Quantitative assessment of anaplerosis from propionate in pig heart in vivo

American Journal of Physiology - Endocrinology and Metabolism

Volumn 284, Issue 2 47-2, 2003, Pages

  Martini, Wenjun Z ^a,b   Stanley, William C ^a,b   Huang, Hazel ^a   Des Rosiers, Christine ^c   Hoppel, Charles L ^a   Brunengraber, Henri ^b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c UNIVERSITY OF MONTREAL   (Canada)

Author keywords

Cataplerosis; Mass isotopomer analysis; Mass spectrometry; Tricarboxylic acid cycle

Indexed keywords

CARNITINE DERIVATIVE; CITRIC ACID; FATTY ACID; GLUCOSE; LACTIC ACID; PROPIONIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALYSIS; CITRIC ACID CYCLE; FATTY ACID TRANSPORT; HEART FUNCTION; HEART MUSCLE BIOPSY; HEART MUSCLE CONTRACTILITY; HEART MUSCLE METABOLISM; HEART MUSCLE OXYGEN CONSUMPTION; HEART RATE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SWINE;

EID: 0037305741     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00354.2002     Document Type: Article

References (29)

1. Ando T, Rasmussen K, Nyhan WL, and Hull D. 3-Hydroxypropionate: significance of oxidation of propionate in patients with propionic acidemia and methylmalonic acidemia. Proc Natl Acad Sci USA 69: 2807-2811, 1972.
2. Ando T, Rasmussen K, Wright JM, and Nyhan WL. Isolation and identification of methylcitrate, a major metabolic product of propionate in patients with propionic acidemia. J Biol Chem 247: 2200-2204, 1972.
3. Bergman G, Atkinson L, Metcalfe J, Jackson N, and Jewitt DE. Beneficial effect of enhanced myocardial carbohydrate utilisation after oxfenicine (L-hydroxyphenylglycine) in angina pectoris. Eur Heart J 1: 247-253, 1980.
4. Chandler MP, Huang H, McElfresh TA, and Stanley WC. Increased non-oxidative glycolysis despite continued fatty acid uptake during demand-induced myocardial ischemia. Am J Physiol Heart Circ Physiol 282: H1871-H1878, 2002.
5. Cole PL, Beamer AD, McGowan N, Cantillon CO, Benfell K, Kelly RA, Hartley LH, Smith TW, and Antman EM. Efficacy and safety of perhexiline maleate in refractory angina. A double-blind placebo-controlled clinical trial of a novel antianginal agent. Circulation 81: 1260-1270, 1990.
6. Comte B, Vincent G, Bouchard B, Jette M, Cordeau S, and Des Rosiers C. A 13C mass isotopomer study of anaplerotic pyruvate carboxylation in perfused rat hearts. J Biol Chem 272: 26125-26131, 1997.
7. Des Rosiers C, Di Donato L, Comte B, Laplante A, Marcoux C, David F, Fernandez CA, and Brunengraber H. Isotopomer analysis of citric acid cycle and gluconeogenesis in rat liver. Reversibility of isocitrate dehydrogenase and involvement of ATP-citrate lyase in gluconeogenesis. J Biol Chem 270: 10027-10036, 1995.
8. Hachey DL, Patterson BW, Reeds PJ, and Elsas LJ. Isotopic determination of organic keto acid pentafluorobenzyl esters in biological fluids by negative chemical ionization gas chromatography/mass spectrometry. Anal Chem 63: 919-923, 1991.
9. Horowitz JD, Sia ST, Macdonald PS, Goble AJ, and Louis WJ. Perhexiline maleate treatment for severe angina pectoriscorrelations with pharmacokinetics. Int J Cardiol 13: 219-229, 1986.
10. Jessen ME, Kovarik TE, Jeffrey FM, Sherry AD, Storey CJ, Chao RY, Ring WS, and Malloy CR. Effects of amino acids on substrate selection, anaplerosis, and left ventricular function in the ischemic reperfused rat heart. J Clin Invest 92: 831-839, 1993.
11. Jucker BM, Rennings AJ, Cline GW, Petersen KF, and Shulman GI. In vivo NMR investigation of intramuscular glucose metabolism in conscious rats. Am J Physiol Endocrinol Metab 273: E139-E148, 1997.
