Citrus bergamia Risso & Poiteau juice protects against renal injury of diet-induced hypercholesterolemia in rats

Phytotherapy Research

Volumn 24, Issue 4, 2010, Pages 514-519

  Trovato, Ada ^a   Taviano, Maria F ^a   Pergolizzi, Simona ^a   Campolo, Loredana ^a   De Pasquale, Rita ^a   Miceli, Natalizia ^a  

^a UNIVERSITY OF MESSINA   (Italy)

Author keywords

Citrus bergamia juice; Hypercholesterolemia; Lipid peroxidation; Radical scavenging activity; Reducing power; Renal injury

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 3,4 METHYLENEDIOXYAMPHETAMINE; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CHOLESTEROL BLOOD LEVEL; CITRUS BERGAMIA; CITRUS FRUIT; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIET SUPPLEMENTATION; DIETARY INTAKE; DISEASE COURSE; FRUIT JUICE; GLOMERULUS FILTRATION; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; IN VITRO STUDY; IN VIVO STUDY; KIDNEY HOMOGENATE; KIDNEY INJURY; LIPID PEROXIDATION; MALE; NONHUMAN; POITEAU; RAT; RUTACEAE; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; BIPHENYL COMPOUNDS; CHOLESTEROL; CITRUS; CREATININE; DRUG EVALUATION, PRECLINICAL; FREE RADICAL SCAVENGERS; HYPERCHOLESTEROLEMIA; KIDNEY; KIDNEY DISEASES; MALE; PHYTOTHERAPY; PICRATES; PLANT EXTRACTS; RATS; RATS, WISTAR; TRIGLYCERIDES;

CITRUS AURANTIUM BERGAMIA; RATTUS;

EID: 77951591651     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2971     Document Type: Article

References (28)

