Anti-infective potential of Citrus bergamia Risso et Poiteau (bergamot) derivatives: a systematic review

Phytotherapy Research

Volumn , Issue , 2016, Pages 1404-1411

  Cirmi, Santa ^a   Bisignano, Carlo ^a   Mandalari, Giuseppina ^a   Navarra, Michele ^a  

^a UNIVERSITY OF MESSINA   (Italy)

Author keywords

anti infective; antimicrobial; bergamot; Citrus bergamia; complementary and alternative medicines; infectious diseases; natural products

Indexed keywords

ANTIINFECTIVE AGENT; CITRUS BERGAMIA EXTRACT; ESSENTIAL OIL; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANTI-INFECTIVE THERAPY; ANTIBIOTIC RESISTANCE; ANTIFUNGAL ACTIVITY; ANTILARVAE ACTIVITY; ANTIMICROBIAL ACTIVITY; ARCOBACTER BUTZLERI; ARTHRODERMA GYPSEUM; ARTHRODERMA OTAE; BACILLUS CEREUS; BACTERIAL GROWTH; BACTERIAL STRAIN; CAMPYLOBACTER JEJUNI; DRUG ACTIVITY; DRUG SCREENING; EPIDERMOPHYTON FLOCCOSUM; ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE; HELICOBACTER PYLORI; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LISTERIA MONOCYTOGENES; MIC50; MYCOPLASMA FERMENTANS; MYCOPLASMA HOMINIS; MYCOPLASMA PNEUMONIAE; NONHUMAN; PENICILLIUM ITALICUM; REVIEW; STAPHYLOCOCCUS AUREUS; STENOTROPHOMONAS MALTOPHILIA; SYSTEMATIC REVIEW; TRADITIONAL MEDICINE; TRICHOPHYTON INTERDIGITALE; TRICHOPHYTON MENTAGROPHYTES; TRICHOPHYTON RUBRUM; TRICHOPHYTON TONSURANS;

EID: 84985996196     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5646     Document Type: Review

References (69)

