Determining Physical Mechanisms of Gene Expression Regulation from Single Cell Gene Expression Data

PLoS Computational Biology

Volumn 12, Issue 8, 2016, Pages

  Ezer, Daphne ^a,b   Moignard, Victoria ^c   Göttgens, Berthold ^c   Adryan, Boris ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CELL PROLIFERATION; CLUSTERING ALGORITHMS; KINETIC PARAMETERS; PARAMETER ESTIMATION; POLYMERASE CHAIN REACTION; SAMPLING; SIMULATED ANNEALING; STEM CELLS; THROUGHPUT; TRANSCRIPTION;

CLUSTERINGS; EXPERIMENTAL APPROACHES; GENE EXPRESSION DATA; GENES EXPRESSION; HIGH-THROUGHPUT; KINETICS PARAMETER; PHYSICAL MECHANISM; REGULATORY MECHANISM; SINGLE CELLS; TURN OFFS;

POPULATION STATISTICS;

GFI1 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 2; UNCLASSIFIED DRUG;

ALGORITHM; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DOWN REGULATION; ESTIMATION OF PARAMETER CHANGES IN KINETICS; GENE EXPRESSION REGULATION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LEUKEMIA; MATHEMATICAL MODEL; POLYMERASE CHAIN REACTION; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; SIMULATED ANNEALING FOR BURSTY EXPRESSION CLUSTERING; STATISTICAL PARAMETERS; UPREGULATION; ANIMAL; BIOLOGY; CELL LINE; COMPUTER SIMULATION; GENE EXPRESSION PROFILING; GENETICS; KINETICS; METABOLISM; MOUSE; PHYSIOLOGY; PROCEDURES; SINGLE CELL ANALYSIS;

ALGORITHMS; ANIMALS; CELL LINE; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEMATOPOIESIS; HUMANS; KINETICS; MICE; SINGLE-CELL ANALYSIS; TRANSCRIPTION FACTORS;

EID: 84988972517     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1005072     Document Type: Article

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