메뉴 건너뛰기




Volumn 38, Issue 1, 2015, Pages 16-26

Magnolol Inhibits the Inflammatory Response in Mouse Mammary Epithelial Cells and a Mouse Mastitis Model

Author keywords

cytokine; lipopolysaccharide (LPS); magnolol; mastitis; mitogen activated protein kinases (MAPKs); nuclear factor kappaB (NF B)

Indexed keywords

ANTIINFLAMMATORY AGENT; BIPHENYL DERIVATIVE; DRUG THERAPY; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIGNAN; LIPOPOLYSACCHARIDE; MAGNOLOL; MITOGEN ACTIVATED PROTEIN KINASE; MYELOPEROXIDASE; PHARMACOLOGY; PROTECTIVE AGENT; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOTAGMIN I; TOLL LIKE RECEPTOR 4;

EID: 84963986683     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-014-0003-2     Document Type: Article
Times cited : (54)

References (41)
  • 1
    • 0023745576 scopus 로고
    • Etiological agents of bovine mastitis
    • COI: 1:STN:280:DyaL1c7nvFCntQ%3D%3D, PID: 3354192
    • Watts, J.L. 1988. Etiological agents of bovine mastitis. Veterinary Microbiology 16: 41–66.
    • (1988) Veterinary Microbiology , vol.16 , pp. 41-66
    • Watts, J.L.1
  • 3
    • 10044299362 scopus 로고    scopus 로고
    • Increase of Escherichia coli inoculum doses induces faster innate immune response in primiparous cows
    • COI: 1:CAS:528:DC%2BD2cXhtVCjtrnO, PID: 15545375
    • Vangroenweghe, F., P. Rainard, M. Paape, L. Duchateau, and C. Burvenich. 2004. Increase of Escherichia coli inoculum doses induces faster innate immune response in primiparous cows. Journal of Dairy Science 87: 4132–4144.
    • (2004) Journal of Dairy Science , vol.87 , pp. 4132-4144
    • Vangroenweghe, F.1    Rainard, P.2    Paape, M.3    Duchateau, L.4    Burvenich, C.5
  • 4
    • 58149127833 scopus 로고    scopus 로고
    • Induction of lactoferrin gene expression by innate immune stimuli in mouse mammary epithelial HC-11 cells
    • COI: 1:CAS:528:DC%2BD1MXktF2gtw%3D%3D, PID: 18534195
    • Li, Y., G.V. Limmon, F. Imani, and C. Teng. 2009. Induction of lactoferrin gene expression by innate immune stimuli in mouse mammary epithelial HC-11 cells. Biochimie 91: 58–67.
    • (2009) Biochimie , vol.91 , pp. 58-67
    • Li, Y.1    Limmon, G.V.2    Imani, F.3    Teng, C.4
  • 5
    • 20444465568 scopus 로고    scopus 로고
    • Lipopolysaccharide and lipoteichoic acid induce different innate immune responses in bovine mammary epithelial cells
    • COI: 1:CAS:528:DC%2BD2MXlsFCksr4%3D, PID: 15882946
    • Strandberg, Y., C. Gray, T. Vuocolo, L. Donaldson, M. Broadway, and R. Tellam. 2005. Lipopolysaccharide and lipoteichoic acid induce different innate immune responses in bovine mammary epithelial cells. Cytokine 31: 72–86.
    • (2005) Cytokine , vol.31 , pp. 72-86
    • Strandberg, Y.1    Gray, C.2    Vuocolo, T.3    Donaldson, L.4    Broadway, M.5    Tellam, R.6
  • 6
    • 84899439216 scopus 로고    scopus 로고
    • Regulation of innate immune responses by transmembrane interactions: lessons from the TLR family
    • COI: 1:CAS:528:DC%2BC2cXivFCjtb8%3D, PID: 24480409
    • Reuven, E.M., A. Fink, and Y. Shai. 2014. Regulation of innate immune responses by transmembrane interactions: lessons from the TLR family. Biochimica et Biophysica Acta 1838(6): 1586–1593.
