메뉴 건너뛰기




Volumn 1863, Issue 9, 2016, Pages 2135-2146

The glucagon-like peptide-1 analogue exendin-4 reverses impaired intracellular Ca2 + signalling in steatotic hepatocytes

Author keywords

Exendin 4; GLP 1; Intracellular Ca2 +; Liver; Steatosis; Store operated Ca2 + entry; Cyclic AMP

Indexed keywords

AMIODARONE; BUCLADESINE; CALCIUM ION; CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL; CYCLIC AMP; DIACYLGLYCEROL; EXENDIN 4; FURA 2; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCOSE; GLYCOGEN; PALMITIC ACID; PHENYLEPHRINE; PROTEIN KINASE C; CALCIUM; HORMONE; PEPTIDE; VENOM;

EID: 84989934412     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2016.05.006     Document Type: Article
Times cited : (39)

References (68)
  • 1
    • 84884860377 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes
    • [1] Birkenfeld, A.L., Shulman, G.I., Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes. Hepatology 59 (2014), 713–723.
    • (2014) Hepatology , vol.59 , pp. 713-723
    • Birkenfeld, A.L.1    Shulman, G.I.2
  • 3
    • 84879905328 scopus 로고    scopus 로고
    • Potential of incretin-based therapies for non-alcoholic fatty liver disease
    • [3] Samson, S.L., Bajaj, M., Potential of incretin-based therapies for non-alcoholic fatty liver disease. J. Diabetes Complicat. 27 (2013), 401–406.
    • (2013) J. Diabetes Complicat. , vol.27 , pp. 401-406
    • Samson, S.L.1    Bajaj, M.2
  • 4
    • 73549103572 scopus 로고    scopus 로고
    • Glucose enhances expression of TRPC1 and calcium entry in endothelial cells
    • [4] Bishara, N.B., Ding, H., Glucose enhances expression of TRPC1 and calcium entry in endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 298 (2010), H171–H178.
    • (2010) Am. J. Physiol. Heart Circ. Physiol. , vol.298 , pp. H171-H178
    • Bishara, N.B.1    Ding, H.2
  • 5
    • 84878808238 scopus 로고    scopus 로고
    • Pharmacology, physiology, and mechanisms of incretin hormone action
    • [5] Campbell, J.E., Drucker, D.J., Pharmacology, physiology, and mechanisms of incretin hormone action. Cell Metab. 17 (2013), 819–837.
    • (2013) Cell Metab. , vol.17 , pp. 819-837
    • Campbell, J.E.1    Drucker, D.J.2
  • 6
    • 84905397741 scopus 로고    scopus 로고
    • Potential roles of glucagon-like peptide-1-based therapies in treating non-alcoholic fatty liver disease
    • [6] Liu, Y., Wei, R., Hong, T.P., Potential roles of glucagon-like peptide-1-based therapies in treating non-alcoholic fatty liver disease. World J. Gastroenterol. 20 (2014), 9090–9097.
    • (2014) World J. Gastroenterol. , vol.20 , pp. 9090-9097
    • Liu, Y.1    Wei, R.2    Hong, T.P.3
  • 7
    • 84940721655 scopus 로고    scopus 로고
    • Calcium homeostasis and organelle function in the pathogenesis of obesity and diabetes
    • [7] Arruda, A.P., Hotamisligil, G.S., Calcium homeostasis and organelle function in the pathogenesis of obesity and diabetes. Cell Metab. 22 (2015), 381–397.
    • (2015) Cell Metab. , vol.22 , pp. 381-397
    • Arruda, A.P.1    Hotamisligil, G.S.2
  • 8
    • 84901944641 scopus 로고    scopus 로고
    • The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
    • [8] Perry, R.J., Samuel, V.T., Petersen, K.F., Shulman, G.I., The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature 510 (2014), 84–91.
    • (2014) Nature , vol.510 , pp. 84-91
    • Perry, R.J.1    Samuel, V.T.2    Petersen, K.F.3    Shulman, G.I.4
  • 9
    • 84902332964 scopus 로고    scopus 로고
    • Calcium-dependent regulation of glucose homeostasis in the liver
    • [9] Bartlett, P.J., Gaspers, L.D., Pierobon, N., Thomas, A.P., Calcium-dependent regulation of glucose homeostasis in the liver. Cell Calcium 55 (2014), 306–316.
