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Volumn 21, Issue 10, 2016, Pages

Anti-inflammatory activity of Citrus bergamia derivatives: Where do we stand?

Author keywords

Antioxidant activity; Bergamot; Citrus bergamia; Complementary and alternative medicines; Flavonoids; Inflammation; Natural products

Indexed keywords

ANTIINFLAMMATORY AGENT; PLANT EXTRACT;

EID: 84989168199     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules21101273     Document Type: Review
Times cited : (63)

References (64)
  • 1
    • 47949099098 scopus 로고    scopus 로고
    • Origin and physiological roles of inflammation
    • Medzhitov, R. Origin and physiological roles of inflammation. Nature 2008, 454, 428-435.
    • (2008) Nature , vol.454 , pp. 428-435
    • Medzhitov, R.1
  • 2
    • 47749150261 scopus 로고    scopus 로고
    • Cancer and inflammation: A complex relationship
    • Mantovani, A.; Pierotti, M.A. Cancer and inflammation: A complex relationship. Cancer Lett. 2008, 267, 180-181.
    • (2008) Cancer Lett. , vol.267 , pp. 180-181
    • Mantovani, A.1    Pierotti, M.A.2
  • 4
    • 84878280763 scopus 로고    scopus 로고
    • A historical overview of natural products in drug discovery
    • Dias, D.A.; Urban, S.; Roessner, U. A historical overview of natural products in drug discovery. Metabolites 2012, 2, 303-336.
    • (2012) Metabolites , vol.2 , pp. 303-336
    • Dias, D.A.1    Urban, S.2    Roessner, U.3
  • 5
    • 84890859996 scopus 로고    scopus 로고
    • Luteolin exhibits anti-inflammatory effects by blocking the activity of heat shock protein 90 in macrophages
    • Chen, D.; Bi, A.; Dong, X.; Jiang, Y.; Rui, B.; Liu, J.; Yin, Z.; Luo, L. Luteolin exhibits anti-inflammatory effects by blocking the activity of heat shock protein 90 in macrophages. Biochem. Biophys. Res. Commun. 2014, 443, 326-332.
    • (2014) Biochem. Biophys. Res. Commun. , vol.443 , pp. 326-332
    • Chen, D.1    Bi, A.2    Dong, X.3    Jiang, Y.4    Rui, B.5    Liu, J.6    Yin, Z.7    Luo, L.8
  • 6
    • 80051896049 scopus 로고    scopus 로고
    • Anti-inflammatory activity of structurally related flavonoids, Apigenin, Luteolin and Fisetin
    • Funakoshi-Tago, M.; Nakamura, K.; Tago, K.; Mashino, T.; Kasahara, T. Anti-inflammatory activity of structurally related flavonoids, Apigenin, Luteolin and Fisetin. Int. Immunopharmacol. 2011, 11, 1150-1159.
    • (2011) Int. Immunopharmacol. , vol.11 , pp. 1150-1159
    • Funakoshi-Tago, M.1    Nakamura, K.2    Tago, K.3    Mashino, T.4    Kasahara, T.5
  • 7
    • 84864431825 scopus 로고    scopus 로고
    • Quercetin, a flavonoid with anti-inflammatory activity, suppresses the development of abdominal aortic aneurysms in mice
    • Wang, L.; Wang, B.; Li, H.; Lu, H.; Qiu, F.; Xiong, L.; Xu, Y.; Wang, G.; Liu, X.; Wu, H.; et al. Quercetin, a flavonoid with anti-inflammatory activity, suppresses the development of abdominal aortic aneurysms in mice. Eur. J. Pharmacol. 2012, 690, 133-141.
    • (2012) Eur. J. Pharmacol. , vol.690 , pp. 133-141
    • Wang, L.1    Wang, B.2    Li, H.3    Lu, H.4    Qiu, F.5    Xiong, L.6    Xu, Y.7    Wang, G.8    Liu, X.9    Wu, H.10
  • 8
    • 35648931015 scopus 로고    scopus 로고
    • Anti-inflammatory mechanisms of apigenin: Inhibition of cyclooxygenase-2 expression, adhesion of monocytes to human umbilical vein endothelial cells, and expression of cellular adhesion molecules
    • Lee, J.H.; Zhou, H.Y.; Cho, S.Y.; Kim, Y.S.; Lee, Y.S.; Jeong, C.S. Anti-inflammatory mechanisms of apigenin: Inhibition of cyclooxygenase-2 expression, adhesion of monocytes to human umbilical vein endothelial cells, and expression of cellular adhesion molecules. Arch. Pharm. Res. 2007, 30, 1318-1327.