    • (2014) Biochimica et Biophysica Acta , vol.1838 , Issue.6 , pp. 1586-1593
    • Reuven, E.M.1    Fink, A.2    Shai, Y.3
  • 7
    • 84895430830 scopus 로고    scopus 로고
    • Toll-like receptor signaling for the induction of mucin expression by lipopolysaccharide in the hen vagina
    • COI: 1:CAS:528:DC%2BC2cXjs1Gjtr0%3D, PID: 24604861
    • Ariyadi, B., N. Isobe, and Y. Yoshimura. 2014. Toll-like receptor signaling for the induction of mucin expression by lipopolysaccharide in the hen vagina. Poultry Science 93: 673–679.
    • (2014) Poultry Science , vol.93 , pp. 673-679
    • Ariyadi, B.1    Isobe, N.2    Yoshimura, Y.3
  • 8
    • 0035066383 scopus 로고    scopus 로고
    • Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
    • COI: 1:CAS:528:DC%2BD3MXislCrsb8%3D, PID: 11274345
    • Kyriakis, J.M., and J. Avruch. 2001. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiological Reviews 81: 807–869.
    • (2001) Physiological Reviews , vol.81 , pp. 807-869
    • Kyriakis, J.M.1    Avruch, J.2
  • 9
    • 0033030207 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase inhibitors-mechanisms and therapeutic potentials
    • COI: 1:CAS:528:DyaK1MXjvFOhtbs%3D, PID: 10454214
    • Lee, J.C., S. Kassis, S. Kumar, A. Badger, and J.L. Adams. 1999. p38 mitogen-activated protein kinase inhibitors-mechanisms and therapeutic potentials. Pharmacology and Therapeutics 82: 389–397.
    • (1999) Pharmacology and Therapeutics , vol.82 , pp. 389-397
    • Lee, J.C.1    Kassis, S.2    Kumar, S.3    Badger, A.4    Adams, J.L.5
  • 10
    • 85172625246 scopus 로고    scopus 로고
    • Riollet, C., Rainard, P., Poutrel B. 2002 Cells and cytokines in inflammatory secretions of bovine mammary gland. In Biology of the Mammary Gland, 247-258. Springer
    • Riollet, C., Rainard, P., Poutrel B. 2002 Cells and cytokines in inflammatory secretions of bovine mammary gland. In Biology of the Mammary Gland, 247-258. Springer.
  • 11
    • 0021069340 scopus 로고
    • Pharmacological properties of magnolol and honokiol extracted from Magnolia officinalis: central depressant effects
    • COI: 1:CAS:528:DyaL2cXksFWktQ%3D%3D, PID: 6657781
    • Watanabe, K., H. Watanabe, Y. Goto, M. Yamaguchi, N. Yamamoto, and K. Hagino. 1983. Pharmacological properties of magnolol and honokiol extracted from Magnolia officinalis: central depressant effects. Planta Medica 49: 103–108.
    • (1983) Planta Medica , vol.49 , pp. 103-108
    • Watanabe, K.1    Watanabe, H.2    Goto, Y.3    Yamaguchi, M.4    Yamamoto, N.5    Hagino, K.6
  • 12
    • 0027299938 scopus 로고
    • Suitability of human chromosome-specific DNA libraries for mutagenicity studies in Macaca fascicularis
    • COI: 1:CAS:528:DyaK3sXltlehurc%3D, PID: 8332080
    • Blakey, D.H., J.M. Bayley, and K.C. Huang. 1993. Suitability of human chromosome-specific DNA libraries for mutagenicity studies in Macaca fascicularis. Mutagenesis 8: 189–192.
    • (1993) Mutagenesis , vol.8 , pp. 189-192
    • Blakey, D.H.1    Bayley, J.M.2    Huang, K.C.3
  • 13
    • 0034047190 scopus 로고    scopus 로고
    • Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages
    • COI: 1:CAS:528:DC%2BD3cXksVOmtLY%3D, PID: 10909270
    • Son, H.J., H.J. Lee, H.S. Yun-Choi, and J.H. Ryu. 2000. Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages. Planta Medica 66: 469–471.
    • (2000) Planta Medica , vol.66 , pp. 469-471
    • Son, H.J.1    Lee, H.J.2    Yun-Choi, H.S.3    Ryu, J.H.4
  • 14
    • 3543134309 scopus 로고    scopus 로고
    • In vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against Propionibacterium sp
    • COI: 1:CAS:528:DC%2BD2cXmt1OnsLY%3D, PID: 15288590
    • Park, J., J. Lee, E. Jung, Y. Park, K. Kim, B. Park, K. Jung, E. Park, J. Kim, and D. Park. 2004. In vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against Propionibacterium sp. European Journal of Pharmacology 496: 189–195.
