메뉴 건너뛰기




Volumn 9, Issue 12, 2015, Pages 11708-11717

Photoactivated Spatiotemporally-Responsive Nanosensors of in Vivo Protease Activity

Author keywords

activity based biomarkers; nanosensors; photoactivatble; proteases

Indexed keywords

BIOACTIVITY; ENZYME ACTIVITY; NANOSENSORS; PEPTIDES; TUMORS;

EID: 84952334266     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/acsnano.5b05946     Document Type: Article
Times cited : (26)

References (53)
  • 1
    • 23944483135 scopus 로고    scopus 로고
    • Post-Transcriptional Control of Gene Expression: A Genome-Wide Perspective
    • Mata, J.; Marguerat, S.; Bähler, J. Post-Transcriptional Control of Gene Expression: A Genome-Wide Perspective Trends Biochem. Sci. 2005, 30, 506-514 10.1016/j.tibs.2005.07.005
    • (2005) Trends Biochem. Sci. , vol.30 , pp. 506-514
    • Mata, J.1    Marguerat, S.2    Bähler, J.3
  • 2
    • 84893781709 scopus 로고    scopus 로고
    • Protein Post-Translational Modifications and Regulation of Pluripotency in Human Stem Cells
    • Wang, Y.-C.; Peterson, S. E.; Loring, J. F. Protein Post-Translational Modifications and Regulation of Pluripotency in Human Stem Cells Cell Res. 2014, 24, 143-160 10.1038/cr.2013.151
    • (2014) Cell Res. , vol.24 , pp. 143-160
    • Wang, Y.-C.1    Peterson, S.E.2    Loring, J.F.3
  • 3
    • 50649112213 scopus 로고    scopus 로고
    • Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry
    • Cravatt, B. F.; Wright, A. T.; Kozarich, J. W. Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry Annu. Rev. Biochem. 2008, 77, 383-414 10.1146/annurev.biochem.75.101304.124125
    • (2008) Annu. Rev. Biochem. , vol.77 , pp. 383-414
    • Cravatt, B.F.1    Wright, A.T.2    Kozarich, J.W.3
  • 4
    • 0033604499 scopus 로고    scopus 로고
    • Active Site-Directed Protein Regulation
    • Kobe, B.; Kemp, B. E. Active Site-Directed Protein Regulation Nature 1999, 402, 373-376 10.1038/46478
    • (1999) Nature , vol.402 , pp. 373-376
    • Kobe, B.1    Kemp, B.E.2
  • 5
    • 57649155302 scopus 로고    scopus 로고
    • Proteases: Multifunctional Enzymes in Life and Disease
    • López-Otín, C.; Bond, J. S. Proteases: Multifunctional Enzymes in Life and Disease J. Biol. Chem. 2008, 283, 30433-30437 10.1074/jbc.R800035200
    • (2008) J. Biol. Chem. , vol.283 , pp. 30433-30437
    • López-Otín, C.1    Bond, J.S.2
  • 6
    • 77953623874 scopus 로고    scopus 로고
    • Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective
    • Khersonsky, O.; Tawfik, D. S. Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective Annu. Rev. Biochem. 2010, 79, 471-505 10.1146/annurev-biochem-030409-143718
    • (2010) Annu. Rev. Biochem. , vol.79 , pp. 471-505
    • Khersonsky, O.1    Tawfik, D.S.2
  • 7
    • 84901418451 scopus 로고    scopus 로고
    • Network Analyses Reveal Pervasive Functional Regulation between Proteases in the Human Protease Web
    • Fortelny, N.; Cox, J. H.; Kappelhoff, R.; Starr, A. E.; Lange, P. F.; Pavlidis, P.; Overall, C. M. Network Analyses Reveal Pervasive Functional Regulation Between Proteases in the Human Protease Web PLoS Biol. 2014, 12, e1001869 10.1371/journal.pbio.1001869