    • (2007) Arch. Pharm. Res. , vol.30 , pp. 1318-1327
    • Lee, J.H.1    Zhou, H.Y.2    Cho, S.Y.3    Kim, Y.S.4    Lee, Y.S.5    Jeong, C.S.6
  • 9
    • 84928637810 scopus 로고    scopus 로고
    • Anti-Inflammatory Effect of Wogonin on RAW 264.7 Mouse Macrophages Induced with Polyinosinic-Polycytidylic Acid
    • Lee, J.Y.; Park, W. Anti-Inflammatory Effect of Wogonin on RAW 264.7 Mouse Macrophages Induced with Polyinosinic-Polycytidylic Acid. Molecules 2015, 20, 6888-6900.
    • (2015) Molecules , vol.20 , pp. 6888-6900
    • Lee, J.Y.1    Park, W.2
  • 10
    • 9744222928 scopus 로고    scopus 로고
    • Potential synergy of phytochemicals in cancer prevention: Mechanism of action
    • Liu, R.H. Potential synergy of phytochemicals in cancer prevention: Mechanism of action. J. Nutr. 2004, 134, 3479s-3485s.
    • (2004) J. Nutr. , vol.134 , pp. 3479s-3485s
    • Liu, R.H.1
  • 12
    • 84938053061 scopus 로고    scopus 로고
    • In vitro effect of bergamot (Citrus bergamia) juice against cagA-positive and-negative clinical isolates of Helicobacter pylori
    • Filocamo, A.; Bisignano, C.; Ferlazzo, N.; Cirmi, S.; Mandalari, G.; Navarra, M. In vitro effect of bergamot (Citrus bergamia) juice against cagA-positive and-negative clinical isolates of Helicobacter pylori. BMC Complement. Altern. Med 2015, 15, 256.
    • (2015) BMC Complement. Altern. Med. , vol.15 , pp. 256
    • Filocamo, A.1    Bisignano, C.2    Ferlazzo, N.3    Cirmi, S.4    Mandalari, G.5    Navarra, M.6
  • 13
    • 84953245123 scopus 로고    scopus 로고
    • In Vitro Antimicrobial Activity and Effect on Biofilm Production of a White Grape Juice (Vitis vinifera) Extract
    • Filocamo, A.; Bisignano, C.; Mandalari, G.; Navarra, M. In Vitro Antimicrobial Activity and Effect on Biofilm Production of a White Grape Juice (Vitis vinifera) Extract. Evid. Based Complement. Altern. Med. 2015, 2015, 856243.
    • (2015) Evid. Based Complement. Altern. Med. , vol.2015
    • Filocamo, A.1    Bisignano, C.2    Mandalari, G.3    Navarra, M.4
  • 14
    • 84942989630 scopus 로고    scopus 로고
    • Flavonoid Fraction of Citrus reticulata Juice Reduces Proliferation and Migration of Anaplastic Thyroid Carcinoma Cells
    • Celano, M.; Maggisano, V.; de Rose, R.F.; Bulotta, S.; Maiuolo, J.; Navarra, M.; Russo, D. Flavonoid Fraction of Citrus reticulata Juice Reduces Proliferation and Migration of Anaplastic Thyroid Carcinoma Cells. Nutr. Cancer 2015, 67, 1183-1190.
    • (2015) Nutr. Cancer , vol.67 , pp. 1183-1190
    • Celano, M.1    Maggisano, V.2    De Rose, R.F.3    Bulotta, S.4    Maiuolo, J.5    Navarra, M.6    Russo, D.7
  • 17
    • 84894031033 scopus 로고    scopus 로고
    • Inflammation, DAMPs, Tumor Development, and Progression: A Vicious Circle Orchestrated by Redox Signaling
    • Castellani, P.; Balza, E.; Rubartelli, A. Inflammation, DAMPs, Tumor Development, and Progression: A Vicious Circle Orchestrated by Redox Signaling. Antioxid. Redox Signal. 2014, 20, 1086-1097.