    • (2014) Cell Calcium , vol.55 , pp. 306-316
    • Bartlett, P.J.1    Gaspers, L.D.2    Pierobon, N.3    Thomas, A.P.4
  • 11
    • 79957605136 scopus 로고    scopus 로고
    • Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
    • [11] Fu, S., Yang, L., Li, P., Hofmann, O., Dicker, L., Hide, W., Lin, X., Watkins, S.M., Ivanov, A.R., Hotamisligil, G.S., Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature 473 (2011), 528–531.
    • (2011) Nature , vol.473 , pp. 528-531
    • Fu, S.1    Yang, L.2    Li, P.3    Hofmann, O.4    Dicker, L.5    Hide, W.6    Lin, X.7    Watkins, S.M.8    Ivanov, A.R.9    Hotamisligil, G.S.10
  • 12
    • 84902661992 scopus 로고    scopus 로고
    • Incretin based therapies: a novel treatment approach for non-alcoholic fatty liver disease
    • [12] Blaslov, K., Bulum, T., Zibar, K., Duvnjak, L., Incretin based therapies: a novel treatment approach for non-alcoholic fatty liver disease. World J. Gastroenterol. 20 (2014), 7356–7365.
    • (2014) World J. Gastroenterol. , vol.20 , pp. 7356-7365
    • Blaslov, K.1    Bulum, T.2    Zibar, K.3    Duvnjak, L.4
  • 13
    • 84875985453 scopus 로고    scopus 로고
    • Glucagon-like peptides 1 and 2 in health and disease: a review
    • [13] Marathe, C.S., Rayner, C.K., Jones, K.L., Horowitz, M., Glucagon-like peptides 1 and 2 in health and disease: a review. Peptides 44 (2013), 75–86.
    • (2013) Peptides , vol.44 , pp. 75-86
    • Marathe, C.S.1    Rayner, C.K.2    Jones, K.L.3    Horowitz, M.4
  • 14
    • 79955627418 scopus 로고    scopus 로고
    • Thermogenesis and related metabolic targets in anti-diabetic therapy
    • [14] Arch, J.R., Thermogenesis and related metabolic targets in anti-diabetic therapy. Handb. Exp. Pharmacol., 2011, 201–255.
    • (2011) Handb. Exp. Pharmacol. , pp. 201-255
    • Arch, J.R.1
  • 15
    • 84910603708 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 receptor agonists on non-alcoholic fatty liver disease and inflammation
    • [15] Wang, X.C., Gusdon, A.M., Liu, H., Qu, S., Effects of glucagon-like peptide-1 receptor agonists on non-alcoholic fatty liver disease and inflammation. World J. Gastroenterol. 20 (2014), 14821–14830.
    • (2014) World J. Gastroenterol. , vol.20 , pp. 14821-14830
    • Wang, X.C.1    Gusdon, A.M.2    Liu, H.3    Qu, S.4
  • 18
    • 41949095679 scopus 로고    scopus 로고
    • 2 + -permeable channels in the hepatocyte plasma membrane and their roles in hepatocyte physiology
    • 2 + -permeable channels in the hepatocyte plasma membrane and their roles in hepatocyte physiology. Biochim. Biophys. Acta 1783 (2008), 651–672.
    • (2008) Biochim. Biophys. Acta , vol.1783 , pp. 651-672
    • Barritt, G.J.1    Chen, J.2    Rychkov, G.Y.3
  • 21
    • 0021923858 scopus 로고
    • Nile red: a selective fluorescent stain for intracellular lipid droplets
    • [21] Greenspan, P., Mayer, E.P., Fowler, S.D., Nile red: a selective fluorescent stain for intracellular lipid droplets. J. Cell Biol. 100 (1985), 965–973.
    • (1985) J. Cell Biol. , vol.100 , pp. 965-973
    • Greenspan, P.1    Mayer, E.P.2    Fowler, S.D.3
  • 23
    • 62149132733 scopus 로고    scopus 로고
    • 2 + channel activation in liver cells: evidence from studies using TRPV1 and taurodeoxycholic acid
    • 2 + channel activation in liver cells: evidence from studies using TRPV1 and taurodeoxycholic acid. Biochem. J. 418 (2009), 553–566.
