Perilipin discerns chronic from acute hepatocellular steatosis

Journal of Hepatology

Volumn 60, Issue 3, 2014, Pages 633-642

  Pawella, Lena Maria ^a   Hashani, Merita ^a   Eiteneuer, Eva ^a   Renner, Marcus ^a   Bartenschlager, Ralf ^b   Schirmacher, Peter ^a   Straub, Beate Katharina ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b Department for Infectious Diseases   (Germany)

Author keywords

Adipophilin; Lipid droplet; MLDP; PAT protein family; Steatohepatitis; TIP47

Indexed keywords

CARRIER PROTEIN; MEMBRANE PROTEIN; PERILIPIN 1; PERILIPIN 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHOPROTEIN; PLIN3 PROTEIN, HUMAN; VESICULAR TRANSPORT PROTEIN;

ACUTE DISEASE; CELL CULTURE; CHRONIC DISEASE; FATTY LIVER; HUMAN; LIPOLYSIS; LIVER TRANSPLANTATION; METABOLISM; PHYSIOLOGY;

ACUTE DISEASE; CARRIER PROTEINS; CELLS, CULTURED; CHRONIC DISEASE; FATTY LIVER; HUMANS; LIPOLYSIS; LIVER TRANSPLANTATION; MEMBRANE PROTEINS; PHOSPHOPROTEINS; PPAR ALPHA; PPAR GAMMA; VESICULAR TRANSPORT PROTEINS;

EID: 84894104800     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2013.11.007     Document Type: Article

References (43)