    • (2004) European Journal of Pharmacology , vol.496 , pp. 189-195
    • Park, J.1    Lee, J.2    Jung, E.3    Park, Y.4    Kim, K.5    Park, B.6    Jung, K.7    Park, E.8    Kim, J.9    Park, D.10
  • 15
    • 84871290824 scopus 로고    scopus 로고
    • Magnolol inhibits lipopolysaccharide-induced inflammatory response by interfering with TLR4 mediated NF-kappaB and MAPKs signaling pathways
    • COI: 1:CAS:528:DC%2BC38XhslGjsbjE, PID: 23127653
    • Fu, Y., B. Liu, N. Zhang, Z. Liu, D. Liang, F. Li, Y. Cao, X. Feng, X. Zhang, and Z. Yang. 2013. Magnolol inhibits lipopolysaccharide-induced inflammatory response by interfering with TLR4 mediated NF-kappaB and MAPKs signaling pathways. Journal of Ethnopharmacology 145: 193–199.
    • (2013) Journal of Ethnopharmacology , vol.145 , pp. 193-199
    • Fu, Y.1    Liu, B.2    Zhang, N.3    Liu, Z.4    Liang, D.5    Li, F.6    Cao, Y.7    Feng, X.8    Zhang, X.9    Yang, Z.10
  • 16
    • 84872322092 scopus 로고    scopus 로고
    • Salidroside attenuates inflammatory responses by suppressing nuclear factor-kappaB and mitogen activated protein kinases activation in lipopolysaccharide-induced mastitis in mice
    • COI: 1:CAS:528:DC%2BC3sXhsVequg%3D%3D, PID: 22915087
    • Li, D., Y. Fu, W. Zhang, G. Su, B. Liu, M. Guo, F. Li, D. Liang, Z. Liu, X. Zhang, et al. 2013. Salidroside attenuates inflammatory responses by suppressing nuclear factor-kappaB and mitogen activated protein kinases activation in lipopolysaccharide-induced mastitis in mice. Inflammation Research 62: 9–15.
    • (2013) Inflammation Research , vol.62 , pp. 9-15
    • Li, D.1    Fu, Y.2    Zhang, W.3    Su, G.4    Liu, B.5    Guo, M.6    Li, F.7    Liang, D.8    Liu, Z.9    Zhang, X.10
  • 17
    • 77953011400 scopus 로고    scopus 로고
    • Isolation, culture and analysis of mouse mammary epithelial cells
    • COI: 1:CAS:528:DC%2BC3cXos1Cks78%3D, PID: 20204626
    • Smalley, M.J. 2010. Isolation, culture and analysis of mouse mammary epithelial cells. Methods in Molecular Biology 633: 139–170.
    • (2010) Methods in Molecular Biology , vol.633 , pp. 139-170
    • Smalley, M.J.1
  • 18
    • 84875311020 scopus 로고    scopus 로고
    • Emodin ameliorates lipopolysaccharide-induced mastitis in mice by inhibiting activation of NF-κB and MAPKs signal pathways
    • COI: 1:CAS:528:DC%2BC3sXmtVamtro%3D, PID: 23499696
    • Li, D., N. Zhang, Y. Cao, W. Zhang, G. Su, Y. Sun, Z. Liu, F. Li, D. Liang, B. Liu, et al. 2013. Emodin ameliorates lipopolysaccharide-induced mastitis in mice by inhibiting activation of NF-κB and MAPKs signal pathways. European Journal of Pharmacology 705: 79–85.
    • (2013) European Journal of Pharmacology , vol.705 , pp. 79-85
    • Li, D.1    Zhang, N.2    Cao, Y.3    Zhang, W.4    Su, G.5    Sun, Y.6    Liu, Z.7    Li, F.8    Liang, D.9    Liu, B.10
  • 19
    • 0036781052 scopus 로고    scopus 로고
    • NF-kappaB regulation in the immune system
    • COI: 1:CAS:528:DC%2BD38XnsVGqsbg%3D, PID: 12360211
    • Li, Q., and I.M. Verma. 2002. NF-kappaB regulation in the immune system. Nature Reviews Immunology 2: 725–734.
