Knockdown of cytosolic glutaredoxin 1 leads to loss of mitochondrial membrane potential: Implication in neurodegenerative diseases

PLoS ONE

Volumn 3, Issue 6, 2008, Pages

  Saeed, Uzma ^a   Durgadoss, Lalitha ^a   Valli, R Khader ^a   Joshi, Dinesh C ^b   Joshi, Preeti G ^b   Ravindranath, Vijayalakshmi ^a  

^a NATIONAL BRAIN RESEARCH CENTRE   (India)

^b NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

3 OXALYLAMINOALANINE; ADENINE NUCLEOTIDE TRANSLOCASE; CYCLOSPORIN A; ESTROGEN; GLUTAREDOXIN; GLUTAREDOXIN 1; OUTER MEMBRANE PROTEIN; SHORT HAIRPIN RNA; THIOCTIC ACID; THIOL GROUP; VOLTAGE DEPENDENT ANION CHANNEL; ANTIOXIDANT; MATRIX METALLOPROTEINASE; PRIMER DNA; REACTIVE OXYGEN METABOLITE;

ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOSOL; DEGENERATIVE DISEASE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HORMONAL REGULATION; HUMAN; HUMAN CELL; LATHYRISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; OXIDATION; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; REGULATORY MECHANISM; CELL MEMBRANE POTENTIAL; ENZYMOLOGY; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; MITOCHONDRION; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PHYSIOLOGY; POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

ANIMALIA;

ANTIOXIDANTS; BASE SEQUENCE; CELL LINE, TUMOR; CYTOSOL; DNA PRIMERS; DOWN-REGULATION; GLUTAREDOXINS; HUMANS; IMMUNOHISTOCHEMISTRY; MATRIX METALLOPROTEINASES; MEMBRANE POTENTIALS; MITOCHONDRIA; NEURODEGENERATIVE DISEASES; POLYMERASE CHAIN REACTION; REACTIVE OXYGEN SPECIES;

EID: 49349105791     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0002459     Document Type: Article

References (47)

