS using myeloablative versus reduced-intensity conditioning: the role of dose intensity. Leukemia 2006, 20:322-328.
    • (2006) Leukemia , vol.20 , pp. 322-328
    • Shimoni, A.1    Hardan, I.2    Shem-Tov, N.3
  • 8
    • 0033656305 scopus 로고    scopus 로고
    • Equivalence of 2 effective graft-versus-host disease prophylaxis regimens: results of a prospective double-blind randomized trial
    • Chao N.J., Snyder D.S., Jain M., et al. Equivalence of 2 effective graft-versus-host disease prophylaxis regimens: results of a prospective double-blind randomized trial. Biol Blood Marrow Transplant 2000, 6:254-261.
    • (2000) Biol Blood Marrow Transplant , vol.6 , pp. 254-261
    • Chao, N.J.1    Snyder, D.S.2    Jain, M.3
  • 9
    • 0034284306 scopus 로고    scopus 로고
    • Cyclosporin A and short-term methotrexate versus cyclosporin A as graft-versus-host disease prophylaxis in patients with severe aplastic anemia given allogeneic bone marrow transplantation from an HLA-identical sibling: results of a GITMO/EBMT randomized trial
    • Locatelli F., Bruno B., Zecca M., et al. Cyclosporin A and short-term methotrexate versus cyclosporin A as graft-versus-host disease prophylaxis in patients with severe aplastic anemia given allogeneic bone marrow transplantation from an HLA-identical sibling: results of a GITMO/EBMT randomized trial. Blood 2000, 96:1690-1697.
    • (2000) Blood , vol.96 , pp. 1690-1697
    • Locatelli, F.1    Bruno, B.2    Zecca, M.3
  • 10
    • 0034665674 scopus 로고    scopus 로고
    • Phase 3 study comparing methotrexate and tacrolimus with methotrexate and cyclosporine for prophylaxis of acute graft-versus-host disease after marrow transplantation from unrelated donors
    • Nash R.A., Antin J.H., Karanes C., et al. Phase 3 study comparing methotrexate and tacrolimus with methotrexate and cyclosporine for prophylaxis of acute graft-versus-host disease after marrow transplantation from unrelated donors. Blood 2000, 96:2062-2068.
    • (2000) Blood , vol.96 , pp. 2062-2068
    • Nash, R.A.1    Antin, J.H.2    Karanes, C.3
  • 11
    • 27644515599 scopus 로고    scopus 로고
    • Influence of T-cell depletion on chronic graft-versus-host disease: results of a multicenter randomized trial in unrelated marrow donor transplantation
    • Pavletic S.Z., Carter S.L., Kernan N.A., et al. Influence of T-cell depletion on chronic graft-versus-host disease: results of a multicenter randomized trial in unrelated marrow donor transplantation. Blood 2005, 106:3308-3313.
    • (2005) Blood , vol.106 , pp. 3308-3313
    • Pavletic, S.Z.1    Carter, S.L.2    Kernan, N.A.3
  • 12
    • 4544313425 scopus 로고    scopus 로고
    • Tacrolimus as monotherapy or combined with minidose methotrexate for graft-versus-host disease prophylaxis after allogeneic peripheral blood stem cell transplantation: long-term outcomes
    • Uberti J.P., Ayash L., Braun T., et al. Tacrolimus as monotherapy or combined with minidose methotrexate for graft-versus-host disease prophylaxis after allogeneic peripheral blood stem cell transplantation: long-term outcomes. Bone Marrow Transplant 2004, 34:425-431.
    • (2004) Bone Marrow Transplant , vol.34 , pp. 425-431
    • Uberti, J.P.1    Ayash, L.2    Braun, T.3
  • 13
    • 0037100280 scopus 로고    scopus 로고
    • Comparison of chronic graft-versus-host disease after transplantation of peripheral blood stem cells versus bone marrow in allogeneic recipients: long-term follow-up of a randomized trial
    • Flowers M.E., Parker P.M., Johnston L.J., et al. Comparison of chronic graft-versus-host disease after transplantation of peripheral blood stem cells versus bone marrow in allogeneic recipients: long-term follow-up of a randomized trial. Blood 2002, 100:415-419.
