메뉴 건너뛰기




Volumn 37, Issue 5, 2014, Pages 1588-1598

Geniposide Plays an Anti-inflammatory Role via Regulating TLR4 and Downstream Signaling Pathways in Lipopolysaccharide-Induced Mastitis in Mice

Author keywords

anti inflammatory; geniposide; lipopolysaccharide (LPS); mitogen activated protein kinase (MAPK); nuclear factor B (NF B); toll like receptor

Indexed keywords

ANTIINFLAMMATORY AGENT; GENIPOSIDE; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; SYNAPTOTAGMIN I; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; IRIDOID; TLR4 PROTEIN, MOUSE;

EID: 84918769608     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-014-9885-2     Document Type: Article
Times cited : (87)

References (39)
  • 1
    • 0036719741 scopus 로고    scopus 로고
    • Bovine mastitis: an evolving disease
    • COI: 1:STN:280:DC%2BD38vpvVyhuw%3D%3D
    • Bradley, A. 2002. Bovine mastitis: an evolving disease. Veterinary Journal 164(2): 116–128.
    • (2002) Veterinary Journal , vol.164 , Issue.2 , pp. 116-128
    • Bradley, A.1
  • 2
    • 67650932893 scopus 로고    scopus 로고
    • Mastitis detection: current trends and future perspectives
    • PID: 19616330, COI: 1:CAS:528:DC%2BD1MXptVeqt74%3D
    • Viguier, C., S. Arora, N. Gilmartin, K. Welbeck, and R. O’Kennedy. 2009. Mastitis detection: current trends and future perspectives. Trends in Biotechnology 27(8): 486–493.
    • (2009) Trends in Biotechnology , vol.27 , Issue.8 , pp. 486-493
    • Viguier, C.1    Arora, S.2    Gilmartin, N.3    Welbeck, K.4    O’Kennedy, R.5
  • 3
    • 2442675425 scopus 로고    scopus 로고
    • Escherichia coli and Staphylococcus aureus elicit differential innate immune responses following intramammary infection
    • PID: 15138171
    • Bannerman, D.D., M.J. Paape, J.W. Lee, X. Zhao, J.C. Hope, and P. Rainard. 2004. Escherichia coli and Staphylococcus aureus elicit differential innate immune responses following intramammary infection. Clinical and Diagnostic Laboratory Immunology 11(3): 463–472.
    • (2004) Clinical and Diagnostic Laboratory Immunology , vol.11 , Issue.3 , pp. 463-472
    • Bannerman, D.D.1    Paape, M.J.2    Lee, J.W.3    Zhao, X.4    Hope, J.C.5    Rainard, P.6
  • 4
    • 0032754358 scopus 로고    scopus 로고
    • Relationship between plasma levels of lipopolysaccharide (LPS) and LPS-binding protein in patients with severe sepsis and septic shock
    • PID: 10515819, COI: 1:CAS:528:DyaK1MXnsVKgsL8%3D
    • Opal, S.M., P.J. Scannon, J.L. Vincent, M. White, S.F. Carroll, J.E. Palardy, N.A. Parejo, J.P. Pribble, and J.H. Lemke. 1999. Relationship between plasma levels of lipopolysaccharide (LPS) and LPS-binding protein in patients with severe sepsis and septic shock. Journal of Infectious Diseases 180(5): 1584–1589.
    • (1999) Journal of Infectious Diseases , vol.180 , Issue.5 , pp. 1584-1589
    • Opal, S.M.1    Scannon, P.J.2    Vincent, J.L.3    White, M.4    Carroll, S.F.5    Palardy, J.E.6    Parejo, N.A.7    Pribble, J.P.8    Lemke, J.H.9
  • 5
    • 0001774520 scopus 로고
    • Influence of inflammation on mammary gland metabolism and milk composition
    • Oliver, S., and L. Calvinho. 1995. Influence of inflammation on mammary gland metabolism and milk composition. Journal of Animal Science 73(suppl 2): 18–33.
