메뉴 건너뛰기




Volumn 19, Issue 1, 2013, Pages 12-21

Defining the Role of Sirolimus in the Management of Graft-versus-Host Disease: From Prophylaxis to Treatment

Author keywords

Sirolimus role in GHVD management

Indexed keywords

METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RAPAMYCIN; TACROLIMUS;

EID: 84871923117     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2012.06.020     Document Type: Review
Times cited : (41)

References (68)
  • 1
    • 0036862285 scopus 로고    scopus 로고
    • Sirolimus (Rapamune) in renal transplantation
    • Johnson R.W. Sirolimus (Rapamune) in renal transplantation. Curr Opin Nephrol Hypertens 2002, 11:603-607.
    • (2002) Curr Opin Nephrol Hypertens , vol.11 , pp. 603-607
    • Johnson, R.W.1
  • 2
    • 0038637946 scopus 로고    scopus 로고
    • Sirolimus in liver transplantation
    • Trotter J.F. Sirolimus in liver transplantation. Transplant Proc 2003, 35(3 suppl):193S-200S.
    • (2003) Transplant Proc , vol.35 , Issue.3 SUPPL.
    • Trotter, J.F.1
  • 3
    • 0032105481 scopus 로고    scopus 로고
    • Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression
    • Sehgal S.N. Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression. Clin Biochem 1998, 31:335-340.
    • (1998) Clin Biochem , vol.31 , pp. 335-340
    • Sehgal, S.N.1
  • 4
    • 0038299000 scopus 로고    scopus 로고
    • Sirolimus: its discovery, biological properties, and mechanism of action
    • Sehgal S.N. Sirolimus: its discovery, biological properties, and mechanism of action. Transplant Proc 2003, 35(3 Suppl):7S-14S.
    • (2003) Transplant Proc , vol.35 , Issue.3 SUPPL.
    • Sehgal, S.N.1
  • 5
    • 10744225688 scopus 로고    scopus 로고
    • A randomized long-term trial of tacrolimus/sirolimus versus tacrolimus/mycophenolate mofetil versus cyclosporine (NEORAL)/sirolimus in renal transplantation. II. Survival, function, and protocol compliance at 1 year
    • Ciancio G., Burke G.W., Gaynor J.J., et al. A randomized long-term trial of tacrolimus/sirolimus versus tacrolimus/mycophenolate mofetil versus cyclosporine (NEORAL)/sirolimus in renal transplantation. II. Survival, function, and protocol compliance at 1 year. Transplantation 2004, 77:252-258.
    • (2004) Transplantation , vol.77 , pp. 252-258
    • Ciancio, G.1    Burke, G.W.2    Gaynor, J.J.3
  • 6
    • 10744220677 scopus 로고    scopus 로고
    • A randomized long-term trial of tacrolimus and sirolimus versus tacrolimus and mycophenolate mofetil versus cyclosporine (NEORAL) and sirolimus in renal transplantation. I. Drug interactions and rejection at one year
    • Ciancio G., Burke G.W., Gaynor J.J., et al. A randomized long-term trial of tacrolimus and sirolimus versus tacrolimus and mycophenolate mofetil versus cyclosporine (NEORAL) and sirolimus in renal transplantation. I. Drug interactions and rejection at one year. Transplantation 2004, 77:244-251.
    • (2004) Transplantation , vol.77 , pp. 244-251
    • Ciancio, G.1    Burke, G.W.2    Gaynor, J.J.3
  • 7
    • 0037910271 scopus 로고    scopus 로고
    • Superior T-cell suppression by rapamycin and FK506 over rapamycin and cyclosporine A because of abrogated cytotoxic T-lymphocyte induction, impaired memory responses, and persistent apoptosis
    • Koenen H.J., Michielsen E.C., Verstappen J., Fasse E., Joosten I. Superior T-cell suppression by rapamycin and FK506 over rapamycin and cyclosporine A because of abrogated cytotoxic T-lymphocyte induction, impaired memory responses, and persistent apoptosis. Transplantation 2003, 75:1581-1590.
    • (2003) Transplantation , vol.75 , pp. 1581-1590
    • Koenen, H.J.1    Michielsen, E.C.2    Verstappen, J.3    Fasse, E.4    Joosten, I.5
  • 8
    • 0035284805 scopus 로고    scopus 로고
    • Uncoupling p70(s6) kinase activation and proliferation: rapamycin-resistant proliferation of human CD8(+) T lymphocytes
    • Slavik J.M., Lim D.G., Burakoff S.J., Hafler D.A. Uncoupling p70(s6) kinase activation and proliferation: rapamycin-resistant proliferation of human CD8(+) T lymphocytes. J Immunol 2001, 166:3201-3209.
