메뉴 건너뛰기
Acta Biochimica Polonica
Volumn 63, Issue 3, 2016, Pages 459-467
Hepatokines and non-alcoholic fatty liver disease
Author keywords

Angiopoietin related growth factor; Fetuin A; Fibroblast growth factor 21; Leukocyte derived chemotaxin 2; Non alcoholic fatty liver disease; Selenoprotein P; Sex hormone binding globulin
Indexed keywords

FETUIN A; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 21; LECT2 PROTEIN, HUMAN; SELENOPROTEIN P; SEX HORMONE BINDING GLOBULIN; SIGNAL PEPTIDE;
EID: 84990206484     PISSN: 0001527X     EISSN: 1734154X     Source Type: Journal    
DOI: 10.18388/abp.2015_1252     Document Type: Review
Times cited : (78)
References (121)
  • 1
    • 24044536090 scopus 로고    scopus 로고
    • Recent concepts in non-alcoholic fatty liver disease
    • Adams LA, Angulo P (2005) Recent concepts in non-alcoholic fatty liver disease. Diabet Med 22: 1129-1133. http://dx.doi.org/10.1111/j.1464-5491.2005.01748.x.
    • (2005) Diabet Med , vol.22 , pp. 1129-1133
    • Adams, L.A.1    Angulo, P.2
  • 3
    • 0024340523 scopus 로고
    • Characterization of a natural inhibitor of the insulin receptor tyrosine kinase: cDNA cloning, purification, and anti-mitogenic activity
    • Auberger P, Falquerho L, Contreres JO, Pages G, Le Cam G, Rossi B, Le Cam A (1989) Characterization of a natural inhibitor of the insulin receptor tyrosine kinase: cDNA cloning, purification, and anti-mitogenic activity. Cell 58: 631-640. http://dx.doi. org/10.1016/0092-8674(89)90098-6.
    • (1989) Cell , vol.58 , pp. 631-640
    • Auberger, P.1    Falquerho, L.2    Contreres, J.O.3    Pages, G.4    Le Cam, G.5    Rossi, B.6    Le Cam, A.7
  • 4
    • 34249711964 scopus 로고    scopus 로고
    • Hepatic fibroblast growth factor 21 is regulated by PPAR alpha and is a key mediator of hepatic lipid metabolism in ketotic states
    • Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E (2007) Hepatic fibroblast growth factor 21 is regulated by PPAR alpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab 5: 426-437. http://dx.doi.org/10.1016/j. cmet.2007.05.002.
    • (2007) Cell Metab , vol.5 , pp. 426-437
    • Badman, M.K.1    Pissios, P.2    Kennedy, A.R.3    Koukos, G.4    Flier, J.S.5    Maratos-Flier, E.6
  • 5
    • 0025251140 scopus 로고
    • Localisation of the human sex hormone-binding globulin gene (SHGB) to the short arm of chromosome 17 (17p12-13)
    • Berube D, Seralini GE, Gagne R, Hammond GL (1990) Localisation of the human sex hormone-binding globulin gene (SHGB) to the short arm of chromosome 17 (17p12-13). Cytogenet Cell Genet 54: 65-67.
    • (1990) Cytogenet Cell Genet , vol.54 , pp. 65-67
    • Berube, D.1    Seralini, G.E.2    Gagne, R.3    Hammond, G.L.4
  • 6
    • 84884860377 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes
    • Birkenfeld AL, Shulman GI (2014) Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes. Hepatology 59: 713-723. http://dx.doi.org/10.1002/hep.26672.
    • (2014) Hepatology , vol.59 , pp. 713-723
    • Birkenfeld, A.L.1    Shulman, G.I.2
  • 8
    • 23944498579 scopus 로고    scopus 로고
    • Selenoprotein P: an extracellular protein with unique physical characteristic and a role in selenium homeostasis
    • Burk RF, Hill KE (2005) Selenoprotein P: an extracellular protein with unique physical characteristic and a role in selenium homeostasis. Annu Rev Nutr 25: 215-235. http://dx.doi.org/10.1146/annurev. nutr.24.012003.132120.
    • (2005) Annu Rev Nutr , vol.25 , pp. 215-235
    • Burk, R.F.1    Hill, K.E.2
  • 9
    • 2442545703 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and orthotopic liver transplantation
    • Burke A, Lucey MR (2004) Non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and orthotopic liver transplantation. Am J Transplant 4: 686-693. http://dx.doi.org/10.1111/j.1600-6143.2004.00432.x.
    • (2004) Am J Transplant , vol.4 , pp. 686-693
    • Burke, A.1    Lucey, M.R.2
  • 10
    • 77952558012 scopus 로고    scopus 로고
    • The natural history of non-alcoholic fatty liver disease
    • Caldwell S, Argo C (2010) The natural history of non-alcoholic fatty liver disease. Dig Dis 28: 162-168. http://dx.doi. org/10.1159/000282081.
    • (2010) Dig Dis , vol.28 , pp. 162-168
    • Caldwell, S.1    Argo, C.2
  • 14
    • 77955069684 scopus 로고    scopus 로고
    • NF-kB mediates lipid-induced fetuin-A expression in hepatocytes that impaires adipocyte function effecting insulin resistance
    • Dasgupta S, Bhattacharya S, Biswas A, Majumdar SS, Mukhopadhyay S, Ray S, Bhatta-Charya S (2010) NF-kB mediates lipid-induced fetuin-A expression in hepatocytes that impaires adipocyte function effecting insulin resistance. Biochem J 429: 451-462. http://dx.doi. org/10.1042/BJ20100330.
    • (2010) Biochem J , vol.429 , pp. 451-462
    • Dasgupta, S.1    Bhattacharya, S.2    Biswas, A.3    Majumdar, S.S.4    Mukhopadhyay, S.5    Ray, S.6    Bhatta-Charya, S.7
  • 15
    • 0344393623 scopus 로고    scopus 로고
    • Tissue distribution and activity testing suggest a similar but not identical function of fetuin-B and fetuin-A
    • Denecke B, Graber S, Schafer C, Heiss A, Woltje M, Jahnen-Dechent W (2003) Tissue distribution and activity testing suggest a similar but not identical function of fetuin-B and fetuin-A. Biochem J 376: 135-145. http://dx.doi.org/10.1042/BJ20030676.
