메뉴 건너뛰기




Volumn 17, Issue 1, 2016, Pages 206-220

Rapid and Efficient Generation of Regulatory T Cells to Commensal Antigens in the Periphery

Author keywords

CNS1 Foxp3; commensal microbiota; Notch2 dependent dendritic cells; peripheral regulatory T cells; pTreg; TGF

Indexed keywords

COMMENSAL ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; LYMPHOCYTE ANTIGEN; NOTCH2 RECEPTOR; PROTEIN BATF3; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; BACTERIAL ANTIGEN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; NOTCH2 PROTEIN, MOUSE;

EID: 84989919497     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.08.092     Document Type: Article
Times cited : (112)

References (55)
  • 1
    • 80052287274 scopus 로고    scopus 로고
    • Helios expression is a marker of T cell activation and proliferation
    • Akimova, T., Beier, U.H., Wang, L., Levine, M.H., Hancock, W.W., Helios expression is a marker of T cell activation and proliferation. PLoS ONE, 6, 2011, e24226.
    • (2011) PLoS ONE , vol.6 , pp. e24226
    • Akimova, T.1    Beier, U.H.2    Wang, L.3    Levine, M.H.4    Hancock, W.W.5
  • 5
    • 84897138296 scopus 로고    scopus 로고
    • Role of the microbiota in immunity and inflammation
    • Belkaid, Y., Hand, T.W., Role of the microbiota in immunity and inflammation. Cell 157 (2014), 121–141.
    • (2014) Cell , vol.157 , pp. 121-141
    • Belkaid, Y.1    Hand, T.W.2
  • 7
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+ CD25- naive T cells to CD4+ CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen, W., Jin, W., Hardegen, N., Lei, K.-j., Li, L., Marinos, N., McGrady, G., Wahl, S.M., Conversion of peripheral CD4+ CD25- naive T cells to CD4+ CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 198 (2003), 1875–1886.
    • (2003) J. Exp. Med. , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.-J.4    Li, L.5    Marinos, N.6    McGrady, G.7    Wahl, S.M.8
  • 8
    • 34547788180 scopus 로고    scopus 로고
    • A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    • Coombes, J.L., Siddiqui, K.R., Arancibia-Carcamo, C.V., Hall, J., Sun, C.M., Belkaid, Y., Powrie, F., A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J. Exp. Med. 204 (2007), 1757–1764.
    • (2007) J. Exp. Med. , vol.204 , pp. 1757-1764
    • Coombes, J.L.1    Siddiqui, K.R.2    Arancibia-Carcamo, C.V.3    Hall, J.4    Sun, C.M.5    Belkaid, Y.6    Powrie, F.7
  • 9
    • 84877044311 scopus 로고    scopus 로고
    • Role of secretory IgA in infection and maintenance of homeostasis
    • Corthesy, B., Role of secretory IgA in infection and maintenance of homeostasis. Autoimmun. Rev. 12 (2013), 661–665.
    • (2013) Autoimmun. Rev. , vol.12 , pp. 661-665
    • Corthesy, B.1
  • 10
    • 84863872794 scopus 로고    scopus 로고
    • Host-microbiota interactions in inflammatory bowel disease
    • Elson, C.O., Cong, Y., Host-microbiota interactions in inflammatory bowel disease. Gut Microbes 3 (2012), 332–344.
    • (2012) Gut Microbes , vol.3 , pp. 332-344
    • Elson, C.O.1    Cong, Y.2
  • 14
    • 0034131557 scopus 로고    scopus 로고
    • Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease
    • Gorelik, L., Flavell, R.A., Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity 12 (2000), 171–181.
    • (2000) Immunity , vol.12 , pp. 171-181
    • Gorelik, L.1    Flavell, R.A.2
  • 15
    • 77955391804 scopus 로고    scopus 로고
    • TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo
    • Gottschalk, R.A., Corse, E., Allison, J.P., TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo. J. Exp. Med. 207 (2010), 1701–1711.
    • (2010) J. Exp. Med. , vol.207 , pp. 1701-1711
    • Gottschalk, R.A.1    Corse, E.2    Allison, J.P.3
  • 16
    • 84856567623 scopus 로고    scopus 로고
    • Expression of Helios in peripherally induced Foxp3+ regulatory T cells
    • Gottschalk, R.A., Corse, E., Allison, J.P., Expression of Helios in peripherally induced Foxp3+ regulatory T cells. J. Immunol. 188 (2012), 976–980.
    • (2012) J. Immunol. , vol.188 , pp. 976-980
