메뉴 건너뛰기




Volumn 3, Issue 9, 2014, Pages 823-833

GLP-1 receptor agonism ameliorates hepatic VLDL overproduction and de novo lipogenesis in insulin resistance

Author keywords

Fasting dyslipidemia; Glucagon like peptide 1 (GLP 1); Hepatic steatosis; Incretin; Insulin resistance; Very low density lipoprotein (VLDL)

Indexed keywords

APOLIPOPROTEIN B100; CARBOHYDRATE; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCOSE; LIPID; MESSENGER RNA; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

EID: 84919696212     PISSN: None     EISSN: 22128778     Source Type: Journal    
DOI: 10.1016/j.molmet.2014.09.005     Document Type: Article
Times cited : (77)

References (38)
  • 2
    • 84873023759 scopus 로고    scopus 로고
    • GLP-1 and GLP-2 as yin and yang of intestinal lipoprotein production: evidence for predominance of GLP-2-stimulated postprandial lipemia in normal and insulin-resistant states
    • Hein G., Baker C., Hsieh J., Farr S., Adeli K. GLP-1 and GLP-2 as yin and yang of intestinal lipoprotein production: evidence for predominance of GLP-2-stimulated postprandial lipemia in normal and insulin-resistant states. Diabetes 2013, 62(2). pmid:PMID:%2023028139.
    • (2013) Diabetes , vol.62 , Issue.2
    • Hein, G.1    Baker, C.2    Hsieh, J.3    Farr, S.4    Adeli, K.5
  • 3
    • 77949273334 scopus 로고    scopus 로고
    • The glucagon-like peptide 1 receptor is essential for postprandial lipoprotein synthesis and secretion in hamsters and mice
    • Hsieh J., Longuet C., Baker C.L., Qin B., Federico L.M., Drucker D.J., et al. The glucagon-like peptide 1 receptor is essential for postprandial lipoprotein synthesis and secretion in hamsters and mice. Diabetologia 2010, 53(3):552-561.
    • (2010) Diabetologia , vol.53 , Issue.3 , pp. 552-561
    • Hsieh, J.1    Longuet, C.2    Baker, C.L.3    Qin, B.4    Federico, L.M.5    Drucker, D.J.6
  • 4
    • 77956230708 scopus 로고    scopus 로고
    • Exenatide suppresses postprandial elevations in lipids and lipoproteins in individuals with impaired glucose tolerance and recent onset type 2 diabetes mellitus
    • Schwartz E.A., Koska J., Mullin M.P., Syoufi I., Schwenke D.C., Reaven P.D. Exenatide suppresses postprandial elevations in lipids and lipoproteins in individuals with impaired glucose tolerance and recent onset type 2 diabetes mellitus. Atherosclerosis 2010, 212(1):217-222.
    • (2010) Atherosclerosis , vol.212 , Issue.1 , pp. 217-222
    • Schwartz, E.A.1    Koska, J.2    Mullin, M.P.3    Syoufi, I.4    Schwenke, D.C.5    Reaven, P.D.6
  • 5
    • 84906259634 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 as a key regulator of lipid and lipoprotein metabolism in fasting and postprandial states
    • Farr S., Taher J., Adeli K. Glucagon-like peptide-1 as a key regulator of lipid and lipoprotein metabolism in fasting and postprandial states. Cardiovascular Hematological Disorders Drug Targets 2014, 14(2):126-136.
    • (2014) Cardiovascular Hematological Disorders Drug Targets , vol.14 , Issue.2 , pp. 126-136
    • Farr, S.1    Taher, J.2    Adeli, K.3
  • 6
    • 38549162147 scopus 로고    scopus 로고
    • Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years
    • Klonoff D.C., Buse J.B., Nielsen L.L., Guan X., Bowlus C.L., Holcombe J.H., et al. Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years. Current Medical Research and Opinion 2008, 24(1):275-286.
    • (2008) Current Medical Research and Opinion , vol.24 , Issue.1 , pp. 275-286
    • Klonoff, D.C.1    Buse, J.B.2    Nielsen, L.L.3    Guan, X.4    Bowlus, C.L.5    Holcombe, J.H.6
  • 7
    • 77956654077 scopus 로고    scopus 로고
    • Weight loss, glycemic control, and changes in cardiovascular biomarkers in patients with type 2 diabetes receiving incretin therapies or insulin in a large cohort database
    • Horton E.S., Silberman C., Davis K.L., Berria R. Weight loss, glycemic control, and changes in cardiovascular biomarkers in patients with type 2 diabetes receiving incretin therapies or insulin in a large cohort database. Diabetes Care 2010, 33(8):1759-1765.