    • (2001) J Immunol , vol.166 , pp. 3201-3209
    • Slavik, J.M.1    Lim, D.G.2    Burakoff, S.J.3    Hafler, D.A.4
  • 9
    • 0036682957 scopus 로고    scopus 로고
    • Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells
    • Hackstein H., Taner T., Logar A.J., Thomson A.W. Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells. Blood 2002, 100:1084-1087.
    • (2002) Blood , vol.100 , pp. 1084-1087
    • Hackstein, H.1    Taner, T.2    Logar, A.J.3    Thomson, A.W.4
  • 11
    • 0038036797 scopus 로고    scopus 로고
    • Rapamycin inhibits IL-4-induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo
    • Hackstein H., Taner T., Zahorchak A.F., et al. Rapamycin inhibits IL-4-induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo. Blood 2003, 101:4457-4463.
    • (2003) Blood , vol.101 , pp. 4457-4463
    • Hackstein, H.1    Taner, T.2    Zahorchak, A.F.3
  • 12
    • 0036053861 scopus 로고    scopus 로고
    • Inhibition of IL-12 signaling Stat4/IFN-gamma pathway by rapamycin is associated with impaired dendritic [correction of dendritc] cell function
    • Chiang P.H., Wang L., Liang Y., et al. Inhibition of IL-12 signaling Stat4/IFN-gamma pathway by rapamycin is associated with impaired dendritic [correction of dendritc] cell function. Transplant Proc 2002, 34:1394-1395.
    • (2002) Transplant Proc , vol.34 , pp. 1394-1395
    • Chiang, P.H.1    Wang, L.2    Liang, Y.3
  • 13
    • 0035412393 scopus 로고    scopus 로고
    • Rapamycin induces apoptosis in monocyte- and CD34-derived dendritic cells but not in monocytes and macrophages
    • Woltman A.M., de Fijter J.W., Kamerling S.W., et al. Rapamycin induces apoptosis in monocyte- and CD34-derived dendritic cells but not in monocytes and macrophages. Blood 2001, 98:174-180.
    • (2001) Blood , vol.98 , pp. 174-180
    • Woltman, A.M.1    de Fijter, J.W.2    Kamerling, S.W.3
  • 14
    • 0037441902 scopus 로고    scopus 로고
    • Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression
    • Woltman A.M., van der Kooij S.W., Coffer P.J., Offringa R., Daha M.R., van Kooten C. Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression. Blood 2003, 101:1439-1445.
    • (2003) Blood , vol.101 , pp. 1439-1445
    • Woltman, A.M.1    van der Kooij, S.W.2    Coffer, P.J.3    Offringa, R.4    Daha, M.R.5    van Kooten, C.6
  • 15
    • 20444373376 scopus 로고    scopus 로고
    • Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    • Battaglia M., Stabilini A., Roncarolo M.G. Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood 2005, 105:4743-4748.
    • (2005) Blood , vol.105 , pp. 4743-4748
    • Battaglia, M.1    Stabilini, A.2    Roncarolo, M.G.3
  • 16
    • 37349080895 scopus 로고    scopus 로고
    • Sirolimus versus cyclosporine therapy increases circulating regulatory T cells, but does not protect renal transplant patients given alemtuzumab induction from chronic allograft injury
    • Ruggenenti P., Perico N., Gotti E., et al. Sirolimus versus cyclosporine therapy increases circulating regulatory T cells, but does not protect renal transplant patients given alemtuzumab induction from chronic allograft injury. Transplantation 2007, 84:956-964.
    • (2007) Transplantation , vol.84 , pp. 956-964
    • Ruggenenti, P.1    Perico, N.2    Gotti, E.3
  • 17
    • 0030061045 scopus 로고    scopus 로고
    • Inhibition by rapamycin of PDGF- and bFGF-induced human tenon fibroblast proliferation in vitro
    • Salas-Prato M., Assalian A., Mehdi A.Z., Duperré J., Thompson P., Brazeau P. Inhibition by rapamycin of PDGF- and bFGF-induced human tenon fibroblast proliferation in vitro. J Glaucoma 1996, 5:54-59.
    • (1996) J Glaucoma , vol.5 , pp. 54-59
    • Salas-Prato, M.1    Assalian, A.2    Mehdi, A.Z.3    Duperré, J.4    Thompson, P.5    Brazeau, P.6
  • 18
    • 0032738763 scopus 로고    scopus 로고
    • Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis
    • Zhu J., Wu J., Frizell E., et al. Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis. Gastroenterology 1999, 117:1198-1204.
