Apigenin and naringenin ameliorate PKCβII-associated endothelial dysfunction via regulating ROS/caspase-3 and NO pathway in endothelial cells exposed to high glucose

Vascular Pharmacology

Volumn 85, Issue , 2016, Pages 39-49

  Qin, Weiwei ^a   Ren, Bei ^a,b   Wang, Shanshan ^a   Liang, Shujun ^a   He, Baiqiu ^a   Shi, Xiaoji ^a   Wang, Liying ^a   Liang, Jingyu ^a   Wu, Feihua ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Taiyuan Institute For Food And Drug Control   (China)

Author keywords

Apigenin; Apoptosis; Endothelial dysfunction; High glucose; Naringenin

Indexed keywords

APIGENIN; CASPASE 3; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; NARINGENIN; NITRIC OXIDE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN KINASE C BETA; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR RELA; FLAVANONE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; VASODILATATION; ANIMAL; AORTA; DRUG EFFECTS; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM;

ANIMALS; AORTA; APIGENIN; APOPTOSIS; CASPASE 3; ENDOTHELIUM, VASCULAR; FLAVANONES; GLUCOSE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PROTEIN KINASE C BETA; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; VASODILATION;

EID: 84990985981     PISSN: 15371891     EISSN: 18793649     Source Type: Journal    
DOI: 10.1016/j.vph.2016.07.006     Document Type: Article

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