    • (2009) Biochem. J. , vol.418 , pp. 553-566
    • Castro, J.1    Aromataris, E.C.2    Rychkov, G.Y.3    Barritt, G.J.4
  • 24
    • 0021895138 scopus 로고
    • 2 + indicators with greatly improved fluorescence properties
    • 2 + indicators with greatly improved fluorescence properties. J. Biol. Chem. 260 (1985), 3440–3450.
    • (1985) J. Biol. Chem. , vol.260 , pp. 3440-3450
    • Grynkiewicz, G.1    Poenie, M.2    Tsien, R.Y.3
  • 25
    • 0024556328 scopus 로고
    • Enzyme immunoassays of adenosine cyclic 3',5'-monophosphate and guanosine cyclic 3',5'-monophosphate using acetylcholinesterase
    • [25] Pradelles, P., Grassi, J., Chabardes, D., Guiso, N., Enzyme immunoassays of adenosine cyclic 3',5'-monophosphate and guanosine cyclic 3',5'-monophosphate using acetylcholinesterase. Anal. Chem. 61 (1989), 447–453.
    • (1989) Anal. Chem. , vol.61 , pp. 447-453
    • Pradelles, P.1    Grassi, J.2    Chabardes, D.3    Guiso, N.4
  • 26
    • 33644803761 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice
    • [26] Ding, X., Saxena, N.K., Lin, S., Gupta, N.A., Anania, F.A., Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice. Hepatology 43 (2006), 173–181.
    • (2006) Hepatology , vol.43 , pp. 173-181
    • Ding, X.1    Saxena, N.K.2    Lin, S.3    Gupta, N.A.4    Anania, F.A.5
  • 27
    • 84862182799 scopus 로고    scopus 로고
    • Exendin-4 reduces glycemia by increasing liver glucokinase activity: an insulin independent effect
    • [27] Dhanesha, N., Joharapurkar, A., Shah, G., Dhote, V., Kshirsagar, S., Bahekar, R., Jain, M., Exendin-4 reduces glycemia by increasing liver glucokinase activity: an insulin independent effect. Pharmacol. Rep. 64 (2012), 140–149.
    • (2012) Pharmacol. Rep. , vol.64 , pp. 140-149
    • Dhanesha, N.1    Joharapurkar, A.2    Shah, G.3    Dhote, V.4    Kshirsagar, S.5    Bahekar, R.6    Jain, M.7
  • 29
    • 84860325681 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonist, exendin-4, regulates feeding-associated neuropeptides in hypothalamic neurons in vivo and in vitro
    • [29] Dalvi, P.S., Nazarians-Armavil, A., Purser, M.J., Belsham, D.D., Glucagon-like peptide-1 receptor agonist, exendin-4, regulates feeding-associated neuropeptides in hypothalamic neurons in vivo and in vitro. Endocrinology 153 (2012), 2208–2222.
    • (2012) Endocrinology , vol.153 , pp. 2208-2222
    • Dalvi, P.S.1    Nazarians-Armavil, A.2    Purser, M.J.3    Belsham, D.D.4
  • 30
    • 34047205064 scopus 로고    scopus 로고
    • Long-term treatment of glucagon-like peptide-1 analog exendin-4 ameliorates diabetic nephropathy through improving metabolic anomalies in db/db mice
    • [30] Park, C.W., Kim, H.W., Ko, S.H., Lim, J.H., Ryu, G.R., Chung, H.W., Han, S.W., Shin, S.J., Bang, B.K., Breyer, M.D., Chang, Y.S., Long-term treatment of glucagon-like peptide-1 analog exendin-4 ameliorates diabetic nephropathy through improving metabolic anomalies in db/db mice. J. Am. Soc. Nephrol. 18 (2007), 1227–1238.
    • (2007) J. Am. Soc. Nephrol. , vol.18 , pp. 1227-1238
    • Park, C.W.1    Kim, H.W.2    Ko, S.H.3    Lim, J.H.4    Ryu, G.R.5    Chung, H.W.6    Han, S.W.7    Shin, S.J.8    Bang, B.K.9    Breyer, M.D.10    Chang, Y.S.11
  • 31
    • 84861810446 scopus 로고    scopus 로고
    • Activation of cyclic adenosine monophosphate-dependent protein kinase a signaling prevents liver ischemia/reperfusion injury in mice
    • [31] Ji, H., Shen, X.D., Zhang, Y., Gao, F., Huang, C.Y., Chang, W.W., Lee, C., Ke, B., Busuttil, R.W., Kupiec-Weglinski, J.W., Activation of cyclic adenosine monophosphate-dependent protein kinase a signaling prevents liver ischemia/reperfusion injury in mice. Liver Transpl. 18 (2012), 659–670.