    • (1995) Journal of Animal Science , vol.73 , pp. 18-33
    • Oliver, S.1    Calvinho, L.2
  • 6
    • 36448984661 scopus 로고    scopus 로고
    • The toll-like receptor-4 (TLR-4) pathway and its possible role in the pathogenesis of Escherichia coli mastitis in dairy cattle
    • De Schepper, S., A. De Ketelaere, D.D. Bannerman, M.J. Paape, L. Peelman, and C. Burvenich. 2008. The toll-like receptor-4 (TLR-4) pathway and its possible role in the pathogenesis of Escherichia coli mastitis in dairy cattle. Veterinary Research 39(1): 1–23.
    • (2008) Veterinary Research , vol.39 , Issue.1 , pp. 1-23
    • De Schepper, S.1    De Ketelaere, A.2    Bannerman, D.D.3    Paape, M.J.4    Peelman, L.5    Burvenich, C.6
  • 7
    • 65349142455 scopus 로고    scopus 로고
    • Neuroprotection of geniposide against hydrogen peroxide induced PC12 cells injury: involvement of PI3 kinase signal pathway
    • J-h, Liu, F. Yin, L.-x. Guo, X.-h. Deng, and Y.-h. Hu. 2009. Neuroprotection of geniposide against hydrogen peroxide induced PC12 cells injury: involvement of PI3 kinase signal pathway. Acta Pharmacologica Sinica 30(2): 159–165.
    • (2009) Acta Pharmacologica Sinica , vol.30 , Issue.2 , pp. 159-165
    • J-h, L.1    Yin, F.2    Guo, L.-X.3    Deng, X.-H.4    Hu, Y.-H.5
  • 8
    • 34547734912 scopus 로고    scopus 로고
    • Penta-acetyl geniposide-induced apoptosis involving transcription of NGF/p75 via MAPK-mediated AP-1 activation in C6 glioma cells
    • PID: 17651887, COI: 1:CAS:528:DC%2BD2sXpt1Smurc%3D
    • Peng, C.H., C.N. Huang, S.P. Hsu, and C.J. Wang. 2007. Penta-acetyl geniposide-induced apoptosis involving transcription of NGF/p75 via MAPK-mediated AP-1 activation in C6 glioma cells. Toxicology 238(2–3): 130–139.
    • (2007) Toxicology , vol.238 , Issue.2-3 , pp. 130-139
    • Peng, C.H.1    Huang, C.N.2    Hsu, S.P.3    Wang, C.J.4
  • 9
    • 65349141758 scopus 로고    scopus 로고
    • Effect of geniposide, a hypoglycemic glucoside, on hepatic regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin
    • PID: 19122671, COI: 1:CAS:528:DC%2BD1MXhsVClu7o%3D
    • Wu, S.Y., G.F. Wang, Z.Q. Liu, J.J. Rao, L. Lu, W. Xu, S.G. Wu, and J.J. Zhang. 2009. Effect of geniposide, a hypoglycemic glucoside, on hepatic regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin. Acta Pharmacologica Sinica 30(2): 202–208.
    • (2009) Acta Pharmacologica Sinica , vol.30 , Issue.2 , pp. 202-208
    • Wu, S.Y.1    Wang, G.F.2    Liu, Z.Q.3    Rao, J.J.4    Lu, L.5    Xu, W.6    Wu, S.G.7    Zhang, J.J.8
  • 10
    • 77953324904 scopus 로고    scopus 로고
    • Geniposide inhibits interleukin-6 and interleukin-8 production in lipopolysaccharide-induced human umbilical vein endothelial cells by blocking p38 and ERK1/2 signaling pathways
    • COI: 1:CAS:528:DC%2BC3cXlvFegsr4%3D
    • Liu, H.T., J.L. He, W.M. Li, Z. Yang, Y.X. Wang, J. Yin, Y.G. Du, and C. Yu. 2010. Geniposide inhibits interleukin-6 and interleukin-8 production in lipopolysaccharide-induced human umbilical vein endothelial cells by blocking p38 and ERK1/2 signaling pathways. Inflammation Research: Official Journal of the European Histamine Research Society 59(6): 451–461.