    • (1999) Gastroenterology , vol.117 , pp. 1198-1204
    • Zhu, J.1    Wu, J.2    Frizell, E.3
  • 19
    • 0035084130 scopus 로고    scopus 로고
    • Rapamycin reduces expression of fibrosis-associated genes in an experimental model of renal ischaemia reperfusion injury
    • Jain S., Bicknell G.R., Whiting P.H., Nicholson M.L. Rapamycin reduces expression of fibrosis-associated genes in an experimental model of renal ischaemia reperfusion injury. Transplant Proc 2001, 33:556-558.
    • (2001) Transplant Proc , vol.33 , pp. 556-558
    • Jain, S.1    Bicknell, G.R.2    Whiting, P.H.3    Nicholson, M.L.4
  • 20
    • 2542422760 scopus 로고    scopus 로고
    • Mammalian target of rapamycin positively regulates collagen type I production via a phosphatidylinositol 3-kinase-independent pathway
    • Shegogue D., Trojanowska M. Mammalian target of rapamycin positively regulates collagen type I production via a phosphatidylinositol 3-kinase-independent pathway. J Biol Chem 2004, 279:23166-23175.
    • (2004) J Biol Chem , vol.279 , pp. 23166-23175
    • Shegogue, D.1    Trojanowska, M.2
  • 21
    • 20044396552 scopus 로고    scopus 로고
    • Activity of sirolimus in patients with myelodysplastic syndrome-results of a pilot study
    • Platzbecker U., Haase M., Herbst R., et al. Activity of sirolimus in patients with myelodysplastic syndrome-results of a pilot study. Br J Haematol 2005, 128:625-630.
    • (2005) Br J Haematol , vol.128 , pp. 625-630
    • Platzbecker, U.1    Haase, M.2    Herbst, R.3
  • 22
    • 0042744837 scopus 로고    scopus 로고
    • Survival of acute myeloid leukemia cells requires PI3 kinase activation
    • Xu Q., Simpson S.E., Scialla T.J., Bagg A., Carroll M. Survival of acute myeloid leukemia cells requires PI3 kinase activation. Blood 2003, 102:972-980.
    • (2003) Blood , vol.102 , pp. 972-980
    • Xu, Q.1    Simpson, S.E.2    Scialla, T.J.3    Bagg, A.4    Carroll, M.5
  • 23
    • 0035312747 scopus 로고    scopus 로고
    • Regulation of translation initiation by FRAP/mTOR
    • Gingras A.C., Raught B., Sonenberg N. Regulation of translation initiation by FRAP/mTOR. Genes Dev 2001, 15:807-826.
    • (2001) Genes Dev , vol.15 , pp. 807-826
    • Gingras, A.C.1    Raught, B.2    Sonenberg, N.3
  • 24
    • 20144363954 scopus 로고    scopus 로고
    • Antileukemic activity of rapamycin in acute myeloid leukemia
    • Récher C., Beyne-Rauzy O., Demur C., et al. Antileukemic activity of rapamycin in acute myeloid leukemia. Blood 2005, 105:2527-2534.
    • (2005) Blood , vol.105 , pp. 2527-2534
    • Récher, C.1    Beyne-Rauzy, O.2    Demur, C.3
  • 25
    • 34347369749 scopus 로고    scopus 로고
    • Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia
    • Chan S.M., Weng A.P., Tibshirani R., Aster J.C., Utz P.J. Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia. Blood 2007, 110:278-286.
    • (2007) Blood , vol.110 , pp. 278-286
    • Chan, S.M.1    Weng, A.P.2    Tibshirani, R.3    Aster, J.C.4    Utz, P.J.5
  • 26
    • 34547123123 scopus 로고    scopus 로고
    • Sirolimus-based graft-versus-host disease prophylaxis protects against cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation: a cohort analysis
    • Marty F.M., Bryar J., Browne S.K., et al. Sirolimus-based graft-versus-host disease prophylaxis protects against cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation: a cohort analysis. Blood 2007, 110:490-500.
    • (2007) Blood , vol.110 , pp. 490-500
    • Marty, F.M.1    Bryar, J.2    Browne, S.K.3
  • 27
    • 60849100558 scopus 로고    scopus 로고
    • Epstein-Barr virus, rapamycin, and host immune responses
    • Krams S.M., Martinez O.M. Epstein-Barr virus, rapamycin, and host immune responses. Curr Opin Organ Transplant 2008, 13:563-568.