    • (2012) Liver Transpl. , vol.18 , pp. 659-670
    • Ji, H.1    Shen, X.D.2    Zhang, Y.3    Gao, F.4    Huang, C.Y.5    Chang, W.W.6    Lee, C.7    Ke, B.8    Busuttil, R.W.9    Kupiec-Weglinski, J.W.10
  • 32
    • 13244291443 scopus 로고    scopus 로고
    • Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway
    • [32] Ding, X., Staudinger, J.L., Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway. J. Pharmacol. Exp. Ther. 312 (2005), 849–856.
    • (2005) J. Pharmacol. Exp. Ther. , vol.312 , pp. 849-856
    • Ding, X.1    Staudinger, J.L.2
  • 33
    • 0021251799 scopus 로고
    • Glucagon-stimulable adenylyl cyclase in rat liver. Effects of chronic uremia and intermittent glucagon administration
    • [33] Dighe, R.R., Rojas, F.J., Birnbaumer, L., Garber, A.J., Glucagon-stimulable adenylyl cyclase in rat liver. Effects of chronic uremia and intermittent glucagon administration. J. Clin. Invest. 73 (1984), 1004–1012.
    • (1984) J. Clin. Invest. , vol.73 , pp. 1004-1012
    • Dighe, R.R.1    Rojas, F.J.2    Birnbaumer, L.3    Garber, A.J.4
  • 34
    • 0022237772 scopus 로고
    • Phosphorylation of carnitine palmitoyltransferase and activation by glucagon in isolated rat hepatocytes
    • [34] Harano, Y., Kashiwagi, A., Kojima, H., Suzuki, M., Hashimoto, T., Shigeta, Y., Phosphorylation of carnitine palmitoyltransferase and activation by glucagon in isolated rat hepatocytes. FEBS Lett. 188 (1985), 267–272.
    • (1985) FEBS Lett. , vol.188 , pp. 267-272
    • Harano, Y.1    Kashiwagi, A.2    Kojima, H.3    Suzuki, M.4    Hashimoto, T.5    Shigeta, Y.6
  • 36
    • 0023099179 scopus 로고
    • Mechanisms of hormonal regulation of hepatic glucose metabolism
    • [36] Exton, J.H., Mechanisms of hormonal regulation of hepatic glucose metabolism. Diabetes Metab. Rev. 3 (1987), 163–183.
    • (1987) Diabetes Metab. Rev. , vol.3 , pp. 163-183
    • Exton, J.H.1
  • 38
    • 0023402206 scopus 로고
    • Regulation of phosphoenolpyruvate carboxykinase gene transcription in H4IIE hepatoma cells: evidence for a primary role of the catalytic subunit of 3',5'-cyclic adenosine monophosphate-dependent protein kinase
    • [38] Beebe, S.J., Koch, S.R., Chu, D.T., Corbin, J.D., Granner, D.K., Regulation of phosphoenolpyruvate carboxykinase gene transcription in H4IIE hepatoma cells: evidence for a primary role of the catalytic subunit of 3',5'-cyclic adenosine monophosphate-dependent protein kinase. Mol. Endocrinol. 1 (1987), 639–647.
    • (1987) Mol. Endocrinol. , vol.1 , pp. 639-647
    • Beebe, S.J.1    Koch, S.R.2    Chu, D.T.3    Corbin, J.D.4    Granner, D.K.5
  • 40
    • 84868120544 scopus 로고    scopus 로고
    • The glucagon-like peptide-1 receptor agonist Exendin 4 has a protective role in ischemic injury of lean and steatotic liver by inhibiting cell death and stimulating lipolysis
    • [40] Gupta, N.A., Kolachala, V.L., Jiang, R., Abramowsky, C., Romero, R., Fifadara, N., Anania, F., Knechtle, S., Kirk, A., The glucagon-like peptide-1 receptor agonist Exendin 4 has a protective role in ischemic injury of lean and steatotic liver by inhibiting cell death and stimulating lipolysis. Am. J. Pathol. 181 (2012), 1693–1701.