    • (2003) Biochem J , vol.376 , pp. 135-145
    • Denecke, B.1    Graber, S.2    Schafer, C.3    Heiss, A.4    Woltje, M.5    Jahnen-Dechent, W.6
  • 16
    • 84865422329 scopus 로고    scopus 로고
    • TNF-a represses β-Klotho expression and impairs FGF21 action in adipose cells: involvement of JNK1 in the FGF21 pathway
    • Diaz-Delfin J, Hondares E, Iglesias R, Giralt M, Caelles C, Villarroya F (2012) TNF-a represses β-Klotho expression and impairs FGF21 action in adipose cells: involvement of JNK1 in the FGF21 pathway. Endocrinology 153: 4238-4245. http://dx.doi.org/10.1210/en.2012-1193.
    • (2012) Endocrinology , vol.153 , pp. 4238-4245
    • Diaz-Delfin, J.1    Hondares, E.2    Iglesias, R.3    Giralt, M.4    Caelles, C.5    Villarroya, F.6
  • 18
    • 84880198084 scopus 로고    scopus 로고
    • Genetic predisposition in NAFLD and NASH: impact on severity of liver disease and response to treatment
    • Dongiovanni P, Anstee QM, Valenti L (2013) Genetic predisposition in NAFLD and NASH: impact on severity of liver disease and response to treatment. Curr Pharm Des 19: 5219-5238. http://dx.doi. org/10.2174/13816128113199990381.
    • (2013) Curr Pharm Des , vol.19 , pp. 5219-5238
    • Dongiovanni, P.1    Anstee, Q.M.2    Valenti, L.3
  • 20
    • 62349113882 scopus 로고    scopus 로고
    • Serum levels of angiopoietin-relatef growth factor in diabetes mellitus and chronic hemodialysis
    • Ebert T, Bachmann A, Losser U, Kratzsch J, Bluher M, Stumvoll M, Fasshauer M (2009) Serum levels of angiopoietin-relatef growth factor in diabetes mellitus and chronic hemodialysis. Metabolism 58: 547-551. http://dx.doi.org/10.1016/j.metabol.2008.11.016.
    • (2009) Metabolism , vol.58 , pp. 547-551
    • Ebert, T.1    Bachmann, A.2    Losser, U.3    Kratzsch, J.4    Bluher, M.5    Stumvoll, M.6    Fasshauer, M.7
  • 21
    • 84928884625 scopus 로고    scopus 로고
    • Relationship between serum levels of angiopoietin-related growth factor and metabolic risk factors
    • Ebert T, Kralish S, Loessner U, Jessnitzer B, Stumvoll M, Fasshauer N, Tonjes A (2014) Relationship between serum levels of angiopoietin-related growth factor and metabolic risk factors. Horm Metab Res 46: 685-690. http://dx.doi.org/10.1055/s-0034-1382078.
    • (2014) Horm Metab Res , vol.46 , pp. 685-690
    • Ebert, T.1    Kralish, S.2    Loessner, U.3    Jessnitzer, B.4    Stumvoll, M.5    Fasshauer, N.6    Tonjes, A.7
  • 24
    • 84870159894 scopus 로고    scopus 로고
    • Modulating fibroblast growth factor 21 in hyperphagic OLATF rats with daily exercise and caloric restriction
    • Fletcher JA, Meers GM, Laughlin GM, Ibdah JA, Thyfault JP, Rector RS (2012) Modulating fibroblast growth factor 21 in hyperphagic OLATF rats with daily exercise and caloric restriction. Appl Physiol Nutr Metab 37: 1054-1062. http://dx.doi.org/10.1139/h2012-091.
    • (2012) Appl Physiol Nutr Metab , vol.37 , pp. 1054-1062
    • Fletcher, J.A.1    Meers, G.M.2    Laughlin, G.M.3    Ibdah, J.A.4    Thyfault, J.P.5    Rector, R.S.6
  • 28
    • 84867732521 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and atherosclerosis
    • Gaudio E, Nobili V, Franchitto A, Onori P, Carpino G (2012) Nonalcoholic fatty liver disease and atherosclerosis. Intern Emerg Med 7(suppl 3): 297-305. http://dx.doi.org/10.1007/s11739-012-0826-5.
    • (2012) Intern Emerg Med , vol.7 , pp. 297-305
    • Gaudio, E.1    Nobili, V.2    Franchitto, A.3    Onori, P.4    Carpino, G.5
  • 29
    • 84879938853 scopus 로고    scopus 로고
    • Circulating levels of FGF-21 in obese youth: associations with liver fat content and markers of liver damage
    • Giannini C, Feldstein AE, Santoro N, Kim G, Kursawe R, Pierpont B, Caprio S (2013) Circulating levels of FGF-21 in obese youth: associations with liver fat content and markers of liver damage. J Clin Endocrinol Metab 98: 2993-3000. http://dx.doi.org/10.1210/jc.2013-1250.
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 2993-3000
    • Giannini, C.1    Feldstein, A.E.2    Santoro, N.3    Kim, G.4    Kursawe, R.5    Pierpont, B.6    Caprio, S.7
  • 32
    • 84864696458 scopus 로고    scopus 로고
    • Fetuin-A: the missing link in lipid-induced inflammation
    • Heinrichsdorff J, Olessky JM (2012) Fetuin-A: the missing link in lipid-induced inflammation. Nat Med 18: 1182-1183. http://dx.doi. org/10.1038/nm.2869.