    • (2014) Antioxid. Redox Signal. , vol.20 , pp. 1086-1097
    • Castellani, P.1    Balza, E.2    Rubartelli, A.3
  • 19
    • 34250874434 scopus 로고    scopus 로고
    • Which comes first: Renal inflammation or oxidative stress in spontaneously hypertensive rats?
    • Biswas, S.K.; de Faria, J.B. Which comes first: Renal inflammation or oxidative stress in spontaneously hypertensive rats? Free Radic. Res. 2007, 41, 216-224.
    • (2007) Free Radic. Res. , vol.41 , pp. 216-224
    • Biswas, S.K.1    De Faria, J.B.2
  • 20
    • 36249024839 scopus 로고    scopus 로고
    • Hypertension increases pro-oxidant generation and decreases antioxidant defense in the kidney in early diabetes
    • Biswas, S.K.; Peixoto, E.B.; Souza, D.S.; de Faria, J.B.L. Hypertension increases pro-oxidant generation and decreases antioxidant defense in the kidney in early diabetes. Am. J. Nephrol. 2008, 28, 133-142.
    • (2008) Am. J. Nephrol. , vol.28 , pp. 133-142
    • Biswas, S.K.1    Peixoto, E.B.2    Souza, D.S.3    De Faria, J.B.L.4
  • 21
    • 84870391497 scopus 로고    scopus 로고
    • Oxidative stress and inflammation: Essential partners in alcoholic liver disease
    • Ambade, A.; Mandrekar, P. Oxidative stress and inflammation: Essential partners in alcoholic liver disease. Int. J. Hepatol. 2012, 2012, 853175.
    • (2012) Int. J. Hepatol. , vol.2012
    • Ambade, A.1    Mandrekar, P.2
  • 22
    • 57049146797 scopus 로고    scopus 로고
    • Oxidative stress and inflammation, a link between chronic kidney disease and cardiovascular disease
    • Cachofeiro, V.; Goicochea, M.; de Vinuesa, S.G.; Oubina, P.; Lahera, V.; Luno, J. Oxidative stress and inflammation, a link between chronic kidney disease and cardiovascular disease. Kidney Int. 2008, 74, S4-S9.
    • (2008) Kidney Int. , vol.74 , pp. S4-S9
    • Cachofeiro, V.1    Goicochea, M.2    De Vinuesa, S.G.3    Oubina, P.4    Lahera, V.5    Luno, J.6
  • 23
    • 33845724468 scopus 로고    scopus 로고
    • Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function
    • Fialkow, L.; Wang, Y.C.; Downey, G.P. Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function. Free Radic. Biol. Med. 2007, 42, 153-164.
    • (2007) Free Radic. Biol. Med. , vol.42 , pp. 153-164
    • Fialkow, L.1    Wang, Y.C.2    Downey, G.P.3
  • 24
    • 84872130535 scopus 로고    scopus 로고
    • Anti-inflammatory therapy in chronic disease: Challenges and opportunities
    • Tabas, I.; Glass, C.K. Anti-inflammatory therapy in chronic disease: Challenges and opportunities. Science 2013, 339, 166-172.
    • (2013) Science , vol.339 , pp. 166-172
    • Tabas, I.1    Glass, C.K.2
  • 26
    • 68949215885 scopus 로고    scopus 로고
    • Role of hydrogen peroxide in NF-kappaB activation: From inducer to modulator
    • Oliveira-Marques, V.; Marinho, H.S.; Cyrne, L.; Antunes, F. Role of hydrogen peroxide in NF-kappaB activation: From inducer to modulator. Antioxid. Redox Signal. 2009, 11, 2223-2243.
    • (2009) Antioxid. Redox Signal. , vol.11 , pp. 2223-2243
    • Oliveira-Marques, V.1    Marinho, H.S.2    Cyrne, L.3    Antunes, F.4
  • 27
    • 0032727865 scopus 로고    scopus 로고
    • Activation of AP-1 and nuclear factor-kappaB transcription factors is involved in hydrogen peroxide-induced apoptotic cell death of oligodendrocytes
    • Vollgraf, U.; Wegner, M.; Richter-Landsberg, C. Activation of AP-1 and nuclear factor-kappaB transcription factors is involved in hydrogen peroxide-induced apoptotic cell death of oligodendrocytes. J. Neurochem. 1999, 73, 2501-2509.