    • (2012) Am. J. Pathol. , vol.181 , pp. 1693-1701
    • Gupta, N.A.1    Kolachala, V.L.2    Jiang, R.3    Abramowsky, C.4    Romero, R.5    Fifadara, N.6    Anania, F.7    Knechtle, S.8    Kirk, A.9
  • 41
    • 77951436599 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway
    • [41] Gupta, N.A., Mells, J., Dunham, R.M., Grakoui, A., Handy, J., Saxena, N.K., Anania, F.A., Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway. Hepatology 51 (2010), 1584–1592.
    • (2010) Hepatology , vol.51 , pp. 1584-1592
    • Gupta, N.A.1    Mells, J.2    Dunham, R.M.3    Grakoui, A.4    Handy, J.5    Saxena, N.K.6    Anania, F.A.7
  • 42
    • 80053001967 scopus 로고    scopus 로고
    • GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing the unfolded protein response and promoting macroautophagy
    • [42] Sharma, S., Mells, J.E., Fu, P.P., Saxena, N.K., Anania, F.A., GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing the unfolded protein response and promoting macroautophagy. PLoS One, 6, 2011, e25269.
    • (2011) PLoS One , vol.6 , pp. e25269
    • Sharma, S.1    Mells, J.E.2    Fu, P.P.3    Saxena, N.K.4    Anania, F.A.5
  • 44
    • 84879442910 scopus 로고    scopus 로고
    • Calcium signaling in the liver
    • [44] Amaya, M.J., Nathanson, M.H., Calcium signaling in the liver. Compr. Physiol. 3 (2013), 515–539.
    • (2013) Compr. Physiol. , vol.3 , pp. 515-539
    • Amaya, M.J.1    Nathanson, M.H.2
  • 45
    • 0026520193 scopus 로고
    • Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis
    • [45] Pilkis, S.J., Granner, D.K., Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis. Annu. Rev. Physiol. 54 (1992), 885–909.
    • (1992) Annu. Rev. Physiol. , vol.54 , pp. 885-909
    • Pilkis, S.J.1    Granner, D.K.2
  • 46
    • 0020561535 scopus 로고
    • Effect of glucagon, phenylephrine, and isoproterenol on glycogenolysis and glucose release from fetal rat hepatocytes in suspension
    • [46] Huhn, W., Schulze, H.P., Dargel, R., Effect of glucagon, phenylephrine, and isoproterenol on glycogenolysis and glucose release from fetal rat hepatocytes in suspension. Biol. Neonate 44 (1983), 153–157.
    • (1983) Biol. Neonate , vol.44 , pp. 153-157
    • Huhn, W.1    Schulze, H.P.2    Dargel, R.3
  • 47
    • 84860497397 scopus 로고    scopus 로고
    • Diacylglycerol activation of protein kinase Cepsilon and hepatic insulin resistance
    • [47] Jornayvaz, F.R., Shulman, G.I., Diacylglycerol activation of protein kinase Cepsilon and hepatic insulin resistance. Cell Metab. 15 (2012), 574–584.
    • (2012) Cell Metab. , vol.15 , pp. 574-584
    • Jornayvaz, F.R.1    Shulman, G.I.2
  • 48
    • 36849040001 scopus 로고    scopus 로고
    • Incretin receptors for glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide are essential for the sustained metabolic actions of vildagliptin in mice
    • [48] Flock, G., Baggio, L.L., Longuet, C., Drucker, D.J., Incretin receptors for glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide are essential for the sustained metabolic actions of vildagliptin in mice. Diabetes 56 (2007), 3006–3013.
    • (2007) Diabetes , vol.56 , pp. 3006-3013
    • Flock, G.1    Baggio, L.L.2    Longuet, C.3    Drucker, D.J.4
  • 50
    • 84860497397 scopus 로고    scopus 로고
    • Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance
    • [50] Jornayvaz, F.R., Shulman, G.I., Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance. Cell Metab. 15 (2012), 574–584.
    • (2012) Cell Metab. , vol.15 , pp. 574-584
    • Jornayvaz, F.R.1    Shulman, G.I.2
  • 51
    • 79953173175 scopus 로고    scopus 로고
    • GLP-1-derived nonapeptide GLP-1(28-36)amide targets to mitochondria and suppresses glucose production and oxidative stress in isolated mouse hepatocytes
    • [51] Tomas, E., Stanojevic, V., Habener, J.F., GLP-1-derived nonapeptide GLP-1(28-36)amide targets to mitochondria and suppresses glucose production and oxidative stress in isolated mouse hepatocytes. Regul. Pept. 167 (2011), 177–184.