1. Bambrick LL, Fiskum G (2008) Mitochondrial dysfunction in mouse trisomy 16 brain. Brain Res 1188: 9-16.
2. Orth M, Schapira AH (2001) Mitochondria and degenerative disorders. Am J Med Genet 106: 27-36.
3. Sriram K, Shankar SK, Boyd MR, Ravindranath V (1998) Thiol oxidation and loss of mitochondrial complex I precede excitatory amino acid-mediated neurodegeneration. J Neurosci 18: 10287-10296.
4. Solans A, Zambrano A, Rodriguez M, Barrientos A (2006) Cytotoxicity of a mutant huntingtin fragment in yeast involves early alterations in mitochondrial OXPHOS complexes II and III. Hum Mol Genet 15: 3063-3081.
5. Benchoua A, Trioulier Y, Zala D, Gaillard MC, Lefort N, et al. (2006) Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin. Mol Biol Cell 17: 1652-1663.
6. Beal MF (2007) Mitochondria and neurodegeneration. Novartis Found Symp 287: 183-192. discussion 192-186.
7. Sriram K, Pai KS, Boyd MR, Ravindranath V (1997) Evidence for generation of oxidative stress in brain by MPTP: in vitro and in vivo studies in mice. Brain Res 749: 44-52.
8. Balijepalli S AJ, Boyd MR, Ravindranath V (1999) Effect of thiol modification on brain mitochondrial complex I activity. Neuroscience letters 272(3): 203-206.
9. Spencer PS, Roy DN, Ludolph A, Hugon J, Dwivedi MP, et al. (1986) Lathyrism: evidence for role of the neuroexcitatory aminoacid BOAA. Lancet 2: 106-1067.
10. Ludolph AC, Spencer PS (1996) Toxic models of upper motor neuron disease. J Neurol Sci 139 Suppl: 53-59.
11. Ross SM, Roy DN, Spencer PS (1989) Beta-N-oxalylamino-L-alanine action on glutamate receptors. J Neurochem 53: 710-715.
12. Diwakar L, Ravindranath V (2007) Inhibition of cystathionine-gamma-lyase leads to loss of glutathione and aggravation of mitochondrial dysfunction mediated by excitatory amino acid in the CNS. Neurochem Int 50: 418-426.
13. Kenchappa RS, Diwakar L, Boyd MR, Ravindranath V (2002) Thioltransferase (glutaredoxin) mediates recovery of motor neurons from excitotoxic mitochondrial injury. J Neurosci 22: 8402-8410.
14. Mannervik B, Axelsson K (1975) Reduction of disulphide bonds in proteins mixed disulphides catalysed by a thioltransferase in rat liver cytosol. Biochem J 149: 785-788.
15. Wells WW, Yang Y, Deits TL, Gan ZR (1993) Thioltransferases. Adv Enzymol Relat Areas Mol Biol 66: 149-201.
16. Holmgren A (1989) Thioredoxin and glutaredoxin systems. J Biol Chem 264: 13963-13966.
17. Luthman M, Eriksson S, Holmgren A, Thelander L (1979) Glutathione-dependent hydrogen donor system for calf thymus ribonucleoside-diphosphate reductase. Proc Natl Acad Sci U S A 76: 2158-2162.
18. Luthman M, Holmgren A (1982) Glutaredoxin from calf thymus. Purification to homogeneity. J Biol Chem 257: 6686-6690.
19. Padilla CA, Martinez-Galisteo E, Barcena JA, Spyrou G, Holmgren A (1995) Purification from placenta, amino acid sequence, structure comparisons and cDNA cloning of human glutaredoxin. Eur J Biochem 227: 27-34.
20. Holmgren A, Aslund F (1995) Glutaredoxin. Methods Enzymol 252: 283-292.
21. Gravina SA, Mieyal JJ (1993) Thioltransferase is a specific glutathionyl mixed disulfide oxidoreductase. Biochemistry 32: 3368-3376.
22. Chrestensen CA, Starke DW, Mieyal JJ (2000) Acute cadmium exposure inactivates thioltransferase (Glutaredoxin), inhibits intracellular reduction of protein-glutathionyl-mixed disulfides, and initiates apoptosis. J Biol Chem 275: 26556-26565.
23. Mieyal JJ, Srinivasan V, Starke DW, Gravina SA, Mieyal P (1995) Glutathionyl specificity of thioltransferase, mechanistic and physiological implications: biothiols in health and disease. Parker L, Cadenas E, eds. New York: Marcel Decker. pp 305-372.
24. Fernandes AP, Holmgren A (2004) Glutaredoxins: glutathione-dependent redox enzymes with functions far beyond a simple thioredoxin backup system. Antioxid Redox Signal 6: 63-74.
25. Kenchappa RS, Ravindranath V (2003) Glutaredoxin is essential for maintenance of brain mitochondrial complex I: studies with MPTP. Faseb J 17: 717-719.
