Neuron-derived FGF10 ameliorates cerebral ischemia injury via inhibiting NF-ΰ B-dependent neuroinflammation and activating PI3K/Akt survival signaling pathway in mice

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Li, Yong Hua ^a   Fu, Hai Long ^a   Tian, Mou Li ^a   Wang, Yong Qiang ^b   Chen, Wei ^a   Cai, Lin Lin ^a   Zhou, Xu Hui ^a   Yuan, Hong Bin ^b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 10; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NEUROPROTECTIVE AGENT; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL; APOPTOSIS; BIOLOGICAL MODEL; BRAIN ISCHEMIA; DISEASE MODEL; DRUG EFFECTS; INFLAMMATION; MALE; METABOLISM; MOUSE; NERVE CELL; PATHOLOGY; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; FIBROBLAST GROWTH FACTOR 10; INFLAMMATION; MALE; MICE; MODELS, BIOLOGICAL; NEURONS; NEUROPROTECTIVE AGENTS; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

EID: 84955481947     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep19869     Document Type: Article

References (60)

1. Mozaffarian, D. et al. Heart disease and stroke statistics-2015 update: A report from the american heart association. Circulation. 131, e29-e322 (2015).
2. Barreto, G., White, R. E., Ouyang, Y., Xu, L. & Giffard, R. G. Astrocytes: Targets for neuroprotection in stroke. Cent Nerv Syst Agents Med Chem. 11, 164-173 (2011).
3. Doyle, K. P., Simon, R. P. & Stenzel-Poore, M. P. Mechanisms of ischemic brain damage. Neuropharmacology. 55, 310-318 (2008).
4. Kuwashiro, T. et al. Significance of plasma adiponectin for diagnosis, neurological severity and functional outcome in ischemic stroke-Research for Biomarkers in Ischemic Stroke (REBIOS). Metabolism. 63, 1093-1103 (2014).
5. Prugger, C. et al. Adipocytokines and the risk of ischemic stroke: The PRIME Study. Ann Neurol. 71, 478-486 (2012).
6. Itoh, N. & Ornitz, D. M. Fibroblast growth factors: From molecular evolution to roles in development, metabolism and disease. J Biochem. 149, 121-130 (2011).
7. Lee, J. et al. Exendin-4 regulates lipid metabolism and fibroblast growth factor 21 in hepatic steatosis. Metabolism. 63, 1041-1048 (2014).
8. Hondares, E. et al. Fibroblast growth factor-21 is expressed in neonatal and pheochromocytoma-induced adult human brown adipose tissue. Metabolism. 63, 312-317 (2014).
9. Liu, J., Xu, Y., Hu, Y. & Wang, G. The role of fibroblast growth factor 21 in the pathogenesis of non-alcoholic fatty liver disease and implications for therapy. Metabolism. 64, 380-390 (2015).
10. Yamasaki, M., Miyake, A., Tagashira, S. & Itoh, N. Structure and expression of the rat mRNA encoding a novel member of the fibroblast growth factor family. J Biol Chem. 271, 15918-15921 (1996).
11. Min, H. et al. Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes Dev. 12, 3156-3161 (1998).
12. Thomson, A. A. & Cunha, G. R. Prostatic growth and development are regulated by FGF10. Development. 126, 3693-3701 (1999).
13. Sakaue, H. et al. Requirement of fibroblast growth factor 10 in development of white adipose tissue. Genes Dev. 16, 908-912 (2002).
14. Jimenez, P. A. & Rampy, M. A. Keratinocyte growth factor-2 accelerates wound healing in incisional wounds. J Surg Res. 81, 238-242 (1999).
15. Vega-Hernandez, M., Kovacs, A., De Langhe, S. & Ornitz, D. M. FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium. Development. 138, 3331-3340 (2011).
16. Li, Y. H., Yang, L. Y., Chen, W., Li, Y. K. & Yuan, H. B. Fibroblast growth factor 10 protects neuron against oxygen-glucose deprivation injury through inducing heme oxygenase-1. Biochem Biophys Res Commun. 456, 225-231 (2015).
17. Milner, R. et al. Responses of endothelial cell and astrocyte matrix-integrin receptors to ischemia mimic those observed in the neurovascular unit. Stroke. 39, 191-197 (2008).