1. B.Q. Starley, C.J. Calcagno, and S.A. Harrison Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection Hepatology 51 2010 1820 1832
2. S. Martin, and R.G. Parton Lipid droplets: a unified view of a dynamic organelle Nat Rev Mol Cell Biol 7 2006 373 378
3. A.R. Kimmel, D.L. Brasaemle, M. McAndrews-Hill, C. Sztalryd, and C. Londos Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins J Lipid Res 51 2010 468 471
4. A.S. Greenberg, J.J. Egan, S.A. Wek, N.B. Garty, E.J. Blanchette-Mackie, and C. Londos Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets J Biol Chem 266 1991 11341 11346
5. H.W. Heid, R. Moll, I. Schwetlick, H.R. Rackwitz, and T.W. Keenan Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases Cell Tissue Res 294 1998 309 321
6. N.E. Wolins, B. Rubin, and D.L. Brasaemle TIP47 associates with lipid droplets J Biol Chem 276 2001 5101 5108
7. N.E. Wolins, J.R. Skinner, M.J. Schoenfish, A. Tzekov, K.G. Bensch, and P.E. Bickel Adipocyte protein S3-12 coats nascent lipid droplets J Biol Chem 278 2003 37713 37721
8. T. Yamaguchi, S. Matsushita, K. Motojima, F. Hirose, and T. Osumi MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-activated receptor alpha J Biol Chem 281 2006 14232 14240
9. P.E. Bickel, J.T. Tansey, and M.A. Welte PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores Biochim Biophys Acta 1791 2009 419 440
10. W.J. Shen, S. Patel, H. Miyoshi, A.S. Greenberg, and F.B. Kraemer Functional interaction of hormone-sensitive lipase and perilipin in lipolysis J Lipid Res 50 2009 2306 2313
11. J.T. Tansey, C. Sztalryd, J. Gruia-Gray, D.L. Roush, J.V. Zee, and O. Gavrilova et al. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity Proc Natl Acad Sci U S A 98 2001 6494 6499
12. J. Martinez-Botas, J.B. Anderson, D. Tessier, A. Lapillonne, B.H. Chang, and M.J. Quast et al. Absence of perilipin results in leanness and reverses obesity in Lepr(db/db) mice Nat Genet 26 2000 474 479
13. B.H. Chang, L. Li, A. Paul, S. Taniguchi, V. Nannegari, and W.C. Heird et al. Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation-related protein Mol Cell Biol 26 2006 1063 1076
14. Y. Imai, G.M. Varela, M.B. Jackson, M.J. Graham, R.M. Crooke, and R.S. Ahima Reduction of hepatosteatosis and lipid levels by an adipose differentiation-related protein antisense oligonucleotide Gastroenterology 132 2007 1947 1954
15. S. Gandotra, C. Le Dour, W. Bottomley, P. Cervera, P. Giral, and Y. Reznik et al. Perilipin deficiency and autosomal dominant partial lipodystrophy N Engl J Med 364 2011 740 748
16. B.K. Straub, P. Stoeffel, H. Heid, R. Zimbelmann, and P. Schirmacher Differential pattern of lipid droplet-associated proteins and de novo perilipin expression in hepatocyte steatogenesis Hepatology 47 2008 1936 1946
17. B.K. Straub, E. Herpel, S. Singer, R. Zimbelmann, K. Breuhahn, and S. Macher-Goeppinger et al. Lipid droplet-associated PAT-proteins show frequent and differential expression in neoplastic steatogenesis Mod Pathol 23 2010 480 492
18. L.M. Pawella, M. Hashani, P. Schirmacher, and B.K. Straub Lipid droplet-associated proteins in steatosis. Effects of induction and siRNA-mediated downregulation of PAT proteins in cell culture models of hepatocyte steatosis Pathologe 31 2010 126 131
19. A.M. Hall, E.M. Brunt, Z. Chen, N. Viswakarma, J.K. Reddy, and N.E. Wolins et al. Dynamic and differential regulation of proteins that coat lipid droplets in fatty liver dystrophic mice J Lipid Res 51 2010 554 563
20. D.J. Orlicky, J.R. Roede, E. Bales, C. Greenwood, A. Greenberg, and D. Petersen et al. Chronic ethanol consumption in mice alters hepatocyte lipid droplet properties Alcohol Clin Exp Res 35 2011 1020 1033
21. B. Sainz Jr., and F.V. Chisari Production of infectious hepatitis C virus by well-differentiated, growth-arrested human hepatoma-derived cells J Virol 80 2006 10253 10257
22. E.M. Eaton, M. Hanlon, L. Bundy, and L. Sealy Characterization of C/EBPbeta isoforms in normal vs. neoplastic mammary epithelial cells J Cell Physiol 189 2001 91 105
23. J.B. Ferrini, E. Rodrigues, V. Dulic, L. Pichard-Garcia, J.M. Fabr, and P. Blanc et al. Expression and DNA-binding activity of C/EBPalpha and C/EBPbeta in human liver and differentiated primary hepatocytes J Hepatol 35 2001 170 177
24. H. Fujii, Y. Ikura, J. Arimoto, K. Sugioka, J.C. Iezzoni, and S.H. Park et al. Expression of perilipin and adipophilin in nonalcoholic fatty liver disease; relevance to oxidative injury and hepatocyte ballooning J Atheroscler Thromb 16 2009 893 901
25. B.K. Straub, B. Gyoengyoesi, M. Koenig, M. Hashani, L.M. Pawella, and E. Herpel et al. Adipophilin/perilipin-2 as a lipid droplet-specific marker for metabolically active cells and diseases associated with metabolic dysregulation Histopathology 62 2013 617 631
26. N.E. Wolins, D.L. Brasaemle, and P.E. Bickel A proposed model of fat packaging by exchangeable lipid droplet proteins FEBS Lett 580 2006 5484 5491
27. D.L. Brasaemle, and N.E. Wolins Packaging of fat: an evolving model of lipid droplet assembly and expansion J Biol Chem 287 2012 2273 2279
28. N. Arimura, T. Horiba, M. Imagawa, M. Shimizu, and R. Sato The peroxisome proliferator-activated receptor gamma regulates expression of the perilipin gene in adipocytes J Biol Chem 279 2004 10070 10076
29. E. Hondares, M. Rosell, J. Diaz-Delfin, Y. Olmos, M. Monsalve, and R. Iglesias et al. Peroxisome proliferator-activated receptor alpha (PPARalpha) induces PPARgamma coactivator 1alpha (PGC-1alpha) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16 J Biol Chem 286 2011 43112 43122
30. A.M. Hall, E.M. Brunt, S. Klein, and B.N. Finck Hepatic expression of cell death-inducing DFFA-like effector C in obese subjects is reduced by marked weight loss Obesity (Silver Spring) 18 2010 417 419
31. R.J. Flach, H. Qin, L. Zhang, and A.M. Bennett Loss of mitogen-activated protein kinase phosphatase-1 protects from hepatic steatosis by repression of cell death-inducing DNA fragmentation factor A (DFFA)-like effector C (CIDEC)/fat-specific protein 27 J Biol Chem 286 2011 22195 22202
32. E. Moran-Salvador, M. Lopez-Parra, V. Garcia-Alonso, E. Titos, M. Martinez-Clemente, and A. Gonzalez-Periz et al. Role for PPARgamma in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts FASEB J 25 2011 2538 2550
33. M.A. Abdelmegeed, S.H. Yoo, L.E. Henderson, F.J. Gonzalez, K.J. Woodcroft, and B.J. Song PPARalpha expression protects male mice from high fat-induced nonalcoholic fatty liver J Nutr 141 2011 603 610
34. Z. Wu, Y. Xie, N.L. Bucher, and S.R. Farmer Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis Genes Dev 9 1995 2350 2363
35. D.P. Ramji, and P. Foka CCAAT/enhancer-binding proteins: structure, function and regulation Biochem J 365 2002 561 575
36. J.M. Schroeder-Gloeckler, S.M. Rahman, R.C. Janssen, L. Qiao, J. Shao, and M. Roper et al. CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice J Biol Chem 282 2007 15717 15729
37. I. Isom, I. Georgoff, M. Salditt-Georgieff, and J.E. Darnell Jr. Persistence of liver-specific messenger RNA in cultured hepatocytes: different regulatory events for different genes J Cell Biol 105 1987 2877 2885
38. M. Iwatani, K. Ikegami, Y. Kremenska, N. Hattori, S. Tanaka, and S. Yagi et al. Dimethyl sulfoxide has an impact on epigenetic profile in mouse embryoid body Stem Cells 24 2006 2549 2556
39. D.L. Brasaemle, T. Barber, A.R. Kimmel, and C. Londos Post-translational regulation of perilipin expression. Stabilization by stored intracellular neutral lipids J Biol Chem 272 1997 9378 9387
40. K. Hsieh, Y.K. Lee, C. Londos, B.M. Raaka, K.T. Dalen, and A.R. Kimmel Perilipin family members preferentially sequester to either triacylglycerol- or cholesteryl ester-specific intracellular lipid storage droplets J Cell Sci 125 2012 4067 4076
41. C. Sztalryd, M. Bell, X. Lu, P. Mertz, S. Hickenbottom, and B.H. Chang et al. Functional compensation for adipose differentiation-related protein (ADFP) by Tip47 in an ADFP null embryonic cell line J Biol Chem 281 2006 34341 34348
42. R.M. Carr, R.T. Patel, V. Rao, R. Dhir, M.J. Graham, and R.M. Crooke et al. Reduction of TIP47 improves hepatic steatosis and glucose homeostasis in mice Am J Physiol Regul Integr Comp Physiol 302 2012 R996 1003
43. B.A. Neuschwander-Tetri, E.M. Brunt, K.R. Wehmeier, D. Oliver, and B.R. Bacon Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone Hepatology 38 2003 1008 1017