메뉴 건너뛰기




Volumn 7, Issue , 2016, Pages

ICER is requisite for Th17 differentiation

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INDUCIBLE CAMP EARLY REPRESSOR; INTERLEUKIN 17; INTERLEUKIN 6; REPRESSOR PROTEIN; RETINOID RELATED ORPHAN RECEPTOR GAMMA; STAT3 PROTEIN; UNCLASSIFIED DRUG;

EID: 84989271289     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms12993     Document Type: Article
Times cited : (64)

References (39)
  • 1
    • 77955171091 scopus 로고    scopus 로고
    • Interleukin-17-producing T cells in lupus
    • Crispin, J. C., Tsokos, G. C. Interleukin-17-producing T cells in lupus. Curr. Opin. Rheumatol. 22, 499-503 (2010).
    • (2010) Curr. Opin. Rheumatol. , vol.22 , pp. 499-503
    • Crispin, J.C.1    Tsokos, G.C.2
  • 2
    • 84867581744 scopus 로고    scopus 로고
    • A validated regulatory network for Th17 cell specification
    • Ciofani, M. et al. A validated regulatory network for Th17 cell specification. Cell 151, 289-303 (2012).
    • (2012) Cell , vol.151 , pp. 289-303
    • Ciofani, M.1
  • 3
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4\+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington, L. E. et al. Interleukin 17-producing CD4\+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6, 1123-1132 (2005).
    • (2005) Nat. Immunol. , vol.6 , pp. 1123-1132
    • Harrington, L.E.1
  • 5
    • 82555196095 scopus 로고    scopus 로고
    • Systemic lupus erythematosus
    • Tsokos, G. C. Systemic lupus erythematosus. N. Engl. J. Med. 365, 2110-2121 (2011).
    • (2011) N. Engl. J. Med. , vol.365 , pp. 2110-2121
    • Tsokos, G.C.1
  • 6
    • 83355166923 scopus 로고    scopus 로고
    • C. CAMPresponsive Element Modulator (CREM)alpha Protein Induces Interleukin 17A Expression and Mediates Epigenetic Alterations at the interleukin-17A Gene Locus in Patients with Systemic Lupus Erythematosus
    • Rauen, T., Hedrich, C. M., Juang, Y. T., Tenbrock, K., Tsokos, G. C. cAMPresponsive element modulator (CREM)alpha protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic lupus erythematosus. J. Biol. Chem. 286, 43437-43446 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 43437-43446
    • Rauen, T.1    Hedrich, C.M.2    Juang, Y.T.3    Tenbrock, K.4    Tsokos, G.5
  • 7
    • 84860210498 scopus 로고    scopus 로고
    • CREMalpha overexpression decreases IL-2 production, induces a T(H)17 phenotype and accelerates autoimmunity
    • Lippe, R. et al. CREMalpha overexpression decreases IL-2 production, induces a T(H)17 phenotype and accelerates autoimmunity. J. Mol. Cell Biol. 4, 121-123 (2012).
    • (2012) J. Mol. Cell Biol. , vol.4 , pp. 121-123
    • Lippe, R.1
  • 8
    • 0026530518 scopus 로고
    • More is better: Activators and repressors from the same gene
    • Foulkes, N. S., Sassone-Corsi, P. More is better: activators and repressors from the same gene. Cell 68, 411-414 (1992).
    • (1992) Cell , vol.68 , pp. 411-414
    • Foulkes, N.S.1    Sassone-Corsi, P.2
  • 9
    • 0026071499 scopus 로고
    • CREM gene: Use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription
    • Foulkes, N. S., Borrelli, E., Sassone-Corsi, P. CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription. Cell 64, 739-749 (1991).