12. Kjekshus JK. Role of free fatty acids in catecholamine-induced cardiac necrosis. Recent Adv Stud Card Struct Metab 6: 183-191, 1975.
13. Laplante A, Vincent G, Poirier M, and Des RC. Effects and metabolism of fumarate in the perfused rat heart. A 13C mass isotopomer study. Am J Physiol Endocrinol Metab 272: E74-E82, 1997.
14. Leclerc J, Des Rosiers C, Montgomery JA, Brunet J, SteMarie L, Reider MW, Fernandez CA, Powers L, David F, and Brunengraber H. Metabolism of R-beta-hydroxypentanoate and of beta-ketopentanoate in conscious dogs. Am J Physiol Endocrinol Metab 268: E446-E452, 1995.
15. Liedtke AJ, Hacker T, Renstrom B, and Nellis SH. Anaplerotic effects of propionate on oxidations of acetate and long-chain fatty acids. Am J Physiol Heart Circ Physiol 270: H2197-H2203, 1996.
16. Mentzer RM Jr, Van Wylen DG, Sodhi J, Weiss RJ, Lasley RD, Willis J, Bunger R, Habil, and Flint LM. Effect of pyruvate on regional ventricular function in normal and stunned myocardium. Ann Surg 209: 629-633, 1989,
17. Minkler PE and Hoppel CL. Quantification of free carnitine, individual short- and medium-chain acylcarnitines, and total carnitine in plasma by high-performance liquid chromatography. Anal Biochem 212: 510-518, 1993.
18. Mongan PD, Fontana JL, Chen R, and Bunger R. Intravenous pyruvate prolongs survival during hemorrhagic shock in swine. Am J Physiol Heart Circ Physiol 277: H2253-H2263, 1999.
19. Panchal AR, Comte B, Huang H, Dudar B, Roth B, Chandler M, Des RC, Brunengraber H, and Stanley WC. Acute hibernation decreases myocardial pyruvate carboxylation and citrate release. Am J Physiol Heart Circ Physiol 281: H1613-H1620, 2001.
20. Panchal AR, Comte B, Huang H, Kerwin T, Darvish A, Rosiers CD, Brunengraber H, and Stanley WC. Partitioning of pyruvate between oxidation and anaplerosis in swine hearts. Am J Physiol Heart Circ Physiol 279: H2390-H2398, 2000.
21. Pisarenko OI, Solomatina ES, Studneva IM, Ivanov VE, Kapelko VI, and Smirnov VN. Effect of glutamic and aspartic acids on adenine nucleotides, nitrogenous compounds and contractile function during underperfusion of isolated rat heart. J Mol Cell Cardiol 15: 53-60, 1983.
22. Roe CR and Ding JH. Mitochondrial fatty acid oxidation disorders. In: The Metabolic and Molecular Bases of Inherited Diseases, edited by Scriver CR, Beaudet AL, Sly WS, and Valle D. New York: McGraw-Hill, 2001, p. 2297-2326.
23. Roe CR, Roe DS, Sweetman L, David F, and Brunengraber H. Treatment of cardiomyopathy and rhabdomyolysis in longchain fat oxidation disorders using an anaplerotic odd-chain triglyceride. J Clin Invest 110: 259-269, 2002.
24. Russell RR, III, Mommessin JI, and Taegtmeyer H. Propionyl-L-carnitine-mediated improvement in contractile function of rat hearts oxidizing acetoacetate. Am J Physiol Heart Circ Physiol 268: H441-H447, 1995.
25. Russell RR III and Taegtmeyer H. Changes in citric acid cycle flux and anaplerosis antedate the functional decline in isolated rat hearts utilizing acetoacetate. J Clin Invest 87: 384-390, 1991.
26. Sherry AD, Malloy CR, Roby RE, Rajagopal A, and Jeffrey FM. Propionate metabolism in the rat heart by 13C n. m. r. spectroscopy. Biochem J 254: 593-598, 1988.
27. Sumegi B, Podanyi B, Forgo P, and Kover KE. Metabolism of [3-13C]pyruvate and [3-13C]propionate in normal and ischaemic rat heart in vivo: 1H- and 13C-NMR studies. Biochem J 312: 75-81, 1995.
28. Vik-Mo H and Mjos OD. Myocardial metabolism and performance during sodium salicylate infusion in dogs. Scand J Clin Lab Invest 36: 763-769, 1976.
29. 13C]glutamate isotopomer measurements. Am J Physiol Endocrinol Metab 266: E1012-E1022, 1994.