Effect of indirubin-3-monoxime against lung cancer as evaluated by histological and transmission electron microscopic studies

Microscopy Research and Technique

Volumn 73, Issue 11, 2010, Pages 1053-1058

  Ravichandran, Kameswaran ^a   Pal, Arttatrana ^b   Ravichandran, Ramanibai ^a  

^a UNIVERSITY OF MADRAS   (India)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

A J mice; Histopathology; Indirubin 3 monoxime; Lung cancer; TEM; B( )P

Indexed keywords

BIOLOGICAL ORGANS; DISEASES; MAMMALS;

A/J MOUSE; BENZO[Α]PYRENE; HISTOPATHOLOGY; INDIRUBIN; INDIRUBIN-3-MONOXIME; LUNG CANCER; MONOXIMES; TRANSMISSION ELECTRON; TRANSMISSION ELECTRON MICROSCOPIC; [BENZO(Α)PYRENE];

CELL DEATH;

MUS;

EID: 77958533749     PISSN: 1059910X     EISSN: 10970029     Source Type: Journal    
DOI: 10.1002/jemt.20832     Document Type: Article

References (31)

1. Bousquet E, Mazieres J, Privat M, Rizzati V, Caranova A, Ledoux A, Mery E, Coduerc B, Favre G, Pradines A. 2009. Loss of RhoB expression promotes migration and invasion of human bronchial cells via activation of AKT1. Cancer Res 69: 6092-6099.
2. Horn L, Sandler A. 2009. Epidermal growth factor receptor inhibitors and antiangiogenicagents for the treatment of non-small cell lung cancer. Clin Cancer Res 15: 5040-5048.
3. Kassie F, Matise I, Negia M, Upadhyaya P, Hecht SS. 2008. Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol. Cancer Prev Res (Phila Pa) 1: 568-576.
4. Hecht SS. 1999. Tobacco smoke carcinogens and lung cancer. J Natl Cancer Inst 91: 1194-1210.
5. Hecht SS, Upadhyaya P, Wang M, Bliss RL, McIntee EJ, Kenney PM. 2002. Inhibition of lung tumorigenesis in A/J mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine and myo-inositol, individually and in combination. Carcinogenesis 23: 1455-1461.
6. Kamaraj S, Ramakrishnan G, Anandakumar P, Jagan S, Devaki T. 2009. Antioxidant and anticancer efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice. Invest New Drugs 27: 214-222.
7. Zhang S, Zhang Y, Xu L, Lin X, Lu J, Di Q, Shi J, Xu J. 2009. Indirubin-3'-monoxime inhibits beta-amyloid-induced neurotoxicity in neuroblastoma SH-SY5Y cells. Neurosci Lett 450: 142-146.
8. Varela AT, Gomes AP, Simoes AM, Teodoro JS, Duarle FV, Rolo AP, Palmeira CM. 2008. Indirubin-3'-oxime impairs mitochondrial oxidative phosphorylation and prevents mitochondrial permeability transition induction. Toxicol Appl Pharmacol 233: 179-185.
9. Xiao Z, Hao Y, Liu B, Qian L. 2002. Indirubin and meisoindigo in the treatment of chronic myelogenous leukemia in China. Leuk Lymphoma 43: 1763-1768.
10. Lee JW, Moon MJ, Min HY, Chung HJ, Park EJ, Park HJ, Hong JY, Kim YC, Lee SK. 2005. Induction of apoptosis by a novel indirubin-5-nitro-3'-monoxime, a CDK inhibitor, in human lung cancer cells. Bioorg Med Chem Lett 5: 3948-3952.
11. Eisenbrand G, Hippe F, Jakobs S, Muehlbeyer S. 2004. Molecular mechanisms of indirubin and its derivatives: Novel anticancer molecules with their origin in traditional Chinese phytomedicine. J Cancer Res Clin Oncol 130: 627-635.
12. Kim SA, Kim YC, Kim SW, Lee SH, Min JJ, Ahn SG, Yoon JH. 2007. Antitumor activity of novel indirubin derivatives in rat tumor model. Clin Cancer Res 13: 253-259.
13. Kamaraj S, Vinodhkumar R, Anandakumar P, Jagan S, Ramakrishnan G, Devaki T. 2007. The effects of quercetin on antioxidant status and tumor markers in the lung and serum of mice treated with benzo(a)pyrene. Biol Pharm Bull 30: 2268-2273.
14. An Y, Kato K, Nakano M, Otsu H, Okada S, Yamanaka K. 2005. Specific induction of oxidative stress in terminal bronchiolar Clara cells during dimethylarsenic-induced lung tumor promoting process in mice. Cancer Lett 230: 57-64.