    • (1991) Cell , vol.64 , pp. 739-749
    • Foulkes, N.S.1    Borrelli, E.2    Sassone-Corsi, P.3
  • 10
    • 0030007975 scopus 로고    scopus 로고
    • F. CAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes
    • Bodor, J., Spetz, A. L., Strominger, J. L., Habener, J. F. cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes. Proc. Natl Acad. Sci. USA 93, 3536-3541 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 3536-3541
    • Bodor, J.1    Spetz, A.L.2    Strominger, J.L.3    Habener, J.4
  • 11
    • 0034978987 scopus 로고    scopus 로고
    • Suppression of T-cell responsiveness by inducible cAMP early repressor (ICER)
    • Bodor, J. et al. Suppression of T-cell responsiveness by inducible cAMP early repressor (ICER). J. Leukoc. Biol. 69, 1053-1059 (2001).
    • (2001) J. Leukoc. Biol. , vol.69 , pp. 1053-1059
    • Bodor, J.1
  • 12
    • 84948783311 scopus 로고    scopus 로고
    • The cAMP response element modulator (CREM) regulates TH2 mediated inflammation
    • Verjans, E. et al. The cAMP response element modulator (CREM) regulates TH2 mediated inflammation. Oncotarget 6, 38538-38551 (2015).
    • (2015) Oncotarget , vol.6 , pp. 38538-38551
    • Verjans, E.1
  • 13
    • 84860333113 scopus 로고    scopus 로고
    • Cutting edge: Protein phosphatase 2A confers susceptibility to autoimmune disease through an IL-17-dependent mechanism
    • Crispin, J. C. et al. Cutting edge: protein phosphatase 2A confers susceptibility to autoimmune disease through an IL-17-dependent mechanism. J. Immunol. 188, 3567-3571 (2012).
    • (2012) J. Immunol. , vol.188 , pp. 3567-3571
    • Crispin, J.C.1
  • 14
    • 84899760423 scopus 로고    scopus 로고
    • CaMK4-dependent activation of AKT/mTOR and CREM-alpha underlies autoimmunity-associated Th17 imbalance
    • Koga, T. et al. CaMK4-dependent activation of AKT/mTOR and CREM-alpha underlies autoimmunity-associated Th17 imbalance. J. Clin. Invest. 124, 2234-2245 (2014).
    • (2014) J. Clin. Invest. , vol.124 , pp. 2234-2245
    • Koga, T.1
  • 15
    • 84870919913 scopus 로고    scopus 로고
    • Interleukin-17 cytokines are critical in development of fatal lupus glomerulonephritis
    • Pisitkun, P. et al. Interleukin-17 cytokines are critical in development of fatal lupus glomerulonephritis. Immunity 37, 1104-1115 (2012).
    • (2012) Immunity , vol.37 , pp. 1104-1115
    • Pisitkun, P.1
  • 16
    • 84930416867 scopus 로고    scopus 로고
    • Interleukin-2 treatment reverses effects of cAMP-responsive element modulator alpha-overexpressing T cells in autoimmune-prone mice
    • Ohl, K., Wiener, A., Schippers, A., Wagner, N., Tenbrock, K. Interleukin-2 treatment reverses effects of cAMP-responsive element modulator alpha-overexpressing T cells in autoimmune-prone mice. Clin. Exp. Immunol. 181, 76-86 (2015).
    • (2015) Clin. Exp. Immunol. , vol.181 , pp. 76-86
    • Ohl, K.1    Wiener, A.2    Schippers, A.3    Wagner, N.4    Tenbrock, K.5
  • 17
    • 79952695731 scopus 로고    scopus 로고
    • Cyclic AMP-mediated immune regulation-overview of mechanisms of action in T cells
    • Mosenden, R., Tasken, K. Cyclic AMP-mediated immune regulation-overview of mechanisms of action in T cells. Cell. Signal. 23, 1009-1016 (2011).