    • (2014) PLoS Biol. , vol.12
    • Fortelny, N.1    Cox, J.H.2    Kappelhoff, R.3    Starr, A.E.4    Lange, P.F.5    Pavlidis, P.6    Overall, C.M.7
  • 9
    • 0034892043 scopus 로고    scopus 로고
    • Increased Expression of Matrix Metalloproteinases (MMP)-2, MMP-9, and the Urokinase-Type Plasminogen Activator Is Associated with Progression from Benign to Advanced Ovarian Cancer
    • Schmalfeldt, B.; Prechtel, D.; Härting, K.; Späthe, K.; Rutke, S.; Konik, E.; Fridman, R.; Berger, U.; Schmitt, M.; Kuhn, W. et al. Increased Expression of Matrix Metalloproteinases (MMP)-2, MMP-9, and the Urokinase-Type Plasminogen Activator Is Associated with Progression from Benign to Advanced Ovarian Cancer Clin. Cancer Res. 2001, 7, 2396-2404
    • (2001) Clin. Cancer Res. , vol.7 , pp. 2396-2404
    • Schmalfeldt, B.1    Prechtel, D.2    Härting, K.3    Späthe, K.4    Rutke, S.5    Konik, E.6    Fridman, R.7    Berger, U.8    Schmitt, M.9    Kuhn, W.10
  • 10
    • 64349085775 scopus 로고    scopus 로고
    • Identification of Selective Inhibitors of Uncharacterized Enzymes by High-Throughput Screening with Fluorescent Activity-Based Probes
    • Bachovchin, D. A.; Brown, S. J.; Rosen, H.; Cravatt, B. F. Identification of Selective Inhibitors of Uncharacterized Enzymes by High-Throughput Screening with Fluorescent Activity-Based Probes Nat. Biotechnol. 2009, 27, 387-394 10.1038/nbt.1531
    • (2009) Nat. Biotechnol. , vol.27 , pp. 387-394
    • Bachovchin, D.A.1    Brown, S.J.2    Rosen, H.3    Cravatt, B.F.4
  • 11
    • 33748595526 scopus 로고    scopus 로고
    • Mechanism-Based Profiling of Enzyme Families
    • Evans, M. J.; Cravatt, B. F. Mechanism-Based Profiling of Enzyme Families Chem. Rev. 2006, 106, 3279-3301 10.1021/cr050288g
    • (2006) Chem. Rev. , vol.106 , pp. 3279-3301
    • Evans, M.J.1    Cravatt, B.F.2
  • 15
    • 84873367817 scopus 로고    scopus 로고
    • Multiplexed Protease Activity Assay for Low-Volume Clinical Samples Using Droplet-Based Microfluidics and Its Application to Endometriosis
    • Chen, C.-H.; Miller, M. A.; Sarkar, A.; Beste, M. T.; Isaacson, K. B.; Lauffenburger, D. A.; Griffith, L. G.; Han, J. Multiplexed Protease Activity Assay for Low-Volume Clinical Samples Using Droplet-Based Microfluidics and Its Application to Endometriosis J. Am. Chem. Soc. 2013, 135, 1645-1648 10.1021/ja307866z
    • (2013) J. Am. Chem. Soc. , vol.135 , pp. 1645-1648
    • Chen, C.-H.1    Miller, M.A.2    Sarkar, A.3    Beste, M.T.4    Isaacson, K.B.5    Lauffenburger, D.A.6    Griffith, L.G.7    Han, J.8
  • 17
    • 75149168815 scopus 로고    scopus 로고
    • Near-Infrared Fluorescence: Application to in Vivo Molecular Imaging
    • Hilderbrand, S. A.; Weissleder, R. Near-Infrared Fluorescence: Application to in Vivo Molecular Imaging Curr. Opin. Chem. Biol. 2010, 14, 71-79 10.1016/j.cbpa.2009.09.029
    • (2010) Curr. Opin. Chem. Biol. , vol.14 , pp. 71-79
    • Hilderbrand, S.A.1    Weissleder, R.2
  • 18
    • 0032951071 scopus 로고    scopus 로고
    • In Vivo Imaging of Tumors with Protease-Activated near-Infrared Fluorescent Probes
