Sinomenine activates astrocytic dopamine D2 receptors and alleviates neuroinflammatory injury via the CRYAB/STAT3 pathway after ischemic stroke in mice

Journal of Neuroinflammation

Volumn 13, Issue 1, 2016, Pages

  Qiu, Jing ^a   Yan, Zhongjun ^b   Tao, Kai ^b   Li, Yansong ^c   Li, Yuqian ^b   Li, Jingchen ^a   Dong, Yushu ^a   Feng, Dayun ^b   Chen, Huisheng ^a  

^a GENERAL HOSPITAL OF NORTHERN THEATER COMMAND   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c The 463 Hospital of Chinese PLA   (China)

Author keywords

Astrocyte; Dopamine D2 receptor (DRD2); Ischemic stroke; Neuroinflammation; Sinomenine

Indexed keywords

ALPHA CRYSTALLIN; DNA; DOPAMINE 2 RECEPTOR; GLUCOSE; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6; OXYGEN; SINOMENINE; STAT3 PROTEIN; TUMOR NECROSIS FACTOR; ANTIRHEUMATIC AGENT; CRYAB PROTEIN, MOUSE; MORPHINAN DERIVATIVE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; ASTROCYTE; BRAIN ISCHEMIA; CELL HYPOXIA; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NEWBORN; NONHUMAN; OXYGEN GLUCOSE DEPRIVATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; BRAIN EDEMA; C57BL MOUSE; CELL CULTURE; CEREBRAL ARTERY DISEASE; CEREBRAL INFARCTION; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; ENCEPHALITIS; HYPOXIA; METABOLISM; NERVOUS SYSTEM DISEASES; PATHOLOGY; PHYSIOLOGY; RNA INTERFERENCE;

ALPHA-CRYSTALLIN B CHAIN; ANIMALS; ANIMALS, NEWBORN; ANTIRHEUMATIC AGENTS; ASTROCYTES; BRAIN EDEMA; CELLS, CULTURED; CEREBRAL INFARCTION; DISEASE MODELS, ANIMAL; ENCEPHALITIS; HYPOXIA; INFARCTION, MIDDLE CEREBRAL ARTERY; MICE; MICE, INBRED C57BL; MORPHINANS; NERVOUS SYSTEM DISEASES; RECEPTORS, DOPAMINE D2; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 84990858741     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-016-0739-8     Document Type: Article

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