    • (1999) J. Neurochem. , vol.73 , pp. 2501-2509
    • Vollgraf, U.1    Wegner, M.2    Richter-Landsberg, C.3
  • 28
    • 80052590666 scopus 로고    scopus 로고
    • The Receptor for Advanced Glycation End-products (RAGE) protects pancreatic tumor cells against oxidative injury
    • Kang, R.; Tang, D.; Livesey, K.M.; Schapiro, N.E.; Lotze, M.T.; Zeh, H.J. The Receptor for Advanced Glycation End-products (RAGE) protects pancreatic tumor cells against oxidative injury. Antioxid. Redox Signal. 2011, 15, 2175-2184.
    • (2011) Antioxid. Redox Signal. , vol.15 , pp. 2175-2184
    • Kang, R.1    Tang, D.2    Livesey, K.M.3    Schapiro, N.E.4    Lotze, M.T.5    Zeh, H.J.6
  • 29
    • 84954348978 scopus 로고    scopus 로고
    • Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases
    • Zhang, Y.J.; Gan, R.Y.; Li, S.; Zhou, Y.; Li, A.N.; Xu, D.P.; Li, H.B. Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases. Molecules 2015, 20, 21138-21156.
    • (2015) Molecules , vol.20 , pp. 21138-21156
    • Zhang, Y.J.1    Gan, R.Y.2    Li, S.3    Zhou, Y.4    Li, A.N.5    Xu, D.P.6    Li, H.B.7
  • 30
    • 84926510061 scopus 로고    scopus 로고
    • Citrus bergamia essential oil: From basic research to clinical application
    • Navarra, M.; Mannucci, C.; Delbo, M.; Calapai, G. Citrus bergamia essential oil: From basic research to clinical application. Front. Pharmacol. 2015, 6, 36.
    • (2015) Front. Pharmacol. , vol.6 , pp. 36
    • Navarra, M.1    Mannucci, C.2    Delbo, M.3    Calapai, G.4
  • 31
    • 84985996196 scopus 로고    scopus 로고
    • Anti-infective potential of Citrus bergamia Risso et Poiteau (bergamot) derivatives: A systematic review
    • Cirmi, S.; Bisignano, C.; Mandalari, G.; Navarra, M. Anti-infective potential of Citrus bergamia Risso et Poiteau (bergamot) derivatives: A systematic review. Phytother. Res. 2016, 30, 1404-1411.
    • (2016) Phytother. Res. , vol.30 , pp. 1404-1411
    • Cirmi, S.1    Bisignano, C.2    Mandalari, G.3    Navarra, M.4
  • 32
    • 34250191484 scopus 로고    scopus 로고
    • Cell signaling pathways in the mechanisms of neuroprotection afforded by bergamot essential oil against NMDA-induced cell death in vitro
    • Corasaniti, M.T.; Maiuolo, J.; Maida, S.; Fratto, V.; Navarra, M.; Russo, R.; Amantea, D.; Morrone, L.A.; Bagetta, G. Cell signaling pathways in the mechanisms of neuroprotection afforded by bergamot essential oil against NMDA-induced cell death in vitro. Br. J. Pharmacol. 2007, 151, 518-529.
    • (2007) Br. J. Pharmacol. , vol.151 , pp. 518-529
    • Corasaniti, M.T.1    Maiuolo, J.2    Maida, S.3    Fratto, V.4    Navarra, M.5    Russo, R.6    Amantea, D.7    Morrone, L.A.8    Bagetta, G.9
  • 36
    • 84907426298 scopus 로고    scopus 로고
    • Flavonoid fraction of Bergamot juice reduces LPS-induced inflammatory response through SIRT1-mediated NF-κB inhibition in THP-1 monocytes
    • Risitano, R.; Currò, M.; Cirmi, S.; Ferlazzo, N.; Campiglia, P.; Caccamo, D.; Ientile, R.; Navarra, M. Flavonoid fraction of Bergamot juice reduces LPS-induced inflammatory response through SIRT1-mediated NF-κB inhibition in THP-1 monocytes. PLoS ONE 2014, 9, e107431.