18. Takano, T., Oberheim, N., Cotrina, M. L. & Nedergaard, M. Astrocytes and ischemic injury. Stroke. 40, S8-12 (2009).
19. Shichita, T., Sakaguchi, R., Suzuki, M. & Yoshimura, A. Post-ischemic inflammation in the brain. Front Immunol. 3, 132 (2012).
20. Stanimirovic, D. & Satoh, K. Inflammatory mediators of cerebral endothelium: A role in ischemic brain inflammation. Brain Pathol. 10, 113-126 (2000).
21. Mullonkal, C. J. & Toledo-Pereyra, L. H. Akt in ischemia and reperfusion. J Invest Surg. 20, 195-203 (2007).
22. Hajihosseini, M. K. et al. Localization and fate of Fgf10-expressing cells in the adult mouse brain implicate Fgf10 in control of neurogenesis. Mol Cell Neurosci. 37, 857-868 (2008).
23. Sahara, S. & O'Leary, D. D. Fgf10 regulates transition period of cortical stem cell differentiation to radial glia controlling generation of neurons and basal progenitors. Neuron. 63, 48-62 (2009).
24. Haan, N. et al. Fgf10-expressing tanycytes add new neurons to the appetite/energy-balance regulating centers of the postnatal and adult hypothalamus. J Neurosci. 33, 6170-6180 (2013).
25. Stork, T., Sheehan, A., Tasdemir-Yilmaz, O. E. & Freeman, M. R. Neuron-glia interactions through the Heartless FGF receptor signaling pathway mediate morphogenesis of Drosophila astrocytes. Neuron. 83, 388-403 (2014).
26. Seo, J. H., Yu, J. H., Suh, H., Kim, M. S. & Cho, S. R. Fibroblast growth factor-2 induced by enriched environment enhances angiogenesis and motor function in chronic hypoxic-ischemic brain injury. PLoS One. 8, e74405 (2013).
27. Qu, X. et al. bFGF Protects Pre-oligodendrocytes from Oxygen/Glucose Deprivation Injury to Ameliorate Demyelination. Cell Mol Neurobiol. 35, 913-920 (2015).
28. Jin, R., Yang, G. & Li, G. Inflammatory mechanisms in ischemic stroke: Role of inflammatory cells. J Leukoc Biol. 87, 779-789 (2010).
29. Vila, N., Castillo, J., Davalos, A. & Chamorro, A. Proinflammatory cytokines and early neurological worsening in ischemic stroke. Stroke. 31, 2325-2329 (2000).
30. Benjamin, J. T. et al. FGF-10 is decreased in bronchopulmonary dysplasia and suppressed by Toll-like receptor activation. Am J Physiol Lung Cell Mol Physiol. 292, L550-558 (2007).
31. Fu, H. et al. Inhibition of glycogen synthase kinase 3 ameliorates liver ischemia/reperfusion injury via an energy-dependent mitochondrial mechanism. J Hepatol. 61, 816-824 (2014).
32. Li, Z., Ni, C. L., Yao, Z., Chen, L. M. & Niu, W. Y. Liraglutide enhances glucose transporter 4 translocation via regulation of AMPactivated protein kinase signaling pathways in mouse skeletal muscle cells. Metabolism. 63, 1022-1030 (2014).
33. Utley, S. et al. Fibroblast growth factor signaling regulates the expansion of A6-expressing hepatocytes in association with AKTdependent beta-catenin activation. J. Hepatol. 60, 1002-1009 (2014).
34. She, J. et al. KGF-2 targets alveolar epithelia and capillary endothelia to reduce high altitude pulmonary oedema in rats. J Cell Mol Med. 16, 3074-3084 (2012).
35. Mailleux, A. A. et al. Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage. Development. 132, 2157-2166 (2005).
36. Taniguchi, F. et al. Activation of mitogen-activated protein kinase pathway by keratinocyte growth factor or fibroblast growth factor-10 promotes cell proliferation in human endometrial carcinoma cells. J Clin Endocrinol Metab. 88, 773-780 (2003).
37. Balwani, S. et al. Regulation of NF-kappaB activation through a novel PI-3K-independent and PKA/Akt-dependent pathway in human umbilical vein endothelial cells. PLoS One. 7, e46528 (2012).
38. Dan, H. C. et al. Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. Genes Dev. 22, 1490-1500 (2008).
39. Grandage, V. L., Gale, R. E., Linch, D. C. & Khwaja, A. PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways. Leukemia. 19, 586-594 (2005).