    • (2010) Diabetes Care , vol.33 , Issue.8 , pp. 1759-1765
    • Horton, E.S.1    Silberman, C.2    Davis, K.L.3    Berria, R.4
  • 8
    • 33748442464 scopus 로고    scopus 로고
    • Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes
    • Sect. 8
    • Blonde L., Klein E.J., Han J., Zhang B., Mac S.M., Poon T.H., et al. Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes. Diabetes, Obesity and Metabolism 2006, 436-447. Sect. 8.
    • (2006) Diabetes, Obesity and Metabolism , pp. 436-447
    • Blonde, L.1    Klein, E.J.2    Han, J.3    Zhang, B.4    Mac, S.M.5    Poon, T.H.6
  • 10
    • 77951436599 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis invitro by modulating elements of the insulin signaling pathway
    • Gupta N.A., Mells J., Dunham R.M., Grakoui A., Handy J., Saxena N.K., et al. Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis invitro by modulating elements of the insulin signaling pathway. Hepatology 2010, 51(5):1584-1592.
    • (2010) Hepatology , vol.51 , Issue.5 , pp. 1584-1592
    • Gupta, N.A.1    Mells, J.2    Dunham, R.M.3    Grakoui, A.4    Handy, J.5    Saxena, N.K.6
  • 12
    • 33644803761 scopus 로고    scopus 로고
    • Obesity pathogenesis; exendin-4, a GLP-1 receptor agonist, reverses hepatic steatosis in ob/ob mice
    • Ding X., Saxena N., Lin S., Gupta N., Anania F. Obesity pathogenesis; exendin-4, a GLP-1 receptor agonist, reverses hepatic steatosis in ob/ob mice. Obesity, Fitness and Wellness Week 2006, 43(1):173-181.
    • (2006) Obesity, Fitness and Wellness Week , vol.43 , Issue.1 , pp. 173-181
    • Ding, X.1    Saxena, N.2    Lin, S.3    Gupta, N.4    Anania, F.5
  • 13
    • 84868307468 scopus 로고    scopus 로고
    • GLP-1 receptor activation inhibits VLDL production and reverses hepatic steatosis by decreasing hepatic lipogenesis in high-fat-fed APOE3-leiden mice
    • Parlevliet E.T., Wang Y., Geerling J.J., Schröder-Van der Elst J.P., Picha K., O'Neil K., et al. GLP-1 receptor activation inhibits VLDL production and reverses hepatic steatosis by decreasing hepatic lipogenesis in high-fat-fed APOE3-leiden mice. PloS One 2012, 7(11):e49152.
    • (2012) PloS One , vol.7 , Issue.11 , pp. e49152
    • Parlevliet, E.T.1    Wang, Y.2    Geerling, J.J.3    Schröder-Van der Elst, J.P.4    Picha, K.5    O'Neil, K.6
  • 14
    • 84871686739 scopus 로고    scopus 로고
    • GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(-/-) mice
    • Panjwani N., Mulvihill E.E., Longuet C., Yusta B., Campbell J.E., Brown T.J., et al. GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(-/-) mice. Endocrinology 2013, 154(1):127.
    • (2013) Endocrinology , vol.154 , Issue.1 , pp. 127
    • Panjwani, N.1    Mulvihill, E.E.2    Longuet, C.3    Yusta, B.4    Campbell, J.E.5    Brown, T.J.6
  • 16
    • 36849040001 scopus 로고    scopus 로고
    • Incretin receptors for glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide are essential for the sustained metabolic actions of vildagliptin in mice
    • Flock G., Baggio L.L., Longuet C., Drucker D.J. Incretin receptors for glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide are essential for the sustained metabolic actions of vildagliptin in mice. Diabetes 2007, 56(12):3006-3013.