    • (2002) Blood , vol.100 , pp. 415-419
    • Flowers, M.E.1    Parker, P.M.2    Johnston, L.J.3
  • 14
    • 0036839562 scopus 로고    scopus 로고
    • Chronic graft-versus-host disease after allogeneic blood stem cell transplantation: long-term results of a randomized study
    • Mohty M., Kuentz M., Michallet M., et al. Chronic graft-versus-host disease after allogeneic blood stem cell transplantation: long-term results of a randomized study. Blood 2002, 100:3128-3134.
    • (2002) Blood , vol.100 , pp. 3128-3134
    • Mohty, M.1    Kuentz, M.2    Michallet, M.3
  • 15
    • 0141461418 scopus 로고    scopus 로고
    • + regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation
    • + regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med 2003, 9:1144-1150.
    • (2003) Nat Med , vol.9 , pp. 1144-1150
    • Edinger, M.1    Hoffmann, P.2    Ermann, J.3
  • 16
    • 0037093217 scopus 로고    scopus 로고
    • + immune regulatory cells inhibits graft-versus-host disease lethality
    • + immune regulatory cells inhibits graft-versus-host disease lethality. Blood 2002, 99:3493-3499.
    • (2002) Blood , vol.99 , pp. 3493-3499
    • Taylor, P.A.1    Lees, C.J.2    Blazar, B.R.3
  • 17
    • 0346690399 scopus 로고    scopus 로고
    • + regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia
    • + regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia. JClin Invest 2003, 112:1688-1696.
    • (2003) JClin Invest , vol.112 , pp. 1688-1696
    • Trenado, A.1    Charlotte, F.2    Fisson, S.3
  • 18
    • 52649147984 scopus 로고    scopus 로고
    • + regulatory T cells ameliorate ongoing chronic graft-versus-host disease
    • + regulatory T cells ameliorate ongoing chronic graft-versus-host disease. Blood 2008, 112:2129-2138.
    • (2008) Blood , vol.112 , pp. 2129-2138
    • Zhao, D.1    Zhang, C.2    Yi, T.3
  • 19
    • 33746809277 scopus 로고    scopus 로고
    • High donor FOXP3-positive regulatory T-cell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT
    • Rezvani K., Mielke S., Ahmadzadeh M., et al. High donor FOXP3-positive regulatory T-cell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT. Blood 2006, 108:1291-1297.
    • (2006) Blood , vol.108 , pp. 1291-1297
    • Rezvani, K.1    Mielke, S.2    Ahmadzadeh, M.3
  • 20
    • 32644448124 scopus 로고    scopus 로고
    • + regulatory T cells are numerically deficient in acute and chronic GvHD
    • + regulatory T cells are numerically deficient in acute and chronic GvHD. Blood 2006, 107:1717-1723.
    • (2006) Blood , vol.107 , pp. 1717-1723
    • Rieger, K.1    Loddenkemper, C.2    Maul, J.3
  • 21
    • 27144500976 scopus 로고    scopus 로고
    • + regulatory T cells in patients with chronic graft-versus-host disease
    • + regulatory T cells in patients with chronic graft-versus-host disease. Blood 2005, 106:2903-2911.
    • (2005) Blood , vol.106 , pp. 2903-2911
    • Zorn, E.1    Kim, H.T.2    Lee, S.J.3
  • 23
    • 33745633856 scopus 로고    scopus 로고
    • + regulatory T-cell function by calcineurin-dependent interleukin-2 production
    • + regulatory T-cell function by calcineurin-dependent interleukin-2 production. Blood 2006, 108:390-399.
    • (2006) Blood , vol.108 , pp. 390-399
    • Zeiser, R.1    Nguyen, V.H.2    Beilhack, A.3
  • 24
    • 84890082174 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase expression drives human regulatory T cell resistance to posttransplantation cyclophosphamide
    • Kanakry C.G., Ganguly S., Zahurak M., et al. Aldehyde dehydrogenase expression drives human regulatory T cell resistance to posttransplantation cyclophosphamide. Sci Transl Med 2013, 5:ra157.
    • (2013) Sci Transl Med , vol.5 , pp. ra157
    • Kanakry, C.G.1    Ganguly, S.2    Zahurak, M.3
  • 26
    • 28744444180 scopus 로고    scopus 로고
    • National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease, I: Diagnosis and Staging Working Group Report
    • Filipovich A.H., Weisdorf D., Pavletic S., et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease, I: Diagnosis and Staging Working Group Report. Biol Blood Marrow Transplant 2005, 11:945-956.