1. Adukwu EC, Allen SC, Phillips CA. 2012. The anti-biofilm activity of lemongrass (Cymbopogon flexuosus) and grapefruit (Citrus paradisi) essential oils against five strains of Staphylococcus aureus. J Appl Microbiol 113(5): 1217–1227.
2. Aro AO, Dzoyem JP, Hlokwe TM, et al. 2015. Some South African Rubiaceae tree leaf extracts have antimycobacterial activity against pathogenic and non-pathogenic Mycobacterium species. Phytother Res 29(7): 1004–1010.
3. Bisignano C, Filocamo A, Faulks RM, et al. 2013b. In vitro antimicrobial activity of pistachio (Pistacia vera L.) polyphenols. Fems Microbiology Letters 341(1): 62–67.
4. Bisignano C, Filocamo A, Ginestra G, et al. 2014. 3,4-DHPEA-EA from Olea Europaea L. is effective against standard and clinical isolates of Staphylococcus sp. Ann Clin Microbiol Antimicrob 13: 24.
5. Bisignano C, Filocamo A, La Camera E, et al. 2013a. Antibacterial activities of almond skins on cagA-positive and-negative clinical isolates of Helicobacter pylori. BMC Microbiol 13: 103.
6. Bisignano C, Filocamo A, Mandalari G, et al. 2015. Effect of a white grape (Vitis vinifera L.) juice extract on the growth and biofilm production of methicillin-resistant and sensitive Staphylococcus species. Clin Microbiol & Case Rep 1(2): 3.
7. Brul S, Coote P. 1999. Preservative agents in foods. Mode of action and microbial resistance mechanisms. Int J Antimicrob Agents 50(1–2): 1–17.
8. Celia C, Trapasso E, Locatelli M, et al. 2013. Anticancer activity of liposomal bergamot essential oil (BEO) on human neuroblastoma cells. Colloids Surf B Biointerfaces 112: 548–553.
9. Chafer M, Sanchez-Gonzalez L, Gonzalez-Martinez C, et al. 2012. Fungal decay and shelf life of oranges coated with chitosan and bergamot, thyme, and tea tree essential oils. J Food Sci 77(8): E182–E187.
10. Cicero AFG, Ferroni A, Ertek S. 2012. Tolerability and safety of commonly used dietary supplements and nutraceuticals with lipid-lowering effects. Expert Opin Drug Saf 11(5): 753–766.
11. Corasaniti MT, Maiuolo J, Maida S, et al. 2007. Cell signaling pathways in the mechanisms of neuroprotection afforded by bergamot essential oil against NMDA-induced cell death in vitro. Br J Pharmacol 151(4): 518–529.
12. Costa R, Dugo P, Navarra M, et al. 2010. Study on the chemical composition variability of some processed bergamot (Citrus bergamia) essential oils. Flavour Fragr J 25(1): 4–12.
13. Currò M, Risitano R, Ferlazzo N, et al. 2016. Citrus bergamia juice extract attenuates β-amyloid-induced pro-inflammatory activation of THP-1 cells through MAPK and AP-1 pathways. Sci Rep 6: 20809.
14. Delle Monache S, Sanita P, Trapasso E, et al. 2013. Mechanisms underlying the anti-tumoral effects of Citrus bergamia juice. PLoS One 8: 4e61484.
15. Dias DA, Urban S, Roessner U. 2012. A historical overview of natural products in drug discovery. Metabolites 2(2): 303–336.
16. Fabio A, Cermelli C, Fabio G, et al. 2007. Screening of the antibacterial effects of a variety of essential oils on microorganisms responsible for respiratory infections. Phytother Res 21(4): 374–377.
17. Ferlazzo N, Cirmi S, Russo M, et al. 2016a. NF-kappaB mediates the antiproliferative and proapoptotic effects of bergamot juice in HepG2 cells. Life Sci 146: 81–91.
18. Ferlazzo N, Visalli G, Cirmi S, et al. 2016b. Natural iron chelators: Protective role in A549 cells of flavonoids-rich extracts of Citrus juices in Fe-induced oxidative stress. Environ Toxicol Pharmacol 43: 248–256.
19. Ferlazzo N, Visalli G, Smeriglio A, et al. 2015. Flavonoid fraction of orange and bergamot juices protect human lung epithelial cells from hydrogen peroxide-induced oxidative stress. Evid Based Complement Alternat Med 2015: 957031.
20. Filocamo A, Bisignano C, Ferlazzo N, et al. 2015a. In vitro effect of bergamot (Citrus bergamia) juice against cagA-positive and-negative clinical isolates of Helicobacter pylori. BMC Complement Altern Med 15: 256.
21. Filocamo A, Bisignano C, Mandalari G, et al. 2015b. In vitro antimicrobial activity and effect on biofilm production of a white grape juice (Vitis vinifera) extract. Evid Based Complement Alternat Med 2015: 856243.
22. Fischbach MA, Walsh CT. 2009. Antibiotics for emerging pathogens. Science 325(5944): 1089–1093.
23. Fisher K, Phillips C. 2009a. The mechanism of action of a citrus oil blend against Enterococcus faecium and Enterococcus faecalis. J Appl Microbiol 106(4): 1343–1349.
