Comprehensive metabolic modeling of multiple13C-isotopomer data sets to study metabolism in perfused working hearts

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 311, Issue 4, 2016, Pages H881-H891

  Crown, Scott B ^a   Kelleher, Joanne K ^b   Rouf, Rosanne ^c   Muoio, Deborah M ^a   Antoniewicz, Maciek R ^d  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Massachusetts Institute of Technology   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF DELAWARE   (United States)

Author keywords

13C MFA; Heart metabolism; Metabolic flux; Parallel labeling experiments; Perfusion

Indexed keywords

ACETYL COENZYME A; CITRATE SYNTHASE; CITRIC ACID; FUMARIC ACID; GLUCOSE C 13; LACTIC ACID C 13; MALIC ACID; OLEATE C 13; PYRUVATE CARBOXYLASE; PYRUVATE DEHYDROGENASE; PYRUVIC ACID C 13; SUCCINIC ACID; TRACER; UNCLASSIFIED DRUG; CARBON; GLUCOSE; LACTIC ACID; OLEIC ACID; PYRUVIC ACID;

ANIMAL TISSUE; ARTICLE; CELL POPULATION; CITRIC ACID CYCLE; CYTOSOL; FATTY ACID OXIDATION; HEART MUSCLE METABOLISM; HEART PERFUSION; INTRACELLULAR TRANSPORT; ISOTOPE TRACING; MALE; METABOLIC FLUX ANALYSIS; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STOICHIOMETRY; ANIMAL; BIOLOGICAL MODEL; CARDIAC MUSCLE; ENERGY METABOLISM; ISOLATED HEART; METABOLISM;

ACETYL COENZYME A; ANIMALS; CARBON ISOTOPES; ENERGY METABOLISM; GLUCOSE; ISOLATED HEART PREPARATION; LACTIC ACID; MALE; METABOLIC FLUX ANALYSIS; METABOLIC NETWORKS AND PATHWAYS; MICE; MODELS, BIOLOGICAL; MODELS, CARDIOVASCULAR; MYOCARDIUM; OLEIC ACID; PYRUVIC ACID;

EID: 84990053583     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00428.2016     Document Type: Article

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