    • (2005) Biol Blood Marrow Transplant , vol.11 , pp. 945-956
    • Filipovich, A.H.1    Weisdorf, D.2    Pavletic, S.3
  • 27
    • 85004963441 scopus 로고
    • Nonparametric estimation from incomplete observations
    • Kaplan E., Meier P. Nonparametric estimation from incomplete observations. JAm Stat Assoc 1958, 84:360-372.
    • (1958) JAm Stat Assoc , vol.84 , pp. 360-372
    • Kaplan, E.1    Meier, P.2
  • 28
    • 0035663624 scopus 로고    scopus 로고
    • Statistical methods for the analysis and presentation of the results of bone marrow transplants, part 2: regression modeling
    • Klein J.P., Rizzo J.D., Zhang M.J., Keiding N. Statistical methods for the analysis and presentation of the results of bone marrow transplants, part 2: regression modeling. Bone Marrow Transplant 2001, 28:1001-1011.
    • (2001) Bone Marrow Transplant , vol.28 , pp. 1001-1011
    • Klein, J.P.1    Rizzo, J.D.2    Zhang, M.J.3    Keiding, N.4
  • 29
    • 0000120995 scopus 로고
    • Aclass of K-sample tests for comparing the cumulative incidence of a competing risk
    • Gray R.J. Aclass of K-sample tests for comparing the cumulative incidence of a competing risk. Ann Stat 1988, 16:1141-1154.
    • (1988) Ann Stat , vol.16 , pp. 1141-1154
    • Gray, R.J.1
  • 30
    • 84876089274 scopus 로고    scopus 로고
    • T-cell-replete HLA-haploidentical hematopoietic transplantation for hematologic malignancies using post-transplantation cyclophosphamide results in outcomes equivalent to those of contemporaneous HLA-matched related and unrelated donor transplantation
    • Bashey A., Zhang X., Sizemore C.A., et al. T-cell-replete HLA-haploidentical hematopoietic transplantation for hematologic malignancies using post-transplantation cyclophosphamide results in outcomes equivalent to those of contemporaneous HLA-matched related and unrelated donor transplantation. JClin Oncol 2013, 31:1310-1316.
    • (2013) JClin Oncol , vol.31 , pp. 1310-1316
    • Bashey, A.1    Zhang, X.2    Sizemore, C.A.3
  • 31
    • 79960465258 scopus 로고    scopus 로고
    • Alternative donor transplantation after reduced-intensity conditioning: results of parallel phase 2 trials using partially HLA-mismatched related bone marrow or unrelated double umbilical cord blood grafts
    • Brunstein C.G., Fuchs E.J., Carter S.L., et al. Alternative donor transplantation after reduced-intensity conditioning: results of parallel phase 2 trials using partially HLA-mismatched related bone marrow or unrelated double umbilical cord blood grafts. Blood 2011, 118:282-288.
    • (2011) Blood , vol.118 , pp. 282-288
    • Brunstein, C.G.1    Fuchs, E.J.2    Carter, S.L.3
  • 32
    • 77951453769 scopus 로고    scopus 로고
    • High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host disease
    • Luznik L., Bolanos-Meade J., Zahurak M., et al. High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host disease. Blood 2010, 115:3224-3230.
    • (2010) Blood , vol.115 , pp. 3224-3230
    • Luznik, L.1    Bolanos-Meade, J.2    Zahurak, M.3
  • 33
    • 43449091559 scopus 로고    scopus 로고
    • HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide
    • Luznik L., O'Donnell P.V., Symons H.J., et al. HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide. Biol Blood Marrow Transplant 2008, 14:641-650.
    • (2008) Biol Blood Marrow Transplant , vol.14 , pp. 641-650
    • Luznik, L.1    O'Donnell, P.V.2    Symons, H.J.3
  • 34
    • 0036045174 scopus 로고    scopus 로고
    • Nonmyeloablative bone marrow transplantation from partially HLA-mismatched related donors using posttransplantation cyclophosphamide
    • O'Donnell P.V., Luznik L., Jones R.J., et al. Nonmyeloablative bone marrow transplantation from partially HLA-mismatched related donors using posttransplantation cyclophosphamide. Biol Blood Marrow Transplant 2002, 8:377-386.