    • Weissleder, R.; Tung, C.-H.; Mahmood, U.; Bogdanov, A. In Vivo Imaging of Tumors with Protease-Activated near-Infrared Fluorescent Probes Nat. Biotechnol. 1999, 17, 375-378 10.1038/7933
    • (1999) Nat. Biotechnol. , vol.17 , pp. 375-378
    • Weissleder, R.1    Tung, C.-H.2    Mahmood, U.3    Bogdanov, A.4
  • 19
    • 77749297971 scopus 로고    scopus 로고
    • Activatable Cell Penetrating Peptides Linked to Nanoparticles as Dual Probes for in Vivo Fluorescence and MR Imaging of Proteases
    • Olson, E. S.; Jiang, T.; Aguilera, T. A.; Nguyen, Q. T.; Ellies, L. G.; Scadeng, M.; Tsien, R. Y. Activatable Cell Penetrating Peptides Linked to Nanoparticles as Dual Probes for in Vivo Fluorescence and MR Imaging of Proteases Proc. Natl. Acad. Sci. U. S. A. 2010, 107, 4311-4316 10.1073/pnas.0910283107
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 4311-4316
    • Olson, E.S.1    Jiang, T.2    Aguilera, T.A.3    Nguyen, Q.T.4    Ellies, L.G.5    Scadeng, M.6    Tsien, R.Y.7
  • 20
    • 78649840996 scopus 로고    scopus 로고
    • Protease Sensing with Nanoparticle Based Platforms
    • Welser, K.; Adsley, R.; Moore, B. M.; Chan, W. C.; Aylott, J. W. Protease Sensing with Nanoparticle Based Platforms Analyst 2010, 136, 29-41 10.1039/C0AN00429D
    • (2010) Analyst , vol.136 , pp. 29-41
    • Welser, K.1    Adsley, R.2    Moore, B.M.3    Chan, W.C.4    Aylott, J.W.5
  • 22
    • 84887001117 scopus 로고    scopus 로고
    • Nanoparticles That Sense Thrombin Activity as Synthetic Urinary Biomarkers of Thrombosis
    • Lin, K. Y.; Kwong, G. A.; Warren, A. D.; Wood, D. K.; Bhatia, S. N. Nanoparticles That Sense Thrombin Activity as Synthetic Urinary Biomarkers of Thrombosis ACS Nano 2013, 7, 9001 10.1021/nn403550c
    • (2013) ACS Nano , vol.7 , pp. 9001
    • Lin, K.Y.1    Kwong, G.A.2    Warren, A.D.3    Wood, D.K.4    Bhatia, S.N.5
  • 23
    • 84896277174 scopus 로고    scopus 로고
    • Point-of-Care Diagnostics for Noncommunicable Diseases Using Synthetic Urinary Biomarkers and Paper Microfluidics
    • Warren, A. D.; Kwong, G. A.; Wood, D. K.; Lin, K. Y.; Bhatia, S. N. Point-of-Care Diagnostics for Noncommunicable Diseases Using Synthetic Urinary Biomarkers and Paper Microfluidics Proc. Natl. Acad. Sci. U. S. A. 2014, 111, 3671-3676 10.1073/pnas.1314651111
    • (2014) Proc. Natl. Acad. Sci. U. S. A. , vol.111 , pp. 3671-3676
    • Warren, A.D.1    Kwong, G.A.2    Wood, D.K.3    Lin, K.Y.4    Bhatia, S.N.5
  • 25
    • 67949124649 scopus 로고    scopus 로고
    • Light-Activated RNA Interference Using Double-Stranded siRNA Precursors Modified Using a Remarkable Regiospecificity of Diazo-Based Photolabile Groups
    • Shah, S.; Jain, P. K.; Kala, A.; Karunakaran, D.; Friedman, S. H. Light-Activated RNA Interference Using Double-Stranded siRNA Precursors Modified Using a Remarkable Regiospecificity of Diazo-Based Photolabile Groups Nucleic Acids Res. 2009, 37, 4508-4517 10.1093/nar/gkp415
    • (2009) Nucleic Acids Res. , vol.37 , pp. 4508-4517
    • Shah, S.1    Jain, P.K.2    Kala, A.3    Karunakaran, D.4    Friedman, S.H.5
  • 26
    • 0029563161 scopus 로고
    • Release of Gelatinase A (Matrix Metalloproteinase 2) Induced by Photolysis of Caged Phosphatidic Acid in HT 1080 Metastatic Fibrosarcoma Cells