    • (2011) Regul. Pept. , vol.167 , pp. 177-184
    • Tomas, E.1    Stanojevic, V.2    Habener, J.F.3
  • 52
    • 84937545993 scopus 로고    scopus 로고
    • Autophagy and lipid droplets in the liver
    • [52] Martinez-Lopez, N., Singh, R., Autophagy and lipid droplets in the liver. Annu. Rev. Nutr. 35 (2015), 215–237.
    • (2015) Annu. Rev. Nutr. , vol.35 , pp. 215-237
    • Martinez-Lopez, N.1    Singh, R.2
  • 54
    • 84859159273 scopus 로고    scopus 로고
    • Liver triacylglycerol lipases
    • [54] Quiroga, A.D., Lehner, R., Liver triacylglycerol lipases. Biochim. Biophys. Acta 1821 (2012), 762–769.
    • (2012) Biochim. Biophys. Acta , vol.1821 , pp. 762-769
    • Quiroga, A.D.1    Lehner, R.2
  • 57
    • 84861913952 scopus 로고    scopus 로고
    • Lipid droplets and cellular lipid metabolism
    • [57] Walther, T.C., Farese, R.V. Jr., Lipid droplets and cellular lipid metabolism. Annu. Rev. Biochem. 81 (2012), 687–714.
    • (2012) Annu. Rev. Biochem. , vol.81 , pp. 687-714
    • Walther, T.C.1    Farese, R.V.2
  • 58
    • 84978174579 scopus 로고    scopus 로고
    • 2 + mobilization under the control of glucagon-like peptide-1 in mouse pancreatic beta-cells
    • 2 + mobilization under the control of glucagon-like peptide-1 in mouse pancreatic beta-cells. Am. J. Physiol. Cell Physiol. 310 (2016), C337–C347.
    • (2016) Am. J. Physiol. Cell Physiol. , vol.310 , pp. C337-C347
    • Takeda, Y.1    Shimayoshi, T.2    Holz, G.G.3    Noma, A.4
  • 59
    • 78650615554 scopus 로고    scopus 로고
    • 2 +-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity
    • 2 +-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity. Proc. Natl. Acad. Sci. U. S. A. 107 (2010), 19320–19325.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 19320-19325
    • Park, S.W.1    Zhou, Y.2    Lee, J.3    Lee, J.4    Ozcan, U.5
  • 60
    • 84919596822 scopus 로고    scopus 로고
    • Structural and functional mechanisms of CRAC channel regulation
    • [60] Shim, A.H., Tirado-Lee, L., Prakriya, M., Structural and functional mechanisms of CRAC channel regulation. J. Mol. Biol. 427 (2015), 77–93.
    • (2015) J. Mol. Biol. , vol.427 , pp. 77-93
    • Shim, A.H.1    Tirado-Lee, L.2    Prakriya, M.3
  • 64
    • 84856072854 scopus 로고    scopus 로고
    • Packaging of fat: an evolving model of lipid droplet assembly and expansion
    • [64] Brasaemle, D.L., Wolins, N.E., Packaging of fat: an evolving model of lipid droplet assembly and expansion. J. Biol. Chem. 287 (2012), 2273–2279.
    • (2012) J. Biol. Chem. , vol.287 , pp. 2273-2279
    • Brasaemle, D.L.1    Wolins, N.E.2
  • 66
    • 84904399681 scopus 로고    scopus 로고
    • Exendin-4 regulates lipid metabolism and fibroblast growth factor 21 in hepatic steatosis
    • [66] Lee, J., Hong, S.W., Park, S.E., Rhee, E.J., Park, C.Y., Oh, K.W., Park, S.W., Lee, W.Y., Exendin-4 regulates lipid metabolism and fibroblast growth factor 21 in hepatic steatosis. Metabolism 63 (2014), 1041–1048.
    • (2014) Metabolism , vol.63 , pp. 1041-1048
    • Lee, J.1    Hong, S.W.2    Park, S.E.3    Rhee, E.J.4    Park, C.Y.5    Oh, K.W.6    Park, S.W.7    Lee, W.Y.8
  • 67


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.