    • (2002) Biol Blood Marrow Transplant , vol.8 , pp. 377-386
    • O'Donnell, P.V.1    Luznik, L.2    Jones, R.J.3
  • 35
    • 84869083138 scopus 로고    scopus 로고
    • Haploidentical transplantation using T cell-replete peripheral blood stem cells and myeloablative conditioning in patients with high-risk hematologic malignancies who lack conventional donors is well tolerated and produces excellent relapse-free survival: results of a prospective phase II trial
    • Solomon S.R., Sizemore C.A., Sanacore M., et al. Haploidentical transplantation using T cell-replete peripheral blood stem cells and myeloablative conditioning in patients with high-risk hematologic malignancies who lack conventional donors is well tolerated and produces excellent relapse-free survival: results of a prospective phase II trial. Biol Blood Marrow Transplant 2012, 18:1859-1866.
    • (2012) Biol Blood Marrow Transplant , vol.18 , pp. 1859-1866
    • Solomon, S.R.1    Sizemore, C.A.2    Sanacore, M.3
  • 36
    • 0036204689 scopus 로고    scopus 로고
    • Posttransplantation cyclophosphamide facilitates engraftment of major histocompatibility complex-identical allogeneic marrow in mice conditioned with low-dose total body irradiation
    • Luznik L., Engstrom L.W., Iannone R., Fuchs E.J. Posttransplantation cyclophosphamide facilitates engraftment of major histocompatibility complex-identical allogeneic marrow in mice conditioned with low-dose total body irradiation. Biol Blood Marrow Transplant 2002, 8:131-138.
    • (2002) Biol Blood Marrow Transplant , vol.8 , pp. 131-138
    • Luznik, L.1    Engstrom, L.W.2    Iannone, R.3    Fuchs, E.J.4
  • 37
    • 0035761436 scopus 로고    scopus 로고
    • Durable engraftment of major histocompatibility complex-incompatible cells after nonmyeloablative conditioning with fludarabine, low-dose total body irradiation, and posttransplantation cyclophosphamide
    • Luznik L., Jalla S., Engstrom L.W., et al. Durable engraftment of major histocompatibility complex-incompatible cells after nonmyeloablative conditioning with fludarabine, low-dose total body irradiation, and posttransplantation cyclophosphamide. Blood 2001, 98:3456-3464.
    • (2001) Blood , vol.98 , pp. 3456-3464
    • Luznik, L.1    Jalla, S.2    Engstrom, L.W.3
  • 38
    • 0032105481 scopus 로고    scopus 로고
    • Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression
    • Sehgal S.N. Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression. Clin Biochem 1998, 31:335-340.
    • (1998) Clin Biochem , vol.31 , pp. 335-340
    • Sehgal, S.N.1
  • 40
    • 0036682957 scopus 로고    scopus 로고
    • Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells
    • Hackstein H., Taner T., Logar A.J., Thomson A.W. Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells. Blood 2002, 100:1084-1087.
    • (2002) Blood , vol.100 , pp. 1084-1087
    • Hackstein, H.1    Taner, T.2    Logar, A.J.3    Thomson, A.W.4
  • 41
    • 0038036797 scopus 로고    scopus 로고
    • Rapamycin inhibits IL-4-induced dendritic cell maturation invitro and dendritic cell mobilization and function invivo
    • Hackstein H., Taner T., Zahorchak A.F., et al. Rapamycin inhibits IL-4-induced dendritic cell maturation invitro and dendritic cell mobilization and function invivo. Blood 2003, 101:4457-4463.
    • (2003) Blood , vol.101 , pp. 4457-4463
    • Hackstein, H.1    Taner, T.2    Zahorchak, A.F.3
  • 42
    • 0037439786 scopus 로고    scopus 로고
    • Rapamycin impairs antigen uptake of human dendritic cells
    • Monti P., Mercalli A., Leone B.E., et al. Rapamycin impairs antigen uptake of human dendritic cells. Transplantation 2003, 75:137-145.