    • Williger, B.-T.; Reich, R.; Neeman, M.; Bercovici, T.; Liscovitch, M. Release of Gelatinase A (Matrix Metalloproteinase 2) Induced by Photolysis of Caged Phosphatidic Acid in HT 1080 Metastatic Fibrosarcoma Cells J. Biol. Chem. 1995, 270, 29656-29659 10.1074/jbc.270.50.29656
    • (1995) J. Biol. Chem. , vol.270 , pp. 29656-29659
    • Williger, B.-T.1    Reich, R.2    Neeman, M.3    Bercovici, T.4    Liscovitch, M.5
  • 27
    • 79851495876 scopus 로고    scopus 로고
    • Patterning of Gene Expression Using New Photolabile Groups Applied to Light Activated RNAi
    • Jain, P. K.; Shah, S.; Friedman, S. H. Patterning of Gene Expression Using New Photolabile Groups Applied to Light Activated RNAi J. Am. Chem. Soc. 2011, 133, 440-446 10.1021/ja107226e
    • (2011) J. Am. Chem. Soc. , vol.133 , pp. 440-446
    • Jain, P.K.1    Shah, S.2    Friedman, S.H.3
  • 32
    • 0033203075 scopus 로고    scopus 로고
    • Calcium Signalling in Cardiac Muscle: Refractoriness Revealed by Coherent Activation
    • DelPrincipe, F.; Egger, M.; Niggli, E. Calcium Signalling in Cardiac Muscle: Refractoriness Revealed by Coherent Activation Nat. Cell Biol. 1999, 1, 323-329 10.1038/14013
    • (1999) Nat. Cell Biol. , vol.1 , pp. 323-329
    • DelPrincipe, F.1    Egger, M.2    Niggli, E.3
  • 33
    • 0141867730 scopus 로고    scopus 로고
    • Application of Two-Photon Flash Photolysis to Reveal Intercellular Communication and Intracellular Ca2+ Movements
    • Soeller, C.; Jacobs, M. D.; Donaldson, P. J.; Cannell, M. B.; Jones, K. T.; Ellis-Davies, G. C. R. Application of Two-Photon Flash Photolysis to Reveal Intercellular Communication and Intracellular Ca2+ Movements J. Biomed. Opt. 2003, 8, 418-427 10.1117/1.1582468
    • (2003) J. Biomed. Opt. , vol.8 , pp. 418-427
    • Soeller, C.1    Jacobs, M.D.2    Donaldson, P.J.3    Cannell, M.B.4    Jones, K.T.5    Ellis-Davies, G.C.R.6
  • 34
    • 84872845357 scopus 로고    scopus 로고
    • Construction of a Photoactivated Insulin Depot
    • Jain, P. K.; Karunakaran, D.; Friedman, S. H. Construction of a Photoactivated Insulin Depot Angew. Chem., Int. Ed. 2013, 52, 1404-1409 10.1002/anie.201207264
    • (2013) Angew. Chem., Int. Ed. , vol.52 , pp. 1404-1409
    • Jain, P.K.1    Karunakaran, D.2    Friedman, S.H.3
  • 36
    • 77956078676 scopus 로고    scopus 로고
    • Cleavage-Sensing Redox Peptide Monolayers for the Rapid Measurement of the Proteolytic Activity of Trypsin and A-Thrombin Enzymes
    • Adjémian, J.; Anne, A.; Cauet, G.; Demaille, C. Cleavage-Sensing Redox Peptide Monolayers for the Rapid Measurement of the Proteolytic Activity of Trypsin and A-Thrombin Enzymes Langmuir 2010, 26, 10347-10356 10.1021/la100397g
    • (2010) Langmuir , vol.26 , pp. 10347-10356
    • Adjémian, J.1    Anne, A.2    Cauet, G.3    Demaille, C.4
  • 38
    • 0034667462 scopus 로고    scopus 로고
    • Treatment of Colorectal Liver Metastases by Adenoviral Transfer of Tissue Inhibitor of Metalloproteinases-2 into the Liver Tissue