    • (2002) Nature Reviews Immunology , vol.2 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 20
    • 77949388928 scopus 로고    scopus 로고
    • Cilostazol is anti-inflammatory in BV2 microglial cells by inactivating nuclear factor-kappaB and inhibiting mitogen-activated protein kinases
    • COI: 1:CAS:528:DC%2BC3cXjs1ektbo%3D, PID: 20128801
    • Jung, W.K., D.Y. Lee, C. Park, Y.H. Choi, I. Choi, S.G. Park, S.K. Seo, S.W. Lee, S.S. Yea, S.C. Ahn, et al. 2010. Cilostazol is anti-inflammatory in BV2 microglial cells by inactivating nuclear factor-kappaB and inhibiting mitogen-activated protein kinases. British Journal of Pharmacology 159: 1274–1285.
    • (2010) British Journal of Pharmacology , vol.159 , pp. 1274-1285
    • Jung, W.K.1    Lee, D.Y.2    Park, C.3    Choi, Y.H.4    Choi, I.5    Park, S.G.6    Seo, S.K.7    Lee, S.W.8    Yea, S.S.9    Ahn, S.C.10
  • 21
    • 52149109984 scopus 로고    scopus 로고
    • Mammary tissue damage during bovine mastitis: causes and control
    • COI: 1:STN:280:DC%2BD1c3lsVymtA%3D%3D
    • Zhao, X., and P. Lacasse. 2008. Mammary tissue damage during bovine mastitis: causes and control. Journal of Animal Science 86: 57–65.
    • (2008) Journal of Animal Science , vol.86 , pp. 57-65
    • Zhao, X.1    Lacasse, P.2
  • 22
    • 67650932893 scopus 로고    scopus 로고
    • Mastitis detection: current trends and future perspectives
    • COI: 1:CAS:528:DC%2BD1MXptVeqt74%3D, PID: 19616330
    • Viguier, C., S. Arora, N. Gilmartin, K. Welbeck, and R. O’Kennedy. 2009. Mastitis detection: current trends and future perspectives. Trends in Biotechnology 27: 486–493.
    • (2009) Trends in Biotechnology , vol.27 , pp. 486-493
    • Viguier, C.1    Arora, S.2    Gilmartin, N.3    Welbeck, K.4    O’Kennedy, R.5
  • 23
    • 84884675611 scopus 로고    scopus 로고
    • The persistence of biofilm-associated antibiotic resistance of Staphylococcus aureus isolated from clinical bovine mastitis cases in Australia
    • COI: 1:CAS:528:DC%2BC3sXhsFSlsL%2FO, PID: 23446489
    • Babra, C., J.G. Tiwari, G. Pier, T.H. Thein, R. Sunagar, S. Sundareshan, S. Isloor, N.R. Hegde, S. de Wet, and M. Deighton. 2013. The persistence of biofilm-associated antibiotic resistance of Staphylococcus aureus isolated from clinical bovine mastitis cases in Australia. Folia Microbiologica 58: 469–474.
    • (2013) Folia Microbiologica , vol.58 , pp. 469-474
    • Babra, C.1    Tiwari, J.G.2    Pier, G.3    Thein, T.H.4    Sunagar, R.5    Sundareshan, S.6    Isloor, S.7    Hegde, N.R.8    de Wet, S.9    Deighton, M.10
  • 24
    • 58849126433 scopus 로고    scopus 로고
    • Toxoplasma gondii-induced foetal resorption in mice involves interferon-gamma-induced apoptosis and spiral artery dilation at the maternofoetal interface
    • COI: 1:CAS:528:DC%2BD1MXhtlSntbc%3D, PID: 18838076
    • Senegas, A., O. Villard, A. Neuville, L. Marcellin, A.W. Pfaff, T. Steinmetz, M. Mousli, J.P. Klein, and E. Candolfi. 2009. Toxoplasma gondii-induced foetal resorption in mice involves interferon-gamma-induced apoptosis and spiral artery dilation at the maternofoetal interface. International Journal for Parasitology 39: 481–487.
    • (2009) International Journal for Parasitology , vol.39 , pp. 481-487
    • Senegas, A.1    Villard, O.2    Neuville, A.3    Marcellin, L.4    Pfaff, A.W.5    Steinmetz, T.6    Mousli, M.7    Klein, J.P.8    Candolfi, E.9
  • 25
    • 0026692865 scopus 로고
    • Effect of taurine on intracellular calcium dynamics of cultured myocardial cells during the calcium paradox
    • COI: 1:CAS:528:DyaK38XmsV2itb4%3D, PID: 1509934
    • Takahashi, K., H. Harada, S.W. Schaffer, and J. Azuma. 1992. Effect of taurine on intracellular calcium dynamics of cultured myocardial cells during the calcium paradox. Advances in Experimental Medicine and Biology 315: 153–161.