    • (2003) Transplantation , vol.75 , pp. 137-145
    • Monti, P.1    Mercalli, A.2    Leone, B.E.3
  • 43
    • 0035084130 scopus 로고    scopus 로고
    • Rapamycin reduces expression of fibrosis-associated genes in an experimental model of renal ischaemia reperfusion injury
    • Jain S., Bicknell G.R., Whiting P.H., Nicholson M.L. Rapamycin reduces expression of fibrosis-associated genes in an experimental model of renal ischaemia reperfusion injury. Transplant Proc 2001, 33:556-558.
    • (2001) Transplant Proc , vol.33 , pp. 556-558
    • Jain, S.1    Bicknell, G.R.2    Whiting, P.H.3    Nicholson, M.L.4
  • 44
    • 0032738763 scopus 로고    scopus 로고
    • Rapamycin inhibits hepatic stellate cell proliferation invitro and limits fibrogenesis in an invivo model of liver fibrosis
    • Zhu J., Wu J., Frizell E., et al. Rapamycin inhibits hepatic stellate cell proliferation invitro and limits fibrogenesis in an invivo model of liver fibrosis. Gastroenterology 1999, 117:1198-1204.
    • (1999) Gastroenterology , vol.117 , pp. 1198-1204
    • Zhu, J.1    Wu, J.2    Frizell, E.3
  • 45
    • 57449092086 scopus 로고    scopus 로고
    • Improved survival in lymphoma patients receiving sirolimus for graft-versus-host disease prophylaxis after allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning
    • Armand P., Gannamaneni S., Kim H.T., et al. Improved survival in lymphoma patients receiving sirolimus for graft-versus-host disease prophylaxis after allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning. JClin Oncol 2008, 26:5767-5774.
    • (2008) JClin Oncol , vol.26 , pp. 5767-5774
    • Armand, P.1    Gannamaneni, S.2    Kim, H.T.3
  • 46
    • 20144363954 scopus 로고    scopus 로고
    • Antileukemic activity of rapamycin in acute myeloid leukemia
    • Recher C., Beyne-Rauzy O., Demur C., et al. Antileukemic activity of rapamycin in acute myeloid leukemia. Blood 2005, 105:2527-2534.
    • (2005) Blood , vol.105 , pp. 2527-2534
    • Recher, C.1    Beyne-Rauzy, O.2    Demur, C.3
  • 47
    • 37349090416 scopus 로고    scopus 로고
    • Evaluation of antileukaemic effects of rapamycin in patients with imatinib-resistant chronic myeloid leukaemia
    • Sillaber C., Mayerhofer M., Bohm A., et al. Evaluation of antileukaemic effects of rapamycin in patients with imatinib-resistant chronic myeloid leukaemia. Eur J Clin Invest 2008, 38:43-52.
    • (2008) Eur J Clin Invest , vol.38 , pp. 43-52
    • Sillaber, C.1    Mayerhofer, M.2    Bohm, A.3
  • 48
    • 0034636055 scopus 로고    scopus 로고
    • The immunosuppressive macrolide RAD inhibits growth of human Epstein-Barr virus-transformed B lymphocytes invitro and invivo: a potential approach to prevention and treatment of posttransplant lymphoproliferative disorders
    • Majewski M., Korecka M., Kossev P., et al. The immunosuppressive macrolide RAD inhibits growth of human Epstein-Barr virus-transformed B lymphocytes invitro and invivo: a potential approach to prevention and treatment of posttransplant lymphoproliferative disorders. Proc Natl Acad Sci USA 2000, 97:4285-4290.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 4285-4290
    • Majewski, M.1    Korecka, M.2    Kossev, P.3
  • 49
    • 34547123123 scopus 로고    scopus 로고
    • Sirolimus-based graft-versus-host disease prophylaxis protects against cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation: a cohort analysis
    • Marty F.M., Bryar J., Browne S.K., et al. Sirolimus-based graft-versus-host disease prophylaxis protects against cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation: a cohort analysis. Blood 2007, 110:490-500.
    • (2007) Blood , vol.110 , pp. 490-500
    • Marty, F.M.1    Bryar, J.2    Browne, S.K.3
  • 50
    • 84885654409 scopus 로고    scopus 로고
    • Sirolimus and post-transplant Cy synergistically maintain mixed chimerism in a mismatched murine model
    • Fitzhugh C.D., Weitzel R.P., Hsieh M.M., et al. Sirolimus and post-transplant Cy synergistically maintain mixed chimerism in a mismatched murine model. Bone Marrow Transplant 2013, 48:1335-1341.