1. Apáti P, Szentmihályi K, Kristó ST et al. 2003. Herbal remedies of Solidago: correlation of phytochemical characteristics and antioxidative properties. J Pharm Biomed Anal 32: 1045-1053.
2. Bank N. 1993. Renal hemodynamic consequences of hyperlipidemia. Miner Electrolyte Metab 19: 165-172.
3. Bentley MD, Rodriguez-Porcel M, Lerman A et al. 2002. Enhanced renal cortical vascularization in experimental hypercholesterolemia. Kidney Int 61: 1056-1063. (Pubitemid 34175475)
4. Bradford MM. 1979. A rapid and sensitive method for the quantification of microgram quantities of protein utilising the principle of protein-dye binding. Anal Biochem 72: 248-254.
5. Chade AR, Rodriguez-Porcel M, Grande JP et al. 2002. Distinct renal injury in early atherosclerosis and renovascular disease. Circulation 106: 1165-1171. (Pubitemid 34970861)
6. Danam RP, Lu MH, Lewis SM, Djuric Z, Tang N, Hart RW. 1999. The effect of dietary fat on malondialdehyde concentrations in Fischer 344 rats. Mech Ageing Dev 110: 87-99. (Pubitemid 29452973)
7. Di Giacomo A. 1989. Il Bergamotto di Reggio Calabria. Laruffa: Reggio Calabria; 102-119.
8. Duh P-D. 1998. Antioxidant activity of burdock (Arctium lappa Linné): Its scavenging effect on free-radical and active oxygen. J Am Oil Chem Soc 75: 455-461.
9. Gattuso G, Caristi C, Gargiulli C, Bellocco E, Toscano G, Leuzzi U. 2006. Flavonoid glycosides in bergamot juice (Citrus bergamia Risso). J Agric Food Chem 54: 3929-3935. (Pubitemid 44030573)
10. Ishiyama A, Atarashi K, Minami M et al. 1999. Role of free radicals in the pathogenesis of lipid-induced glomerulosclerosis in rats. Kidney Int 55: 1348-1358. (Pubitemid 29157133)
11. Kaplan R, Aynedjian HS, Schlondorff D, Bank N. 1990. Renal vasoconstriction caused by short-term cholesterol feeding is corrected by thromboxane antagonist or probucol. J Clin Invest 86: 1707-1714. (Pubitemid 20372624)
12. Kasiske BL, O'Donnell MP, Cleary MP, Keane WF. 1988. Treatment of hyperlipidemia reduces glomerular injury in obese Zucker rats. Kidney Int 33: 667-672.
13. Kasiske BL, O'Donnell MP, Schmitz PG, Kim Y, Keane WF. 1990. Renal injury of diet-induced hypercholesterolemia in rats. Kidney Int 37: 880-891. (Pubitemid 20089220)
14. Keane WF, Kasiske BL, O'Donnell MP. 1988. Lipids and progressive glomerulosclerosis. A model analogous to atherosclerosis. Am J Nephrol 8: 261-271.
15. Kim J-S. 2005. Radical scavenging capacity and antioxidant activity of the E Vitamer fraction in rice bran. J Food Sci 70: 208-213.
16. Litchfield Jr JT, Wilcoxon F. 1949. A simplified method of evaluating dose-effect experiments. J. Pharmacol Exp Ther 96: 99-113.
17. + loss and lipid peroxidation induced by oxygen-free radicals in human red cells. Pharmacol Res Commun 18: 61-72.
18. Mateos R, Lecumberri E, Ramos S, Goya L, Bravo L. 2005. Determination of malondialdehyde (MDA) by high-performance liquid chromatography in serum and liver as a biomarker for oxidative stress. Application to a rat model for hypercholesterolemia and evaluation of the effect of diets rich in phenolic antioxidants from fruits. J Chromatogr B Analyt Technol Biomed Life Sci 827: 76-82. (Pubitemid 41551599)
19. Miceli N, Mondello MR, Monforte MT et al. 2007. Hypolipidemic effects of Citrus bergamia Risso et Poiteau juice in rats fed a hypercholesterolemic diet. J Agric Food Chem 55: 10671-10677.
20. Nagase M, Ando K, Nagase T, Kaname S, Sawamura T, Fujita T. 2001. Redox-sensitive regulation of lox-1 gene expression in vascular endothelium. Biochem Biophys Res Commun 281: 720-725. (Pubitemid 32917860)
21. Napoli C, Lerman LO. 2001. Involvement of oxidation-sensitive mechanisms in the cardiovascular effects of hypercholesterolemia. Mayo Clin Proc 76: 619-631. (Pubitemid 32536755)
22. Ohinishi M, Morishita H, Iwahashi H et al. 1994. Inhibitory effects of chlorogenic acid on linoleic acid, peroxidation and haemolysis. Phytochemistry 36: 579-583. (Pubitemid 2097572)
23. Ohkawa H, Oshishi N, Yagi K. 1979. Assay for lipid peroxidation in animal tissues by thiobarbituric acid reaction. Anal Biochem 95: 351-358. (Pubitemid 9194347)
24. Oyaizu M. 1986. Studies on products of browning reaction: antioxidative activities of products of browning reaction prepared from glucosamine. Jpn J Nutr 44: 307-315.
25. Singh D, Chopra K. 2004. The effect of naringin, a bioflavonoid on ischemia-reperfusion induced renal injury in rats. Pharmacol Res 50: 187-193. (Pubitemid 38737251)
26. Stulak JM, Lerman A, Porcel MR et al. 2001. Renal vascular function in hypercholesterolemia is preserved by chronic antioxidant supplementation. J Am Soc Nephrol 12: 1882-1891. (Pubitemid 32801363)
27. Wardle EN. 1999. Antioxidants in the prevention of renal disease. Ren Fail 21: 581-591.
28. Wheeler DC, Chana RS, Topley N, Petersen MM, Davies M, Williams JD. 1994. Oxidation of low density lipoprotein by mesangial cells may promote glomerular injury. Kidney Int 45: 1628-1636. (Pubitemid 24207498)