Low copy number of mitochondrial DNA (mtDNA) predicts worse prognosis in early-stage laryngeal cancer patients

Diagnostic Pathology

Volumn 9, Issue 1, 2014, Pages

  Dang, Siwen ^a   Qu, Yiping ^a   Wei, Jing ^a   Shao, Yuan ^a   Yang, Qi ^a   Ji, Meiju ^a   Shi, Bingyin ^a   Hou, Peng ^a  

^a THE FIRST AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

Clinical outcomes; Copy number; Laryngeal cancer; Mitochondrial DNA (mtDNA); Real time quantitative PCR

Indexed keywords

MITOCHONDRIAL DNA;

ARTICLE; CANCER STAGING; COPY NUMBER VARIATION; FEMALE; GENETICS; HUMAN; KAPLAN MEIER METHOD; LARYNX TUMOR; MALE; MIDDLE AGED; MORTALITY; PATHOLOGY; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; REAL TIME POLYMERASE CHAIN REACTION;

DNA COPY NUMBER VARIATIONS; DNA, MITOCHONDRIAL; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; LARYNGEAL NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84893201269     PISSN: None     EISSN: 17461596     Source Type: Journal    
DOI: 10.1186/1746-1596-9-28     Document Type: Article

References (38)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011, 61:69-90.
2. Choong N, Vokes E. Expanding role of the medical oncologist in the management of head and neck cancer. CA Cancer J Clin 2008, 58:32-53.
3. Almadori G, Bussu F, Paludettii G. Predictive factors of neck metastases in laryngeal squamous cell carcinoma. Towards an integrated clinico-molecular classification. Acta Otorhinolaryngol Ital 2006, 26:326-334.
4. Gourin CG, Conger BT, Sheils WC, Bilodeau PA, Coleman TA, Porubsky ES. The effect of treatment on survival in patients with advanced laryngeal carcinoma. Laryngoscope 2009, 119:1312-1317.
5. Johansen LV, Grau C, Overgaard J. Laryngeal carcinoma-multivariate analysis of prognostic factors in 1252 consecutive patients treated with primary radiotherapy. Acta Oncol 2003, 42:771-778.
6. Lohynska R, Slavicek A, Bahanan A, Novakova P. Predictors of local failure in early laryngeal cancer. Neoplasma 2005, 52:483-488.
7. Marioni G, Marchese-Ragona R, Cartei G, Marchese F, Staffieri A. Current opinion in diagnosis and treatment of laryngeal carcinoma. Cancer Treat Rev 2006, 32:504-515.
8. Nguyen-Tan PF, Le QT, Quivey JM, Singer M, Terris DJ, Goffinet DR, Fu KK. Treatment results and prognostic factors of advanced T3-4 laryngeal carcinoma: the University of California, San Francisco (UCSF) and Stanford University Hospital (SUH) experience. Int J Radiat Oncol Biol Phys 2001, 50:1172-1180.
9. Yu L, Xiao-li D, Cheng T, Hong-gang L. Human telomerase RNA component (hTERC) gene amplification detected by FISH in precancerous lesions and carcinoma of the larynx. Diagn Pathol 2002, 7:34.
10. Yurdanur S, Seda G, Sinan A, Filiz K, Bedri K. Poor prognostic clinicopathologic features correlate with VEGF expression but not with PTEN expression in squamous cell carcinoma of the larynx. Diagn Pathol 2010, 5:35.
11. Hans-Ullrich V, Matthias S, Sylvia H, Philipp S, Rudolf H, Hans M-H, Matthias E. Differential diagnosis of laryngeal spindle cell carcinoma and inflammatory myofibroblastic tumor ? report of two cases with similar morphology. Diagn Pathol 2007, 2:1.
12. Jiang WW, Masayesva B, Zahurak M, Carvalho AL, Rosenbaum E, Mambo E, Zhou S, Minhas K, Benoit N, Westra WH, Alberg A, Sidransky D, Koch W, Califano J. Increased mitochondrial DNA content in saliva associated with head and neck cancer. Clin Cancer Res 2005, 11:2486-2491.
13. Jiang WW, Rosenbaum E, Mambo E, Zahurak M, Masayesva B, Carvalho AL, Zhou S, Westra WH, Alberg AJ, Sidransky D, Koch W, Califano JA. Decreased mitochondrial DNA content in posttreatment salivary rinses from head and neck cancer patients. Clin Cancer Res 2006, 12:1564-1569.
14. Hatefi Y. The mitochondrial electron transport and oxidative phosphorylation system. Annu Rev Biochem 1985, 54:1015-1069.
15. Fernández-Silva P, Enriquez JA, Montoya J. Replication and transcription of mammalian mitochondrial DNA. Exp Physiol 2003, 88:41-56.
