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Volumn 23, Issue 4, 2016, Pages 402-409

Role of the CARMA1/BCL10/MALT1 complex in lymphoid malignancies

Author keywords

AP 1; CARD11; immunodeficiency; lymphoma; NF B

Indexed keywords

CARMA1 PROTEIN; MALT1 PROTEIN; MULTIPROTEIN COMPLEX; PROTEIN BCL 10; PROTEINASE; SCAFFOLD PROTEIN; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; BCL10 PROTEIN, HUMAN; CARD11 PROTEIN, HUMAN; CASPASE; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; GUANYLATE CYCLASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MALT1 PROTEIN, HUMAN; PROTEIN BINDING; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TUMOR PROTEIN;

EID: 84964727060     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0000000000000257     Document Type: Review
Times cited : (59)

References (57)
  • 1
    • 79961108913 scopus 로고    scopus 로고
    • From MALT lymphoma to the CBM signalosome: Three decades of discovery
    • Rosebeck S, Rehman AO, Lucas PC, McAllister-Lucas LM. From MALT lymphoma to the CBM signalosome: three decades of discovery. Cell Cycle 2011; 10: 2485-2496
    • (2011) Cell Cycle , vol.10 , pp. 2485-2496
    • Rosebeck, S.1    Rehman, A.O.2    Lucas, P.C.3    McAllister-Lucas, L.M.4
  • 2
    • 28844502409 scopus 로고    scopus 로고
    • Phosphorylation of CARMA1: The link(er) to NF-kappaB activation
    • Rueda D, Thome M. Phosphorylation of CARMA1: the link(er) to NF-kappaB activation. Immunity 2005; 23: 551-553
    • (2005) Immunity , vol.23 , pp. 551-553
    • Rueda, D.1    Thome, M.2
  • 3
    • 84884563162 scopus 로고    scopus 로고
    • Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: Nucleation-induced filamentous assembly
    • Qiao Q, Yang C, Zheng C. et al. Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly. Mol Cell 2013; 51: 766-779
    • (2013) Mol Cell , vol.51 , pp. 766-779
    • Qiao, Q.1    Yang, C.2    Zheng, C.3
  • 4
    • 84954361682 scopus 로고    scopus 로고
    • The paracaspase MALT1: Biological function and potential for therapeutic inhibition
    • Jaworski M, Thome M. The paracaspase MALT1: biological function and potential for therapeutic inhibition. Cell Mol Life Sci 2016; 73: 459-473
    • (2016) Cell Mol Life Sci , vol.73 , pp. 459-473
    • Jaworski, M.1    Thome, M.2
  • 5
    • 84905487884 scopus 로고    scopus 로고
    • The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency
    • Turvey SE, Durandy A, Fischer A. et al. The CARD11-BCL10-MALT1 (CBM) signalosome complex: stepping into the limelight of human primary immunodeficiency. J Allergy Clin Immunol 2014; 134: 276-284
    • (2014) J Allergy Clin Immunol , vol.134 , pp. 276-284
    • Turvey, S.E.1    Durandy, A.2    Fischer, A.3
  • 6
    • 84875185728 scopus 로고    scopus 로고
    • Targeting pathological B cell receptor signalling in lymphoid malignancies
    • Young RM, Staudt LM. Targeting pathological B cell receptor signalling in lymphoid malignancies. Nat Rev Drug Discov 2013; 12: 229-243
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 229-243
    • Young, R.M.1    Staudt, L.M.2
  • 7
    • 41149136296 scopus 로고    scopus 로고
    • Oncogenic CARD11 mutations in human diffuse large B cell lymphoma
    • Lenz G, Davis RE, Ngo VN. et al. Oncogenic CARD11 mutations in human diffuse large B cell lymphoma. Science 2008; 319: 1676-1679
    • (2008) Science , vol.319 , pp. 1676-1679
    • Lenz, G.1    Davis, R.E.2    Ngo, V.N.3
  • 8
    • 66649127621 scopus 로고    scopus 로고
    • Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma
    • Compagno M, Lim WK, Grunn A. et al. Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma. Nature 2009; 459: 717-721
    • (2009) Nature , vol.459 , pp. 717-721
    • Compagno, M.1    Lim, W.K.2    Grunn, A.3
  • 9
    • 84949107950 scopus 로고    scopus 로고
    • The mutational landscape of cutaneous T cell lymphoma and Sezary syndrome
    • da Silva Almeida AC, Abate F, Khiabanian H. et al. The mutational landscape of cutaneous T cell lymphoma and Sezary syndrome. Nat Genet 2015; 47: 1465-1470
    • (2015) Nat Genet , vol.47 , pp. 1465-1470
    • Da Silva Almeida, A.C.1    Abate, F.2    Khiabanian, H.3
  • 10
    • 84949096789 scopus 로고    scopus 로고
    • Genomic profiling of Sezary syndrome identifies alterations of key T cell signaling and differentiation genes
    • Wang L, Ni X, Covington KR. et al. Genomic profiling of Sezary syndrome identifies alterations of key T cell signaling and differentiation genes. Nat Genet 2015; 47: 1426-1434
    • (2015) Nat Genet , vol.47 , pp. 1426-1434
    • Wang, L.1    Ni, X.2    Covington, K.R.3
  • 11
    • 84945344219 scopus 로고    scopus 로고
    • Integrated molecular analysis of adult T cell leukemia/lymphoma
    • Kataoka K, Nagata Y, Kitanaka A. et al. Integrated molecular analysis of adult T cell leukemia/lymphoma. Nat Genet 2015; 47: 1304-1315
    • (2015) Nat Genet , vol.47 , pp. 1304-1315
    • Kataoka, K.1    Nagata, Y.2    Kitanaka, A.3
  • 12
    • 84870784256 scopus 로고    scopus 로고
    • Congenital B cell lymphocytosis explained by novel germline CARD11 mutations
    • Snow AL, Xiao W, Stinson JR. et al. Congenital B cell lymphocytosis explained by novel germline CARD11 mutations. J Exp Med 2012; 209: 2247-2261
    • (2012) J Exp Med , vol.209 , pp. 2247-2261
    • Snow, A.L.1    Xiao, W.2    Stinson, J.R.3
  • 13
    • 84941188229 scopus 로고    scopus 로고
    • Germline CARD11 mutation in a patient with severe congenital B cell lymphocytosis
    • Brohl AS, Stinson JR, Su HC. et al. Germline CARD11 mutation in a patient with severe congenital B cell lymphocytosis. J Clin Immunol 2014; 35: 32-46
    • (2014) J Clin Immunol , vol.35 , pp. 32-46
    • Brohl, A.S.1    Stinson, J.R.2    Su, H.C.3
  • 14
    • 84941169989 scopus 로고    scopus 로고
    • Mild B-cell lymphocytosis in patients with a CARD11 C49Y mutation
    • Buchbinder D, Stinson JR, Nugent DJ. et al. Mild B-cell lymphocytosis in patients with a CARD11 C49Y mutation. J Allergy Clin Immunol 2015; 136: 819-821
    • (2015) J Allergy Clin Immunol , vol.136 , pp. 819-821
    • Buchbinder, D.1    Stinson, J.R.2    Nugent, D.J.3
  • 15
    • 84993993649 scopus 로고    scopus 로고
    • CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas
    • Juilland M, Gonzalez M, Erdmann T. et al. CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas. Blood 2016; 127: 1780-1789
    • (2016) Blood , vol.127 , pp. 1780-1789
    • Juilland, M.1    Gonzalez, M.2    Erdmann, T.3
  • 17
    • 84922364525 scopus 로고    scopus 로고
    • Jun-regulated genes promote interaction of diffuse large B-cell lymphoma with the microenvironment
    • BlonskaM, Zhu Y, Chuang HH. et al. Jun-regulated genes promote interaction of diffuse large B-cell lymphoma with the microenvironment. Blood 2015; 125: 981-991
    • (2015) Blood , vol.125 , pp. 981-991
    • BlonskaM Zhu, Y.1    Chuang, H.H.2
  • 18
    • 39449131430 scopus 로고    scopus 로고
    • T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20
    • Coornaert B, Baens M, Heyninck K. et al. T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. Nat Immunol 2008; 9: 263-271
    • (2008) Nat Immunol , vol.9 , pp. 263-271
