Parallel labeling experiments validate Clostridium acetobutylicum metabolic network model for 13C metabolic flux analysis

Metabolic Engineering

Volumn 26, Issue , 2014, Pages 23-33

  Au, Jennifer ^a   Choi, Jungik ^a   Jones, Shawn W ^a   Venkataramanan, Keerthi P ^a   Antoniewicz, Maciek R ^a  

^a UNIVERSITY OF DELAWARE   (United States)

Author keywords

13C flux analysis; Isotopic tracers; Mass spectrometry; Network model validation; Statistical analysis

Indexed keywords

STATISTICAL METHODS;

CLOSTRIDIUM ACETOBUTYLICUM; FLUX ANALYSIS; ISOTOPIC TRACER; METABOLIC FLUX ANALYSIS; METABOLIC NETWORK MODELS; NETWORK MODEL VALIDATIONS;

MASS SPECTROMETRY;

2 OXOGLUTARIC ACID; ASPARTIC ACID; BACTERIAL ENZYME; CARBON 13; CITRAMALATE SYNTHASE; FUMARIC ACID; ISOLEUCINE; MALIC ACID; SUCCINIC ACID; SUCCINYL COENZYME A; SYNTHETASE; TRACER; UNCLASSIFIED DRUG; BACTERIAL PROTEIN;

ARTICLE; BACTERIAL CELL; BACTERIAL METABOLISM; BACTERIAL STRAIN; CARBON METABOLISM; CITRIC ACID CYCLE; CLOSTRIDIUM ACETOBUTYLICUM; CONTROLLED STUDY; ENZYME ACTIVITY; EXPERIMENTAL MODEL; EXPERIMENTAL STUDY; ISOTOPE LABELING; METABOLIC FLUX ANALYSIS; NONHUMAN; PREDICTION; QUANTITATIVE ANALYSIS; BIOLOGICAL MODEL; CARBON NUCLEAR MAGNETIC RESONANCE; EVALUATION STUDY; METABOLISM; PHYSIOLOGY; PROCEDURES; SIGNAL TRANSDUCTION; VALIDATION STUDY;

BACTERIAL PROTEINS; CARBON-13 MAGNETIC RESONANCE SPECTROSCOPY; CITRIC ACID CYCLE; CLOSTRIDIUM ACETOBUTYLICUM; ISOTOPE LABELING; METABOLIC FLUX ANALYSIS; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION;

EID: 84907920598     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2014.08.002     Document Type: Article

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