Red Maca (Lepidium meyenii) did not affect cell viability despite increased androgen receptor and prostate-specific antigen gene expression in the human prostate cancer cell line LNCaP

Andrologia

Volumn 48, Issue 8, 2016, Pages 922-926

  Diaz P ^a,b   Cardenas, H ^a,b   Orihuela, P A ^a,b  

^a UNIVERSIDAD DE SANTIAGO DE CHILE   (Chile)

^b CENTER FOR THE DEVELOPMENT OF NANOSCIENCE AND NANOTECHNOLOGY CEDENNA   (Chile)

Author keywords

androgen receptor; cell viability; LNCaP cells; red Maca

Indexed keywords

2 METHOXYESTRADIOL; ANDROGEN RECEPTOR; ANTINEOPLASTIC AGENT; LEPIDIUM MEYENII EXTRACT; MESSENGER RNA; PACLITAXEL; PROSTATE SPECIFIC ANTIGEN;

APOPTOSIS; AQUEOUS SOLUTION; ARTICLE; CANCER INHIBITION; CELL VIABILITY; CONTROLLED STUDY; DRUG POTENTIATION; GENE EXPRESSION; HUMAN; HUMAN CELL; LEPIDIUM; LEPIDIUM MEYENII; LNCAP CELL LINE; MALE; MTS ASSAY; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 84988934999     PISSN: 03034569     EISSN: 14390272     Source Type: Journal    
DOI: 10.1111/and.12681     Document Type: Article

References (37)