    • (2013) Bone Marrow Transplant , vol.48 , pp. 1335-1341
    • Fitzhugh, C.D.1    Weitzel, R.P.2    Hsieh, M.M.3
  • 51
    • 58149388343 scopus 로고    scopus 로고
    • Sirolimus is associated with veno-occlusive disease of the liver after myeloablative allogeneic stem cell transplantation
    • Cutler C., Stevenson K., Kim H.T., et al. Sirolimus is associated with veno-occlusive disease of the liver after myeloablative allogeneic stem cell transplantation. Blood 2008, 112:4425-4431.
    • (2008) Blood , vol.112 , pp. 4425-4431
    • Cutler, C.1    Stevenson, K.2    Kim, H.T.3
  • 52
    • 84859465951 scopus 로고    scopus 로고
    • Sirolimus and mycophenolate mofetil as GVHD prophylaxis in myeloablative, matched-related donor hematopoietic cell transplantation
    • Johnston L., Florek M., Armstrong R., et al. Sirolimus and mycophenolate mofetil as GVHD prophylaxis in myeloablative, matched-related donor hematopoietic cell transplantation. Bone Marrow Transplant 2012, 47:581-588.
    • (2012) Bone Marrow Transplant , vol.47 , pp. 581-588
    • Johnston, L.1    Florek, M.2    Armstrong, R.3
  • 53
    • 84864608769 scopus 로고    scopus 로고
    • Possible correlation of sirolimus plasma concentration with sinusoidal obstructive syndrome of the liver in patients undergoing myeloablative allogeneic hematopoietic cell transplantation
    • Kiel P.J., Vargo C.A., Patel G.P., et al. Possible correlation of sirolimus plasma concentration with sinusoidal obstructive syndrome of the liver in patients undergoing myeloablative allogeneic hematopoietic cell transplantation. Pharmacotherapy 2012, 32:441-445.
    • (2012) Pharmacotherapy , vol.32 , pp. 441-445
    • Kiel, P.J.1    Vargo, C.A.2    Patel, G.P.3
  • 54
    • 79956053688 scopus 로고    scopus 로고
    • Prophylaxis with sirolimus and tacrolimus+/- antithymocyte globulin reduces the risk of acute graft-versus-host disease without an overall survival benefit following allogeneic stem cell transplantation
    • Rosenbeck L.L., Kiel P.J., Kalsekar I., et al. Prophylaxis with sirolimus and tacrolimus+/- antithymocyte globulin reduces the risk of acute graft-versus-host disease without an overall survival benefit following allogeneic stem cell transplantation. Biol Blood Marrow Transplant 2011, 17:916-922.
    • (2011) Biol Blood Marrow Transplant , vol.17 , pp. 916-922
    • Rosenbeck, L.L.1    Kiel, P.J.2    Kalsekar, I.3
  • 55
    • 84867592111 scopus 로고    scopus 로고
    • Peripheral-blood stem cells versus bone marrow from unrelated donors
    • Anasetti C., Logan B.R., Lee S.J., et al. Peripheral-blood stem cells versus bone marrow from unrelated donors. NEngl J Med 2012, 367:1487-1496.
    • (2012) NEngl J Med , vol.367 , pp. 1487-1496
    • Anasetti, C.1    Logan, B.R.2    Lee, S.J.3
  • 56
    • 0033566347 scopus 로고    scopus 로고
    • Peripheral blood stem cell transplantation from unrelated donors: a comparison with marrow transplantation
    • Ringden O., Remberger M., Runde V., et al. Peripheral blood stem cell transplantation from unrelated donors: a comparison with marrow transplantation. Blood 1999, 94:455-464.
    • (1999) Blood , vol.94 , pp. 455-464
    • Ringden, O.1    Remberger, M.2    Runde, V.3
  • 57
    • 0032406754 scopus 로고    scopus 로고
    • Arandomised, prospective comparison of allogeneic bone marrow and peripheral blood progenitor cell transplantation in the treatment of haematological malignancies
    • Vigorito A.C., Azevedo W.M., Marques J.F., et al. Arandomised, prospective comparison of allogeneic bone marrow and peripheral blood progenitor cell transplantation in the treatment of haematological malignancies. Bone Marrow Transplant 1998, 22:1145-1151.