    • (2012) Nat Med , vol.18 , pp. 1182-1183
    • Heinrichsdorff, J.1    Olessky, J.M.2
  • 33
    • 84864246433 scopus 로고    scopus 로고
    • Liver transplantation in nonalcoholic steatohepatitis is associated with high mortality and post-transplant complications: a single-center experience
    • Heuer M, Kaiser GM, Kahraman A, Banysch M, Saner FH, Mathe Z, Gerken G, Paul A, Canbay A, Treckmann JW (2012) Liver transplantation in nonalcoholic steatohepatitis is associated with high mortality and post-transplant complications: a single-center experience. Digestion 86: 107-113. http://dx.doi.org/10.1159/000339344.
    • (2012) Digestion , vol.86 , pp. 107-113
    • Heuer, M.1    Kaiser, G.M.2    Kahraman, A.3    Banysch, M.4    Saner, F.H.5    Mathe, Z.6    Gerken, G.7    Paul, A.8    Canbay, A.9    Treckmann, J.W.10
  • 34
    • 0030587491 scopus 로고    scopus 로고
    • Human selenoprotein P gene maps to 5q31
    • Hill KE, Dasouki M, Philips JA 3rd, Burk RF (1996) Human selenoprotein P gene maps to 5q31. Genomics 36: 550-551. http://dx.doi. org/10.1006/geno.1996.0505.
    • (1996) Genomics , vol.36 , pp. 550-551
    • Hill, K.E.1    Dasouki, M.2    Philips, J.A.3    Burk, R.F.4
  • 35
    • 84899586662 scopus 로고    scopus 로고
    • Low serum sex hormone-binding globulin is associated with nonalcoholic fatty liver disease in type 2 diabetic patients
    • Hua X, Sun Y, Zhong Y, Feng W, Huang H, Wang W, Zhang T, Hu Y (2014) Low serum sex hormone-binding globulin is associated with nonalcoholic fatty liver disease in type 2 diabetic patients. Clin Endocrinol (Oxf) 80: 877-883. http://dx.doi.org/10.1111/cen.12360.
    • (2014) Clin Endocrinol (Oxf) , vol.80 , pp. 877-883
    • Hua, X.1    Sun, Y.2    Zhong, Y.3    Feng, W.4    Huang, H.5    Wang, W.6    Zhang, T.7    Hu, Y.8
  • 36
    • 84884210651 scopus 로고    scopus 로고
    • Obesity as the common soil of non-alcoholic fatty liver disease and diabetes: role of adipokines
    • Hui E, Xu A, Yang HB, Lam KSL (2013) Obesity as the common soil of non-alcoholic fatty liver disease and diabetes: role of adipokines. J Diabetes Investig 4: 413-425. http://dx.doi.org/10.1111/jdi.12093.
    • (2013) J Diabetes Investig , vol.4 , pp. 413-425
    • Hui, E.1    Xu, A.2    Yang, H.B.3    Lam, K.S.L.4
  • 37
    • 84908200877 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 is regulated by the IREa-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis
    • Jiang S, Yan C, Fang QC, Shao ML, Zhang YL, Liu Y, Deng YP, Shan B, Liu JQ, Li HT, Yang L, Zhou J, Dai Z, Liu Y, Jia WP (2014) Fibroblast growth factor 21 is regulated by the IREa-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis. J Biol Chem 289: 29751-29765. http://dx.doi.org/10.1074/jbc.M114.565960.
    • (2014) J Biol Chem , vol.289 , pp. 29751-29765
    • Jiang, S.1    Yan, C.2    Fang, Q.C.3    Shao, M.L.4    Zhang, Y.L.5    Liu, Y.6    Deng, Y.P.7    Shan, B.8    Liu, J.Q.9    Li, H.T.10    Yang, L.11    Zhou, J.12    Dai, Z.13    Liu, Y.14    Jia, W.P.15
  • 38
    • 84910100321 scopus 로고    scopus 로고
    • The single nucleotide polymorphism rs499765 is associated with fibroblast growth factor 21 and nonalcoholic fatty liver disease in Chinese population with normal glucose tolerance
    • Jiang S, Zhang R, Li H, Fang Q, Jiang F, Hou X, Hu C, Jia W (2014) The single nucleotide polymorphism rs499765 is associated with fibroblast growth factor 21 and nonalcoholic fatty liver disease in Chinese population with normal glucose tolerance. J Nutrigenet Nutrigenomics 7: 121-129. http://dx.doi.org/10.1159/000367943.
    • (2014) J Nutrigenet Nutrigenomics , vol.7 , pp. 121-129
    • Jiang, S.1    Zhang, R.2    Li, H.3    Fang, Q.4    Jiang, F.5    Hou, X.6    Hu, C.7    Jia, W.8
  • 39
    • 79751508907 scopus 로고    scopus 로고
    • Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases
    • Kadamatsu T, Tabata M, Oike Y (2011) Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases. FEBS J 278: 559-564. http://dx.doi.org/10.1111/j.1742-4658.2010.07979.x.
    • (2011) FEBS J , vol.278 , pp. 559-564
    • Kadamatsu, T.1    Tabata, M.2    Oike, Y.3
  • 43
    • 0019757020 scopus 로고
    • Secretion of testosterone-estradiol-binding globulin by a human hepatoma-derived cell line
    • Khan MS, Knowles BB, Aden DP, Rosner W (1981) Secretion of testosterone-estradiol-binding globulin by a human hepatoma-derived cell line. J Clin Endocrinol Metab 53: 448-449. http://dx.doi. org/10.1210/jcem-53-2-448.
    • (1981) J Clin Endocrinol Metab , vol.53 , pp. 448-449
    • Khan, M.S.1    Knowles, B.B.2    Aden, D.P.3    Rosner, W.4
  • 45
    • 84925513492 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress
    • Kim SH, Kim KH, Kim H-K, Kim M-J, Back SH, Konishi M, Itoh N, Lee M-S (2015) Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress. Diabetologia 58: 809-818. http://dx.doi. org/10.1007/s00125-014-3475-6.