    • Gottschalk, R.A.1    Corse, E.2    Allison, J.P.3
  • 23
    • 84879124602 scopus 로고    scopus 로고
    • Truncated form of TGF-betaRII, but not its absence, induces memory CD8+ T cell expansion and lymphoproliferative disorder in mice
    • Ishigame, H., Mosaheb, M.M., Sanjabi, S., Flavell, R.A., Truncated form of TGF-betaRII, but not its absence, induces memory CD8+ T cell expansion and lymphoproliferative disorder in mice. J. Immunol. 190 (2013), 6340–6350.
    • (2013) J. Immunol. , vol.190 , pp. 6340-6350
    • Ishigame, H.1    Mosaheb, M.M.2    Sanjabi, S.3    Flavell, R.A.4
  • 28
    • 84922600148 scopus 로고    scopus 로고
    • Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon
    • Knoop, K.A., McDonald, K.G., McCrate, S., McDole, J.R., Newberry, R.D., Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon. Mucosal Immunol. 8 (2015), 198–210.
    • (2015) Mucosal Immunol. , vol.8 , pp. 198-210
    • Knoop, K.A.1    McDonald, K.G.2    McCrate, S.3    McDole, J.R.4    Newberry, R.D.5
  • 29
    • 80755175886 scopus 로고    scopus 로고
    • Balancing acts: the role of TGF-beta in the mucosal immune system
    • Konkel, J.E., Chen, W., Balancing acts: the role of TGF-beta in the mucosal immune system. Trends Mol. Med. 17 (2011), 668–676.
    • (2011) Trends Mol. Med. , vol.17 , pp. 668-676
    • Konkel, J.E.1    Chen, W.2
  • 32
    • 70350440009 scopus 로고    scopus 로고
    • TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes
    • Leung, M.W., Shen, S., Lafaille, J.J., TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes. J. Exp. Med. 206 (2009), 2121–2130.
    • (2009) J. Exp. Med. , vol.206 , pp. 2121-2130
    • Leung, M.W.1    Shen, S.2    Lafaille, J.J.3
  • 35
    • 79959271087 scopus 로고    scopus 로고
    • Intestinal homeostasis and its breakdown in inflammatory bowel disease
    • Maloy, K.J., Powrie, F., Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature 474 (2011), 298–306.
    • (2011) Nature , vol.474 , pp. 298-306
    • Maloy, K.J.1    Powrie, F.2
  • 36
    • 17144400393 scopus 로고    scopus 로고
    • TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells
    • Marie, J.C., Letterio, J.J., Gavin, M., Rudensky, A.Y., TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells. J. Exp. Med. 201 (2005), 1061–1067.
    • (2005) J. Exp. Med. , vol.201 , pp. 1061-1067
    • Marie, J.C.1    Letterio, J.J.2    Gavin, M.3    Rudensky, A.Y.4
  • 37
    • 34548131112 scopus 로고    scopus 로고
    • Regulatory T cells expressing interleukin 10 develop from Foxp3(+) and Foxp3(-) precursor cells in the absence of interleukin 10
    • Maynard, C.L., Harrington, L.E., Janowski, K.M., Oliver, J.R., Zindl, C.L., Rudensky, A.Y., Weaver, C.T., Regulatory T cells expressing interleukin 10 develop from Foxp3(+) and Foxp3(-) precursor cells in the absence of interleukin 10. Nat. Immunol. 8 (2007), 931–941.
    • (2007) Nat. Immunol. , vol.8 , pp. 931-941
    • Maynard, C.L.1    Harrington, L.E.2    Janowski, K.M.3    Oliver, J.R.4    Zindl, C.L.5    Rudensky, A.Y.6    Weaver, C.T.7
  • 39
    • 79958251745 scopus 로고    scopus 로고
    • T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
    • Moran, A.E., Holzapfel, K.L., Xing, Y., Cunningham, N.R., Maltzman, J.S., Punt, J., Hogquist, K.A., T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J. Exp. Med. 208 (2011), 1279–1289.
    • (2011) J. Exp. Med. , vol.208 , pp. 1279-1289
    • Moran, A.E.1    Holzapfel, K.L.2    Xing, Y.3    Cunningham, N.R.4    Maltzman, J.S.5    Punt, J.6    Hogquist, K.A.7
  • 40
    • 84921786777 scopus 로고    scopus 로고
    • Regional specialization within the intestinal immune system
    • Mowat, A.M., Agace, W.W., Regional specialization within the intestinal immune system. Nat. Rev. Immunol. 14 (2014), 667–685.
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 667-685
    • Mowat, A.M.1    Agace, W.W.2
  • 43
    • 35848931007 scopus 로고    scopus 로고
    • IgA response to symbiotic bacteria as a mediator of gut homeostasis