    • (1992) Advances in Experimental Medicine and Biology , vol.315 , pp. 153-161
    • Takahashi, K.1    Harada, H.2    Schaffer, S.W.3    Azuma, J.4
  • 26
    • 84881489438 scopus 로고    scopus 로고
    • Astragalin suppresses inflammatory responses via down-regulation of NF-κB signaling pathway in lipopolysaccharide-induced mastitis in a murine model
    • COI: 1:CAS:528:DC%2BC3sXhtlGqtrfP, PID: 23928506
    • Li, F., D. Liang, Z. Yang, T. Wang, W. Wang, X. Song, M. Guo, E. Zhou, D. Li, and Y. Cao. 2013. Astragalin suppresses inflammatory responses via down-regulation of NF-κB signaling pathway in lipopolysaccharide-induced mastitis in a murine model. International Immunopharmacology 17: 478–482.
    • (2013) International Immunopharmacology , vol.17 , pp. 478-482
    • Li, F.1    Liang, D.2    Yang, Z.3    Wang, T.4    Wang, W.5    Song, X.6    Guo, M.7    Zhou, E.8    Li, D.9    Cao, Y.10
  • 27
    • 84918769608 scopus 로고    scopus 로고
    • Geniposide plays an anti-inflammatory role via regulating TLR4 and downstream signaling pathways in lipopolysaccharide-induced mastitis in mice
    • Song, X., Zhang, W., Wang, T., Jiang, H., Zhang, Z., Fu, Y., Yang, Z., Cao, Y., Zhang, N. 2014. Geniposide plays an anti-inflammatory role via regulating TLR4 and downstream signaling pathways in lipopolysaccharide-induced mastitis in mice. Inflammation 1-11.
    • (2014) Inflammation , pp. 1-11
    • Song, X.1    Zhang, W.2    Wang, T.3    Jiang, H.4    Zhang, Z.5    Fu, Y.6    Yang, Z.7    Cao, Y.8    Zhang, N.9
  • 28
    • 64749084915 scopus 로고    scopus 로고
    • Honokiol, a multifunctional antiangiogenic and antitumor agent
    • COI: 1:CAS:528:DC%2BD1MXkt1ChsbY%3D, PID: 19203212
    • Fried, L.E., and J.L. Arbiser. 2009. Honokiol, a multifunctional antiangiogenic and antitumor agent. Antioxidants and Redox Signaling 11: 1139–1148.
    • (2009) Antioxidants and Redox Signaling , vol.11 , pp. 1139-1148
    • Fried, L.E.1    Arbiser, J.L.2
  • 29
    • 33644778607 scopus 로고    scopus 로고
    • Genome-wide expression analysis of lipopolysaccharide-induced mastitis in a mouse model
    • COI: 1:CAS:528:DC%2BD28XmtFWjsrg%3D, PID: 16495566
    • Zheng, J., A.D. Watson, and D.E. Kerr. 2006. Genome-wide expression analysis of lipopolysaccharide-induced mastitis in a mouse model. Infection and Immunity 74: 1907–1915.
    • (2006) Infection and Immunity , vol.74 , pp. 1907-1915
    • Zheng, J.1    Watson, A.D.2    Kerr, D.E.3
  • 30
    • 0021742157 scopus 로고
    • Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity
    • COI: 1:CAS:528:DyaL2MXktVym, PID: 6092199
    • Krawisz, J., P. Sharon, and W. Stenson. 1984. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Gastroenterology 87: 1344–1350.
    • (1984) Gastroenterology , vol.87 , pp. 1344-1350
    • Krawisz, J.1    Sharon, P.2    Stenson, W.3
  • 31
    • 33744516058 scopus 로고    scopus 로고
    • TNFalpha induces chromosomal abnormalities independent of ROS through IKK, JNK, p38 and caspase pathways
    • COI: 1:CAS:528:DC%2BD28XltlKnt78%3D, PID: 16723255
    • Higashimoto, T., A. Panopoulos, C.L. Hsieh, and E. Zandi. 2006. TNFalpha induces chromosomal abnormalities independent of ROS through IKK, JNK, p38 and caspase pathways. Cytokine 34: 39–50.