    • (2010) Inflammation Research : Official Journal of the European Histamine Research Society , vol.59 , Issue.6 , pp. 451-461
    • Liu, H.T.1    He, J.L.2    Li, W.M.3    Yang, Z.4    Wang, Y.X.5    Yin, J.6    Du, Y.G.7    Yu, C.8
  • 11
    • 84865161234 scopus 로고    scopus 로고
    • LPS-induced iNOS expression in N9 microglial cells is suppressed by geniposide via ERK, p38 and nuclear factor-κB signaling pathways
    • PID: 22710392, COI: 1:CAS:528:DC%2BC38XhtlehsrrE
    • Zhang, G., J.-L. He, X.-Y. Xie, and C. Yu. 2012. LPS-induced iNOS expression in N9 microglial cells is suppressed by geniposide via ERK, p38 and nuclear factor-κB signaling pathways. International Journal of Molecular Medicine 30(3): 561–568.
    • (2012) International Journal of Molecular Medicine , vol.30 , Issue.3 , pp. 561-568
    • Zhang, G.1    He, J.-L.2    Xie, X.-Y.3    Yu, C.4
  • 12
    • 84869214410 scopus 로고    scopus 로고
    • Geniposide, from Gardenia jasminoides Ellis, inhibits the inflammatory response in the primary mouse macrophages and mouse models
    • PID: 22878137, COI: 1:CAS:528:DC%2BC38XhslOkurbJ
    • Fu, Y., B. Liu, J. Liu, Z. Liu, D. Liang, F. Li, D. Li, Y. Cao, X. Zhang, N. Zhang, et al. 2012. Geniposide, from Gardenia jasminoides Ellis, inhibits the inflammatory response in the primary mouse macrophages and mouse models. International Immunopharmacology 14(4): 792–798.
    • (2012) International Immunopharmacology , vol.14 , Issue.4 , pp. 792-798
    • Fu, Y.1    Liu, B.2    Liu, J.3    Liu, Z.4    Liang, D.5    Li, F.6    Li, D.7    Cao, Y.8    Zhang, X.9    Zhang, N.10
  • 14
    • 0014793274 scopus 로고
    • Experimental bacterial mastitis in the mouse
    • PID: 4989101, COI: 1:STN:280:DyaE3c3mvVymsg%3D%3D
    • Chandler, R.L. 1970. Experimental bacterial mastitis in the mouse. Journal of Medical Microbiology 3(2): 273–282.
    • (1970) Journal of Medical Microbiology , vol.3 , Issue.2 , pp. 273-282
    • Chandler, R.L.1
  • 15
    • 0016200105 scopus 로고
    • Experimental staphylococcal mastitis in the mouse: effects of extracellular products and whole bacterial cells from a high-virulence and a low-virulence strain of Staphylococcus aureus
    • PID: 4834505, COI: 1:STN:280:DyaE2c3lsFCntQ%3D%3D
    • Anderson, J.C. 1974. Experimental staphylococcal mastitis in the mouse: effects of extracellular products and whole bacterial cells from a high-virulence and a low-virulence strain of Staphylococcus aureus. Journal of Medical Microbiology 7(2): 205–212.
    • (1974) Journal of Medical Microbiology , vol.7 , Issue.2 , pp. 205-212
    • Anderson, J.C.1
  • 16
    • 0032434397 scopus 로고    scopus 로고
    • Clonal characterization of mouse mammary luminal epithelial and myoepithelial cells separated by fluorescence-activated cell sorting
    • COI: 1:STN:280:DyaK1M%2FgvVehtw%3D%3D
    • Smalley, M.J., J. Titley, and M.J. O’Hare. 1998. Clonal characterization of mouse mammary luminal epithelial and myoepithelial cells separated by fluorescence-activated cell sorting. In Vitro Cellular & Developmental Biology Animal 34(9): 711–721.