    • Brand, K.; Baker, A. H.; Perez-Cantó, A.; Possling, A.; Sacharjat, M.; Geheeb, M.; Arnold, W. Treatment of Colorectal Liver Metastases by Adenoviral Transfer of Tissue Inhibitor of Metalloproteinases-2 into the Liver Tissue Cancer Res. 2000, 60, 5723-5730
    • (2000) Cancer Res. , vol.60 , pp. 5723-5730
    • Brand, K.1    Baker, A.H.2    Perez-Cantó, A.3    Possling, A.4    Sacharjat, M.5    Geheeb, M.6    Arnold, W.7
  • 39
    • 79959267832 scopus 로고    scopus 로고
    • Validation of the Histone Methyltransferase EZH2 as a Therapeutic Target for Various Types of Human Cancer and as a Prognostic Marker
    • Takawa, M.; Masuda, K.; Kunizaki, M.; Daigo, Y.; Takagi, K.; Iwai, Y.; Cho, H.-S.; Toyokawa, G.; Yamane, Y.; Maejima, K. et al. Validation of the Histone Methyltransferase EZH2 as a Therapeutic Target for Various Types of Human Cancer and as a Prognostic Marker Cancer Sci. 2011, 102, 1298-1305 10.1111/j.1349-7006.2011.01958.x
    • (2011) Cancer Sci. , vol.102 , pp. 1298-1305
    • Takawa, M.1    Masuda, K.2    Kunizaki, M.3    Daigo, Y.4    Takagi, K.5    Iwai, Y.6    Cho, H.-S.7    Toyokawa, G.8    Yamane, Y.9    Maejima, K.10
  • 40
    • 84880531962 scopus 로고    scopus 로고
    • Engineered Culture Models for Studies of Tumor-Microenvironment Interactions
    • Infanger, D. W.; Lynch, M. E.; Fischbach, C. Engineered Culture Models for Studies of Tumor-Microenvironment Interactions Annu. Rev. Biomed. Eng. 2013, 15, 29-53 10.1146/annurev-bioeng-071811-150028
    • (2013) Annu. Rev. Biomed. Eng. , vol.15 , pp. 29-53
    • Infanger, D.W.1    Lynch, M.E.2    Fischbach, C.3
  • 41
    • 84855961163 scopus 로고    scopus 로고
    • Nanoparticle Delivery of Cancer Drugs
    • Wang, A. Z.; Langer, R.; Farokhzad, O. C. Nanoparticle Delivery of Cancer Drugs Annu. Rev. Med. 2012, 63, 185-198 10.1146/annurev-med-040210-162544
    • (2012) Annu. Rev. Med. , vol.63 , pp. 185-198
    • Wang, A.Z.1    Langer, R.2    Farokhzad, O.C.3
  • 42
    • 84858665432 scopus 로고    scopus 로고
    • Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile
    • Hrkach, J.; Hoff, D. V.; Ali, M. M.; Andrianova, E.; Auer, J.; Campbell, T.; Witt, D. D.; Figa, M.; Figueiredo, M.; Horhota, A. et al. Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile Sci. Transl. Med. 2012, 4, 128ra39-ra128ra39 10.1126/scitranslmed.3003651
    • (2012) Sci. Transl. Med. , vol.4 , pp. 128ra39-ra1312839
    • Hrkach, J.1    Hoff, D.V.2    Ali, M.M.3    Andrianova, E.4    Auer, J.5    Campbell, T.6    Witt, D.D.7    Figa, M.8    Figueiredo, M.9    Horhota, A.10
  • 44
    • 84888091303 scopus 로고    scopus 로고
    • Photoswitchable Nanoparticles for in Vivo Cancer Chemotherapy
    • Tong, R.; Chiang, H. H.; Kohane, D. S. Photoswitchable Nanoparticles for in Vivo Cancer Chemotherapy Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 19048-19053 10.1073/pnas.1315336110
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 19048-19053
    • Tong, R.1    Chiang, H.H.2    Kohane, D.S.3
  • 46
    • 84925508647 scopus 로고    scopus 로고
    • Light-Triggered in Vivo Activation of Adhesive Peptides Regulates Cell Adhesion, Inflammation and Vascularization of Biomaterials