40. Fang, N. et al. TRIB3 alters endoplasmic reticulum stress-induced beta-cell apoptosis via the NF-kappaB pathway. Metabolism. 63, 822-830 (2014).
41. Wang, L., Li, G., Chen, Q. & Ke, D. Octanoylated ghrelin attenuates angiogenesis induced by oxLDL in human coronary artery endothelial cells via the GHSR1a-mediated NF-kappaB pathway. Metabolism. 64, 1262-1271 (2015).
42. Buchtova, M. et al. Instability restricts signaling of multiple fibroblast growth factors. Cell Mol. Life Sci. 72, 2445-2459 (2015).
43. Bryant, D. M. & Stow, J. L. Nuclear translocation of cell-surface receptors: Lessons from fibroblast growth factor. Traffic. 6, 947-954 (2005).
44. Rodriguez-Enfedaque, A. et al. FGF1 nuclear translocation is required for both its neurotrophic activity and its p53-dependent apoptosis protection. Biochim Biophys Acta. 1793, 1719-1727 (2009).
45. Fukui, S. et al. Nuclear accumulation of basic fibroblast growth factor in human astrocytic tumors. Cancer. 97, 3061-3067 (2003).
46. Fukui, S. et al. Nuclear accumulation of basic fibroblast growth factor as a predictor for the recurrence of pituitary adenomas. J Neurooncol. 57, 221-229 (2002).
47. Liu, X. & Zhu, X. Z. Increased expression and nuclear accumulation of basic fibroblast growth factor in primary cultured astrocytes following ischemic-like insults. Brain Res Mol Brain Res. 71, 171-177 (1999).
48. Hawker, J. R. Jr. & Granger, H. J. Nuclear accumulation of exogenous basic fibroblast growth factor in endothelial, fibroblast, and myoblast cell lines results in diverse biological responses. In Vitro Cell Dev Biol Anim. 30A, 653-663 (1994).
49. Liu, L. & Duff, K. A technique for serial collection of cerebrospinal fluid from the cisterna magna in mouse. J Vis Exp. 10, 960-962 (2008).
50. Wang, P. et al. Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway. Ann Neurol. 69, 360-374 (2011).
51. Wang, P. et al. Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia. Autophagy. 8, 77-87 (2012).
52. Astrup, J., Siesjo, B. K. & Symon, L. Thresholds in cerebral ischemia-the ischemic penumbra. Stroke. 12, 723-725 (1981).
53. Wang, P. et al. ARRB1/beta-arrestin-1 mediates neuroprotection through coordination of BECN1-dependent autophagy in cerebral ischemia. Autophagy. 10, 1535-1548 (2014).
54. Kwon, O. et al. GPR30 mediates anorectic estrogen-induced STAT3 signaling in the hypothalamus. Metabolism. 63, 1455-1461 (2014).
55. Wang, P. et al. Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: Role of nicotinamide mononucleotide. Cardiovasc Res. 81, 370-380 (2009).
56. Song, J. et al. Nicotinamide phosphoribosyltransferase is required for the calorie restriction-mediated improvements in oxidative stress, mitochondrial biogenesis, and metabolic adaptation. J Gerontol A Biol Sci Med Sci. 69, 44-57 (2014).
57. Wang, P. et al. Intracellular NAMPT-NAD +SIRT1 cascade improves post-ischaemic vascular repair by modulating Notch signalling in endothelial progenitors. Cardiovasc Res. 104, 477-488 (2014).
58. Pereira, M. J. et al. FKBP5 expression in human adipose tissue increases following dexamethasone exposure and is associated with insulin resistance. Metabolism. 63, 1198-1208 (2014).
59. Ganji, S. H., Kashyap, M. L. & Kamanna, V. S. Niacin inhibits fat accumulation, oxidative stress, and inflammatory cytokine IL-8 in cultured hepatocytes: Impact on non-alcoholic fatty liver disease. Metabolism. 64, 982-990 (2015).
60. Wu, Y. J. et al. Dipeptidyl peptidase-4 inhibitor, vildagliptin, inhibits pancreatic beta cell apoptosis in association with its effects suppressing endoplasmic reticulum stress in db/db mice. Metabolism. 64, 226-235 (2015).