    • (2014) PLoS ONE , vol.9
    • Risitano, R.1    Currò, M.2    Cirmi, S.3    Ferlazzo, N.4    Campiglia, P.5    Caccamo, D.6    Ientile, R.7    Navarra, M.8
  • 37
    • 84914166696 scopus 로고    scopus 로고
    • The anti-inflammatory and antioxidant effects of bergamot juice extract (BJe) in an experimental model of inflammatory bowel disease
    • Impellizzeri, D.; Bruschetta, G.; di Paola, R.; Ahmad, A.; Campolo, M.; Cuzzocrea, S.; Esposito, E.; Navarra, M. The anti-inflammatory and antioxidant effects of bergamot juice extract (BJe) in an experimental model of inflammatory bowel disease. Clin. Nutr. 2015, 34, 1146-1154.
    • (2015) Clin. Nutr. , vol.34 , pp. 1146-1154
    • Impellizzeri, D.1    Bruschetta, G.2    Di Paola, R.3    Ahmad, A.4    Campolo, M.5    Cuzzocrea, S.6    Esposito, E.7    Navarra, M.8
  • 38
    • 84957818799 scopus 로고    scopus 로고
    • Citrus bergamia Juice Extract Attenuates beta-Amyloid-Induced Pro-Inflammatory Activation of THP-1 Cells Through MAPK and AP-1 Pathways
    • Currò, M.; Risitano, R.; Ferlazzo, N.; Cirmi, S.; Gangemi, C.; Caccamo, D.; Ientile, R.; Navarra, M. Citrus bergamia Juice Extract Attenuates beta-Amyloid-Induced Pro-Inflammatory Activation of THP-1 Cells Through MAPK and AP-1 Pathways. Sci. Rep. 2016, 6, 20809.
    • (2016) Sci. Rep. , vol.6 , pp. 20809
    • Currò, M.1    Risitano, R.2    Ferlazzo, N.3    Cirmi, S.4    Gangemi, C.5    Caccamo, D.6    Ientile, R.7    Navarra, M.8
  • 39
    • 84981554839 scopus 로고    scopus 로고
    • Anti-inflammatory and Antioxidant Effects of Flavonoid-Rich Fraction of Bergamot Juice (BJe) in a Mouse Model of Intestinal Ischemia/Reperfusion Injury
    • Impellizzeri, D.; Cordaro, M.; Campolo, M.; Gugliandolo, E.; Esposito, E.; Benedetto, F.; Cuzzocrea, S.; Navarra, M. Anti-inflammatory and Antioxidant Effects of Flavonoid-Rich Fraction of Bergamot Juice (BJe) in a Mouse Model of Intestinal Ischemia/Reperfusion Injury. Front. Pharmacol. 2016, 7, 203.
    • (2016) Front. Pharmacol. , vol.7 , pp. 203
    • Impellizzeri, D.1    Cordaro, M.2    Campolo, M.3    Gugliandolo, E.4    Esposito, E.5    Benedetto, F.6    Cuzzocrea, S.7    Navarra, M.8
  • 41
    • 84897084127 scopus 로고    scopus 로고
    • Effect of Citrus bergamia juice on human neuroblastoma cells in vitro and in metastatic xenograft models
    • Navarra, M.; Ursino, M.R.; Ferlazzo, N.; Russo, M.; Schumacher, U.; Valentiner, U. Effect of Citrus bergamia juice on human neuroblastoma cells in vitro and in metastatic xenograft models. Fitoterapia 2014, 95, 83-92.
    • (2014) Fitoterapia , vol.95 , pp. 83-92
    • Navarra, M.1    Ursino, M.R.2    Ferlazzo, N.3    Russo, M.4    Schumacher, U.5    Valentiner, U.6
  • 44
    • 84962013808 scopus 로고    scopus 로고
    • Bergamot Reduces Plasma Lipids, Atherogenic Small Dense LDL, and Subclinical Atherosclerosis in Subjects with Moderate Hypercholesterolemia: A 6 Months Prospective Study
    • Toth, P.P.; Patti, A.M.; Nikolic, D.; Giglio, R.V.; Castellino, G.; Biancucci, T.; Geraci, F.; David, S.; Montalto, G.; Rizvi, A.; et al. Bergamot Reduces Plasma Lipids, Atherogenic Small Dense LDL, and Subclinical Atherosclerosis in Subjects with Moderate Hypercholesterolemia: A 6 Months Prospective Study. Front. Pharmacol. 2015, 6, 299.