    • (2008) Curr Opin Organ Transplant , vol.13 , pp. 563-568
    • Krams, S.M.1    Martinez, O.M.2
  • 28
    • 0034636055 scopus 로고    scopus 로고
    • The immunosuppressive macrolide RAD inhibits growth of human Epstein-Barr virus-transformed B lymphocytes in vitro and in vivo: a potential approach to prevention and treatment of posttransplant lymphoproliferative disorders
    • Majewski M., Korecka M., Kossev P., et al. The immunosuppressive macrolide RAD inhibits growth of human Epstein-Barr virus-transformed B lymphocytes in vitro and in vivo: a potential approach to prevention and treatment of posttransplant lymphoproliferative disorders. Proc Natl Acad Sci U S A 2000, 97:4285-4290.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 4285-4290
    • Majewski, M.1    Korecka, M.2    Kossev, P.3
  • 29
    • 79953049807 scopus 로고    scopus 로고
    • Rapamycin reverses splenomegaly and inhibits tumor development in a transgenic model of Epstein-Barr virus-related Burkitt's lymphoma
    • Cen O., Longnecker R. Rapamycin reverses splenomegaly and inhibits tumor development in a transgenic model of Epstein-Barr virus-related Burkitt's lymphoma. Mol Cancer Ther 2011, 10:679-686.
    • (2011) Mol Cancer Ther , vol.10 , pp. 679-686
    • Cen, O.1    Longnecker, R.2
  • 30
    • 0037979084 scopus 로고    scopus 로고
    • Rituximab in association with rapamycin for post-transplant lymphoproliferative disease treatment
    • Garcia V.D., Bonamigo Filho J.L., Neumann J., et al. Rituximab in association with rapamycin for post-transplant lymphoproliferative disease treatment. Transpl Int 2003, 16:202-206.
    • (2003) Transpl Int , vol.16 , pp. 202-206
    • Garcia, V.D.1    Bonamigo Filho, J.L.2    Neumann, J.3
  • 31
    • 77950676475 scopus 로고    scopus 로고
    • Indications, tolerance and complications of a sirolimus and calcineurin inhibitor immunosuppression regimen: intermediate experience in pediatric heart transplantation recipients
    • Matthews K., Gossett J., Kappelle P.V., Jellen G., Pahl E. Indications, tolerance and complications of a sirolimus and calcineurin inhibitor immunosuppression regimen: intermediate experience in pediatric heart transplantation recipients. Pediatr Transplant 2010, 14:402-408.
    • (2010) Pediatr Transplant , vol.14 , pp. 402-408
    • Matthews, K.1    Gossett, J.2    Kappelle, P.V.3    Jellen, G.4    Pahl, E.5
  • 32
    • 64649097287 scopus 로고    scopus 로고
    • Sirolimus in pediatric liver transplantation: a single-center experience
    • Gibelli N.E., Tannuri U., Pinho-Apezzato M.L., et al. Sirolimus in pediatric liver transplantation: a single-center experience. Transplant Proc 2009, 41:901-903.
    • (2009) Transplant Proc , vol.41 , pp. 901-903
    • Gibelli, N.E.1    Tannuri, U.2    Pinho-Apezzato, M.L.3
  • 33
    • 0034720548 scopus 로고    scopus 로고
    • Sirolimus-induced thrombocytopenia and leukopenia in renal transplant recipients: risk factors, incidence, progression, and management
    • Hong J.C., Kahan B.D. Sirolimus-induced thrombocytopenia and leukopenia in renal transplant recipients: risk factors, incidence, progression, and management. Transplantation 2000, 69:2085-2090.
    • (2000) Transplantation , vol.69 , pp. 2085-2090
    • Hong, J.C.1    Kahan, B.D.2
  • 34
    • 34547453885 scopus 로고    scopus 로고
    • Comparison of sirolimus and everolimus in their effects on blood lipid profiles and haematological parameters in heart transplant recipients
    • Tenderich G., Fuchs U., Zittermann A., Muckelbauer R., Berthold H.K., Koerfer R. Comparison of sirolimus and everolimus in their effects on blood lipid profiles and haematological parameters in heart transplant recipients. Clin Transplant 2007, 21:536-543.
    • (2007) Clin Transplant , vol.21 , pp. 536-543
    • Tenderich, G.1    Fuchs, U.2    Zittermann, A.3    Muckelbauer, R.4    Berthold, H.K.5    Koerfer, R.6
  • 35
    • 0032573044 scopus 로고    scopus 로고
    • Immunosuppressive effects and safety of a sirolimus/cyclosporine combination regimen for renal transplantation
    • Kahan B.D., Podbielski J., Napoli K.L., Katz S.M., Meier-Kriesche H.U., Van Buren C.T. Immunosuppressive effects and safety of a sirolimus/cyclosporine combination regimen for renal transplantation. Transplantation 1998, 66:1040-1046.
    • (1998) Transplantation , vol.66 , pp. 1040-1046
    • Kahan, B.D.1    Podbielski, J.2    Napoli, K.L.3    Katz, S.M.4    Meier-Kriesche, H.U.5    Van Buren, C.T.6
  • 36
    • 0030064388 scopus 로고    scopus 로고
    • The side effect profile of sirolimus: a phase I study in quiescent cyclosporine-prednisone-treated renal transplant patients
    • Murgia M.G., Jordan S., Kahan B.D. The side effect profile of sirolimus: a phase I study in quiescent cyclosporine-prednisone-treated renal transplant patients. Kidney Int 1996, 49:209-216.