    • (2015) Diabetologia , vol.58 , pp. 809-818
    • Kim, S.H.1    Kim, K.H.2    Kim, H.-K.3    Kim, M.-J.4    Back, S.H.5    Konishi, M.6    Itoh, N.7    Lee, M.-S.8
  • 46
    • 36348964879 scopus 로고    scopus 로고
    • Angiopoietin-related growth factor suppresses gluconeogenesis through the Akt/Forkhead box class 01-dependent pathway in hepatocytes
    • Kitazawa M, Ohizumi Y, Oike Y, Hishinua T, Hashimoto S (2007) Angiopoietin-related growth factor suppresses gluconeogenesis through the Akt/Forkhead box class 01-dependent pathway in hepatocytes. J Pharmacol Exp Ther 323: 787-793. http://dx.doi.org/10.1124/jpet.107.127530.
    • (2007) J Pharmacol Exp Ther , vol.323 , pp. 787-793
    • Kitazawa, M.1    Ohizumi, Y.2    Oike, Y.3    Hishinua, T.4    Hashimoto, S.5
  • 49
    • 84939564435 scopus 로고    scopus 로고
    • Association between endogenous sex hormones and liver fat in a multiethnic study of atherosclerosis
    • Lazo M, Zeb I, Nasir K, Tracy RP, Budoff MJ, Ouyang P, Vaidya D (2015) Association between endogenous sex hormones and liver fat in a multiethnic study of atherosclerosis. Clin Gastroenterol Hepatol 13: 1686-1693. http://dx.doi.org/10.1016/j.cgh.2014.12.033.
    • (2015) Clin Gastroenterol Hepatol , vol.13 , pp. 1686-1693
    • Lazo, M.1    Zeb, I.2    Nasir, K.3    Tracy, R.P.4    Budoff, M.J.5    Ouyang, P.6    Vaidya, D.7
  • 51
    • 84990217563 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 concentration in obese children with nonalcoholic fatty liver disease
    • (abstract).
    • Lebensztejn DM, Wasilewska N, Bobrus-Chociej A, Werpachowska I, Tarasow E (2016) Fibroblast growth factor 21 concentration in obese children with nonalcoholic fatty liver disease. Hepatol Int 10(suppl 1): 398-399 (abstract).
    • (2016) Hepatol Int , vol.10 , pp. 398-399
    • Lebensztejn, D.M.1    Wasilewska, N.2    Bobrus-Chociej, A.3    Werpachowska, I.4    Tarasow, E.5
  • 52
    • 84904399681 scopus 로고    scopus 로고
    • Exendin-4 regulates lipid metabolism and fibroblast growth factor-21 in hepatic steatosis
    • Lee J, Hong SW, Park SE, Rhee EJ, Park CY, Oh KW, Park SW, Lee WY (2014) Exendin-4 regulates lipid metabolism and fibroblast growth factor-21 in hepatic steatosis. Metabolism 63: 1041-1048. http://dx.doi.org/10.1016/j.metabol.2014.04.011.
    • (2014) Metabolism , vol.63 , pp. 1041-1048
    • Lee, J.1    Hong, S.W.2    Park, S.E.3    Rhee, E.J.4    Park, C.Y.5    Oh, K.W.6    Park, S.W.7    Lee, W.Y.8
  • 53
    • 84874117479 scopus 로고    scopus 로고
    • High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: a 3-year prospective study in China
    • Li H, Dong K, Fang Q, Hou X, Zhou M, Bao Y, Xiang K, Xu A, Jia W (2013) High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: a 3-year prospective study in China. J Hepatol 58: 557-563. http://dx.doi. org/10.1016/j.jhep.2012.10.029.
    • (2013) J Hepatol , vol.58 , pp. 557-563
    • Li, H.1    Dong, K.2    Fang, Q.3    Hou, X.4    Zhou, M.5    Bao, Y.6    Xiang, K.7    Xu, A.8    Jia, W.9
  • 54
    • 77957359658 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride
    • Li H, Fang Q, Gao F, Fan J, Zjou J, Wang X, Zhang H, Pan X, Bao Y, Xiang K, Xu A, Jia W (2010) Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride. J Hepatol 53: 934-940. http://dx.doi.org/10.1016/j.jhep.2010.05.018.
    • (2010) J Hepatol , vol.53 , pp. 934-940
    • Li, H.1    Fang, Q.2    Gao, F.3    Fan, J.4    Zjou, J.5    Wang, X.6    Zhang, H.7    Pan, X.8    Bao, Y.9    Xiang, K.10    Xu, A.11    Jia, W.12
  • 55
    • 84874800718 scopus 로고    scopus 로고
    • Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology
    • Li H, Zhang J, Jia W (2013) Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology. Front Med 7: 25-30. http://dx.doi.org/10.1007/s11684-013-0244-8.
    • (2013) Front Med , vol.7 , pp. 25-30
    • Li, H.1    Zhang, J.2    Jia, W.3
  • 56
    • 80755189417 scopus 로고    scopus 로고
    • The effects of fibroblast growth factor-21 knockdown and over-expression on its signaling pathway and glucose-lipid metabolism in vitro
    • Li K, Li L, Yang M, Liu H, Boden G, Yang G (2012) The effects of fibroblast growth factor-21 knockdown and over-expression on its signaling pathway and glucose-lipid metabolism in vitro. Mol Cell Endocrinol 348: 21-26. http://dx.doi.org/10.1016/j.mce.2011.07.026.
    • (2012) Mol Cell Endocrinol , vol.348 , pp. 21-26
    • Li, K.1    Li, L.2    Yang, M.3    Liu, H.4    Boden, G.5    Yang, G.6
  • 57
    • 84921771693 scopus 로고    scopus 로고
    • The role of fibroblast growth factor 21 in the pathogenesis of non-alcoholic fatty liver disease and implications for therapy
    • Liu J, Xu Y, Hu Y, Wang G (2015) The role of fibroblast growth factor 21 in the pathogenesis of non-alcoholic fatty liver disease and implications for therapy. Metabolism 64: 380-390. http://dx.doi. org/10.1016/j.metabol.2014.11.009.