    • (1998) Bone Marrow Transplant , vol.22 , pp. 1145-1151
    • Vigorito, A.C.1    Azevedo, W.M.2    Marques, J.F.3
  • 58
    • 9444243839 scopus 로고    scopus 로고
    • Duration of immunosuppressive treatment for chronic graft-versus-host disease
    • Stewart B.L., Storer B., Storek J., et al. Duration of immunosuppressive treatment for chronic graft-versus-host disease. Blood 2004, 104:3501-3506.
    • (2004) Blood , vol.104 , pp. 3501-3506
    • Stewart, B.L.1    Storer, B.2    Storek, J.3
  • 59
    • 35548967577 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation following reduced-intensity conditioning can induce durable clinical and molecular remissions in relapsed lymphomas: pre-transplant disease status and histotype heavily influence outcome
    • Corradini P., Dodero A., Farina L., et al. Allogeneic stem cell transplantation following reduced-intensity conditioning can induce durable clinical and molecular remissions in relapsed lymphomas: pre-transplant disease status and histotype heavily influence outcome. Leukemia 2007, 21:2316-2323.
    • (2007) Leukemia , vol.21 , pp. 2316-2323
    • Corradini, P.1    Dodero, A.2    Farina, L.3
  • 60
    • 33644833398 scopus 로고    scopus 로고
    • Treatment for acute myelogenous leukemia by low-dose, total-body, irradiation-based conditioning and hematopoietic cell transplantation from related and unrelated donors
    • Hegenbart U., Niederwieser D., Sandmaier B.M., et al. Treatment for acute myelogenous leukemia by low-dose, total-body, irradiation-based conditioning and hematopoietic cell transplantation from related and unrelated donors. JClin Oncol 2006, 24:444-453.
    • (2006) JClin Oncol , vol.24 , pp. 444-453
    • Hegenbart, U.1    Niederwieser, D.2    Sandmaier, B.M.3
  • 61
    • 0037114621 scopus 로고    scopus 로고
    • Chemoresistant or aggressive lymphoma predicts for a poor outcome following reduced-intensity allogeneic progenitor cell transplantation: an analysis from the Lymphoma Working Party of the European Group for Blood and Bone Marrow Transplantation
    • Robinson S.P., Goldstone A.H., Mackinnon S., et al. Chemoresistant or aggressive lymphoma predicts for a poor outcome following reduced-intensity allogeneic progenitor cell transplantation: an analysis from the Lymphoma Working Party of the European Group for Blood and Bone Marrow Transplantation. Blood 2002, 100:4310-4316.
    • (2002) Blood , vol.100 , pp. 4310-4316
    • Robinson, S.P.1    Goldstone, A.H.2    Mackinnon, S.3
  • 62
    • 84856421828 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with relapsed or refractory Hodgkin lymphoma: results of the HDR-ALLO study, a prospective clinical trial by the Grupo Espanol de Linfomas/Trasplante de Medula Osea (GEL/TAMO) and the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation
    • Sureda A., Canals C., Arranz R., et al. Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with relapsed or refractory Hodgkin lymphoma: results of the HDR-ALLO study, a prospective clinical trial by the Grupo Espanol de Linfomas/Trasplante de Medula Osea (GEL/TAMO) and the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation. Haematologica 2012, 97:310-317.
    • (2012) Haematologica , vol.97 , pp. 310-317
    • Sureda, A.1    Canals, C.2    Arranz, R.3
  • 63
    • 39149133203 scopus 로고    scopus 로고
    • Sustained remissions of high-risk acute myeloid leukemia and myelodysplastic syndrome after reduced-intensity conditioning allogeneic hematopoietic transplantation: chronic graft-versus-host disease is the strongest factor improving survival
    • Valcarcel D., Martino R., Caballero D., et al. Sustained remissions of high-risk acute myeloid leukemia and myelodysplastic syndrome after reduced-intensity conditioning allogeneic hematopoietic transplantation: chronic graft-versus-host disease is the strongest factor improving survival. JClin Oncol 2008, 26:577-584.