    • (1996) Kidney Int , vol.49 , pp. 209-216
    • Murgia, M.G.1    Jordan, S.2    Kahan, B.D.3
  • 37
    • 33745288559 scopus 로고    scopus 로고
    • Wound healing complications with de novo sirolimus versus mycophenolate mofetil-based regimen in cardiac transplant recipients
    • Kuppahally S., Al-Khaldi A., Weisshaar D., et al. Wound healing complications with de novo sirolimus versus mycophenolate mofetil-based regimen in cardiac transplant recipients. Am J Transplant 2006, 6(5 Pt 1):986-992.
    • (2006) Am J Transplant , vol.6 , Issue.5 PART 1 , pp. 986-992
    • Kuppahally, S.1    Al-Khaldi, A.2    Weisshaar, D.3
  • 38
    • 0028898108 scopus 로고
    • Effects of rapamycin on growth factor-stimulated vascular smooth muscle cell DNA synthesis. Inhibition of basic fibroblast growth factor and platelet-derived growth factor action and antagonism of rapamycin by FK506
    • Cao W., Mohacsi P., Shorthouse R., Pratt R., Morris R.E. Effects of rapamycin on growth factor-stimulated vascular smooth muscle cell DNA synthesis. Inhibition of basic fibroblast growth factor and platelet-derived growth factor action and antagonism of rapamycin by FK506. Transplantation 1995, 59:390-395.
    • (1995) Transplantation , vol.59 , pp. 390-395
    • Cao, W.1    Mohacsi, P.2    Shorthouse, R.3    Pratt, R.4    Morris, R.E.5
  • 39
    • 33645833623 scopus 로고    scopus 로고
    • Brief communication: sirolimus-associated pneumonitis: 24 cases in renal transplant recipients
    • Champion L., Stern M., Israël-Biet D., et al. Brief communication: sirolimus-associated pneumonitis: 24 cases in renal transplant recipients. Ann Intern Med 2006, 144:505-509.
    • (2006) Ann Intern Med , vol.144 , pp. 505-509
    • Champion, L.1    Stern, M.2    Israël-Biet, D.3
  • 40
    • 20044379939 scopus 로고    scopus 로고
    • Cutaneous adverse events in renal transplant recipients receiving sirolimus-based therapy
    • Mahé E., Morelon E., Lechaton S., et al. Cutaneous adverse events in renal transplant recipients receiving sirolimus-based therapy. Transplantation 2005, 79:476-482.
    • (2005) Transplantation , vol.79 , pp. 476-482
    • Mahé, E.1    Morelon, E.2    Lechaton, S.3
  • 41
    • 44449083419 scopus 로고    scopus 로고
    • Poor tolerance of sirolimus in a steroid avoidance regimen for renal transplantation
    • Smith M.P., Newstead C.G., Ahmad N., et al. Poor tolerance of sirolimus in a steroid avoidance regimen for renal transplantation. Transplantation 2008, 85:636-639.
    • (2008) Transplantation , vol.85 , pp. 636-639
    • Smith, M.P.1    Newstead, C.G.2    Ahmad, N.3
  • 42
    • 20844456461 scopus 로고    scopus 로고
    • Sirolimus and thrombotic microangiopathy after allogeneic hematopoietic stem cell transplantation
    • Cutler C., Henry N.L., Magee C., et al. Sirolimus and thrombotic microangiopathy after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2005, 11:551-557.
    • (2005) Biol Blood Marrow Transplant , vol.11 , pp. 551-557
    • Cutler, C.1    Henry, N.L.2    Magee, C.3
  • 43
    • 0037356937 scopus 로고    scopus 로고
    • Thrombotic micro-angiopathy with sirolimus-based immunosuppression: potentiation of calcineurin-inhibitor-induced endothelial damage?
    • Robson M., Côte I., Abbs I., Koffman G., Goldsmith D. Thrombotic micro-angiopathy with sirolimus-based immunosuppression: potentiation of calcineurin-inhibitor-induced endothelial damage?. Am J Transplant 2003, 3:324-327.
    • (2003) Am J Transplant , vol.3 , pp. 324-327
    • Robson, M.1    Côte, I.2    Abbs, I.3    Koffman, G.4    Goldsmith, D.5
  • 44
    • 0037297156 scopus 로고    scopus 로고
    • Sirolimus may promote thrombotic microangiopathy
    • Saikali J.A., Truong L.D., Suki W.N. Sirolimus may promote thrombotic microangiopathy. Am J Transplant 2003, 3:229-230.