    • (2015) Front. Pharmacol. , vol.6 , pp. 299
    • Toth, P.P.1    Patti, A.M.2    Nikolic, D.3    Giglio, R.V.4    Castellino, G.5    Biancucci, T.6    Geraci, F.7    David, S.8    Montalto, G.9    Rizvi, A.10
  • 45
    • 75749131543 scopus 로고    scopus 로고
    • Study on the chemical composition variability of some processed bergamot (Citrus bergamia) essential oils
    • Costa, R.; Dugo, P.; Navarra, M.; Raymo, V.; Dugo, G.; Mondello, L. Study on the chemical composition variability of some processed bergamot (Citrus bergamia) essential oils. Flavour Fragance J. 2010, 25, 4-12.
    • (2010) Flavour Fragance J. , vol.25 , pp. 4-12
    • Costa, R.1    Dugo, P.2    Navarra, M.3    Raymo, V.4    Dugo, G.5    Mondello, L.6
  • 46
    • 37349064440 scopus 로고    scopus 로고
    • Distribution of flavonoids and furocoumarins in juices from cultivars of Citrus bergamia Risso
    • Gattuso, G.; Barreca, D.; Caristi, C.; Gargiulli, C.; Leuzzi, U. Distribution of flavonoids and furocoumarins in juices from cultivars of Citrus bergamia Risso. J. Agric. Food Chem. 2007, 55, 9921-9927.
    • (2007) J. Agric. Food Chem. , vol.55 , pp. 9921-9927
    • Gattuso, G.1    Barreca, D.2    Caristi, C.3    Gargiulli, C.4    Leuzzi, U.5
  • 47
    • 84923061688 scopus 로고    scopus 로고
    • Chemical Composition of Bergamot (Citrus bergamia Risso) Essential Oil Obtained by Hydrodistillation
    • Nabiha, B.; Abdelfatteh, E.O.; Faten, K.; Hervé, C.; Moncef, C.M. Chemical Composition of Bergamot (Citrus bergamia Risso) Essential Oil Obtained by Hydrodistillation. Iran. J. Chem. Chem. Eng. 2010, 4, 60-62.
    • (2010) Iran. J. Chem. Chem. Eng. , vol.4 , pp. 60-62
    • Nabiha, B.1    Abdelfatteh, E.O.2    Faten, K.3    Hervé, C.4    Moncef, C.M.5
  • 48
    • 33746132390 scopus 로고    scopus 로고
    • Characteristic odour components of bergamot (Citrus bergamia Risso) essential oil
    • Sawamura, M.; Onishi, Y.; Ikemoto, J.; Tu, N.T.M.; Phi, N.T.L. Characteristic odour components of bergamot (Citrus bergamia Risso) essential oil. Flavour Fragance J. 2006, 21, 609-615.
    • (2006) Flavour Fragance J. , vol.21 , pp. 609-615
    • Sawamura, M.1    Onishi, Y.2    Ikemoto, J.3    Tu, N.T.M.4    Phi, N.T.L.5
  • 49
    • 70450162772 scopus 로고    scopus 로고
    • The structure and pharmacological functions of coumarins and their derivatives
    • Wu, L.; Wang, X.; Xu, W.; Farzaneh, F.; Xu, R. The structure and pharmacological functions of coumarins and their derivatives. Curr. Med. Chem. 2009, 16, 4236-4260.
    • (2009) Curr. Med. Chem. , vol.16 , pp. 4236-4260
    • Wu, L.1    Wang, X.2    Xu, W.3    Farzaneh, F.4    Xu, R.5
  • 52
    • 50449111165 scopus 로고    scopus 로고
    • Update on uses and properties of citrus flavonoids: New findings in anticancer, cardiovascular, and anti-inflammatory activity
    • Benavente-Garcia, O.; Castillo, J. Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity. J. Agric. Food Chem. 2008, 56, 6185-6205.
    • (2008) J. Agric. Food Chem. , vol.56 , pp. 6185-6205
    • Benavente-Garcia, O.1    Castillo, J.2
  • 53
    • 0035001464 scopus 로고    scopus 로고
    • Biological properties of citrus flavonoids pertaining to cancer and inflammation
    • Manthey, J.A.; Grohmann, K.; Guthrie, N. Biological properties of citrus flavonoids pertaining to cancer and inflammation. Curr. Med. Chem. 2001, 8, 135-153.
