Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: A potential role for Epac

Biochemical Journal

Volumn 456, Issue 3, 2013, Pages 463-473

  Vang, Amanda G ^a   Housley, William ^a   Dong, Hongli ^a   Basole, Chaitali ^a   Ben Sasson, Shlomo Z ^b   Kream, Barbara E ^a   Epstein, Paul M ^a   Clark, Robert B ^a   Brocke, Stefan ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Cyclic nucleotide phosphodiesterase; Immune tolerance; Immunosuppression; Inducible cAMP early repressor (ICER); T cell proliferation

Indexed keywords

ANTIPORTER; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT MODULATOR; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP; INDUCIBLE CAMP EARLY REPRESSOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; CREM PROTEIN, MOUSE; CYCLIC AMP DEPENDENT PROTEIN KINASE; EPAC PROTEIN, MOUSE; GUANINE NUCLEOTIDE EXCHANGE FACTOR;

ANIMAL CELL; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL ACTIVATION; CELL PROLIFERATION; CELL SURVIVAL; CELLULAR IMMUNITY; CONTROLLED STUDY; DEGRADATION; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; IN VIVO STUDY; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; CYTOLOGY; GENETICS; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; KNOCKOUT MOUSE; PHYSIOLOGY;

ANIMALS; CELL PROLIFERATION; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT MODULATOR; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FEMALE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; IMMUNE TOLERANCE; MICE; MICE, KNOCKOUT; T-LYMPHOCYTES, REGULATORY;

EID: 84888399645     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20130064     Document Type: Article

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