    • (2003) Am J Transplant , vol.3 , pp. 229-230
    • Saikali, J.A.1    Truong, L.D.2    Suki, W.N.3
  • 45
    • 0038386382 scopus 로고    scopus 로고
    • Sirolimus-induced thrombotic microangiopathy in a renal transplant recipient
    • Barone G.W., Gurley B.J., Abul-Ezz S.R., Gökden N. Sirolimus-induced thrombotic microangiopathy in a renal transplant recipient. Am J Kidney Dis 2003, 42:202-206.
    • (2003) Am J Kidney Dis , vol.42 , pp. 202-206
    • Barone, G.W.1    Gurley, B.J.2    Abul-Ezz, S.R.3    Gökden, N.4
  • 47
    • 0032424338 scopus 로고    scopus 로고
    • New trails in transplantation: how to exploit the potential of sirolimus in clinical transplantation
    • Groth C.G., Brattström C., Claesson K., Bäckman L. New trails in transplantation: how to exploit the potential of sirolimus in clinical transplantation. Transplant Proc 1998, 30:4064-4065.
    • (1998) Transplant Proc , vol.30 , pp. 4064-4065
    • Groth, C.G.1    Brattström, C.2    Claesson, K.3    Bäckman, L.4
  • 48
    • 33746530366 scopus 로고    scopus 로고
    • Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre study. The Rapamune US Study Group
    • Kahan B.D. Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre study. The Rapamune US Study Group. Lancet 2000, 356:194-202.
    • (2000) Lancet , vol.356 , pp. 194-202
    • Kahan, B.D.1
  • 49
    • 0035956745 scopus 로고    scopus 로고
    • A worldwide, phase III, randomized, controlled, safety and efficacy study of a sirolimus/cyclosporine regimen for prevention of acute rejection in recipients of primary mismatched renal allografts
    • RAPAMUNE Global Study Group
    • MacDonald A.S. A worldwide, phase III, randomized, controlled, safety and efficacy study of a sirolimus/cyclosporine regimen for prevention of acute rejection in recipients of primary mismatched renal allografts. Transplantation 2001, 71:271-280. RAPAMUNE Global Study Group.
    • (2001) Transplantation , vol.71 , pp. 271-280
    • MacDonald, A.S.1
  • 50
    • 0035042276 scopus 로고    scopus 로고
    • Pharmacokinetic interactions augment toxicities of sirolimus/cyclosporine combinations
    • Podder H., Stepkowski S.M., Napoli K.L., et al. Pharmacokinetic interactions augment toxicities of sirolimus/cyclosporine combinations. J Am Soc Nephrol 2001, 12:1059-1071.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 1059-1071
    • Podder, H.1    Stepkowski, S.M.2    Napoli, K.L.3
  • 51
    • 66949177968 scopus 로고    scopus 로고
    • Comparison of tacrolimus and sirolimus (Tac/Sir) versus tacrolimus, sirolimus, and mini-methotrexate (Tac/Sir/MTX) as acute graft-versus-host disease prophylaxis after reduced-intensity conditioning allogeneic peripheral blood stem cell transplantation
    • Ho V.T., Aldridge J., Kim H.T., et al. Comparison of tacrolimus and sirolimus (Tac/Sir) versus tacrolimus, sirolimus, and mini-methotrexate (Tac/Sir/MTX) as acute graft-versus-host disease prophylaxis after reduced-intensity conditioning allogeneic peripheral blood stem cell transplantation. Biol Blood Marrow Transplant 2009, 15:844-850.
    • (2009) Biol Blood Marrow Transplant , vol.15 , pp. 844-850
    • Ho, V.T.1    Aldridge, J.2    Kim, H.T.3
  • 52
    • 77649224551 scopus 로고    scopus 로고
    • A phase II pilot study of tacrolimus/sirolimus GVHD prophylaxis for sibling donor hematopoietic stem cell transplantation using 3 conditioning regimens
    • Rodriguez R., Nakamura R., Palmer J.M., et al. A phase II pilot study of tacrolimus/sirolimus GVHD prophylaxis for sibling donor hematopoietic stem cell transplantation using 3 conditioning regimens. Blood 2010, 115:1098-1105.
    • (2010) Blood , vol.115 , pp. 1098-1105
    • Rodriguez, R.1    Nakamura, R.2    Palmer, J.M.3
  • 53
    • 33947578933 scopus 로고    scopus 로고
    • Extended follow-up of methotrexate-free immunosuppression using sirolimus and tacrolimus in related and unrelated donor peripheral blood stem cell transplantation
    • Cutler C., Li S., Ho V.T., et al. Extended follow-up of methotrexate-free immunosuppression using sirolimus and tacrolimus in related and unrelated donor peripheral blood stem cell transplantation. Blood 2007, 109:3108-3114.