    • Coornaert, B.1    Baens, M.2    Heyninck, K.3
  • 19
    • 80052282195 scopus 로고    scopus 로고
    • Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines
    • Hailfinger S, Nogai H, Pelzer C. et al. Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines. Proc Natl Acad Sci U S A 2011; 108: 14596-14601
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 14596-14601
    • Hailfinger, S.1    Nogai, H.2    Pelzer, C.3
  • 20
    • 84905643250 scopus 로고    scopus 로고
    • MALT1 auto-proteolysis is essential for NF-kappaB-dependent gene transcription in activated lymphocytes
    • Baens M, Bonsignore L, Somers R. et al. MALT1 auto-proteolysis is essential for NF-kappaB-dependent gene transcription in activated lymphocytes. PLoS One 2014; 9: e103774
    • (2014) PLoS One , vol.9 , pp. e103774
    • Baens, M.1    Bonsignore, L.2    Somers, R.3
  • 21
    • 84946720709 scopus 로고    scopus 로고
    • The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-kappaB signalling
    • Klein T, Fung SY, Renner F. et al. The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-kappaB signalling. Nat Commun 2015; 6: 8777
    • (2015) Nat Commun , vol.6 , pp. 8777
    • Klein, T.1    Fung, S.Y.2    Renner, F.3
  • 22
    • 84960378041 scopus 로고    scopus 로고
    • MALT1 cleaves the E3 ubiquitin ligase HOIL-1 in activated T cells, generating a dominant negative inhibitor of LUBAC-induced NF-kappaB signaling
    • Elton L, Carpentier I, Staal J. et al. MALT1 cleaves the E3 ubiquitin ligase HOIL-1 in activated T cells, generating a dominant negative inhibitor of LUBAC-induced NF-kappaB signaling. FEBS J 2015; 283: 403-412
    • (2015) FEBS J , vol.283 , pp. 403-412
    • Elton, L.1    Carpentier, I.2    Staal, J.3
  • 23
    • 39449085547 scopus 로고    scopus 로고
    • The proteolytic activity of the paracaspase MALT1 is key in T cell activation
    • Rebeaud F, Hailfinger S, Posevitz-Fejfar A. et al. The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nat Immunol 2008; 9: 272-281
    • (2008) Nat Immunol , vol.9 , pp. 272-281
    • Rebeaud, F.1    Hailfinger, S.2    Posevitz-Fejfar, A.3
  • 24
    • 79955592698 scopus 로고    scopus 로고
    • T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1
    • Staal J, Driege Y, Bekaert T. et al. T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1. EMBO J 2011; 30: 1742-1752
    • (2011) EMBO J , vol.30 , pp. 1742-1752
    • Staal, J.1    Driege, Y.2    Bekaert, T.3
  • 25
    • 84878315256 scopus 로고    scopus 로고
    • Malt1-induced cleavage of regnase-1 in CD4(θ) helper T cells regulates immune activation
    • Uehata T, Iwasaki H, Vandenbon A. et al. Malt1-induced cleavage of regnase-1 in CD4(θ) helper T cells regulates immune activation. Cell 2013; 153: 1036-1049
    • (2013) Cell , vol.153 , pp. 1036-1049
    • Uehata, T.1    Iwasaki, H.2    Vandenbon, A.3
  • 26
    • 84908209291 scopus 로고    scopus 로고
    • Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation
    • Jeltsch KM, Hu D, Brenner S. et al. Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation. Nat Immunol 2014; 15: 1079-1089
    • (2014) Nat Immunol , vol.15 , pp. 1079-1089
    • Jeltsch, K.M.1    Hu, D.2    Brenner, S.3
  • 27
    • 41149136296 scopus 로고    scopus 로고
    • Oncogenic CARD11 mutations in human diffuse large B cell lymphoma
    • Lenz G, Davis RE, Ngo VN. et al. Oncogenic CARD11 mutations in human diffuse large B cell lymphoma. Science 2008; 319: 1676-1679
    • (2008) Science , vol.319 , pp. 1676-1679
    • Lenz, G.1    Davis, R.E.2    Ngo, V.N.3
  • 28
    • 73849145729 scopus 로고    scopus 로고
    • Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
    • Davis RE, Ngo VN, Lenz G. et al. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature 2010; 463: 88-92
    • (2010) Nature , vol.463 , pp. 88-92
    • Davis, R.E.1    Ngo, V.N.2    Lenz, G.3
  • 29
    • 84946616221 scopus 로고    scopus 로고
    • Survival of human lymphoma cells requires B-cell receptor engagement by self-Antigens
    • Young RM, Wu T, Schmitz R. et al. Survival of human lymphoma cells requires B-cell receptor engagement by self-Antigens. Proc Natl Acad Sci U S A 2015; 112: 13447-13454
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 13447-13454
    • Young, R.M.1    Wu, T.2    Schmitz, R.3
  • 30
    • 84872856782 scopus 로고    scopus 로고
    • Genetic heterogeneity of diffuse large B-cell lymphoma
    • Zhang J, Grubor V, Love CL. et al. Genetic heterogeneity of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A 2013; 110: 1398-1403
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 1398-1403
    • Zhang, J.1    Grubor, V.2    Love, C.L.3
  • 31
    • 80052029516 scopus 로고    scopus 로고
    • Frequent mutation of histonemodifying genes in non-Hodgkin lymphoma
    • Morin RD, Mendez-Lago M, Mungall AJ. et al. Frequent mutation of histonemodifying genes in non-Hodgkin lymphoma. Nature 2011; 476: 298-303
    • (2011) Nature , vol.476 , pp. 298-303
    • Morin, R.D.1    Mendez-Lago, M.2    Mungall, A.J.3
  • 32
    • 84857942952 scopus 로고    scopus 로고
    • Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing
    • Lohr JG, Stojanov P, Lawrence MS. et al. Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing. Proc Natl Acad Sci U S A 2012; 109: 3879-3884
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 3879-3884
    • Lohr, J.G.1    Stojanov, P.2    Lawrence, M.S.3
  • 33
    • 80052269038 scopus 로고    scopus 로고
    • Analysis of the coding genome of diffuse large B-cell lymphoma
    • Pasqualucci L, Trifonov V, Fabbri G. et al. Analysis of the coding genome of diffuse large B-cell lymphoma. Nat Genet 2011; 43: 830-837
    • (2011) Nat Genet , vol.43 , pp. 830-837
    • Pasqualucci, L.1    Trifonov, V.2    Fabbri, G.3
  • 34
    • 84938994998 scopus 로고    scopus 로고
    • Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma
    • Wilson WH, Young RM, Schmitz R. et al. Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma. Nat Med 2015; 21: 922-926
    • (2015) Nat Med , vol.21 , pp. 922-926
    • Wilson, W.H.1    Young, R.M.2    Schmitz, R.3
  • 35
    • 84891867381 scopus 로고    scopus 로고
    • Pharmacological and genomic profiling identifies NF-kappaB-targeted treatment strategies for mantle cell lymphoma
    • Rahal R, Frick M, Romero R. et al. Pharmacological and genomic profiling identifies NF-kappaB-targeted treatment strategies for mantle cell lymphoma. Nat Med 2014; 20: 87-92
    • (2014) Nat Med , vol.20 , pp. 87-92
    • Rahal, R.1    Frick, M.2    Romero, R.3
  • 36
    • 80052929598 scopus 로고    scopus 로고
    • Is there a role for antigen selection in mantle cell lymphoma'. Immunogenetic support from a series of 807 cases
    • Hadzidimitriou A, Agathangelidis A, Darzentas N. et al. Is there a role for antigen selection in mantle cell lymphoma'. Immunogenetic support from a series of 807 cases. Blood 2011; 118: 3088-3095
    • (2011) Blood , vol.118 , pp. 3088-3095
    • Hadzidimitriou, A.1    Agathangelidis, A.2    Darzentas, N.3
  • 37
    • 84862990370 scopus 로고    scopus 로고
    • Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice
    • Vicente-Duenas C, Fontan L, Gonzalez-Herrero I. et al. Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice. Proc Natl Acad Sci U S A 2012; 109: 10534-10539
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 10534-10539
    • Vicente-Duenas, C.1    Fontan, L.2    Gonzalez-Herrero, I.3
  • 38
    • 77950538241 scopus 로고    scopus 로고
    • Emu-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-kappaB pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma
    • Li Z, Wang H, Xue L. et al. Emu-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-kappaB pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma. Blood 2009; 114: 4158-4168
    • (2009) Blood , vol.114 , pp. 4158-4168
    • Li, Z.1    Wang, H.2    Xue, L.3
  • 39
    • 84908118594 scopus 로고    scopus 로고
    • Human T-cell leukaemia virus type i and adult T-cell leukaemia-lymphoma
    • Ishitsuka K, Tamura K. Human T-cell leukaemia virus type I and adult T-cell leukaemia-lymphoma. Lancet Oncol 2014; 15: e517-e526
    • (2014) Lancet Oncol , vol.15 , pp. e517-e526
    • Ishitsuka, K.1    Tamura, K.2
  • 40
    • 84897520067 scopus 로고    scopus 로고
    • PLCG1 mutations in cutaneous T-cell lymphomas
    • Vaque JP, Gomez-Lopez G, Monsalvez V. et al. PLCG1 mutations in cutaneous T-cell lymphomas. Blood 2014; 123: 2034-2043
    • (2014) Blood , vol.123 , pp. 2034-2043
    • Vaque, J.P.1    Gomez-Lopez, G.2    Monsalvez, V.3
  • 41
    • 28844500398 scopus 로고    scopus 로고
    • Phosphorylation of the CARMA1 linker controls NF-kappaB activation
    • Sommer K, Guo B, Pomerantz JL. et al. Phosphorylation of the CARMA1 linker controls NF-kappaB activation. Immunity 2005; 23: 561-574
    • (2005) Immunity , vol.23 , pp. 561-574
    • Sommer, K.1    Guo, B.2    Pomerantz, J.L.3
  • 42
    • 0027224017 scopus 로고
    • Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function
    • Stein B, Baldwin AS Jr, Ballard DW. et al. Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function. EMBO J 1993; 12: 3879-3891
    • (1993) EMBO J , vol.12 , pp. 3879-3891
    • Stein, B.1    Baldwin, A.S.2    Ballard, D.W.3
  • 43
    • 0000935584 scopus 로고    scopus 로고
    • Molecular and cellular biology of interleukin-6 and its receptor
    • Keller ET, Wanagat J, Ershler WB. Molecular and cellular biology of interleukin-6 and its receptor. Front Biosci 1996; 1: d340-d357
    • (1996) Front Biosci , vol.1 , pp. d340-d357
    • Keller, E.T.1    Wanagat, J.2    Ershler, W.B.3
  • 44
    • 0242691046 scopus 로고    scopus 로고
    • AP-1: A double-edged sword in tumorigenesis
    • Eferl R, Wagner EF. AP-1: a double-edged sword in tumorigenesis. Nat Rev Cancer 2003; 3: 859-868
    • (2003) Nat Rev Cancer , vol.3 , pp. 859-868
    • Eferl, R.1    Wagner, E.F.2
  • 45
    • 0036707522 scopus 로고    scopus 로고
    • CARMA1 is a critical lipid raft-Associated regulator of TCR-induced NF-kappa B activation
    • Gaide O, Favier B, Legler DF. et al. CARMA1 is a critical lipid raft-Associated regulator of TCR-induced NF-kappa B activation. Nat Immunol 2002; 3: 836-843
    • (2002) Nat Immunol , vol.3 , pp. 836-843
    • Gaide, O.1    Favier, B.2    Legler, D.F.3
  • 46
    • 33846235557 scopus 로고    scopus 로고
    • The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway
    • Blonska M, Pappu BP, Matsumoto R. et al. The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway. Immunity 2007; 26: 55-66
    • (2007) Immunity , vol.26 , pp. 55-66
    • Blonska, M.1    Pappu, B.P.2    Matsumoto, R.3
  • 47
    • 79251574621 scopus 로고    scopus 로고
    • Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation
    • Rosebeck S, Madden L, Jin X. et al. Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation. Science 2011; 331: 468-472
    • (2011) Science , vol.331 , pp. 468-472
    • Rosebeck, S.1    Madden, L.2    Jin, X.3
  • 48
    • 84928125250 scopus 로고    scopus 로고
    • Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2-MALT1 in MALT lymphoma
    • Nie Z, Du MQ, McAllister-Lucas LM. et al. Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2-MALT1 in MALT lymphoma. Nat Commun 2015; 6: 5908
    • (2015) Nat Commun , vol.6 , pp. 5908
    • Nie, Z.1    Du, M.Q.2    McAllister-Lucas, L.M.3
  • 49
    • 84867898782 scopus 로고    scopus 로고
    • A20: Linking a complex regulator of ubiquitylation to immunity and human disease
    • Ma A, Malynn BA. A20: linking a complex regulator of ubiquitylation to immunity and human disease. Nat Rev Immunol 2012; 12: 774-785
    • (2012) Nat Rev Immunol , Issue.12 , pp. 774-785
    • Ma, A.1    Malynn, B.A.2
  • 51
    • 84897942317 scopus 로고    scopus 로고
    • Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms
    • Yang Y, Schmitz R, Mitala J. et al. Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms. Cancer Disc 2014; 4: 480-493
    • (2014) Cancer Disc , vol.4 , pp. 480-493
    • Yang, Y.1    Schmitz, R.2    Mitala, J.3
  • 52
    • 84958909948 scopus 로고    scopus 로고
    • The paracaspase MALT1 dampens NF-kappaB signaling by cleaving the LUBAC subunit HOIL-1
    • Hailfinger S, Schmitt A, Schulze-Osthoff K. The paracaspase MALT1 dampens NF-kappaB signaling by cleaving the LUBAC subunit HOIL-1. FEBS J 2015; 283: 400-402
    • (2015) FEBS J , vol.283 , pp. 400-402
    • Hailfinger, S.1    Schmitt, A.2    Schulze-Osthoff, K.3
  • 53
    • 84870769441 scopus 로고    scopus 로고
    • Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL
    • Nagel D, Spranger S, Vincendeau M. et al. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell 2012; 22: 825-837
    • (2012) Cancer Cell , vol.22 , pp. 825-837
    • Nagel, D.1    Spranger, S.2    Vincendeau, M.3
  • 54
    • 84870856936 scopus 로고    scopus 로고
    • MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo
    • Fontan L, Yang C, Kabaleeswaran V. et al. MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell 2012; 22: 812-824
    • (2012) Cancer Cell , vol.22 , pp. 812-824
    • Fontan, L.1    Yang, C.2    Kabaleeswaran, V.3
  • 55
    • 84921492418 scopus 로고    scopus 로고
    • Activity-based probes for detection of active MALT1 paracaspase in immune cells and lymphomas
    • Eitelhuber AC, Vosyka O, Nagel D. et al. Activity-based probes for detection of active MALT1 paracaspase in immune cells and lymphomas. Chem Biol 2015; 22: 129-138
    • (2015) Chem Biol , vol.22 , pp. 129-138
    • Eitelhuber, A.C.1    Vosyka, O.2    Nagel, D.3
  • 56
    • 84921527332 scopus 로고    scopus 로고
    • Probes to monitor activity of the paracaspase MALT1
    • Hachmann J, Edgington-Mitchell LE, Poreba M. et al. Probes to monitor activity of the paracaspase MALT1. Chem Biol 2015; 22: 139-147
    • (2015) Chem Biol , vol.22 , pp. 139-147
    • Hachmann, J.1    Edgington-Mitchell, L.E.2    Poreba, M.3
  • 57
    • 84968754838 scopus 로고    scopus 로고
    • The paracaspaseMALT1 cleaves the LUBAC subunit HOIL1 during antigen receptor signaling
    • [Epub ahead of print]
    • Douanne T, Gavard J, Bide're N. The paracaspaseMALT1 cleaves the LUBAC subunit HOIL1 during antigen receptor signaling. J Cell Sci 2016. [Epub ahead of print]
    • (2016) J Cell Sci
    • Douanne, T.1    Gavard, J.2    Bide're, N.3


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