    • Lee, T. T.; García, J. R.; Paez, J. I.; Singh, A.; Phelps, E. A.; Weis, S.; Shafiq, Z.; Shekaran, A.; del Campo, A.; García, A. J. Light-Triggered in Vivo Activation of Adhesive Peptides Regulates Cell Adhesion, Inflammation and Vascularization of Biomaterials Nat. Mater. 2015, 14, 352-360 10.1038/nmat4157
    • (2015) Nat. Mater. , vol.14 , pp. 352-360
    • Lee, T.T.1    García, J.R.2    Paez, J.I.3    Singh, A.4    Phelps, E.A.5    Weis, S.6    Shafiq, Z.7    Shekaran, A.8    Del Campo, A.9    García, A.J.10
  • 47
    • 0345862188 scopus 로고    scopus 로고
    • Prevention of Non-Melanoma Skin Cancer by Targeting Ultraviolet-B-Light Signalling
    • Bowden, G. T. Prevention of Non-Melanoma Skin Cancer by Targeting Ultraviolet-B-Light Signalling Nat. Rev. Cancer 2004, 4, 23-35 10.1038/nrc1253
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 23-35
    • Bowden, G.T.1
  • 48
    • 84884969965 scopus 로고    scopus 로고
    • Plasmonic Photothermal Heating of Intraperitoneal Tumors through the Use of an Implanted Near-Infrared Source
    • Bagley, A. F.; Hill, S.; Rogers, G. S.; Bhatia, S. N. Plasmonic Photothermal Heating of Intraperitoneal Tumors through the Use of an Implanted Near-Infrared Source ACS Nano 2013, 7, 8089-8097 10.1021/nn4033757
    • (2013) ACS Nano , vol.7 , pp. 8089-8097
    • Bagley, A.F.1    Hill, S.2    Rogers, G.S.3    Bhatia, S.N.4
  • 50
    • 78650902662 scopus 로고    scopus 로고
    • Optogenetics
    • Deisseroth, K. Optogenetics Nat. Methods 2011, 8, 26-29 10.1038/nmeth.f.324
    • (2011) Nat. Methods , vol.8 , pp. 26-29
    • Deisseroth, K.1
  • 51
    • 84866696910 scopus 로고    scopus 로고
    • Photonic Gene Circuits by Optically Addressable siRNA-Au Nanoantennas
    • Lee, S. E.; Sasaki, D. Y.; Park, Y.; Xu, R.; Brennan, J. S.; Bissell, M. J.; Lee, L. P. Photonic Gene Circuits by Optically Addressable siRNA-Au Nanoantennas ACS Nano 2012, 6, 7770-7780 10.1021/nn301744x
    • (2012) ACS Nano , vol.6 , pp. 7770-7780
    • Lee, S.E.1    Sasaki, D.Y.2    Park, Y.3    Xu, R.4    Brennan, J.S.5    Bissell, M.J.6    Lee, L.P.7
  • 52
    • 84887007647 scopus 로고    scopus 로고
    • Near-Infrared Light Photocontrolled Targeting, Bioimaging, and Chemotherapy with Caged Upconversion Nanoparticles in Vitro and in Vivo
    • Chien, Y.-H.; Chou, Y.-L.; Wang, S.-W.; Hung, S.-T.; Liau, M.-C.; Chao, Y.-J.; Su, C.-H.; Yeh, C.-S. Near-Infrared Light Photocontrolled Targeting, Bioimaging, and Chemotherapy with Caged Upconversion Nanoparticles in Vitro and in Vivo ACS Nano 2013, 7, 8516-8528 10.1021/nn402399m
    • (2013) ACS Nano , vol.7 , pp. 8516-8528
    • Chien, Y.-H.1    Chou, Y.-L.2    Wang, S.-W.3    Hung, S.-T.4    Liau, M.-C.5    Chao, Y.-J.6    Su, C.-H.7    Yeh, C.-S.8
  • 53
    • 84901843462 scopus 로고    scopus 로고
    • Reversible Protein Inactivation by Optogenetic Trapping in Cells
    • Lee, S.; Park, H.; Kyung, T.; Kim, N. Y.; Kim, S.; Kim, J.; Heo, W. D. Reversible Protein Inactivation by Optogenetic Trapping in Cells Nat. Methods 2014, 11, 633-636 10.1038/nmeth.2940
    • (2014) Nat. Methods , vol.11 , pp. 633-636
    • Lee, S.1    Park, H.2    Kyung, T.3    Kim, N.Y.4    Kim, S.5    Kim, J.6    Heo, W.D.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.