16. Shadel GS. Expression and maintenance of mitochondrial DNA: new insights into human disease pathology. Am J Pathol 2008, 172:1445-1456.
17. Chinnery PF, Hudson G. Mitochondrial genetics. Br Med Bull 2013, 106:135-159.
18. Gredilla R, Bohr VA, Stevnsner T. Mitochondrial DNA repair and association with aging-an update. Exp Gerontol 2010, 45:478-488.
19. Guo W, Yang D, Xu H, Zhang Y, Huang J, Yang Z, Chen X, Huang Z. Mutations in the D-loop region and increased copy number of mitochondrial DNA in human laryngeal squamous cell carcinoma. Mol Biol Rep 2013, 40:13-20.
20. Shi J, Zhang G, Yao D, Liu W, Wang N, Ji M, He N, Shi B, Hou P. Prognostic significance of aberrant gene methylation in gastric cancer. Am J Cancer Res 2012, 2:116-129.
21. Zhang G, Qu Y, Dang S, Yang Q, Shi B, Hou P. Variable copy number of mitochondrial DNA (mtDNA) predicts worse prognosis in advanced gastric cancer patients. Diagn Pathol 2013, 8:173.
22. Shi J, Yao D, Liu W, Wang N, Lv H, Zhang G, Ji M, Xu L, He N, Shi B, Hou P. Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer. BMC Cancer 2012, 12:50.
23. Xing J, Chen M, Wood CG, Lin J, Spitz MR, Ma J, Amos C, Shields PG, Benowitz NL, Gu J, De Andrade M, Swan GE, Wu X. Mitochondrial DNA content: its genetic heritability and association with renal cell carcinoma. J Natl Cancer Inst 2008, 100:1104-1112.
24. Liao LM, Baccarelli A, Shu XO, Gao YT, Ji BT, Yang G, Li HL, Hoxha M, Dioni L, Rothman N, Zheng W, Chow WH. Mitochondrial DNA copy number and risk of gastric cancer: a report from the Shanghai Women's Health Study. Cancer Epidemiol Biomarkers Prev 2011, 20:1944-1949.
25. Wallace DC. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet 2005, 39:359-407.
26. Wallace DC. Mitochondria and cancer. Nat Rev Cancer 2012, 12:685-698.
27. Clay Montier LL, Deng JJ, Bai Y. Number matters: control of mammalian mitochondrial DNA copy number. J Genet Genomics 2009, 36:125-131.
28. Copeland WC, Wachsman JT, Johnson FM, Penta JS. Mitochondrial DNA alterations in cancer. Cancer Invest 2002, 20:557-569.
29. Verschoor ML, Wilson LA, Singh G. Mechanisms associated with mitochondrial-generated reactive oxygen species in cancer. Can J Physiol Pharmacol 2010, 88:204-219.
30. Verschoor ML, Ungard R, Harbottle A, Jakupciak JP, Parr RL, Singh G. Mitochondria and cancer: past, present, and future. Biomed Res Int 2013, 2013:612369.
31. Kroemer G. Mitochondrial control of apoptosis: an introduction. Biochem Biophys Res Commun 2003, 304:433-435.
32. Zheng S, Qian P, Li F, Qian G, Wang C, Wu G, Li Q, Chen Y, Li J, Li H, He B, Ji F. Association of mitochondrial DNA variations with lung cancer risk in a Han Chinese population from southwestern China. PLoS One 2012, 7:e31322.
33. Masuda S, Kadowaki T, Kumaki N, Tang X, Tokuda Y, Yoshimura S, Takekoshi S, Osamura RY. Analysis of gene alterations of mitochondrial DNA D-loop regions to determine breast cancer clonality. Br J Cancer 2012, 107:2016-2023.
34. Xu E, Sun W, Gu J, Chow WH, Ajani JA, Wu X. Association of mitochondrial DNA copy number in peripheral blood leukocytes with risk of esophageal adenocarcinoma. Carcinogenesis 2013, 34:2521-2524.
35. Warowicka A, Kwasniewska A, Gozdzicka-Jozefiak A. Alterations in mtDNA: a qualitative and quantitative study associated with cervical cancer development. Gynecol Oncol 2013, 129:193-198.
36. Lee HC, Lu CY, Fahn HJ, Wei YH. Aging- and smoking-associated alteration in the relative content of mitochondrial DNA in human lung. FEBS Lett 1998, 441:292-296.
37. Mondal R, Ghosh SK, Choudhury JH, Seram A, Sinha K, Hussain M, Laskar RS, Rabha B, Dey P, Ganguli S, Nathchoudhury M, Talukdar FR, Chaudhuri B, Dhar B. Mitochondrial DNA copy number and risk of oral cancer: a report from Northeast India. PLoS One 2013, 8:e57771.
38. Stoeltzing O, McCarty MF, Wey JS, Fan F, Liu W, Belcheva A, Bucana CD, Semenza GL, Ellis LM. Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation. J Natl Cancer Inst 2004, 96:946-956.