Development of new Malt1 inhibitors and probes

Bioorganic and Medicinal Chemistry

Volumn 24, Issue 15, 2016, Pages 3312-3329

  Xin, Bo Tao ^a   Schimmack, Gisela ^b   Du, Yimeng ^a   Florea, Bogdan I ^a   van der Marel, Gijsbert A ^a   Driessen, Christoph ^c   Krappmann, Daniel ^b   Overkleeft, Herman S ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c CANTONAL HOSPITAL ST GALLEN   (Switzerland)

Author keywords

Activity based protein profiling; Lymphoma; Malt1; Malt1 inhibitors; Mechanism based inhibitor

Indexed keywords

1 [6 [[2 [[1 [4 (2 CHLOROACETAMIDO)PHENYL] 5 (3,4 DICHLOROPHENYL) 1H 1,2,4 TRIAZOL 3 YL]OXY]ETHYL]AMINO] 6 OXOHEXYL] 3,3 DIMETHYL 2 [5 (1,3,3 TRIMETHYLINDOLIN 2 YLIDENE)PENTA 1,3 DIEN 1 YL] 3H INDOL 1 IUM CHLORIDE; 1 [[6 [4 [4 [5,5 DIFLUORO 3,7 BIS(4 METHOXYPHENYL) 5H 4L4,5L4 DIPYRROLO[1,2 C:20,10 F][1,3,2]DIAZABORININ 10 YL]BUTYL] 1H 1,2,3 TRIAZOL 1 YL]HEXANOYL] LEVO VALYL LEVO ARGINYL] N (1 FLUORO 6 GUANIDIN 2 OXOHEXAN 3 YL)PYRROLIDINE 2 CARBOXAMIDE; 2 CHLORO N [4 [3 (2 METHOXYETHOXY) 5 (3 METHOXYPHENYL) 1H 1,2,4 TRIAZOL 1 YL]PHENYL]ACETAMIDE; 2 CHLORO N [4 [3 (2 METHOXYETHOXY) 5 (3 TOLYL) 1H 1,2,4 TRIAZOL 1 YL]PHENYL]ACETAMIDE; 2 CHLORO N [4 [3 (2 METHOXYETHOXY) 5 (4 METHOXYPHENYL) 1H 1,2,4 TRIAZOL 1 YL]PHENYL]ACETAMIDE; 2 CHLORO N [4 [3 (2 METHOXYETHOXY) 5 (4 TOLYL) 1H 1,2,4 TRIAZOL 1 YL]PHENYL]ACETAMIDE; 2 CHLORO N [4 [3 (2 METHOXYETHOXY) 5 PHENYL 1H 1,2,4 TRIAZOL 1 YL]PHENYL]ACETAMIDE; 2 CHLORO N [4 [3 (2 METHOXYETHOXY) 5 [3 (TRIFLUOROMETHYL)PHENYL] 1H 1,2,4 TRIAZOL 1 YL]PHENYL]ACETAMIDE; 2 CHLORO N [4 [3 (2 METHOXYETHOXY) 5 [4 (TRIFLUOROMETHYL)PHENYL] 1H 1,2,4 TRIAZOL 1 YL]PHENYL]ACETAMIDE; 2 CHLORO N [4 [5 (3 CHLOROPHENYL) 3 (2 METHOXYETHOXY) 1H 1,2,4 TRIAZOL 1 YL]PHENYL]ACETAMIDE; 2 CHLORO N [4 [5 (3 FLUOROPHENYL) 3 (2 METHOXYETHOXY) 1H 1,2,4 TRIAZOL 1 YL]PHENYL]ACETAMIDE; 2 CHLORO N [4 [5 (3,4 DIFLUOROPHENYL) 3 (2 METHOXYETHOXY) 1H 1,2,4 TRIAZOL 1 YL]PHENYL]ACETAMIDE; 2 CHLORO N [4 [5 (3,4 DIMETHOXYPHENYL) 3 (2 METHOXYETHOXY) 1H 1,2,4 TRIAZOL 1 YL]PHENYL]ACETAMIDE; 2 CHLORO N [4 [5 (3,4 DIMETHYLPHENYL) 3 (2 METHOXYETHOXY) 1H 1,2,4 TRIAZOL 1 YL]PHENYL]ACETAMIDE; 2 CHLORO N [4 [5 (4 CHLOROPHENYL) 3 (2 METHOXYETHOXY) 1H 1,2,4 TRIAZOL 1 YL]PHENYL]ACETAMIDE; 2 CHLORO N [4 [5 (4 FLUOROPHENYL) 3 (2 METHOXYETHOXY) 1H 1,2,4 TRIAZOL 1 YL]PHENYL]ACETAMIDE; ACETAMIDE DERIVATIVE; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1; N [4 [5 (3 BROMOPHENYL) 3 (2 METHOXYETHOXY) 1H 1,2,4 TRIAZOL 1 YL]PHENYL] 2 CHLOROACETAMIDE; N [4 [5 (3,4 DICHLOROPHENYL) 3 (2 METHOXYETHOXY) 1H 1,2,4 TRIAZOL 1 YL]PHENYL]ACRYLAMIDE; N [4 [5 (4 BROMOPHENYL) 3 (2 METHOXYETHOXY) 1H 1,2,4 TRIAZOL 1 YL]PHENYL] 2 CHLOROACETAMIDE; N [4 [5 (BENZO[D][1,3]DIOXOL 5 YL) 3 (2 METHOXYETHOXY) 1H 1,2,4 TRIAZOL 1 YL]PHENYL] 2 CHLOROACETAMIDE; N [4 [5 [(1,10 BIPHENYL) 4 YL] 3 (2 METHOXYETHOXY) 1H 1,2,4 TRIAZOL 1 YL]PHENYL] 2 CHLOROACETAMIDE; PROTEINASE; REAGENT; UNCLASSIFIED DRUG; CARBAMIC ACID DERIVATIVE; CASPASE; CASPASE INHIBITOR; MALT1 PROTEIN, HUMAN; TRIAZOLE DERIVATIVE; TUMOR PROTEIN;

ARTICLE; CONCENTRATION RESPONSE; DRUG DETERMINATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC50; IN VITRO STUDY; PROTEIN DETERMINATION; WILD TYPE; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG DEVELOPMENT; ENZYMOLOGY; HUMAN; JURKAT CELL LINE; LYMPHOMA, LARGE B-CELL, DIFFUSE; METABOLISM; PROCEDURES; SYNTHESIS; TUMOR CELL LINE;

CARBAMATES; CASPASE INHIBITORS; CASPASES; CELL LINE, TUMOR; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; JURKAT CELLS; LYMPHOMA, LARGE B-CELL, DIFFUSE; NEOPLASM PROTEINS; TRIAZOLES;

EID: 84964409702     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2016.03.035     Document Type: Article

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