    • (2015) Metabolism , vol.64 , pp. 380-390
    • Liu, J.1    Xu, Y.2    Hu, Y.3    Wang, G.4
  • 60
    • 84859327136 scopus 로고    scopus 로고
    • Inverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes
    • Misu H, Ishikura K, Kurita S, Takeshita Y, Ota T, Saito Y, Takahashi K, Kaneko S, Takamura T (2012) Inverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes. PLoS One 7: e34952. http://dx.doi.org/10.1371/journal. pone.0034952.
    • (2012) PLoS One , vol.7
    • Misu, H.1    Ishikura, K.2    Kurita, S.3    Takeshita, Y.4    Ota, T.5    Saito, Y.6    Takahashi, K.7    Kaneko, S.8    Takamura, T.9
  • 62
    • 84855302030 scopus 로고    scopus 로고
    • Fetuin A and the cardiovascular system
    • Mori K, Emoto M, Inaba M (2012) Fetuin A and the cardiovascular system. Adv Clin Chem 56: 175-195. http://dx.doi.org/10.1016/B978-0-12-394317-0.00010-8.
    • (2012) Adv Clin Chem , vol.56 , pp. 175-195
    • Mori, K.1    Emoto, M.2    Inaba, M.3
  • 64
    • 33646367662 scopus 로고    scopus 로고
    • Association of serum fetuin-A with insulin resistance in type-2 diabetic and nondiabetic subject
    • Mori K, Emoto M, Yokoyama H, Araki T, Teramura M, Koyama H, Shoji T, Inaba M, Nishizawa Y (2006) Association of serum fetuin-A with insulin resistance in type-2 diabetic and nondiabetic subject. Diabetes Care 29: 468. http://dx.doi.org/10.2337/diacare. 29.02.06.dc05-1484.
    • (2006) Diabetes Care , vol.29 , pp. 468
    • Mori, K.1    Emoto, M.2    Yokoyama, H.3    Araki, T.4    Teramura, M.5    Koyama, H.6    Shoji, T.7    Inaba, M.8    Nishizawa, Y.9
  • 66
    • 79952993729 scopus 로고    scopus 로고
    • Serum levels of angiopoietin-related growth factor are increased in metabolic syndrome
    • Namkung J, Koh SB, Kong ID, Choi J-W, Yeh B-I (2011) Serum levels of angiopoietin-related growth factor are increased in metabolic syndrome. Metabolism 60: 564-568. http://dx.doi.org/10.1016/j.metabol. 2010.05.013.
    • (2011) Metabolism , vol.60 , pp. 564-568
    • Namkung, J.1    Koh, S.B.2    Kong, I.D.3    Choi, J.-W.4    Yeh, B.-I.5
  • 67
    • 0034697846 scopus 로고    scopus 로고
    • Identification of a novel FGF, FGF-21, preferentially expressed in the liver
    • Nishimura T, Nakatake Y, Konishi M, Itoh N (2000) Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochim Biophys Acta 1492: 203-206. http://dx.doi.org/10.1016/S0167-4781(00)00067-1.
    • (2000) Biochim Biophys Acta , vol.1492 , pp. 203-206
    • Nishimura, T.1    Nakatake, Y.2    Konishi, M.3    Itoh, N.4
  • 72
    • 84870736698 scopus 로고    scopus 로고
    • Increased fetuin-A concentration in impaired glucose tolerance with or without nonalcoholic fatty liver disease, but not impaired fasting glucose
    • Ou H-Y, Yang Y-C, Wu H-T, Wu J-S, Lu F-H, Chang C-J (2012) Increased fetuin-A concentration in impaired glucose tolerance with or without nonalcoholic fatty liver disease, but not impaired fasting glucose. J Clin Endocrinol Metab 97: 4717-4723. http://dx.doi. org/10.1210/jc.2012-2414.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 4717-4723
    • Ou, H.-Y.1    Yang, Y.-C.2    Wu, H.-T.3    Wu, J.-S.4    Lu, F.-H.5    Chang, C.-J.6
  • 73
    • 79961058891 scopus 로고    scopus 로고
    • Pediatric nonalcoholic fatty liver disease, metabolic syndrome and cardiovascular risk
    • Pacifico L, Nobili V, Anania C, Verdecchia P, Chiesa C (2011) Pediatric nonalcoholic fatty liver disease, metabolic syndrome and cardiovascular risk. World J Gastroenterol 17: 3082-3091. http://dx.doi. org/10.3748/wjg.v17.i26.3082.
    • (2011) World J Gastroenterol , vol.17 , pp. 3082-3091
    • Pacifico, L.1    Nobili, V.2    Anania, C.3    Verdecchia, P.4    Chiesa, C.5
  • 75
    • 79954558287 scopus 로고    scopus 로고
    • Adipokines and redox signaling: impact on fatty liver disease
    • Parola M, Marra F (2011) Adipokines and redox signaling: impact on fatty liver disease. Antioxid Redox Signal 15: 461-483. http://dx.doi. org/10.1089/ars.2010.3848.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 461-483
    • Parola, M.1    Marra, F.2
  • 76
    • 0001513835 scopus 로고
    • Fetuin, a new globulin isolated from serum
    • Pedersen KO (1944). Fetuin, a new globulin isolated from serum. Nature 154: 575. http://dx.doi.org/10.1038/154575a0.
    • (1944) Nature , vol.154 , pp. 575
    • Pedersen, K.O.1
  • 77
    • 84901944641 scopus 로고    scopus 로고
    • The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
    • Perry RJ, Samuel VT, Petersen KF, Shulman GI (2014) The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature 510: 84-91. http://dx.doi.org/10.1038/nature13478.