1. Andriole, G., Bruchovsky, N., Chung, L. W., Matsumoto, A. M., Rittmaster, R., Roehrborn, C., … & Tindall, D. (2004). Dihydrotestosterone and the prostate: The scientific rationale for 5alpha-reductase inhibitors in the treatment of benign prostatic hyperplasia. Journal of Urology, 172, 1399–1403.
2. Bogani, P., Simonini, F., Iriti, M., Rossoni, M., Faoro, F., Poletti, A., & Visioli, F. (2006). Lepidium meyenii (Maca) does not exert direct androgenic activities. Journal of Ethnopharmacology, 104, 415–417.
3. Brooks, N. A., Wilcox, G., Walker, K. Z., Ashton, J. F., Cox, M. B., & Stojanovska, L. (2008). Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content. Menopause, 15, 1157–1162.
4. Campbell, J. K., Stroud, C. K., Nakamura, M. T., Lila, M. A., & Erdman, J. W. Jr (2006). Serum testosterone is reduced following short-term phytofluene, lycopene, or tomato powder consumption in F344 rats. Journal of Nutrition, 136, 2813–2819.
5. Chiao, J. W., Wu, H., Ramaswamy, G., Conaway, C. C., Chung, F. L., Wang, L., & Liu, D. (2004). Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrest. Carcinogenesis, 25, 1403–1408.
6. Cicero, A. F., Bandieri, E., & Arletti, R. (2001). Lepidium meyenii Walp. improves sexual behaviour in male rats independently from its action on spontaneous locomotor activity. Journal of Ethnopharmacology, 75, 225–229.
7. Cooper, L. A., & Page, S. T. (2014). Androgens and prostate disease. Asian Journal of Andrology, 16, 248–255.
8. Costello, L. C., Franklin, R. B., Feng, P., Tan, M., & Bagasra, O. (2005). Zinc and prostate cancer: A critical scientific, medical, and public interest issue (United States). Cancer Causes and Control, 16, 901–915.
9. Dini, I., Tenore, G. C., & Dini, A. (2002). Glucosinolates from Maca (Lepidium meyenii). Biochemical Systematics and Ecology, 30, 1087–1090.
10. Fahey, J. W., Zalcmann, A. T., & Talalay, P. (2001). The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. Phytochemistry, 56, 5–51.
11. Ferruelo, A., Romero, I., Cabrera, P. M., Arance, I., Andrés, G., & Angulo, J. C. (2014). Effects of resveratrol and other wine polyphenols on the proliferation, apoptosis and androgen receptor expression in LNCaP cells. Actas Urologicas Espanolas, 38, 397–404.
12. Fleshner, N. (2005). Defining high-risk prostate cancer: Current status. Canadian Journal of Urology, 12(Suppl 1), 14–17.
13. Ge, X., Fares, F. A., & Yannai, S. (1999). Induction of apoptosis in MCF-7 cells by indole-3-carbinol is independent of p53 and bax. Anticancer Research, 19, 3199–3203.
14. Gonzales, G. F., Córdova, A., Vega, K., Chung, A., Villena, A., Góñez, C., & Castillo, S. (2002). Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men. Andrologia, 34, 367–372.
15. Gonzales, G. F., Gasco, M., Malheiros-Pereira, A., & Gonzales-Castañeda, C. (2008). Antagonistic effect of Lepidium meyenii (red maca) on prostatic hyperplasia in adult mice. Andrologia, 40, 179–185.
16. Gonzales, C., Leiva-Revilla, J., Rubio, J., Gasco, M., & Gonzales, G. F. (2012). Effect of red maca (Lepidium meyenii) on prostate zinc levels in rats with testosterone-induced prostatic hyperplasia. Andrologia, 44(Suppl 1), 362–369.
17. Gonzales, G. F., Rubio, J., Chung, A., Gasco, M., & Villegas, L. (2003). Effect of alcoholic extract of Lepidium meyenii (Maca) on testicular function in male rats. Asian Journal of Andrology, 5, 349–352.
18. Hotte, S. J., & Saad, F. (2010). Current management of castrate-resistant prostate cancer. Current Oncology (Toronto, Ont.), 17(Suppl 2), S72–S79.
19. Islam, M. A., Bekele, R., Vanden Berg, J. H., Kuswanti, Y., Thapa, O., Soltani, S., … Murk, A. J. (2015). Deconjugation of soy isoflavone glucuronides needed for estrogenic activity. Toxicology in Vitro, 29, 706–715.
20. Kato, S., Sadarangani, A., Lange, S., Villalón, M., Brañes, J., Brosens, J. J., … & Cuello, M. (2007). The oestrogen metabolite 2-methoxyoestradiol alone or in combination with tumour necrosis factor-related apoptosis-inducing ligand mediates apoptosis in cancerous but not healthy cells of the human endometrium. Endocrine-Related Cancer, 14, 351–368.
21. Koochekpour, S., Lee, T. J., Wang, R., Culig, Z., Delorme, N., Caffey, S., … & Aguirre, J. (2007). Prosaposin upregulates AR and PSA expression and activity in prostate cancer cells (LNCaP). Prostate, 67, 178–189.
22. Le, H. T., Schaldach, C. M., Firestone, G. L., & Bjeldanes, L. F. (2003). Plant-derived 3,3′-Diindolylmethane is a strong androgen antagonist in human prostate cancer cells. Journal of Biological Chemistry, 278, 21136–21145.
23. Li, G., Ammermann, U., & Quiros, C. F. (2001). Glucosinolate contents in maca (Lepidium peruvianum Chacon) seeds, sprouts, mature plants and several derived commercial products. Economic Botany, 55, 255–262.
24. Livak, K. J., & Schmittgen, T. D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(T) (-Delta Delta C) method. Methods, 25, 402–408.
25. Milligan, S. R., Kalita, J. C., Pocock, V., Van De Kauter, V., Stevens, J. F., Deinzer, M. L., … & De Keukeleire, D. (2000). The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. Journal of Clinical Endocrinology and Metabolism, 85, 4912–4915.
26. Nachshon-Kedmi, M., Yannai, S., & Fares, F. A. (2001). Induction of apoptosis in human prostate cancer cell line, PC3, by 3,3′-diindolylmethane through the mitochondrial pathway. British Journal of Cancer, 91, 1358–1363.
27. Parada-Bustamante, A., Valencia, C., Reuquen, P., Diaz, P., Rincion-Rodriguez, R., & Orihuela, P. A. (2015). Role of 2-methoxyestradiol, an endogenous estrogen metabolite, in health and disease. Mini Reviews in Medicinal Chemistry, 15, 427–438.
28. Piacente, S., Carbone, V., Plaza, A., Zampelli, A., & Pizza, C. (2002). Investigation of the tuber constituents of maca (Lepidium meyenii Walp.). Journal of Agriculture and Food Chemistry, 50, 5621–5625.
29. Shapiro, T. A., Fahey, J. W., Wade, K. L., Stephenson, K. K., & Talalay, P. (1998). Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables. Cancer Epidemiology, Biomarkers & Prevention, 7, 1091–1100.
30. Steers, W. D. (2001). 5alpha-reductase activity in the prostate. Urology, 58, 17–24.
31. Talalay, P., & Fahey, J. W. (2001). Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. Journal of Nutrition, 131(Suppl 11), 3027S–3033S.
32. Tellez, M. R., Khan, I. A., Kobaisy, M., Schrader, K. K., Dayan, F. E., & Osbrink, W. (2002). Composition of the essential oil of Lepidium meyenii (Walp). Phytochemistry, 61, 149–155.
33. Thompson, I. M. (2001). Pharmacologic agents in complementary medicine in prostatic disease. Drugs of Today (Barcelona, Spain: 1998), 37, 427–433.
34. Valentová, K., Buckiová, D., Kren, V., Peknicová, J., Ulrichová, J., & Simánek, V. (2006). The in vitro biological activity of Lepidium meyenii extracts. Cell Biology and Toxicology, 22, 91–99.
35. Wattenberg, L. W. (1980). Inhibitors of chemical carcinogens. Journal of Environmental Pathology and Toxicology, 4, 35–52.
36. Wong, C. P., Hsu, A., Buchanan, A., Palomera-Sanchez, Z., Beaver, L. M., Houseman, E. A., … & Ho, E. (2014). Effects of sulforaphane and 3,3′-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells. PLoS One, 9, e86787.
37. Xu, H., Yu, X., Qu, S., & Sui, D. (2013). Juglone, isolated from Juglans mandshurica Maxim, induces apoptosis via down-regulation of AR expression in human prostate cancer LNCaP cells. Bioorganic & Medicinal Chemistry Letters, 23, 3631–3634.