    • (2011) Cell. Signal. , vol.23 , pp. 1009-1016
    • Mosenden, R.1    Tasken, K.2
  • 18
    • 84931275719 scopus 로고    scopus 로고
    • The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation
    • Hernandez, J. B. et al. The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation. Nat. Commun. 6, 7216 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 7216
    • Hernandez, J.B.1
  • 19
    • 34447265236 scopus 로고    scopus 로고
    • CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: A role for DNA methylation
    • Kim, H. P., Leonard, W. J. CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation. J. Exp. Med. 204, 1543-1551 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 1543-1551
    • Kim, H.P.1    Leonard, W.J.2
  • 20
    • 84891112617 scopus 로고    scopus 로고
    • TGF-beta-mediated Foxp3 gene expression is cooperatively regulated by Stat5 Creb and AP-1 through CNS2
    • Ogawa, C. et al. TGF-beta-mediated Foxp3 gene expression is cooperatively regulated by Stat5, Creb, and AP-1 through CNS2. J. Immunol. 192, 475-483 (2014).
    • (2014) J. Immunol. , vol.192 , pp. 475-483
    • Ogawa, C.1
  • 21
    • 36248965294 scopus 로고    scopus 로고
    • TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
    • McGeachy, M. J. et al. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat. Immunol. 8, 1390-1397 (2007).
    • (2007) Nat. Immunol. , vol.8 , pp. 1390-1397
    • McGeachy, M.J.1
  • 22
    • 77955068537 scopus 로고    scopus 로고
    • Review: T helper 17 cells: Their role in glomerulonephritis
    • Ooi, J. D., Kitching, A. R., Holdsworth, S. R. Review: T helper 17 cells: their role in glomerulonephritis. Nephrology (Carlton) 15, 513-521 (2010).
    • (2010) Nephrology (Carlton) , vol.15 , pp. 513-521
    • Ooi, J.D.1    Kitching, A.R.2    Holdsworth, S.R.3
  • 23
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • Park, H. et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 6, 1133-1141 (2005).
    • (2005) Nat. Immunol. , vol.6 , pp. 1133-1141
    • Park, H.1
  • 24
    • 84911495641 scopus 로고    scopus 로고
    • The immunopathogenesis of psoriasis
    • Kim, J., Krueger, J. G. The immunopathogenesis of psoriasis. Dermatol. Clin. 33, 13-23 (2015).
    • (2015) Dermatol. Clin. , vol.33 , pp. 13-23
    • Kim, J.1    Krueger, J.G.2
  • 25
    • 84930409363 scopus 로고    scopus 로고
    • T cell signaling abnormalities contribute to aberrant immune cell function and autoimmunity
    • Moulton, V. R., Tsokos, G. C. T cell signaling abnormalities contribute to aberrant immune cell function and autoimmunity. J. Clin. Invest. 125, 2220-2227 (2015).
    • (2015) J. Clin. Invest. , vol.125 , pp. 2220-2227
    • Moulton, V.R.1    Tsokos, G.C.2
  • 28
    • 77953196382 scopus 로고    scopus 로고
    • Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice
    • Kyttaris, V. C., Zhang, Z., Kuchroo, V. K., Oukka, M., Tsokos, G. C. Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr mice. J. Immunol. 184, 4605-4609 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 4605-4609
    • Kyttaris, V.C.1    Zhang, Z.2    Kuchroo, V.K.3    Oukka, M.4    Tsokos, G.C.5
  • 29
    • 58849162766 scopus 로고    scopus 로고
    • Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys
    • Crispin, J. C. et al. Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys. J. Immunol. 181, 8761-8766 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 8761-8766
    • Crispin, J.C.1
  • 30
    • 84943819103 scopus 로고    scopus 로고
    • The role of serum IL-17 and IL-6 as biomarkers of disease activity and predictors of remission in patients with lupus nephritis
    • Abdel Galil, S. M., Ezzeldin, N., El-Boshy, M. E. The role of serum IL-17 and IL-6 as biomarkers of disease activity and predictors of remission in patients with lupus nephritis. Cytokine 76, 280-287 (2015).