    • (2014) Nature , vol.510 , pp. 84-91
    • Perry, R.J.1    Samuel, V.T.2    Petersen, K.F.3    Shulman, G.I.4
  • 83
    • 57349109502 scopus 로고    scopus 로고
    • Fetuin A and its relations to metabolic syndrome and fatty liver disease in obese children before and after weight loss
    • Reinehr T, Roth CL (2008) Fetuin A and its relations to metabolic syndrome and fatty liver disease in obese children before and after weight loss. J Clin Endocrinol Metab 93: 4479-4485. http://dx.doi. org/10.1210/jc.2008-1505.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 4479-4485
    • Reinehr, T.1    Roth, C.L.2
  • 84
    • 84861996283 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 (FGF-21) and its relation to obesity, metabolic syndrome, and nonalcoholic fatty liver in children: a longitudinal analysis
    • Reinehr T, Woelfle J, Wunsch R, Roth CL (2012) Fibroblast growth factor 21 (FGF-21) and its relation to obesity, metabolic syndrome, and nonalcoholic fatty liver in children: a longitudinal analysis. J Clin Endocrinol Metab 97: 2143-2150. http://dx.doi.org/10.1210/jc.2012-1221.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 2143-2150
    • Reinehr, T.1    Woelfle, J.2    Wunsch, R.3    Roth, C.L.4
  • 85
    • 84879295847 scopus 로고    scopus 로고
    • Adipo-myokines: two sides of the same coin-mediators of inflammation and mediators of exercise
    • Reschke S, Eckel J (2013) Adipo-myokines: two sides of the same coin-mediators of inflammation and mediators of exercise. Mediators Inflamm 2013: 320724. http://dx.doi.org/10.1155/2013/320724.
    • (2013) Mediators Inflamm , vol.2013
    • Reschke, S.1    Eckel, J.2
  • 86
    • 33745107554 scopus 로고    scopus 로고
    • Mechanisms of disease: hepatic steatosis in type 2 diabetes-pathogenesis and clinical relevance
    • Roden (2006) Mechanisms of disease: hepatic steatosis in type 2 diabetes-pathogenesis and clinical relevance. Nat Clin Pract Endocrinol Metab 6: 335-348. http://dx.doi.org/10.1038/ncpendmet0190.
    • (2006) Nat Clin Pract Endocrinol Metab , vol.6 , pp. 335-348
    • Roden1
  • 88
    • 77953122859 scopus 로고    scopus 로고
    • Serum fetuin A, cardiovascular risk factor, and six-year follow-up outcome in patients with coronary heart disease
    • Roos M, von Eynatten M, Heemann U, Rothenbacher D, Brenner H, Breitling LP (2010) Serum fetuin A, cardiovascular risk factor, and six-year follow-up outcome in patients with coronary heart disease. Am J Cardiol 105: 1666-1672. http://dx.doi.org/10.1016/j.amjcard. 2010.01.342.
    • (2010) Am J Cardiol , vol.105 , pp. 1666-1672
    • Roos, M.1    von Eynatten, M.2    Heemann, U.3    Rothenbacher, D.4    Brenner, H.5    Breitling, L.P.6
  • 92
    • 80054888593 scopus 로고    scopus 로고
    • Serum sex hormone-binding globulin levels are independently associated with nonalcoholic fatty liver disease in people with type 2 diabetes
    • Shin JY, Kim S-K, Lee MY, Kim HS, Ye BI, Shin YG, Baik SK, Chung CH (2011) Serum sex hormone-binding globulin levels are independently associated with nonalcoholic fatty liver disease in people with type 2 diabetes. Diabetes Res Clin Pract 94: 156-162. http://dx.doi.org/10.1016/j.diabres.2011.07.029.
    • (2011) Diabetes Res Clin Pract , vol.94 , pp. 156-162
    • Shin, J.Y.1    Kim, S.-K.2    Lee, M.Y.3    Kim, H.S.4    Ye, B.I.5    Shin, Y.G.6    Baik, S.K.7    Chung, C.H.8
  • 93
    • 23644433509 scopus 로고    scopus 로고
    • A synonymous coding polymorphism in the a2-Heremans-Schmid glycoprotein gene is associated with type 2 diabetes in French Caucasian
    • Siddiq A, Lepretre F, Hercberg S, Froguel P, Gibson F (2005) A synonymous coding polymorphism in the a2-Heremans-Schmid glycoprotein gene is associated with type 2 diabetes in French Caucasian. Diabetes 54: 2477-2481. http://dx.doi.org/10.2337/diabetes. 54.8.2477.
    • (2005) Diabetes , vol.54 , pp. 2477-2481
    • Siddiq, A.1    Lepretre, F.2    Hercberg, S.3    Froguel, P.4    Gibson, F.5
  • 94
    • 84905020685 scopus 로고    scopus 로고
    • Adiponectin upregulates SHGB production: molecular mechanisms and potential implication
    • Simo R, Saez-Lopez C, Lecube A, Hernandez C, Fort JM, Selva DM (2014) Adiponectin upregulates SHGB production: molecular mechanisms and potential implication. Endocrinology 155: 2820-2830. http://dx.doi.org/10.1210/en.2014-1072.
    • (2014) Endocrinology , vol.155 , pp. 2820-2830
    • Simo, R.1    Saez-Lopez, C.2    Lecube, A.3    Hernandez, C.4    Fort, J.M.5    Selva, D.M.6
  • 96
    • 0027333427 scopus 로고
    • Serum a2-HS-glycoprotein is an inhibitor of the human insulin receptor at the tyrosine kinase level
    • Srinivas PR, Wagner AS, Reddy LU, Deutsch DD, Leon MA, Goustin AS, Grunberger G (1993) Serum a2-HS-glycoprotein is an inhibitor of the human insulin receptor at the tyrosine kinase level. Mol Endocrinol 7: 1445-1455. http://dx.doi.org/10.1210/mend.7.11.7906861.
    • (1993) Mol Endocrinol , vol.7 , pp. 1445-1455
    • Srinivas, P.R.1    Wagner, A.S.2    Reddy, L.U.3    Deutsch, D.D.4    Leon, M.A.5    Goustin, A.S.6    Grunberger, G.7
  • 97
    • 84875549943 scopus 로고    scopus 로고
    • The role of hepatokines in metabolism
    • Stefan N, Haring H-U (2013) The role of hepatokines in metabolism. Nat Rev Endocrinol 9: 144-152. http://dx.doi.org/10.1038/nrendo. 2012.258.