    • (2007) Diabetes , vol.56 , Issue.12 , pp. 3006-3013
    • Flock, G.1    Baggio, L.L.2    Longuet, C.3    Drucker, D.J.4
  • 17
    • 0032566004 scopus 로고    scopus 로고
    • Tissue distribution of rat glucagon receptor and GLP-1 receptor gene expression
    • Dunphy J.L., Taylor R.G., Fuller P.J. Tissue distribution of rat glucagon receptor and GLP-1 receptor gene expression. Molecular and Cellular Endocrinology 1998, 141(1-2):179-186.
    • (1998) Molecular and Cellular Endocrinology , vol.141 , Issue.1-2 , pp. 179-186
    • Dunphy, J.L.1    Taylor, R.G.2    Fuller, P.J.3
  • 18
    • 70450235041 scopus 로고    scopus 로고
    • Exendin-4 promotes liver cell proliferation and enhances the PDX-1-induced liver to pancreas transdifferentiation process
    • Aviv V., Meivar-Levy I., Rachmut I.H., Rubinek T., Mor E., Ferber S. Exendin-4 promotes liver cell proliferation and enhances the PDX-1-induced liver to pancreas transdifferentiation process. Journal of Biological Chemistry 2009, 284(48):33509-33520.
    • (2009) Journal of Biological Chemistry , vol.284 , Issue.48 , pp. 33509-33520
    • Aviv, V.1    Meivar-Levy, I.2    Rachmut, I.H.3    Rubinek, T.4    Mor, E.5    Ferber, S.6
  • 19
    • 0031029936 scopus 로고    scopus 로고
    • Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem
    • Larsen P.J., Tang-Christensen M., Holst J.J., Ørskov C. Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem. Neuroscience 1997, 77(1):257-270.
    • (1997) Neuroscience , vol.77 , Issue.1 , pp. 257-270
    • Larsen, P.J.1    Tang-Christensen, M.2    Holst, J.J.3    Ørskov, C.4
  • 20
    • 31044456099 scopus 로고    scopus 로고
    • Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage
    • Knauf C., Cani P.D., Perrin C., Iglesias M.A., Maury J.F., Bernard E., et al. Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage. Journal of Clinical Investigation 2005, 115(12):3554-3563.
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.12 , pp. 3554-3563
    • Knauf, C.1    Cani, P.D.2    Perrin, C.3    Iglesias, M.A.4    Maury, J.F.5    Bernard, E.6
  • 21
    • 65949097938 scopus 로고    scopus 로고
    • Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity
    • Nogueiras R., Perez-Tilve D., Veyrat-Durebex C., Morgan D.A., Varela L., Haynes W.G., et al. Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. Journal of Neuroscience 2009, 29(18):5916.
    • (2009) Journal of Neuroscience , vol.29 , Issue.18 , pp. 5916
    • Nogueiras, R.1    Perez-Tilve, D.2    Veyrat-Durebex, C.3    Morgan, D.A.4    Varela, L.5    Haynes, W.G.6
  • 22
    • 0034708682 scopus 로고    scopus 로고
    • Mechanisms of hepatic very low density lipoprotein overproduction in insulin resistance. evidence for enhanced lipoprotein assembly, reduced intracellular ApoB degradation, and increased microsomal triglyceride transfer protein in a fructose-fed hamster model
    • Taghibiglou C., Carpentier A., Van Iderstine S.C., Chen B., Rudy D., Aiton A., et al. Mechanisms of hepatic very low density lipoprotein overproduction in insulin resistance. evidence for enhanced lipoprotein assembly, reduced intracellular ApoB degradation, and increased microsomal triglyceride transfer protein in a fructose-fed hamster model. Journal of Biological Chemistry 2000, 275(12):8416-8425.
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.12 , pp. 8416-8425
    • Taghibiglou, C.1    Carpentier, A.2    Van Iderstine, S.C.3    Chen, B.4    Rudy, D.5    Aiton, A.6
  • 23
    • 0034004914 scopus 로고    scopus 로고
    • Intracellular mechanisms regulating apoB-containing lipoprotein assembly and secretion in primary hamster hepatocytes
    • Taghibiglou C., Rudy D., Van Iderstine S.C., Aiton A., Cavallo D., Cheung R., et al. Intracellular mechanisms regulating apoB-containing lipoprotein assembly and secretion in primary hamster hepatocytes. Journal of Lipid Research 2000, 41(4):499.