26. Diwakar L, Kenchappa RS, Annepu J, Ravindranath V (2007) Downregulation of glutaredoxin but not glutathione loss leads to mitochondrial dysfunction in female mice CNS: implications in excitotoxicity. Neurochem Int 51: 37-46.
27. Karunakaran S, Saeed U, Ramakrishnan S, Koumar RC, Ravindranath V (2007) Constitutive expression and functional characterization of mitochondrial glutaredoxin (Grx2) in mouse and human brain. Brain Res 1185: 8-17.
28. Fernando MR, Lechner JM, Lofgren S, Gladyshev VN, Lou MF (2006) Mitochondrial thioltransferase (glutaredoxin 2) has GSH-dependent and thioredoxin reductase-dependent peroxidase activities in vitro and in lens epithelial cells. Faseb J 20: 2645-2647.
29. Gladyshev VN, Liu A, Novoselov SV, Krysan K, Sun QA, et al. (2001) Identification and characterization of a new mammalian glutaredoxin (thioltransferase), Grx2. J Biol Chem 276: 30374-30380.
30. Lundberg M, Johansson C, Chandra J, Enoksson M, Jacobsson G, et al. (2001) Cloning and expression of a novel human glutaredoxin (Grx2) with mitochondrial and nuclear isoforms. J Biol Chem 276: 26269-26275.
31. Gallogly MM, Mieyal JJ (2007) Mechanisms of reversible protein glutathionylation in redox signaling and oxidative stress. Curr Opin Pharmacol 7: 381-391.
32. Jonsson TJ, Lowther WT (2007) The peroxiredoxin repair proteins. Subcell Biochem 44: 115-141.
33. Rhee SG, Jeong W, Chang TS, Woo HA (2007) Sulfiredoxin, the cysteine sulfinic acid reductase specific to 2-Cys peroxiredoxin: its discovery, mechanism of action, and biological significance. Kidney Int Suppl. pp S3-8.
34. Findlay VJ, Townsend DM, Morris TE, Fraser JP, He L, et al. (2006) A novel role for human sulfiredoxin in the reversal of glutathionylation. Cancer Res 66: 6800-6806.
35. Salmeen A, Andersen JN, Myers MP, Meng TC, Hinks JA, et al. (2003) Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate. Nature 423: 769-773.
36. Petronilli V, Costantini P, Scorrano L, Colonna R, Passamonti S, et al. (1994) The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents. J Biol Chem 269: 16638-16642.
37. Haouzi D, Cohen I, Vieira HL, Poncet D, Boya P, et al. (2002) Mitochondrial permeability transition as a novel principle of hepatorenal toxicity in vivo. Apoptosis 7: 395-405.
38. Yang Z, Cheng W, Hong L, Chen W, Wang Y, et al. (2007) Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 cells. Mol Biol Cell 18: 4681-4689.
39. Halestrap AP, Brennerb C (2003) The adenine nucleotide translocase: a central component of the mitochondrial permeability transition pore and key player in cell death. Curr Med Chem 10: 1507-1525.
40. Pai HV, Starke DW, Lesnefsky EJ, Hoppel CL, Mieyal JJ (2007) What is the functional significance of the unique location of glutaredoxin 1 (GRx1) in the intermembrane space of mitochondria? Antioxid Redox Signal 9: 2027-2033.
41. Baines CP, Kaiser RA, Sheiko T, Craigen WJ, Molkentin JD (2007) Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death. Nat Cell Biol 9: 550-555.
42. Yagoda N, von Rechenberg M, Zaganjor E, Bauer AJ, Yang WS, et al. (2007) RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature 447: 864-868.
43. Borgne-Sanchez A, Dupont S, Langonne A, Baux L, Lecoeur H, et al. (2007) Targeted Vpr-derived peptides reach mitochondria to induce apoptosis of alphaVbeta3-expressing endothelial cells. Cell Death Differ 14: 422-435.
44. Kim R, Emi M, Tanabe K, Murakami S, Uchida Y, et al. (2006) Regulation and interplay of apoptotic and non-apoptotic cell death. J Pathol 208: 319-326.
45. Kim R, Emi M, Tanabe K (2005) Caspase-dependent and -independent cell death pathways after DNA damage (Review). Oncol Rep 14: 595-599.
46. Kenchappa RS, Diwakar L, Annepu J, Ravindranath V (2004) Estrogen and neuroprotection: higher constitutive expression of glutaredoxin in female mice offers protection against MPTP-mediated neurodegeneration. Faseb J 18: 1102-1104.
47. Sen I, Joshi DC, Joshi PG, Joshi NB (2008) NMDA and non-NMDA receptor-mediated differential Ca(2+) load and greater vulnerability of motor neurons in spinal cord cultures. Neurochem Int 52: 247-255.