    • (2007) Blood , vol.109 , pp. 3108-3114
    • Cutler, C.1    Li, S.2    Ho, V.T.3
  • 54
    • 79956053688 scopus 로고    scopus 로고
    • Prophylaxis with sirolimus and tacrolimus ± antithymocyte globulin reduces the risk of acute graft-versus-host disease without an overall survival benefit following allogeneic stem cell transplantation
    • Rosenbeck L.L., Kiel P.J., Kalsekar I., et al. Prophylaxis with sirolimus and tacrolimus ± antithymocyte globulin reduces the risk of acute graft-versus-host disease without an overall survival benefit following allogeneic stem cell transplantation. Biol Blood Marrow Transplant 2011, 17:916-922.
    • (2011) Biol Blood Marrow Transplant , vol.17 , pp. 916-922
    • Rosenbeck, L.L.1    Kiel, P.J.2    Kalsekar, I.3
  • 55
    • 67349198571 scopus 로고    scopus 로고
    • Calcineurin inhibitor-free GVHD prophylaxis with sirolimus, mycophenolate mofetil and ATG in Allo-SCT for leukemia patients with high relapse risk: an observational cohort study
    • Schleuning M., Judith D., Jedlickova Z., et al. Calcineurin inhibitor-free GVHD prophylaxis with sirolimus, mycophenolate mofetil and ATG in Allo-SCT for leukemia patients with high relapse risk: an observational cohort study. Bone Marrow Transplant 2009, 43:717-723.
    • (2009) Bone Marrow Transplant , vol.43 , pp. 717-723
    • Schleuning, M.1    Judith, D.2    Jedlickova, Z.3
  • 56
    • 84871920187 scopus 로고    scopus 로고
    • BMT CTN #0402. A phase III randomized, multicenter trial comparing sirolimus/tacrolimus with tacrolimus/methotrexate as graft-versus-host disease (GVHD) prophylaxis after HLA-matched, related peripheral blood stem cell transplantation (BMT CTN #0402). Available at: .
    • BMT CTN #0402. A phase III randomized, multicenter trial comparing sirolimus/tacrolimus with tacrolimus/methotrexate as graft-versus-host disease (GVHD) prophylaxis after HLA-matched, related peripheral blood stem cell transplantation (BMT CTN #0402). Available at: http://clinicaltrials.gov/ct2/show/NCT00406393.
  • 57
    • 24944495973 scopus 로고    scopus 로고
    • Sequential regimen of chemotherapy, reduced-intensity conditioning for allogeneic stem-cell transplantation, and prophylactic donor lymphocyte transfusion in high-risk acute myeloid leukemia and myelodysplastic syndrome
    • Schmid C., Schleuning M., Ledderose G., Tischer J., Kolb H.J. Sequential regimen of chemotherapy, reduced-intensity conditioning for allogeneic stem-cell transplantation, and prophylactic donor lymphocyte transfusion in high-risk acute myeloid leukemia and myelodysplastic syndrome. J Clin Oncol 2005, 23:5675-5687.
    • (2005) J Clin Oncol , vol.23 , pp. 5675-5687
    • Schmid, C.1    Schleuning, M.2    Ledderose, G.3    Tischer, J.4    Kolb, H.J.5
  • 58
    • 33746607667 scopus 로고    scopus 로고
    • Long-term survival in refractory acute myeloid leukemia after sequential treatment with chemotherapy and reduced-intensity conditioning for allogeneic stem cell transplantation
    • Schmid C., Schleuning M., Schwerdtfeger R., et al. Long-term survival in refractory acute myeloid leukemia after sequential treatment with chemotherapy and reduced-intensity conditioning for allogeneic stem cell transplantation. Blood 2006, 108:1092-1099.
    • (2006) Blood , vol.108 , pp. 1092-1099
    • Schmid, C.1    Schleuning, M.2    Schwerdtfeger, R.3
  • 59
    • 80052369626 scopus 로고    scopus 로고
    • Sirolimus demonstrates activity in the primary therapy of acute graft-versus-host disease without systemic glucocorticoids
    • Pidala J., Tomblyn M., Nishihori T., et al. Sirolimus demonstrates activity in the primary therapy of acute graft-versus-host disease without systemic glucocorticoids. Haematologica 2011, 96:1351-1356.
    • (2011) Haematologica , vol.96 , pp. 1351-1356
    • Pidala, J.1    Tomblyn, M.2    Nishihori, T.3
  • 60
    • 72949097168 scopus 로고    scopus 로고
    • Rapamycin for refractory acute graft-versus-host disease
    • Ghez D., Rubio M.T., Maillard N., et al. Rapamycin for refractory acute graft-versus-host disease. Transplantation 2009, 88:1081-1087.