    • (2000) Journal of Lipid Research , vol.41 , Issue.4 , pp. 499
    • Taghibiglou, C.1    Rudy, D.2    Van Iderstine, S.C.3    Aiton, A.4    Cavallo, D.5    Cheung, R.6
  • 25
    • 84861101892 scopus 로고    scopus 로고
    • Glycine normalizes hepatic triglyceride-rich VLDL secretion by triggering the CNS in high-fat fed rats
    • Yue J.T.Y., Mighiu P.I., Naples M., Adeli K., Lam T.K.T. Glycine normalizes hepatic triglyceride-rich VLDL secretion by triggering the CNS in high-fat fed rats. Circulation Research 2012, 110(10):1345-1354.
    • (2012) Circulation Research , vol.110 , Issue.10 , pp. 1345-1354
    • Yue, J.T.Y.1    Mighiu, P.I.2    Naples, M.3    Adeli, K.4    Lam, T.K.T.5
  • 26
    • 84857185142 scopus 로고    scopus 로고
    • Exendin-4 improves steatohepatitis by increasing Sirt1 expression in high-fat diet-induced obese C57BL/6J mice
    • Lee J., Hong S., Chae S.W., Kim D.H., Choi J.H., Bae J.C., et al. Exendin-4 improves steatohepatitis by increasing Sirt1 expression in high-fat diet-induced obese C57BL/6J mice. PloS One 2012, 7(2):e31394.
    • (2012) PloS One , vol.7 , Issue.2 , pp. e31394
    • Lee, J.1    Hong, S.2    Chae, S.W.3    Kim, D.H.4    Choi, J.H.5    Bae, J.C.6
  • 27
    • 67649649953 scopus 로고    scopus 로고
    • Minireview: finding the sweet spot: peripheral versus central glucagon-like peptide 1 action in feeding and glucose homeostasis
    • Williams D.L. Minireview: finding the sweet spot: peripheral versus central glucagon-like peptide 1 action in feeding and glucose homeostasis. Endocrinology 2009, 150(7):2997-3001.
    • (2009) Endocrinology , vol.150 , Issue.7 , pp. 2997-3001
    • Williams, D.L.1
  • 28
    • 0030725291 scopus 로고    scopus 로고
    • Intracellular degradation of newly synthesized apolipoprotein B
    • Yao Z., Tran K., McLeod R.S. Intracellular degradation of newly synthesized apolipoprotein B. Journal of Lipid Research 1997, 38(10):1937.
    • (1997) Journal of Lipid Research , vol.38 , Issue.10 , pp. 1937
    • Yao, Z.1    Tran, K.2    McLeod, R.S.3
  • 29
    • 80053001967 scopus 로고    scopus 로고
    • GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing the unfolded protein response and promoting macroautophagy
    • Sharma S., Mells J.E., Fu P.P., Saxena N.K., Anania F.A. GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing the unfolded protein response and promoting macroautophagy. PLOS One 2011, 6(9).
    • (2011) PLOS One , vol.6 , Issue.9
    • Sharma, S.1    Mells, J.E.2    Fu, P.P.3    Saxena, N.K.4    Anania, F.A.5
  • 30
    • 84862692484 scopus 로고    scopus 로고
    • Linagliptin improves insulin sensitivity and hepatic steatosis in diet-induced obesity
    • Kern M., Klöting N., Niessen H.G., Thomas L., Stiller D., Mark M., et al. Linagliptin improves insulin sensitivity and hepatic steatosis in diet-induced obesity. PloS One 2012, 7(6):e38744.
    • (2012) PloS One , vol.7 , Issue.6 , pp. e38744
    • Kern, M.1    Klöting, N.2    Niessen, H.G.3    Thomas, L.4    Stiller, D.5    Mark, M.6
  • 31
    • 6344226251 scopus 로고    scopus 로고
    • Effect of carbohydrate overfeeding on whole body macronutrient metabolism and expression of lipogenic enzymes in adipose tissue of lean and overweight humans
    • Minehira K., Vega N., Vidal H., Acheson K., Tappy L. Effect of carbohydrate overfeeding on whole body macronutrient metabolism and expression of lipogenic enzymes in adipose tissue of lean and overweight humans. International Journal of Obesity 2004, 28(10):1291-1298.
    • (2004) International Journal of Obesity , vol.28 , Issue.10 , pp. 1291-1298
    • Minehira, K.1    Vega, N.2    Vidal, H.3    Acheson, K.4    Tappy, L.5
  • 32
    • 80052517174 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced bya high-fat diet in nonalcoholic steatohepatitis
    • Svegliati-Baroni G., Saccomanno S., Rychlicki C., Agostinelli L., De Minicis S., Candelaresi C., et al. Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced bya high-fat diet in nonalcoholic steatohepatitis. Liver International 2011, 31(9):1285-1297.