    • (2013) Nat Rev Endocrinol , vol.9 , pp. 144-152
    • Stefan, N.1    Haring, H.-U.2
  • 98
    • 84878433548 scopus 로고    scopus 로고
    • Circulating fetuin-A and free fatty acids interact to predict insulin resistance in humans
    • Stefan N, Haring H-U (2013) Circulating fetuin-A and free fatty acids interact to predict insulin resistance in humans. Nat Med 19: 394-395. http://dx.doi.org/10.1038/nm.3116.
    • (2013) Nat Med , vol.19 , pp. 394-395
    • Stefan, N.1    Haring, H.-U.2
  • 99
    • 33746367157 scopus 로고    scopus 로고
    • Alpha2-Heremans-Schmid glycoprotein/fetuin A is associated with insulin resistance and fat accumulation in the liver in humans
    • Stefan N, Hennige AM, Staiger H, Machann J, Schick F, Krober SM, Machicao F, Fritsche A, Haring H-U (2006) Alpha2-Heremans-Schmid glycoprotein/fetuin A is associated with insulin resistance and fat accumulation in the liver in humans. Diabetes Care 29: 853-857. http://dx.doi.org/10.2337/diacare.29.04.06.dc05-1938.
    • (2006) Diabetes Care , vol.29 , pp. 853-857
    • Stefan, N.1    Hennige, A.M.2    Staiger, H.3    Machann, J.4    Schick, F.5    Krober, S.M.6    Machicao, F.7    Fritsche, A.8    Haring, H.-U.9
  • 100
    • 57349116780 scopus 로고    scopus 로고
    • Causes and metabolic consequences of fatty liver
    • Stefan N, Kantartzis K, Haring H-U (2008) Causes and metabolic consequences of fatty liver. Endocr Rev 29: 939-960. http://dx.doi. org/10.1210/er.2008-0009.
    • (2008) Endocr Rev , vol.29 , pp. 939-960
    • Stefan, N.1    Kantartzis, K.2    Haring, H.-U.3
  • 101
    • 74049133977 scopus 로고    scopus 로고
    • Sex hormone-binding globulin and risk of type 2 diabetes
    • Stefan N, Schick F, Haring H-U (2009) Sex hormone-binding globulin and risk of type 2 diabetes. N Eng J Med 361: 2675-2676. http://dx.doi.org/10.1056/NEJMc0910143.
    • (2009) N Eng J Med , vol.361 , pp. 2675-2676
    • Stefan, N.1    Schick, F.2    Haring, H.-U.3
  • 102
    • 84918819322 scopus 로고    scopus 로고
    • Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease
    • Stefan N, Schick F, Haring H-U (2014) Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease. N End J Med 371: 2236-2237. http://dx.doi.org/10.1056/NEJMc 1412427#SA3.
    • (2014) N End J Med , vol.371 , pp. 2236-2237
    • Stefan, N.1    Schick, F.2    Haring, H.-U.3
  • 104
    • 20144365466 scopus 로고    scopus 로고
    • Sex-hormone-binding globulin and the free androgen index are related to cardiovascular risk factor in multiethnic premenopausal and perimenopausel women enrolled in the Study of Women Across the Nation (SWAN)
    • Sutton-Tyrrell K, Wildman RP, Matthews KA, Chae C, Lasley BL, Brockwell S, Pasternak RC, Lloyd-Jones D, Sowers MF, Torrens JL, SWAN investigators (2005) Sex-hormone-binding globulin and the free androgen index are related to cardiovascular risk factor in multiethnic premenopausal and perimenopausel women enrolled in the Study of Women Across the Nation (SWAN). Circulation 111: 1242-1249. http://dx.doi.org/10.1161/01.CIR.0000157697.54255.CE.
    • (2005) Circulation , vol.111 , pp. 1242-1249
    • Sutton-Tyrrell, K.1    Wildman, R.P.2    Matthews, K.A.3    Chae, C.4    Lasley, B.L.5    Brockwell, S.6    Pasternak, R.C.7    Lloyd-Jones, D.8    Sowers, M.F.9    Torrens, J.L.10
  • 105
    • 73249130996 scopus 로고    scopus 로고
    • High glucose induces transactivation of the a2-HS glycoprotein gene through the ERK1/2 signaling pathway
    • Takata H, Ikeda Y, Suehiro T, Ishibashi A, Inoue M, Kumon Y, Terada Y (2009) High glucose induces transactivation of the a2-HS glycoprotein gene through the ERK1/2 signaling pathway. J Atheroscler Thromb 16: 448-456. http://dx.doi.org/10.5551/jat.No950.
    • (2009) J Atheroscler Thromb , vol.16 , pp. 448-456
    • Takata, H.1    Ikeda, Y.2    Suehiro, T.3    Ishibashi, A.4    Inoue, M.5    Kumon, Y.6    Terada, Y.7
  • 106
    • 84925778793 scopus 로고    scopus 로고
    • Role of fibroblast growth factor 21 in early stage of NASH induced by methionine-and choline-deficient diet
    • Tanaka N, Takahashi S, Zhang Y, Krausz KW, Smith PB, Patterson AD, Gonzalez FJ (2015) Role of fibroblast growth factor 21 in early stage of NASH induced by methionine-and choline-deficient diet. Biochim Biophys Acta 1852: 1242-1252. http://dx.doi.org/10.1016/j. bbadis.2015.02.012.
    • (2015) Biochim Biophys Acta , vol.1852 , pp. 1242-1252
    • Tanaka, N.1    Takahashi, S.2    Zhang, Y.3    Krausz, K.W.4    Smith, P.B.5    Patterson, A.D.6    Gonzalez, F.J.7
  • 107
    • 33644700376 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and risk of future cardiovascular events among type 2 diabetic patients
    • Targher G, Bertolini L, Poli F, Rodella S, Scala L, Tessari R, Zenari L, Falezza G (2005) Nonalcoholic fatty liver disease and risk of future cardiovascular events among type 2 diabetic patients. Diabetes 54: 3541-3546. http://dx.doi.org/10.2337/diabetes.54.12.3541.