    • Peterson, D.A., McNulty, N.P., Guruge, J.L., Gordon, J.I., IgA response to symbiotic bacteria as a mediator of gut homeostasis. Cell Host Microbe 2 (2007), 328–339.
    • (2007) Cell Host Microbe , vol.2 , pp. 328-339
    • Peterson, D.A.1    McNulty, N.P.2    Guruge, J.L.3    Gordon, J.I.4
  • 44
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
    • Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., Medzhitov, R., Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118 (2004), 229–241.
    • (2004) Cell , vol.118 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3    Edberg, S.4    Medzhitov, R.5
  • 45
    • 84883172356 scopus 로고    scopus 로고
    • Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens
    • Satpathy, A.T., Briseno, C.G., Lee, J.S., Ng, D., Manieri, N.A., Kc, W., Wu, X., Thomas, S.R., Lee, W.L., Turkoz, M., et al. Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nat. Immunol. 14 (2013), 937–948.
    • (2013) Nat. Immunol. , vol.14 , pp. 937-948
    • Satpathy, A.T.1    Briseno, C.G.2    Lee, J.S.3    Ng, D.4    Manieri, N.A.5    Kc, W.6    Wu, X.7    Thomas, S.R.8    Lee, W.L.9    Turkoz, M.10
  • 46
    • 84866403123 scopus 로고    scopus 로고
    • Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut
    • Schlenner, S.M., Weigmann, B., Ruan, Q., Chen, Y., von Boehmer, H., Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut. J. Exp. Med. 209 (2012), 1529–1535.
    • (2012) J. Exp. Med. , vol.209 , pp. 1529-1535
    • Schlenner, S.M.1    Weigmann, B.2    Ruan, Q.3    Chen, Y.4    von Boehmer, H.5
  • 49
    • 34547757390 scopus 로고    scopus 로고
    • Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    • Sun, C.M., Hall, J.A., Blank, R.B., Bouladoux, N., Oukka, M., Mora, J.R., Belkaid, Y., Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J. Exp. Med. 204 (2007), 1775–1785.
    • (2007) J. Exp. Med. , vol.204 , pp. 1775-1785
    • Sun, C.M.1    Hall, J.A.2    Blank, R.B.3    Bouladoux, N.4    Oukka, M.5    Mora, J.R.6    Belkaid, Y.7
  • 51
    • 84927587431 scopus 로고    scopus 로고
    • Distinct modes of antigen presentation promote the formation, differentiation, and activity of foxp3+ regulatory T cells in vivo
    • Weissler, K.A., Garcia, V., Kropf, E., Aitken, M., Bedoya, F., Wolf, A.I., Erikson, J., Caton, A.J., Distinct modes of antigen presentation promote the formation, differentiation, and activity of foxp3+ regulatory T cells in vivo. J. Immunol. 194 (2015), 3784–3797.
    • (2015) J. Immunol. , vol.194 , pp. 3784-3797
    • Weissler, K.A.1    Garcia, V.2    Kropf, E.3    Aitken, M.4    Bedoya, F.5    Wolf, A.I.6    Erikson, J.7    Caton, A.J.8
  • 52
    • 84885447087 scopus 로고    scopus 로고
    • Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism
    • Welty, N.E., Staley, C., Ghilardi, N., Sadowsky, M.J., Igyarto, B.Z., Kaplan, D.H., Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism. J. Exp. Med. 210 (2013), 2011–2024.
    • (2013) J. Exp. Med. , vol.210 , pp. 2011-2024
    • Welty, N.E.1    Staley, C.2    Ghilardi, N.3    Sadowsky, M.J.4    Igyarto, B.Z.5    Kaplan, D.H.6
  • 53
    • 33645054315 scopus 로고    scopus 로고
    • Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells
    • Worbs, T., Bode, U., Yan, S., Hoffmann, M.W., Hintzen, G., Bernhardt, G., Forster, R., Pabst, O., Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells. J. Exp. Med. 203 (2006), 519–527.
    • (2006) J. Exp. Med. , vol.203 , pp. 519-527
    • Worbs, T.1    Bode, U.2    Yan, S.3    Hoffmann, M.W.4    Hintzen, G.5    Bernhardt, G.6    Forster, R.7    Pabst, O.8
  • 55
    • 76749133610 scopus 로고    scopus 로고
    • Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
    • Zheng, Y., Josefowicz, S., Chaudhry, A., Peng, X.P., Forbush, K., Rudensky, A.Y., Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 463 (2010), 808–812.
    • (2010) Nature , vol.463 , pp. 808-812
    • Zheng, Y.1    Josefowicz, S.2    Chaudhry, A.3    Peng, X.P.4    Forbush, K.5    Rudensky, A.Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.