Aberrant germinal center formation, follicular T-helper cells, and germinal center B-cells were involved in chronic graft-versus-host disease

Annals of Hematology

Volumn 94, Issue 9, 2015, Pages 1493-1504

  Shao, Liang ^a,b   Lie, Albert K W ^a   Zhang, You ^b   Wong, Cheuk Hong ^a   Kwong, Yok Lam ^a,c  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b KUNMING MEDICAL UNIVERSITY   (China)

^c QUEEN MARY HOSPITAL   (Hong Kong)

Author keywords

Chronic graft versus host disease; Follicular T helper cells; Germinal center B cells

Indexed keywords

B CELL ACTIVATING FACTOR RECEPTOR; CD45 ANTIGEN; EVEROLIMUS; INDUCIBLE T CELL COSTIMULATOR; INTERLEUKIN 17; INTERLEUKIN 4; ICOSL PROTEIN, MOUSE; INDUCIBLE T CELL COSTIMULATOR LIGAND; MTOR PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE;

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CHRONIC GRAFT VERSUS HOST DISEASE; FEMALE; FLOW CYTOMETRY; GERMINAL CENTER; HELPER CELL; MINOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T CELL DEPLETION; ANIMAL; BAGG ALBINO MOUSE; CHRONIC DISEASE; DBA MOUSE; GENE EXPRESSION REGULATION; GRAFT VERSUS HOST REACTION; IMMUNOLOGY; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; B-LYMPHOCYTES; CHRONIC DISEASE; FEMALE; GENE EXPRESSION REGULATION; GERMINAL CENTER; GRAFT VS HOST DISEASE; INDUCIBLE T-CELL CO-STIMULATOR LIGAND; INTERLEUKIN-17; INTERLEUKIN-4; MICE; MICE, INBRED BALB C; MICE, INBRED DBA; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, HELPER-INDUCER; TOR SERINE-THREONINE KINASES;

EID: 84938743616     PISSN: 09395555     EISSN: 14320584     Source Type: Journal    
DOI: 10.1007/s00277-015-2394-z     Document Type: Article

References (31)