    • (1998) In Vitro Cellular & Developmental Biology Animal , vol.34 , Issue.9 , pp. 711-721
    • Smalley, M.J.1    Titley, J.2    O’Hare, M.J.3
  • 17
    • 84871692422 scopus 로고    scopus 로고
    • Lipopolysaccharide increases Toll-like receptor 4 and downstream Toll-like receptor signaling molecules expression in bovine endometrial epithelial cells
    • PID: 23218938
    • Fu, Y., L. Bo, X. Feng, Z. Liu, D. Liang, F. Li, D. Li, Y. Cao, S. Feng, and X. Zhang. 2012. Lipopolysaccharide increases Toll-like receptor 4 and downstream Toll-like receptor signaling molecules expression in bovine endometrial epithelial cells. Veterinary Immunology and Immunopathology 151: 20–27.
    • (2012) Veterinary Immunology and Immunopathology , vol.151 , pp. 20-27
    • Fu, Y.1    Bo, L.2    Feng, X.3    Liu, Z.4    Liang, D.5    Li, F.6    Li, D.7    Cao, Y.8    Feng, S.9    Zhang, X.10
  • 18
    • 84881489438 scopus 로고    scopus 로고
    • Astragalin suppresses inflammatory responses via down-regulation of NF-kappaB signaling pathway in lipopolysaccharide-induced mastitis in a murine model
    • PID: 23928506, COI: 1:CAS:528:DC%2BC3sXhtlGqtrfP
    • Li, F., D. Liang, Z. Yang, T. Wang, W. Wang, X. Song, M. Guo, E. Zhou, D. Li, Y. Cao, et al. 2013. Astragalin suppresses inflammatory responses via down-regulation of NF-kappaB signaling pathway in lipopolysaccharide-induced mastitis in a murine model. International Immunopharmacology 17(2): 478–482.
    • (2013) International Immunopharmacology , vol.17 , Issue.2 , pp. 478-482
    • Li, F.1    Liang, D.2    Yang, Z.3    Wang, T.4    Wang, W.5    Song, X.6    Guo, M.7    Zhou, E.8    Li, D.9    Cao, Y.10
  • 19
    • 84878422114 scopus 로고    scopus 로고
    • Shikonin exerts anti-inflammatory effects in a murine model of lipopolysaccharide-induced acute lung injury by inhibiting the nuclear factor-kappaB signaling pathway
    • PID: 23651796, COI: 1:CAS:528:DC%2BC3sXptFKnu7s%3D
    • Liang, D., Y. Sun, Y. Shen, F. Li, X. Song, E. Zhou, F. Zhao, Z. Liu, Y. Fu, M. Guo, et al. 2013. Shikonin exerts anti-inflammatory effects in a murine model of lipopolysaccharide-induced acute lung injury by inhibiting the nuclear factor-kappaB signaling pathway. International Immunopharmacology 16(4): 475–480.
    • (2013) International Immunopharmacology , vol.16 , Issue.4 , pp. 475-480
    • Liang, D.1    Sun, Y.2    Shen, Y.3    Li, F.4    Song, X.5    Zhou, E.6    Zhao, F.7    Liu, Z.8    Fu, Y.9    Guo, M.10
  • 20
    • 33645636734 scopus 로고    scopus 로고
    • Mouse models to study the pathogenesis and control of bovine mastitis. A review
    • PID: 16605156, COI: 1:STN:280:DC%2BD287pvFWjtA%3D%3D
    • Notebaert, S., and E. Meyer. 2006. Mouse models to study the pathogenesis and control of bovine mastitis. A review. The Veterinary quarterly 28(1): 2–13.