24. Fisher K, Phillips C. 2009b. In vitro inhibition of vancomycin-susceptible and vancomycin-resistant Enterococcus faecium and E. faecalis in the presence of citrus essential oils. Br J Biomed Sci 66(4): 180–185.
25. Fisher K, Phillips CA. 2006. The effect of lemon, orange and bergamot essential oils and their components on the survival of Campylobacter jejuni, Escherichia coli O157, Listeria monocytogenes, Bacillus cereus and Staphylococcus aureus in vitro and in food systems. J Appl Microbiol 101(6): 1232–1240.
26. Fisher K, Rowe C, Phillips CA. 2007. The survival of three strains of Arcobacter butzleri in the presence of lemon, orange and bergamot essential oils and their components in vitro and on food. Lett Appl Microbiol 44(5): 495–499.
27. Furneri PM, Mondello L, Mandalari G, et al. 2012. In vitro antimycoplasmal activity of Citrus bergamia essential oil and its major components. Eur J Med Chem 52: 66–69.
28. Gattuso G, Barreca D, Caristi C, et al. 2007. Distribution of flavonoids and furocoumarins in juices from cultivars of Citrus bergamia Risso. J Agric Food Chem 55(24): 9921–9927.
29. Gordon RJ, Lowy FD. 2008. Pathogenesis of methicillin-resistant Staphylococcus aureus infection. Clin Infect Dis 46(Suppl 5): S350–359.
30. Gould IM. 2008. The epidemiology of antibiotic resistance. Int J Antimicrob Agents 32(Suppl 1): S2–9.
31. Gwatkin DR, Guillot M, Heuveline P. 1999. The burden of disease among the global poor. Lancet 354(9178): 586–589.
32. Hotez PJ, Remme JH, Buss P, et al. 2004. Combating tropical infectious diseases: report of the Disease Control Priorities in Developing Countries Project. Clin Infect Dis 38(6): 871–878.
33. Impellizzeri D, Bruschetta G, Di Paola R, et al. 2015. The anti-inflammatory and antioxidant effects of bergamot juice extract (BJe) in an experimental model of inflammatory bowel disease. Clin Nutr 34(6): 1146–1154.
34. Inouye S, Yamaguchi H, Takizawa T. 2001. Screening of the antibacterial effects of a variety of essential oils on respiratory tract pathogens, using a modified dilution assay method. J Infect Chemother 7(4): 251–254.
35. Kenny O, Brunton NP, Walsh D, et al. 2015. Characterisation of antimicrobial extracts from dandelion root (Taraxacum officinale) using LC-SPE-NMR. Phytother Res 29(4): 526–532.
36. Khalifa HO, Kamimoto M, Shimamoto T, et al. 2015. Antimicrobial effects of blueberry, raspberry, and strawberry aqueous extracts and their effects on virulence gene expression in Vibrio cholerae. Phytother Res 29(11): 1791–1797.
37. Lee HS. 2006. Mosquito larvicidal activity of aromatic medicinal plant oils against Aedes aegypti and Culex pipiens pallens. J Am Mosq Control Assoc 22(2): 292–295.
38. Lezama-Davila CM, Pan L, Isaac-Marquez AP, et al. 2014. Pentalinon andrieuxii root extract is effective in the topical treatment of cutaneous leishmaniasis caused by Leishmania mexicana. Phytother Res 28(6): 909–916.
39. Lv F, Liang H, Yuan QP, et al. 2011. In vitro antimicrobial effects and mechanism of action of selected plant essential oil combinations against four food-related microorganisms. Food Res Int 44(9): 3057–3064.
40. Mandalari G, Bennett RN, Bisignano G, et al. 2006a. Characterization of flavonoids and pectins from bergamot (Citrus bergamia Risso) peel, a major byproduct of essential oil extraction. J Agric Food Chem 54(1): 197–203.
41. Mandalari G, Bennett RN, Bisignano G, et al. 2007a. Antimicrobial activity of flavonoids extracted from bergamot (Citrus bergamia Risso) peel, a byproduct of the essential oil industry. J Appl Microbiol 103(6): 2056–2064.
42. Mandalari G, Bennett RN, Kirby AR, et al. 2006b. Enzymatic hydrolysis of flavonoids and pectic oligosaccharides from bergamot (Citrus bergamia Risso) peel. J Agric Food Chem 54(21): 8307–8313.
43. Mandalari G, Bisignano C, D'Arrigo M, et al. 2010. Antimicrobial potential of polyphenols extracted from almond skins. Lett Appl Microbiol 51(1): 83–89.
44. Mandalari G, Palop CN, Tuohy K, et al. 2007b. In vitro evaluation of the prebiotic activity of a pectic oligosaccharide-rich extract enzymatically derived from bergamot peel. Appl Microbiol Biotechnol 73(5): 1173–1179.
45. Mellou F, Lazari D, Skaltsa H, et al. 2005. Biocatalytic preparation of acylated derivatives of flavonoid glycosides enhances their antioxidant and antimicrobial activity. J Biotechnol 116(3): 295–304.
46. Mollace V, Sacco I, Janda E, et al. 2011. Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies. Fitoterapia 82(3): 309–316.
