Role of pyruvate dehydrogenase inhibition in the development of hypertrophy in the hyperthyroid rat heart: A combined magnetic resonance imaging and hyperpolarized magnetic resonance spectroscopy study

Circulation

Volumn 123, Issue 22, 2011, Pages 2552-2561

  Atherton, Helen J ^a,c   Dodd, Michael S ^a   Heather, Lisa C ^a   Schroeder, Marie A ^a   Griffin, Julian L ^b   Radda, George K ^a   Clarke, Kieran ^a   Tyler, Damian J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

hyperthyroidism; magnetic resonance spectroscopy; pyruvate dehydrogenase complex

Indexed keywords

BIOLOGICAL MARKER; CARBON 13; DICHLOROACETIC ACID; GLUCOSE; LIOTHYRONINE; PYRUVATE DEHYDROGENASE; PYRUVIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CINEANGIOCARDIOGRAPHY; CITRIC ACID CYCLE; CONTROLLED STUDY; ENZYME INHIBITION; GLUCOSE OXIDATION; HEART HYPERTROPHY; HEART OUTPUT; HYPERPOLARIZATION; HYPERTHYROIDISM; IN VIVO STUDY; LONG TERM CARE; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; RAT; SHORT COURSE THERAPY; WISTAR RAT;

ANIMALS; CARDIOMEGALY; DICHLOROACETATE; HYPERTHYROIDISM; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, WISTAR;

EID: 79958777022     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.110.011387     Document Type: Article

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