    • (2008) JClin Oncol , vol.26 , pp. 577-584
    • Valcarcel, D.1    Martino, R.2    Caballero, D.3
  • 64
    • 33846516354 scopus 로고    scopus 로고
    • Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma
    • Haritunians T., Mori A., O'Kelly J., et al. Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma. Leukemia 2006, 21:333-339.
    • (2006) Leukemia , vol.21 , pp. 333-339
    • Haritunians, T.1    Mori, A.2    O'Kelly, J.3
  • 65
    • 0037207525 scopus 로고    scopus 로고
    • Rapamycin-induced G1 arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3, cyclin E, cyclin A, and survivin
    • Decker T., Hipp S., Ringshausen I., et al. Rapamycin-induced G1 arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3, cyclin E, cyclin A, and survivin. Blood 2003, 101:278-285.
    • (2003) Blood , vol.101 , pp. 278-285
    • Decker, T.1    Hipp, S.2    Ringshausen, I.3
  • 66
    • 23944453915 scopus 로고    scopus 로고
    • Arapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein β and NF-κB activity in Hodgkin and anaplastic large cell lymphomas
    • Jundt F., Raetzel N., Müller C., et al. Arapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein β and NF-κB activity in Hodgkin and anaplastic large cell lymphomas. Blood 2005, 106:1801-1807.
    • (2005) Blood , vol.106 , pp. 1801-1807
    • Jundt, F.1    Raetzel, N.2    Müller, C.3
  • 67
    • 33746490507 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibition induces cell cycle arrest in diffuse large B cell lymphoma (DLBCL) cells and sensitises DLBCL cells to rituximab
    • Wanner K., Hipp S., Oelsner M., et al. Mammalian target of rapamycin inhibition induces cell cycle arrest in diffuse large B cell lymphoma (DLBCL) cells and sensitises DLBCL cells to rituximab. Br J Haematol 2006, 134:475-484.
    • (2006) Br J Haematol , vol.134 , pp. 475-484
    • Wanner, K.1    Hipp, S.2    Oelsner, M.3
  • 68
    • 68949102180 scopus 로고    scopus 로고
    • Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma
    • Hess G., Herbrecht R., Romaguera J., et al. Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma. JClin Oncol 2009, 27:3822-3829.
    • (2009) JClin Oncol , vol.27 , pp. 3822-3829
    • Hess, G.1    Herbrecht, R.2    Romaguera, J.3
  • 69
    • 84863971730 scopus 로고    scopus 로고
    • Amulticenter phase II trial (SAKK 36/06) of single-agent everolimus (RAD001) in patients with relapsed or refractory mantle cell lymphoma
    • Renner C., Zinzani P.L., Gressin R., et al. Amulticenter phase II trial (SAKK 36/06) of single-agent everolimus (RAD001) in patients with relapsed or refractory mantle cell lymphoma. Haematologica 2012, 97:1085-1091.
    • (2012) Haematologica , vol.97 , pp. 1085-1091
    • Renner, C.1    Zinzani, P.L.2    Gressin, R.3
  • 70
    • 78149239933 scopus 로고    scopus 로고
    • Temsirolimus has activity in non-mantle cell non-Hodgkin's lymphoma subtypes: the University of Chicago Phase II Consortium
    • Smith S.M., van Besien K., Karrison T., et al. Temsirolimus has activity in non-mantle cell non-Hodgkin's lymphoma subtypes: the University of Chicago Phase II Consortium. JClin Oncol 2010, 28:4740-4746.
    • (2010) JClin Oncol , vol.28 , pp. 4740-4746
    • Smith, S.M.1    van Besien, K.2    Karrison, T.3
  • 71
    • 79751526328 scopus 로고    scopus 로고
    • Aphase II trial of the oral mTOR inhibitor everolimus in relapsed aggressive lymphoma
    • Witzig T.E., Reeder C.B., LaPlant B.R., et al. Aphase II trial of the oral mTOR inhibitor everolimus in relapsed aggressive lymphoma. Leukemia 2011, 25:341-347.
    • (2011) Leukemia , vol.25 , pp. 341-347
    • Witzig, T.E.1    Reeder, C.B.2    LaPlant, B.R.3


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