47. Navarra M, Ferlazzo N, Cirmi S, et al. 2015a. Effects of bergamot essential oil and its extractive fractions on SH-SY5Y human neuroblastoma cell growth. J Pharm Pharmacol 67(8): 1042–1053.
48. Navarra M, Mannucci C, Delbo M, et al. 2015b. Citrus bergamia essential oil: from basic research to clinical application. Front Pharmacol 6: 36.
49. Navarra M, Ursino MR, Ferlazzo N, et al. 2014. Effect of Citrus bergamia juice on human neuroblastoma cells in vitro and in metastatic xenograft models. Fitoterapia 95: 83–92.
50. Newman DJ, Cragg GM. 2012. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod 75(3): 311–335.
51. Oussalah M, Caillet S, Lacroix M. 2006. Mechanism of action of Spanish oregano, Chinese cinnamon, and savory essential oils against cell membranes and walls of Escherichia coli O157:H7 and Listeria monocytogenes. J Food Prot 69(5): 1046–1055.
52. Phillips CA, Gkatzionis K, Laird K, et al. 2012. Identification and quantification of the antimicrobial components of a citrus essential oil vapor. Nat Prod Commun 7(1): 103–107.
53. Plaza P, Torres R, Usall J, et al. 2004. Evaluation of the potential of commercial post-harvest application of essential oils to control citrus decay. J Hortic Sci & Biotech 79(6): 935–940.
54. Pogacar MS, Klancnik A, Bucar F, et al. 2015. Alpinia katsumadai extracts inhibit adhesion and invasion of Campylobacter jejuni in animal and human foetal small intestine cell lines. Phytother Res 29(10): 1585–1589.
55. Rapisarda A, Germanò M. 2013. Citrus bergamia Risso & Poiteau botanical classification, morphology and anatomy. In Citrus bergamia–Bergamot and its Derivatives, Dugo G, Bonaccorsi I (ed). CCR Press; 9–11.
56. Risitano R, Curro M, Cirmi S, et al. 2014. Flavonoid fraction of bergamot juice reduces LPS-induced inflammatory response through SIRT1-mediated NF-kappaB inhibition in THP-1 monocytes. PLoS One 9(9): e107431.
57. Romano L, Battaglia F, Masucci L, et al. 2005. In vitro activity of bergamot natural essence and furocoumarin-free and distilled extracts, and their associations with boric acid, against clinical yeast isolates. J Antimicrob Chemother 55(1): 110–114.
58. Said-Salim B, Mathema B, Braughton K, et al. 2005. Differential distribution and expression of Panton–Valentine leucocidin among community-acquired methicillin-resistant Staphylococcus aureus strains. J Clin Microbiol 43(7): 3373–3379.
59. Sanchez-Gonzalez L, Chafer M, Chiralt A, et al. 2010. Physical properties of edible chitosan films containing bergamot essential oil and their inhibitory action on Penicillium italicum. Carbohydr Polym 82(2): 277–283.
60. Sanguinetti M, Posteraro B, Romano L, et al. 2007. In vitro activity of Citrus bergamia (bergamot) oil against clinical isolates of dermatophytes. J Antimicrob Chemother 59(2): 305–308.
61. Schlipköter U, Flahault A. 2010. Communicable diseases: achievements and challenges for public health. Public Health Rev 32(1): 29.
62. Sherif M, Mohran Z, Fathy H, et al. 2004. Universal high-level primary metronidazole resistance in Helicobacter pylori isolated from children in Egypt. J Clin Microbiol 42(10): 4832–4834.
63. Skocibusic M, Bezic N, Dunkic V, et al. 2004. Antibacterial activity of Achillea clavennae essential oil against respiratory tract pathogens. Fitoterapia 75(7–8): 733–736.
64. Smith-Palmer A, Stewart J, Fyfe L. 1998. Antimicrobial properties of plant essential oils and essences against five important food-borne pathogens. Lett Appl Microbiol 26(2): 118–122.
65. Tiwari SK, Khan AA, Ahmed KS, et al. 2005. Rapid diagnosis of Helicobacter pylori infection in dyspeptic patients using salivary secretion: a non-invasive approach. Singapore Med J 46(5): 224–228.
66. Tortorano AM, Posteraro B, Viviani MA, et al. 2009. Molecular identification and in vitro antifungal susceptibilities of 28 zygomycetes isolates: FIMUA-ECMM survey of zygomycosis in Italy. J Chemother 21(3): 363–364.
67. Toth PP, Patti AM, Nikolic D, et al. 2016. Bergamot reduces plasma lipids, atherogenic small dense LDL, and subclinical atherosclerosis in subjects with moderate hypercholesterolemia: a 6 months prospective study. Front Pharmacol 6: 299.
68. Visalli G, Ferlazzo N, Cirmi S, et al. 2014. Bergamot juice extract inhibits proliferation by inducing apoptosis in human colon cancer cells. Anticancer Agents Med Chem 14(10): 1402–1413.
69. Zetola N, Francis JS, Nuermberger EL, et al. 2005. Community-acquired meticillin-resistant Staphylococcus aureus: an emerging threat. Lancet Infect Dis 5(5): 275–286.