1. Blazar BR, Murphy WJ, Abedi M (2012) Advances in graft-versus-host disease biology and therapy. Nat Rev Immunol 12(6):443–458
2. Blazar B, White ES, Couriel D (2012) Understanding chronic GVHD from different angles. Biol Blood Marrow Transplant 18(1 Suppl):S184–S188
3. Patriarca F, Skert C, Sperotto A, Zaja F, Falleti E, Mestroni R et al (2006) The development of autoantibodies after allogeneic stem cell transplantation is related with chronic graft-vs-host disease and immune recovery. Exp Hematol 34(3):389–396
4. Kharfan-Dabaja MA, Bazarbachi A (2010) Emerging role of CD20 blockade in allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 16(10):1347–1354
5. Sarantopoulos S, Stevenson KE, Kim HT, Washel WS, Bhuiya NS, Cutler CS et al (2011) Recovery of B-cell homeostasis after rituximab in chronic graft-versus-host disease. Blood 117(7):2275–2283
6. Arai S, Sahaf B, Narasimhan B, Chen GL, Jones CD, Lowsky R et al (2012) Prophylactic rituximab after allogeneic transplantation decreases B-cell alloimmunity with low chronic GVHD incidence. Blood 119(25):6145–6154
7. Vinuesa CG, Chang PP (2013) Innate B cell helpers reveal novel types of antibody responses. Nat Immunol 14(2):119–126
8. Zotos D, Tarlinton DM (2012) Determining germinal centre B cell fate. Trends Immunol 33(6):281–288
9. Tangye SG, Ma CS, Brink R, Deenick EK (2013) The good, the bad and the ugly - TFH cells in human health and disease. Nat Rev Immunol 13(6):412–426
10. Simpson N, Gatenby PA, Wilson A, Malik S, Fulcher DA, Tangye SG et al (2010) Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum 62(1):234–244
11. Li XY, Wu ZB, Ding J, Zheng ZH, Li XY, Chen LN, Zhu P (2012) Role of the frequency of blood CD4(+) CXCR5(+) CCR6(+) T cells in autoimmunity in patients with Sjögren’s syndrome. Biochem Biophys Res Commun 422(2):238–244
12. Liu R, Wu Q, Su D, Che N, Chen H, Geng L et al (2012) A regulatory effect of IL-21 on T follicular helper-like cell and B cell in rheumatoid arthritis. Arthritis Res Ther 14(6):R255
13. Zhu C, Ma J, Liu Y, Tong J, Tian J, Chen J et al (2012) Increased frequency of follicular helper T cells in patients with autoimmune thyroid disease. J Clin Endocrinol Metab 97(3):943–950
14. Tackenberg B, Kruth J, Bartholomaeus JE, Schlegel K, Oertel WH, Willcox N et al (2007) Clonal expansions of CD4+ B helper T cells in autoimmune myasthenia gravis. Eur J Immunol 37(3):849–863
15. Ma CS, Deenick EK, Batten M, Tangye SG (2012) The origins, function, and regulation of T follicular helper cells. J Exp Med 209(7):1241–1253
16. King C, Sprent J (2012) Emerging cellular networks for regulation of T follicular helper cells. Trends Immunol 33(2):59–65
17. Crotty S (2011) Follicular helper CD4 T cells (TFH). Annu Rev Immunol 29:621–663
18. Zhang C, Todorov I, Zhang Z, Liu Y, Kandeel F, Forman S et al (2006) Donor CD4+ T and B cells in transplants induce chronic graft-versus-host disease with autoimmune manifestations. Blood 107(7):2993–3001
19. Kaplan DH, Anderson BE, McNiff JM, Jain D, Shlomchik MJ, Shlomchik WD (2004) Target antigens determine graft-versus-host disease phenotype. J Immunol 173(9):5467–5475
20. Pang A, Au WY, Kwong YL (2004) Caveolin-1 gene is coordinately regulated with the multidrug resistance 1 gene in normal and leukemic bone marrow. Leuk Res 28(9):973–977
21. Shimabukuro-Vornhagen A, Hallek MJ, Storb RF, von Bergwelt-Baildon MS (2009) The role of B cells in the pathogenesis of graft-versus-host disease. Blood 114(24):4919–4927
22. Akiba H, Takeda K, Kojima Y, Usui Y, Harada N, Yamazaki T et al (2005) The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo. J Immunol 175(4):2340–2348
23. Sweet RA, Lee SK, Vinuesa CG (2012) Developing connections amongst key cytokines and dysregulated germinal centers in autoimmunity. Curr Opin Immunol 24(6):658–664
24. Rodriguez R, Nakamura R, Palmer JM, Parker P, Shayani S, Nademanee A et al (2010) A phase II pilot study of tacrolimus/sirolimus GVHD prophylaxis for sibling donor hematopoietic stem cell transplantation using 3 conditioning regimens. Blood 115(5):1098–1105
25. Schmitt N, Ueno H (2013) Human T follicular helper cells: development and subsets. Adv Exp Med Biol 785:87–94
26. Socié G (2011) Chronic GVHD: B cells come of age. Blood 117(7):2086–2087
27. Sarantopoulos S, Stevenson KE, Kim HT, Cutler CS, Bhuiya NS, Schowalter M et al (2009) Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease. Blood 113(16):3865–3874
28. Kuzmina Z, Krenn K, Petkov V, Körmöczi U, Weigl R, Rottal A et al (2013) CD19(+)CD21(low) B cells and patients at risk for NIH-defined chronic graft-versus-host disease with bronchiolitis obliterans syndrome. Blood 121(10):1886–1895
29. Greinix HT, Pohlreich D, Kouba M, Körmöczi U, Lohmann I, Feldmann K et al (2008) Elevated numbers of immature/transitional CD21− B lymphocytes and deficiency of memory CD27+ B cells identify patients with active chronic graft-versus-host disease. Biol Blood Marrow Transplant 14(2):208–219
30. Srinivasan M, Flynn R, Price A, Ranger A, Browning JL, Taylor PA et al (2012) Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans. Blood 119(6):1570–1580
31. Flynn R, Du J, Veenstra RG, Reichenbach DK, Panoskaltsis-Mortari A, Taylor PA, et al (2014) Increased T follicular helper cells and germinal center B cells are required for chronic GVHD (cGVHD) and bronchiolitis obliterans. Blood 123(25):3988–98