    • (2006) The Veterinary quarterly , vol.28 , Issue.1 , pp. 2-13
    • Notebaert, S.1    Meyer, E.2
  • 21
    • 33646541106 scopus 로고    scopus 로고
    • Innate immunity of the bovine mammary gland
    • PID: 16611554, COI: 1:CAS:528:DC%2BD28Xls1Srtr0%3D
    • Rainard, P., and C. Riollet. 2006. Innate immunity of the bovine mammary gland. Veterinary Research 37(3): 369–400.
    • (2006) Veterinary Research , vol.37 , Issue.3 , pp. 369-400
    • Rainard, P.1    Riollet, C.2
  • 22
    • 1042302206 scopus 로고    scopus 로고
    • Short-term changes of mRNA expression of various inflammatory factors and milk proteins in mammary tissue during LPS-induced mastitis
    • PID: 14757184, COI: 1:CAS:528:DC%2BD2cXnvVelug%3D%3D
    • Schmitz, S., M.W. Pfaffl, H.H.D. Meyer, and R.M. Bruckmaier. 2004. Short-term changes of mRNA expression of various inflammatory factors and milk proteins in mammary tissue during LPS-induced mastitis. Domestic Animal Endocrinology 26(2): 111–126.
    • (2004) Domestic Animal Endocrinology , vol.26 , Issue.2 , pp. 111-126
    • Schmitz, S.1    Pfaffl, M.W.2    Meyer, H.H.D.3    Bruckmaier, R.M.4
  • 24
    • 0041677606 scopus 로고    scopus 로고
    • Principles of interleukin (IL)-6-type cytokine signalling and its regulation
    • PID: 12773095, COI: 1:CAS:528:DC%2BD3sXmtF2hurs%3D
    • Heinrich, P.C., I. Behrmann, S. Haan, H.M. Hermanns, G. Muller-Newen, and F. Schaper. 2003. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochemical Journal 374(Pt 1): 1–20.
    • (2003) Biochemical Journal , vol.374 , pp. 1-20
    • Heinrich, P.C.1    Behrmann, I.2    Haan, S.3    Hermanns, H.M.4    Muller-Newen, G.5    Schaper, F.6
  • 27
    • 43049179999 scopus 로고    scopus 로고
    • LPS/TLR4 signal transduction pathway
    • COI: 1:CAS:528:DC%2BD1cXlslynt7c%3D
    • Lu, Y.C., W.C. Yeh, and P.S. Ohashi. 2008. LPS/TLR4 signal transduction pathway. Cytokines 42(2): 145–151.
    • (2008) Cytokines , vol.42 , Issue.2 , pp. 145-151
    • Lu, Y.C.1    Yeh, W.C.2    Ohashi, P.S.3
  • 28
    • 0029146930 scopus 로고
    • Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway
    • COI: 1:CAS:528:DyaK2MXntFSrsrg%3D
    • Chen, Z., J. Hagler, V.J. Palombella, F. Melandri, D. Scherer, D. Ballard, and T. Maniatis. 1995. Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway. Genes & Development 9(13): 1586–1597.
    • (1995) Genes & Development , vol.9 , Issue.13 , pp. 1586-1597
    • Chen, Z.1    Hagler, J.2    Palombella, V.J.3    Melandri, F.4    Scherer, D.5    Ballard, D.6    Maniatis, T.7
  • 29
    • 84877632700 scopus 로고    scopus 로고
    • Baicalin plays an anti-inflammatory role through reducing nuclear factor-kappa B and p38 phosphorylation in S. aureus-induced mastitis
    • PID: 23523628
    • Guo, M.Y., N.S. Zhang, D.P. Li, D.J. Liang, Z.C. Liu, F.Y. Li, Y.H. Fu, Y.G. Cao, X.M. Deng, and Z.T. Yang. 2013. Baicalin plays an anti-inflammatory role through reducing nuclear factor-kappa B and p38 phosphorylation in S. aureus-induced mastitis. International Immunopharmacology 16(2): 125–130.