    • (2015) Cytokine , vol.76 , pp. 280-287
    • Abdel Galil, S.M.1    Ezzeldin, N.2    El-Boshy, M.E.3
  • 31
    • 33847375175 scopus 로고    scopus 로고
    • Increased expression of STAT3 in SLE T cells contributes to enhanced chemokine-mediated cell migration
    • Harada, T. et al. Increased expression of STAT3 in SLE T cells contributes to enhanced chemokine-mediated cell migration. Autoimmunity 40, 1-8 (2007).
    • (2007) Autoimmunity , vol.40 , pp. 1-8
    • Harada, T.1
  • 32
    • 84888399645 scopus 로고    scopus 로고
    • Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: A potential role for Epac
    • Vang, A. G. et al. Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac. Biochem. J. 456, 463-473 (2013).
    • (2013) Biochem. J. , vol.456 , pp. 463-473
    • Vang, A.G.1
  • 33
    • 0031229830 scopus 로고    scopus 로고
    • Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus
    • Hochberg, M. C. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 40, 1725 (1997).
    • (1997) Arthritis Rheum. , vol.40 , pp. 1725
    • Hochberg, M.C.1
  • 34
    • 0026777352 scopus 로고
    • Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE
    • Bombardier, C., Gladman, D. D., Urowitz, M. B., Caron, D., Chang, C. H. Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum. 35, 630-640 (1992).
    • (1992) Arthritis Rheum. , vol.35 , pp. 630-640
    • Bombardier, C.1    Gladman, D.D.2    Urowitz, M.B.3    Caron, D.4    Chang, C.H.5
  • 35
    • 63149134464 scopus 로고    scopus 로고
    • Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activity
    • Sunahori, K., Juang, Y. T., Tsokos, G. C. Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activity. J. Immunol. 182, 1500-1508 (2009).
    • (2009) J. Immunol. , vol.182 , pp. 1500-1508
    • Sunahori, K.1    Juang, Y.T.2    Tsokos, G.C.3
  • 36
    • 0029916946 scopus 로고    scopus 로고
    • Severe impairment of spermatogenesis in mice lacking the CREM gene
    • Blendy, J. A., Kaestner, K. H., Weinbauer, G. F., Nieschlag, E., Schutz, G. Severe impairment of spermatogenesis in mice lacking the CREM gene. Nature 380, 162-165 (1996).
    • (1996) Nature , vol.380 , pp. 162-165
    • Blendy, J.A.1    Kaestner, K.H.2    Weinbauer, G.F.3    Nieschlag, E.4    Schutz, G.5
  • 37
    • 80355139376 scopus 로고    scopus 로고
    • Quantitative assessment of immune cells in the injured spinal cord tissue by flow cytometry: A novel use for a cell purification method
    • Nguyen, H. X., Beck, K. D.,erson, A. J. Quantitative assessment of immune cells in the injured spinal cord tissue by flow cytometry: a novel use for a cell purification method. J. Vis. Exp. 50, e2698 (2011).
    • (2011) J. Vis. Exp. , vol.50 , pp. 2698
    • Nguyen, H.X.1    Beck, K.D.2    Anderson, A.J.3
  • 38
    • 79958141014 scopus 로고    scopus 로고
    • Reduced locomotor sensitization induced by methamphetamine and altered gene expression in ICER overexpressing mice
    • Han, W. et al. [Reduced locomotor sensitization induced by methamphetamine and altered gene expression in ICER overexpressing mice]. Nihon Shinkei Seishin Yakurigaku Zasshi 31, 79-80 (2011).
    • (2011) Nihon Shinkei Seishin Yakurigaku Zasshi , vol.31 , pp. 79-80
    • Han, W.1
  • 39
    • 54549100120 scopus 로고    scopus 로고
    • Interactions among the transcription factors Runx1 RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells
    • Zhang, F., Meng, G., Strober, W. Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells. Nat. Immunol. 9, 1297-1306 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 1297-1306
    • Zhang, F.1    Meng, G.2    Strober, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.