    • (2006) Cytokine , vol.34 , pp. 39-50
    • Higashimoto, T.1    Panopoulos, A.2    Hsieh, C.L.3    Zandi, E.4
  • 32
    • 77956693903 scopus 로고    scopus 로고
    • Neolitsea sericea essential oil attenuates LPS-induced inflammation in RAW 264.7 macrophages by suppressing NF-kappaB and MAPK activation
    • COI: 1:CAS:528:DC%2BC3cXhtFSksrzF, PID: 20839643
    • Yoon, W.J., J.Y. Moon, J.Y. Kang, G.O. Kim, N.H. Lee, and C.G. Hyun. 2010. Neolitsea sericea essential oil attenuates LPS-induced inflammation in RAW 264.7 macrophages by suppressing NF-kappaB and MAPK activation. Natural Product Communications 5: 1311–1316.
    • (2010) Natural Product Communications , vol.5 , pp. 1311-1316
    • Yoon, W.J.1    Moon, J.Y.2    Kang, J.Y.3    Kim, G.O.4    Lee, N.H.5    Hyun, C.G.6
  • 33
    • 47549094358 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha up-regulates the expression of CCL2 and adhesion molecules of human proximal tubular epithelial cells through MAPK signaling pathways
    • COI: 1:CAS:528:DC%2BD1cXhtFant73N, PID: 18656701
    • Ho, A.W., C.K. Wong, and C.W. Lam. 2008. Tumor necrosis factor-alpha up-regulates the expression of CCL2 and adhesion molecules of human proximal tubular epithelial cells through MAPK signaling pathways. Immunobiology 213: 533–544.
    • (2008) Immunobiology , vol.213 , pp. 533-544
    • Ho, A.W.1    Wong, C.K.2    Lam, C.W.3
  • 34
    • 0022340429 scopus 로고
    • Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors
    • COI: 1:CAS:528:DyaL2MXltVehtL4%3D
    • Shalaby, M.R., B.B. Aggarwal, E. Rinderknecht, L.P. Svedersky, B.S. Finkle, and M.A. Palladino Jr. 1985. Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors. Journal of Immunology 135: 2069–2073.
    • (1985) Journal of Immunology , vol.135 , pp. 2069-2073
    • Shalaby, M.R.1    Aggarwal, B.B.2    Rinderknecht, E.3    Svedersky, L.P.4    Finkle, B.S.5    Palladino, M.A.6
  • 36
    • 84856641109 scopus 로고    scopus 로고
    • NF-kappaB, the first quarter-century: remarkable progress and outstanding questions
    • COI: 1:CAS:528:DC%2BC38XitlWgtLw%3D, PID: 22302935
    • Hayden, M.S., and S. Ghosh. 2012. NF-kappaB, the first quarter-century: remarkable progress and outstanding questions. Genes and Development 26: 203–234.
    • (2012) Genes and Development , vol.26 , pp. 203-234
    • Hayden, M.S.1    Ghosh, S.2
  • 37
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NF-kappaB transcription factors in the immune system
    • COI: 1:CAS:528:DC%2BD1MXlsFSlt7o%3D, PID: 19302050
    • Vallabhapurapu, S., and M. Karin. 2009. Regulation and function of NF-kappaB transcription factors in the immune system. Annual Review of Immunology 27: 693–733.
    • (2009) Annual Review of Immunology , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 40
    • 29144511607 scopus 로고    scopus 로고
    • MAPK signalling pathways as molecular targets for anti-inflammatory therapy-from molecular mechanisms to therapeutic benefits
    • COI: 1:CAS:528:DC%2BD2MXhtlags7bE, PID: 16198162
    • Kaminska, B. 2005. MAPK signalling pathways as molecular targets for anti-inflammatory therapy-from molecular mechanisms to therapeutic benefits. Biochimica et Biophysica Acta 1754: 253–262.
    • (2005) Biochimica et Biophysica Acta , vol.1754 , pp. 253-262
    • Kaminska, B.1
  • 41
    • 33646908228 scopus 로고    scopus 로고
    • Phosphoinositide-mediated adaptor recruitment controls toll-like receptor signaling
    • PID: 16751103
    • Medzhitov, R., and J.C. Kagan. 2006. Phosphoinositide-mediated adaptor recruitment controls toll-like receptor signaling. Cell 125: 943–955.
    • (2006) Cell , vol.125 , pp. 943-955
    • Medzhitov, R.1    Kagan, J.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.