Development of Light-Activated CRISPR Using Guide RNAs with Photocleavable Protectors

Angewandte Chemie - International Edition

Volumn 55, Issue 40, 2016, Pages 12440-12444

  Jain, Piyush K ^a   Ramanan, Vyas ^a   Schepers, Arnout G ^a   Dalvie, Nisha S ^a   Panda, Apekshya ^a   Fleming, Heather E ^a   Bhatia, Sangeeta N ^a,b,c,d,e  

^a Massachusetts Institute of Technology   (United States)

^b Department of Electrical Engineering and Computer Science   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

CRISPR; DNA cleavage; gene technology; nucleic acids; photochemistry

Indexed keywords

NUCLEIC ACIDS; PHOTOCHEMICAL REACTIONS; RNA;

CELLULAR EVENTS; CRISPR; DNA CLEAVAGE; GENE TECHNOLOGY; PHOTO ACTIVATIONS;

DNA SEQUENCES;

GREEN FLUORESCENT PROTEIN; GUIDE RNA;

CHEMISTRY; CRISPR CAS SYSTEM; GENETICS; HELA CELL LINE; HUMAN; LIGHT; METABOLISM; NUCLEIC ACID HYBRIDIZATION; NUCLEOTIDE SEQUENCE; PHOTOLYSIS; RADIATION RESPONSE;

BASE SEQUENCE; CRISPR-CAS SYSTEMS; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; LIGHT; NUCLEIC ACID HYBRIDIZATION; PHOTOLYSIS; RNA, GUIDE;

EID: 84990183833     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201606123     Document Type: Article

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