    • (2001) Curr. Med. Chem. , vol.8 , pp. 135-153
    • Manthey, J.A.1    Grohmann, K.2    Guthrie, N.3
  • 54
    • 84924298691 scopus 로고    scopus 로고
    • Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: An updated review of their molecular mechanisms and experimental models
    • Parhiz, H.; Roohbakhsh, A.; Soltani, F.; Rezaee, R.; Iranshahi, M. Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models. Phytother. Res. 2015, 29, 323-331.
    • (2015) Phytother. Res. , vol.29 , pp. 323-331
    • Parhiz, H.1    Roohbakhsh, A.2    Soltani, F.3    Rezaee, R.4    Iranshahi, M.5
  • 55
    • 77951591651 scopus 로고    scopus 로고
    • Citrus bergamia Risso & Poiteau juice protects against renal injury of diet-induced hypercholesterolemia in rats
    • Trovato, A.; Taviano, M.F.; Pergolizzi, S.; Campolo, L.; de Pasquale, R.; Miceli, N. Citrus bergamia Risso & Poiteau juice protects against renal injury of diet-induced hypercholesterolemia in rats. Phytother. Res. 2010, 24, 514-519.
    • (2010) Phytother. Res. , vol.24 , pp. 514-519
    • Trovato, A.1    Taviano, M.F.2    Pergolizzi, S.3    Campolo, L.4    De Pasquale, R.5    Miceli, N.6
  • 58
    • 79955084668 scopus 로고    scopus 로고
    • Bergamot (Citrus bergamia Risso) fruit extracts and identified components alter expression of interleukin 8 gene in cystic fibrosis bronchial epithelial cell lines
    • Borgatti, M.; Mancini, I.; Bianchi, N.; Guerrini, A.; Lampronti, I.; Rossi, D.; Sacchetti, G.; Gambari, R. Bergamot (Citrus bergamia Risso) fruit extracts and identified components alter expression of interleukin 8 gene in cystic fibrosis bronchial epithelial cell lines. BMC Biochem. 2011, 12, 1.
    • (2011) BMC Biochem. , vol.12 , pp. 1
    • Borgatti, M.1    Mancini, I.2    Bianchi, N.3    Guerrini, A.4    Lampronti, I.5    Rossi, D.6    Sacchetti, G.7    Gambari, R.8
  • 59
    • 84863306890 scopus 로고    scopus 로고
    • Protective effects of an extract from Citrus bergamia against inflammatory injury in interferon-gamma and histamine exposed human keratinocytes
    • Graziano, A.C.; Cardile, V.; Crasci, L.; Caggia, S.; Dugo, P.; Bonina, F.; Panico, A. Protective effects of an extract from Citrus bergamia against inflammatory injury in interferon-gamma and histamine exposed human keratinocytes. Life Sci. 2012, 90, 968-974.
    • (2012) Life Sci. , vol.90 , pp. 968-974
    • Graziano, A.C.1    Cardile, V.2    Crasci, L.3    Caggia, S.4    Dugo, P.5    Bonina, F.6    Panico, A.7
  • 62
    • 0026801151 scopus 로고
    • Epidermal growth factor suppresses nitric oxide and hydrogen peroxide production by keratinocytes. Potential role for nitric oxide in the regulation of wound healing
    • Heck, D.E.; Laskin, D.L.; Gardner, C.R.; Laskin, J.D. Epidermal growth factor suppresses nitric oxide and hydrogen peroxide production by keratinocytes. Potential role for nitric oxide in the regulation of wound healing. J. Biol. Chem. 1992, 267, 21277-21280.
    • (1992) J. Biol. Chem. , vol.267 , pp. 21277-21280
    • Heck, D.E.1    Laskin, D.L.2    Gardner, C.R.3    Laskin, J.D.4
  • 64
    • 75149118999 scopus 로고    scopus 로고
    • Neuroinflammation in Alzheimer's disease and mild cognitive impairment: A field in its infancy
    • McGeer, E.G.; McGeer, P.L. Neuroinflammation in Alzheimer's disease and mild cognitive impairment: A field in its infancy. J. Alzheimers Dis. 2010, 19, 355-361.
    • (2010) J. Alzheimers Dis. , vol.19 , pp. 355-361
    • McGeer, E.G.1    McGeer, P.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.