MALT1 Protease Activation Triggers Acute Disruption of Endothelial Barrier Integrity via CYLD Cleavage

Cell Reports

Volumn 17, Issue 1, 2016, Pages 221-232

  Klei, Linda R ^a   Hu, Dong ^a   Panek, Robert ^b   Alfano, Danielle N ^a   Bridwell, Rachel E ^a   Bailey, Kelly M ^b   Oravecz Wilson, Katherine I ^b   Concel, Vincent J ^a   Hess, Emily M ^a   Van Beek, Matthew ^b   Delekta, Phillip C ^b   Gu, Shufang ^b   Watkins, Simon C ^a   Ting, Adrian T ^c   Gough, Peter J ^d   Foley, Kevin P ^d   Bertin, John ^d   McAllister Lucas, Linda M ^a,e   Lucas, Peter C ^a,e  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d GLAXOSMITHKLINE   (United States)

^e UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Bcl10; CARD10; CARMA3; CYLD; endothelial permeability; G protein coupled receptor (GPCR); MALT1 protease; NF B; Protease activated receptor 1 (PAR1); thrombin

Indexed keywords

CYLD PROTEIN; DEUBIQUITINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MALT1 PROTEIN; PROTEINASE; THROMBIN; UNCLASSIFIED DRUG; CARD10 PROTEIN, MOUSE; CASPASE; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; CYLD PROTEIN, MOUSE; CYSTEINE PROTEINASE; I KAPPA B KINASE; MALT1 PROTEIN, MOUSE; PROTEINASE ACTIVATED RECEPTOR 1; TUMOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CYTOLOGY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; INFLAMMATION; LYMPHOCYTE; MEMBRANE DAMAGE; MICROTUBULE; MOUSE; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; PERMEABILITY; PRIMARY CELL CULTURE; TRANSGENIC MOUSE; TRANSPORT AT THE CELLULAR LEVEL; ULTRASTRUCTURE;

ANIMALS; BIOLOGICAL TRANSPORT; CARD SIGNALING ADAPTOR PROTEINS; CASPASES; CELL LINE; CYSTEINE ENDOPEPTIDASES; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; I-KAPPA B KINASE; MICE; MICE, TRANSGENIC; MICROTUBULES; NEOPLASM PROTEINS; NF-KAPPA B; PERMEABILITY; PRIMARY CELL CULTURE; RECEPTOR, PAR-1; SIGNAL TRANSDUCTION; THROMBIN;

EID: 84989917883     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.08.080     Document Type: Article

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