    • (2013) International Immunopharmacology , vol.16 , Issue.2 , pp. 125-130
    • Guo, M.Y.1    Zhang, N.S.2    Li, D.P.3    Liang, D.J.4    Liu, Z.C.5    Li, F.Y.6    Fu, Y.H.7    Cao, Y.G.8    Deng, X.M.9    Yang, Z.T.10
  • 30
    • 14844365015 scopus 로고    scopus 로고
    • NF-kappaB inhibition accelerates apoptosis of bovine neutrophils
    • PID: 15720975, COI: 1:CAS:528:DC%2BD2MXivVOrsrc%3D
    • Notebaert, S., L. Duchateau, and E. Meyer. 2005. NF-kappaB inhibition accelerates apoptosis of bovine neutrophils. Veterinary Research 36(2): 229–240.
    • (2005) Veterinary Research , vol.36 , Issue.2 , pp. 229-240
    • Notebaert, S.1    Duchateau, L.2    Meyer, E.3
  • 31
    • 84884717895 scopus 로고    scopus 로고
    • Escherichia coli induces bovine neutrophil cell death independent from caspase-3/-7/-1, but with phosphatidylserine exposure prior to membrane rupture
    • PID: 23510559, COI: 1:CAS:528:DC%2BC3sXktlKmu70%3D
    • Demeyere, K., Q. Remijsen, D. Demon, K. Breyne, S. Notebaert, F. Boyen, C.J. Guérin, P. Vandenabeele, and E. Meyer. 2013. Escherichia coli induces bovine neutrophil cell death independent from caspase-3/-7/-1, but with phosphatidylserine exposure prior to membrane rupture. Veterinary Immunology and Immunopathology 153(1): 45–56.
    • (2013) Veterinary Immunology and Immunopathology , vol.153 , Issue.1 , pp. 45-56
    • Demeyere, K.1    Remijsen, Q.2    Demon, D.3    Breyne, K.4    Notebaert, S.5    Boyen, F.6    Guérin, C.J.7    Vandenabeele, P.8    Meyer, E.9
  • 32
    • 84877774613 scopus 로고    scopus 로고
    • p-Cymene modulates in vitro and in vivo cytokine production by inhibiting MAPK and NF-kappa B activation
    • PID: 23207717, COI: 1:CAS:528:DC%2BC3sXnsFGhtrg%3D
    • Zhong, W.T., G.F. Chi, L.X. Jiang, L.W. Soromou, N. Chen, M.X. Huo, W.X. Guo, X.M. Deng, and H.H. Feng. 2013. p-Cymene modulates in vitro and in vivo cytokine production by inhibiting MAPK and NF-kappa B activation. Inflammation 36(3): 529–537.
    • (2013) Inflammation , vol.36 , Issue.3 , pp. 529-537
    • Zhong, W.T.1    Chi, G.F.2    Jiang, L.X.3    Soromou, L.W.4    Chen, N.5    Huo, M.X.6    Guo, W.X.7    Deng, X.M.8    Feng, H.H.9
  • 33
    • 0035282334 scopus 로고    scopus 로고
    • Mammalian MAP kinase signalling cascades
    • PID: 11242034, COI: 1:CAS:528:DC%2BD3MXhvVSgs7k%3D
    • Chang, L., and M. Karin. 2001. Mammalian MAP kinase signalling cascades. Nature 410(6824): 37–40.
    • (2001) Nature , vol.410 , Issue.6824 , pp. 37-40
    • Chang, L.1    Karin, M.2
  • 34
    • 84918813225 scopus 로고    scopus 로고
    • IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling (reprinted from Science, vol 278, pg 1612-1615, 1997)
    • COI: 1:CAS:528:DC%2BC38XhvV2ks7%2FF
    • Muzio, M., J. Ni, P. Feng, and V.M. Dixit. 2013. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling (reprinted from Science, vol 278, pg 1612-1615, 1997). Journal of Immunology 190(1): 16–19.