    • (2009) Transplantation , vol.88 , pp. 1081-1087
    • Ghez, D.1    Rubio, M.T.2    Maillard, N.3
  • 61
    • 77955570085 scopus 로고    scopus 로고
    • Sirolimus for treatment of steroid-refractory acute graft-versus-host disease
    • Hoda D., Pidala J., Salgado-Vila N., et al. Sirolimus for treatment of steroid-refractory acute graft-versus-host disease. Bone Marrow Transplant 2010, 45:1347-1351.
    • (2010) Bone Marrow Transplant , vol.45 , pp. 1347-1351
    • Hoda, D.1    Pidala, J.2    Salgado-Vila, N.3
  • 62
    • 34248652434 scopus 로고    scopus 로고
    • Sirolimus as part of immunosuppressive therapy for refractory chronic graft-versus-host disease
    • Jurado M., Vallejo C., Pérez-Simón J.A., et al. Sirolimus as part of immunosuppressive therapy for refractory chronic graft-versus-host disease. Biol Blood Marrow Transplant 2007, 13:701-706.
    • (2007) Biol Blood Marrow Transplant , vol.13 , pp. 701-706
    • Jurado, M.1    Vallejo, C.2    Pérez-Simón, J.A.3
  • 63
    • 24944570255 scopus 로고    scopus 로고
    • Sirolimus in combination with tacrolimus and corticosteroids for the treatment of resistant chronic graft-versus-host disease
    • Couriel D.R., Saliba R., Escalón M.P., et al. Sirolimus in combination with tacrolimus and corticosteroids for the treatment of resistant chronic graft-versus-host disease. Br J Haematol 2005, 130:409-417.
    • (2005) Br J Haematol , vol.130 , pp. 409-417
    • Couriel, D.R.1    Saliba, R.2    Escalón, M.P.3
  • 64
    • 84871921710 scopus 로고    scopus 로고
    • A Phase II/III Randomized, Multicenter Trial Comparing Sirolimus Plus Prednisone, Sirolimus/Extracorporeal Photopheresis Plus Prednisone, and Sirolimus/Calcineurin Inhibitor Plus Prednisone for the Treatment of Chronic Graft-versus-Host Disease. Available at: .
    • Goldberg J. A Phase II/III Randomized, Multicenter Trial Comparing Sirolimus Plus Prednisone, Sirolimus/Extracorporeal Photopheresis Plus Prednisone, and Sirolimus/Calcineurin Inhibitor Plus Prednisone for the Treatment of Chronic Graft-versus-Host Disease. Available at: http://www.mskcc.org/cancer-care/trial/10-201.
    • Goldberg, J.1
  • 65
    • 57449092086 scopus 로고    scopus 로고
    • Improved survival in lymphoma patients receiving sirolimus for graft-versus-host disease prophylaxis after allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning
    • Armand P., Gannamaneni S., Kim H.T., et al. Improved survival in lymphoma patients receiving sirolimus for graft-versus-host disease prophylaxis after allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning. J Clin Oncol 2008, 26:5767-5774.
    • (2008) J Clin Oncol , vol.26 , pp. 5767-5774
    • Armand, P.1    Gannamaneni, S.2    Kim, H.T.3
  • 66
    • 41849148993 scopus 로고    scopus 로고
    • Sirolimus in combination with cyclosporine or tacrolimus plus methotrexate for prevention of graft-versus-host disease following hematopoietic cell transplantation from unrelated donors
    • Furlong T., Kiem H.P., Appelbaum F.R., et al. Sirolimus in combination with cyclosporine or tacrolimus plus methotrexate for prevention of graft-versus-host disease following hematopoietic cell transplantation from unrelated donors. Biol Blood Marrow Transplant 2008, 14:531-537.
    • (2008) Biol Blood Marrow Transplant , vol.14 , pp. 531-537
    • Furlong, T.1    Kiem, H.P.2    Appelbaum, F.R.3
  • 67
    • 0035660613 scopus 로고    scopus 로고
    • Sirolimus (rapamycin) for the treatment of steroid-refractory acute graft-versus-host disease
    • Benito A.I., Furlong T., Martin P.J., et al. Sirolimus (rapamycin) for the treatment of steroid-refractory acute graft-versus-host disease. Transplantation 2001, 72:1924-1929.
    • (2001) Transplantation , vol.72 , pp. 1924-1929
    • Benito, A.I.1    Furlong, T.2    Martin, P.J.3
  • 68
    • 33745633856 scopus 로고    scopus 로고
    • Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production
    • Zeiser R., Nguyen V.H., Beilhack A., et al. Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production. Blood 2006, 108:390-399.
    • (2006) Blood , vol.108 , pp. 390-399
    • Zeiser, R.1    Nguyen, V.H.2    Beilhack, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.