    • (2005) Diabetes , vol.54 , pp. 3541-3546
    • Targher, G.1    Bertolini, L.2    Poli, F.3    Rodella, S.4    Scala, L.5    Tessari, R.6    Zenari, L.7    Falezza, G.8
  • 108
    • 77957375969 scopus 로고    scopus 로고
    • Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease
    • Targher G, Day CP, Bonora E (2010) Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Eng J Med 363: 1341-1350. http://dx.doi.org/10.1056/NEJMra0912063.
    • (2010) N Eng J Med , vol.363 , pp. 1341-1350
    • Targher, G.1    Day, C.P.2    Bonora, E.3
  • 109
    • 79960029926 scopus 로고    scopus 로고
    • Systematic review: the epidemiology and natural history on non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
    • Vernon G, Baranova A, Younossi ZM (2011) Systematic review: the epidemiology and natural history on non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther 34: 274-285. http://dx.doi.org/10.1111/j.1365-2036.2011.04724.x.
    • (2011) Aliment Pharmacol Ther , vol.34 , pp. 274-285
    • Vernon, G.1    Baranova, A.2    Younossi, Z.M.3
  • 112
    • 0030217827 scopus 로고    scopus 로고
    • Purification and primary amino acid sequence of a novel neutrophil chemotactic factor LECT2
    • Yamagoe S, Yamakawa Y, Matsuo Y, Minowada J, Mizuno S, Suzuki K (1996) Purification and primary amino acid sequence of a novel neutrophil chemotactic factor LECT2. Immunol Lett 52: 9-13. http://dx.doi.org/10.1016/0165-2478(96)02572-2.
    • (1996) Immunol Lett , vol.52 , pp. 9-13
    • Yamagoe, S.1    Yamakawa, Y.2    Matsuo, Y.3    Minowada, J.4    Mizuno, S.5    Suzuki, K.6
  • 113
    • 0032481611 scopus 로고    scopus 로고
    • Molecular cloning of human and bovine LECT2 having a neutrophil chemotactic activity and its specific expression in the liver
    • Yamagoe S, Mizuno S, Suzuki K (1998) Molecular cloning of human and bovine LECT2 having a neutrophil chemotactic activity and its specific expression in the liver. Biochem Biophys Acta 1396: 105-113. http://dx.doi.org/10.1016/S0167-4781(97)00181-4.
    • (1998) Biochem Biophys Acta , vol.1396 , pp. 105-113
    • Yamagoe, S.1    Mizuno, S.2    Suzuki, K.3
  • 114
    • 80052845230 scopus 로고    scopus 로고
    • Circulating fibroblast growth factor 21 levels are closely associated with hepatic fat content
    • Yan H, Xia M, Chang X, Xu Q, Bian H, Zeng M, Rao S, Yao X, Tu Y, Jia W, Gao X (2011) Circulating fibroblast growth factor 21 levels are closely associated with hepatic fat content. PLoS One 6: e24895. http://dx.doi.org/10.1371/journal.pone.0024895.
    • (2011) PLoS One , vol.6
    • Yan, H.1    Xia, M.2    Chang, X.3    Xu, Q.4    Bian, H.5    Zeng, M.6    Rao, S.7    Yao, X.8    Tu, Y.9    Jia, W.10    Gao, X.11
  • 115
    • 79961235988 scopus 로고    scopus 로고
    • Serum selenoprotein P levels in patients with type 2 diabetes and prediabetes: implications for insulin resistance, inflammation, and atherosclerosis
    • Yang SJ, Hwang SY, Choi HY, Yoo HJ, Seo JA, Kim SG, Kim NH, Baik SH, Choi DS, Choi KM (2011) Serum selenoprotein P levels in patients with type 2 diabetes and prediabetes: implications for insulin resistance, inflammation, and atherosclerosis. J Clin Endocrinol Metab 96: 1325-1329. http://dx.doi.org/10.1210/jc.2011-0620.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 1325-1329
    • Yang, S.J.1    Hwang, S.Y.2    Choi, H.Y.3    Yoo, H.J.4    Seo, J.A.5    Kim, S.G.6    Kim, N.H.7    Baik, S.H.8    Choi, D.S.9    Choi, K.M.10
  • 118
    • 84923239473 scopus 로고    scopus 로고
    • Hepatokines as a link between obesity and cardiovascular disease
    • Yoo HJ, Choi KM (2015) Hepatokines as a link between obesity and cardiovascular disease. Diabetes Metab J 39: 10-15. http://dx.doi. org/10.4093/dmj.2015.39.1.10.
    • (2015) Diabetes Metab J , vol.39 , pp. 10-15
    • Yoo, H.J.1    Choi, K.M.2
  • 120
    • 79960844094 scopus 로고    scopus 로고
    • The link between fibroblast growth factor 21 and sterol regulatory element binding protein 1c during lipogenesis in hepatocytes
    • Zhang Y, Lei T, Huang JF, Wang SB, Zhou LL, Yang ZQ, Chen XD (2011) The link between fibroblast growth factor 21 and sterol regulatory element binding protein 1c during lipogenesis in hepatocytes. Mol Cell Endocrinol 342: 41-47. http://dx.doi.org/10.1016/j. mce.2011.05.003.
    • (2011) Mol Cell Endocrinol , vol.342 , pp. 41-47
    • Zhang, Y.1    Lei, T.2    Huang, J.F.3    Wang, S.B.4    Zhou, L.L.5    Yang, Z.Q.6    Chen, X.D.7
  • 121
    • 84949776698 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 analogs for treating metabolic disorders
    • Zhang Y, Lei T (2015) Fibroblast growth factor 21 analogs for treating metabolic disorders. Front Endocrinol (Laussanne) 8: 168. http://dx.doi.org/10.3389/fendo.2015.00168.
    • (2015) Front Endocrinol (Laussanne) , vol.8 , pp. 168
    • Zhang, Y.1    Lei, T.2

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.