    • (2013) Journal of Immunology , vol.190 , Issue.1 , pp. 16-19
    • Muzio, M.1    Ni, J.2    Feng, P.3    Dixit, V.M.4
  • 35
    • 0037040883 scopus 로고    scopus 로고
    • Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1
    • PID: 11744690, COI: 1:CAS:528:DC%2BD38XitFynu70%3D
    • McDermott, E.P., and L.A.J. O’Neill. 2002. Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1. Journal of Biological Chemistry 277(10): 7808–7815.
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.10 , pp. 7808-7815
    • McDermott, E.P.1    O’Neill, L.A.J.2
  • 36
    • 11144290631 scopus 로고    scopus 로고
    • LPS, TLR4 and infectious disease diversity
    • PID: 15608698, COI: 1:CAS:528:DC%2BD2cXhtVyqtrbN
    • Miller, S.I., R.K. Ernst, and M.W. Bader. 2005. LPS, TLR4 and infectious disease diversity. Nature Reviews Microbiology 3(1): 36–46.
    • (2005) Nature Reviews Microbiology , vol.3 , Issue.1 , pp. 36-46
    • Miller, S.I.1    Ernst, R.K.2    Bader, M.W.3
  • 37
    • 17344374020 scopus 로고    scopus 로고
    • The dynamics of LPS recognition: complex orchestration of multiple receptors
    • PID: 15826372, COI: 1:CAS:528:DC%2BD2MXjslGkt7o%3D
    • Triantafilou, M., and K. Triantafilou. 2005. The dynamics of LPS recognition: complex orchestration of multiple receptors. Journal of Endotoxin Research 11(1): 5–11.
    • (2005) Journal of Endotoxin Research , vol.11 , Issue.1 , pp. 5-11
    • Triantafilou, M.1    Triantafilou, K.2
  • 38
    • 0347128294 scopus 로고    scopus 로고
    • Mastitis increases mammary mRNA abundance of β-defensin 5, toll-like-receptor 2 (TLR2), and TLR4 but not TLR9 in cattle
    • PID: 14715566, COI: 1:CAS:528:DC%2BD2cXht1egt74%3D
    • Goldammer, T., H. Zerbe, A. Molenaar, H.-J. Schuberth, R. Brunner, S. Kata, and H.-M. Seyfert. 2004. Mastitis increases mammary mRNA abundance of β-defensin 5, toll-like-receptor 2 (TLR2), and TLR4 but not TLR9 in cattle. Clinical and Diagnostic Laboratory Immunology 11(1): 174–185.
    • (2004) Clinical and Diagnostic Laboratory Immunology , vol.11 , Issue.1 , pp. 174-185
    • Goldammer, T.1    Zerbe, H.2    Molenaar, A.3    Schuberth, H.-J.4    Brunner, R.5    Kata, S.6    Seyfert, H.-M.7
  • 39
    • 84866735550 scopus 로고    scopus 로고
    • Geniposide reduces inflammatory responses of oxygen-glucose deprived rat microglial cells via inhibition of the TLR4 signaling pathway
    • PID: 22869019, COI: 1:CAS:528:DC%2BC38XhtFCrt7bI
    • Wang, J., J. Hou, P. Zhang, D. Li, C. Zhang, and J. Liu. 2012. Geniposide reduces inflammatory responses of oxygen-glucose deprived rat microglial cells via inhibition of the TLR4 signaling pathway. Neurochemical Research 37(10): 2235–2248.
    • (2012) Neurochemical Research , vol.37 , Issue.10 , pp. 2235-2248
    • Wang, J.1    Hou, J.2    Zhang, P.3    Li, D.4    Zhang, C.5    Liu, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.