Indirubin Inhibits LPS-Induced Inflammation via TLR4 Abrogation Mediated by the NF-kB and MAPK Signaling Pathways

Inflammation

Volumn 40, Issue 1, 2017, Pages 1-12

  Lai, Jin lun ^a   Liu, Yu hui ^a   Liu, Chang ^a   Qi, Ming pu ^a   Liu, Rui ning ^a   Zhu, Xi fang ^a   Zhou, Qiu ge ^a   Chen, Ying yu ^a   Guo, Ai zhen ^a   Hu, Chang min ^a  

^a HUAZHONG AGRICULTURAL UNIVERSITY   (China)

Author keywords

indirubin; inflammation; lipopolysaccharide (LPS); MAPK; NF kB; TLR4

Indexed keywords

CYCLOOXYGENASE 2; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; I KAPPA B KINASE ALPHA; INDIRUBIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR; AUTACOID; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOLE DERIVATIVE; LIPOPOLYSACCHARIDE; TLR4 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BREAST EPITHELIUM CELL; BREAST TISSUE; CELL PROTECTION; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; DRUG MECHANISM; FEMALE; HISTOPATHOLOGY; INFLAMMATION; MASTITIS; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; PHYSIOLOGY;

ANIMALS; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INDOLES; INFLAMMATION; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MASTITIS; MICE; NF-KAPPA B; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84990891724     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-016-0447-7     Document Type: Article

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