    • (2011) Liver International , vol.31 , Issue.9 , pp. 1285-1297
    • Svegliati-Baroni, G.1    Saccomanno, S.2    Rychlicki, C.3    Agostinelli, L.4    De Minicis, S.5    Candelaresi, C.6
  • 33
    • 84897883235 scopus 로고    scopus 로고
    • Identification and characterization of GLP-1 receptor-expressing cells using a new transgenic mouse model
    • Richards P., Parker H.E., Adriaenssens A.E., Hodgson J.M., Cork S.C., Trapp S., et al. Identification and characterization of GLP-1 receptor-expressing cells using a new transgenic mouse model. Diabetes 2014, 63(4):1224.
    • (2014) Diabetes , vol.63 , Issue.4 , pp. 1224
    • Richards, P.1    Parker, H.E.2    Adriaenssens, A.E.3    Hodgson, J.M.4    Cork, S.C.5    Trapp, S.6
  • 34
    • 84860573203 scopus 로고    scopus 로고
    • Hypothalamic neuropeptide Y (NPY) controls hepatic VLDL-triglyceride secretion in rats via the sympathetic nervous system
    • Bruinstroop E., Pei L., Ackermans M.T., Foppen E., Borgers A.J., Kwakkel J., et al. Hypothalamic neuropeptide Y (NPY) controls hepatic VLDL-triglyceride secretion in rats via the sympathetic nervous system. Diabetes 2012, 61(5):1043.
    • (2012) Diabetes , vol.61 , Issue.5 , pp. 1043
    • Bruinstroop, E.1    Pei, L.2    Ackermans, M.T.3    Foppen, E.4    Borgers, A.J.5    Kwakkel, J.6
  • 35
    • 33846988243 scopus 로고    scopus 로고
    • Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins
    • Lam T.K.T., Gutierrez-Juarez R., Pocai A., Bhanot S., Tso P., Schwartz G.J., et al. Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins. Nature medicine 2007, 13(2):171-180.
    • (2007) Nature medicine , vol.13 , Issue.2 , pp. 171-180
    • Lam, T.K.T.1    Gutierrez-Juarez, R.2    Pocai, A.3    Bhanot, S.4    Tso, P.5    Schwartz, G.J.6
  • 36
    • 57649192347 scopus 로고    scopus 로고
    • Brain glucagon-like peptide-1 regulates arterial blood flow, heart rate, and insulin sensitivity
    • Cabou C., Campistron G., Marsollier N., Leloup C., Cruciani-Guglielmacci C., Pénicaud L., et al. Brain glucagon-like peptide-1 regulates arterial blood flow, heart rate, and insulin sensitivity. Diabetes 2008, 57(10):2577-2587.
    • (2008) Diabetes , vol.57 , Issue.10 , pp. 2577-2587
    • Cabou, C.1    Campistron, G.2    Marsollier, N.3    Leloup, C.4    Cruciani-Guglielmacci, C.5    Pénicaud, L.6
  • 37
    • 34748898831 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats
    • Vahl T.P., Tauchi M., Durler T.S., Elfers E.E., Fernandes T.M., Bitner R.D., et al. Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats. Endocrinology 2007, 148(10):4965-4973.
    • (2007) Endocrinology , vol.148 , Issue.10 , pp. 4965-4973
    • Vahl, T.P.1    Tauchi, M.2    Durler, T.S.3    Elfers, E.E.4    Fernandes, T.M.5    Bitner, R.D.6
  • 38
    • 41349098117 scopus 로고    scopus 로고
    • An albumin-exendin-4 conjugate engages central and peripheral circuits regulating murine energy and glucose homeostasis
    • Baggio L.L., Huang Q., Cao X., Drucker D.J. An albumin-exendin-4 conjugate engages central and peripheral circuits regulating murine energy and glucose homeostasis. Gastroenterology 2008, 134(4):1137-1147.
    • (2008) Gastroenterology , vol.134 , Issue.4 , pp. 1137-1147
    • Baggio, L.L.1    Huang, Q.2    Cao, X.3    Drucker, D.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.