15. Kishino D, Kiura K, Takigawa N, Katayama H, Kuyuma S, Sato K, Okado T, Tanimoto M. 2009. Effect of gefitinib on N-nitrosamine-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mice. Lung Cancer 65: 284-289.
16. Wang ZY, Hong JY, Huang MT, Reuhl KR, Conney AH, Yang CS. 1992. Inhibition of N-nitrosodiethylamine- and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorigenesis in A/J mice by green tea and black tea. Cancer Res 52: 1943-1947.
17. Wattenberg LW, Wiedmann TS, Estensen RD, Zimmerman CL, Galbraith AR, Steele VE, Kelloff GJ. 2000. Chemoprevention of pulmonary carcinogenesis by brief exposures to aerosolized budesonide or beclomethasone dipropionate and by the combination of aerosolized budesonide and dietary myo-inositol. Carcinogenesis 21: 179-182.
18. Tormanen U, Nuorva K, Soini Y, Paakko P. 1999. Apoptotic activity is increased in parallel with the metaplasia-dysplasia-carcinoma sequence of the bronchial epithelium. Br J Cancer 79: 996-1002.
19. Hu G, Cassano PA. 2000. Antioxidant nutrients and pulmonary function: The Third National Health and Nutrition Examination Survey (NHANES III). Am J Epidemiol 151: 975-981.
20. Ribas J, Bettayeb K, Ferandin Y, Knockaert M, Garrofe-Ochoa X, Totzke F, Schachtele C, Mester J, Polychronopoulus P, Magiatis P, Skaltsounis AL, Boix J, Meijer L. 2006. 7-Bromoindirubin-3'-oxime induces caspase-independent cell death. Oncogene 25: 6304-6318.
21. Mapelli M, Massimiliano L, Crovace C, Seeliger MA, Tsai LH, Meijer L, Musacchio A. 2005. Mechanism of CDK5/p25 binding by CDK inhibitors. J Med Chem 48: 671-679.
22. Sugihara K, Okayama T, Kitamura S, Yamashita K, Yasuda M, Miyairi S, Minobe Y, Ohta S. 2008. Comparative study of aryl hydrocarbon receptor ligand activities of six chemicals in vitro and in vivo. Arch Toxicol 82: 5-11.
23. Myrianthopoulos V, Magiatis P, Ferandin Y, Skaltsounis AL, Meijer L, Mikros E. 2007. An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. J Med Chem 50: 4027-4037.
24. Dumstorf CA, Mukhopadhyay S, Krishnan E, Haribabu B, McGregor WG. 2009. REV1 is implicated in the development of carcinogen-induced lung cancer. Mol Cancer Res 7: 247-254.
25. Balansky R, Ganchev G, Iltcheva M, Steele VE, D'Agostini F, De Flora S. 2007. Potent carcinogenicity of cigarette smoke in mice exposed early in life. Carcinogenesis 28: 2236-2243.
26. Perabo FG, Frossler C, Landwehrs G, Schmidt DH, Von Rucker A, Wirger A, Muller SC. 2006. Indirubin-3'-monoxime, a CDK inhibitor induces growth inhibition and apoptosis-independent up-regulation of surviving in transitional cell cancer. Anticancer Res 26: 2129-2135.
27. Hoessel R, Leclerc S, Endicott JA, Nobel ME, Lawrie A, Tunnah P, Leost M, Damiens E, Marie D, Marko D, Niederberger E, Tang W, Eisenbrand G, Meijer L. 1999. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat Cell Biol 1: 60-67.
28. Nishiumi S, Yamamoto N, Kodoi R, Fukuda I, Yoshida K, Ashida H. 2008. Antagonistic and agonistic effects of indigoids on the transformation of an aryl hydrocarbon receptor. Arch Biochem Biophys 470: 187-199.
29. Pirnia F, Frese S, Gloor B, Hotz MA, Luethi A, Gugger M, Betticher DC, Borner MM. 2006. Ex vivo assessment of chemotherapy-induced apoptosis and associated molecular changes in patient tumor samples. Anticancer Res 26: 1765-1772.
30. Rho JK, Choi YJ, Ryoo BY, Na II, Yang SH, Kim CH, Lee JC. 2007, p53 enhances gefitinib-induced growth inhibition and apoptosis by regulation of Fas in non-small cell lung cancer. Cancer Res 67: 1163-1169.
31. Shi J, Shen HM. 2008. Critical role of Bid and Bax in indirubin-3'-monoxime-induced apoptosis in human cancer cells. Biochem Pharmacol 75: 1729-1742.