Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton

Nature Cell Biology

Volumn 4, Issue 4, 2002, Pages 294-301

  Krendel, Mira ^a   Zenke, Frank T ^b   Bokoch, Gary M ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b MERCK KGAA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MUTANT PROTEIN; RHO FACTOR;

ANIMAL CELL; ARTICLE; CELL INTERACTION; CELL STRUCTURE; CONTROLLED STUDY; CYTOARCHITECTURE; CYTOSKELETON; DEPOLYMERIZATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MICROTUBULE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; REGULATORY MECHANISM;

ACTINS; ANIMALS; CDC42 GTP-BINDING PROTEIN; COS CELLS; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GENES, REPORTER; GUANINE NUCLEOTIDE EXCHANGE FACTORS; GUANINE NUCLEOTIDES; HELA CELLS; HUMANS; MICROSCOPY, FLUORESCENCE; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; MODELS, GENETIC; PLASMIDS; PRECIPITIN TESTS; PROTEIN STRUCTURE, TERTIARY; RAC1 GTP-BINDING PROTEIN; RAS GTPASE-ACTIVATING PROTEINS; RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS; RHOA GTP-BINDING PROTEIN; TIME FACTORS; TRANSFECTION;

ANIMALIA;

EID: 0036228955     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb773     Document Type: Article

References (31)

1. Effect of colcemid on the locomotory behaviour of fibroblasts
2. Pseudopodial activity at the active edge of migrating fibroblast is decreased after drug-induced microtubule depolymerization
3. Low concentrations of nocodazole interfere with fibroblast locomotion without significantly affecting microtubule level: Implications for the role of dynamic microtubules in cell locomotion
4. Fibroblast contractility and actin organization are stimulated by microtubule inhibitors
5. Cell motility: Can Rho GTPases and microtubules point the way?
6. Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts
7. Microtubule disruption induces the formation of actin stress fibres and focal adhesions in cultured cells: Possible involvement of the rho signal cascade
8. Microtubule depolymerization induces stress fibres, focal adhesions, and DNA synthesis via the GTP-binding protein Rho
9. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
10. Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases
11. The Dbl-related protein, Lfc, localizes to microtubules and mediates the activation of Rac signalling pathways in cells
12. Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules
13. Targeting histone deacetylase complexes via KRAB-zinc finger proteins: The PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2α subunit of NuRD
14. Analysis of MAP 4 function in living cells using green fluorescent protein (GFP) chimeras
15. Posttranslational modifications of α tubulin: Detyrosination and acetylation differentiate populations of interphase microtubules in cultured cells
16. Rho guanosine triphosphatase mediates the selective stabilization of microtubules induced by lysophosphatidic acid
17. Activation of the Lbc Rho exchange factor proto-oncogene by truncation of an extended C terminus that regulates transformation and targeting
18. Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway
19. Timing of cyclin D1 expression within G1 phase is controlled by Rho
20. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
21. Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases
22. The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF
23. Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Gα13
24. A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho
25. Lfc and Lsc oncoproteins represent two new guanine nucleotide exchange factors for the Rho GTP-binding protein
26. Microtubule-actomyosin interactions in cortical flow and cytokinesis
27. A requirement for Rho and Cdc42 during cytokinesis in Xenopus embryos
28. The small GTP-binding protein rho regulates cortical activities in cultured cells during division
29. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro
30. p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1)
31. Measurement of nucleotide exchange and hydrolysis activities in immunoprecipitates