Effect of red maca (Lepidium meyenii) on prostate zinc levels in rats with testosterone-induced prostatic hyperplasia

Andrologia

Volumn 44, Issue SUPPL.1, 2012, Pages 362-369

  Gonzales, C ^a   Leiva Revilla, J ^a   Rubio, J ^a   Gasco, M ^a   Gonzales, G F ^a  

^a UNIVERSIDAD PERUANA CAYETANO HEREDIA   (Peru)

Author keywords

Preputial gland; Prostate weight; Prostatic zinc levels; Red maca; Seminal vesicle

Indexed keywords

FINASTERIDE; LEPIDIUM MEYENII EXTRACT; TESTOSTERONE; ZINC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; MALE; MEDICINAL PLANT; NONHUMAN; ORGAN WEIGHT; PREPUTIAL GLAND; PROSTATE; PROSTATE HYPERTROPHY; PROSTATE WEIGHT; PROSTATE ZINC LEVEL; RAT; SEMINAL VESICLE; TISSUE LEVEL;

ANIMALS; FINASTERIDE; LEPIDIUM; MALE; ORGAN SIZE; PLANT EXTRACTS; PROSTATE; PROSTATIC HYPERPLASIA; RATS; RATS, SPRAGUE-DAWLEY; TESTOSTERONE; ZINC;

EID: 84861495933     PISSN: 03034569     EISSN: 14390272     Source Type: Journal    
DOI: 10.1111/j.1439-0272.2011.01190.x     Document Type: Article

References (52)

1. Abbasi AA, Prasad AS, Rabbani P, DuMouchelle E (1980) Experimental zinc deficiency in man. Effect on testicular function. J Lab Clin Med96:544-550.
2. Bartsch G, Rittmaster RS, Klocker H (2002) Dihydrotestosterone and the concept of 5α-reductase inhibition in human benign prostatic hyperplasia. World J Urol19:413-425.
3. Bauman DR, Steckelbroeck S, Peehl DM, Penning TM (2006) Transcript profiling of the ándrogen signal in normal prostate, benign prostatic hyperplasia, and prostate cancer. Endocrinology147:5806-5816.
4. Bogani P, Simonini F, Iriti M, Rossoni M, Faoro F, Poletti A, Visioli F (2006) Lepidium meyenii (maca) does not exert direct androgenic activities. J Ethnopharmacol104:415-417.
5. Brooks NA, Wilcox G, Walker KZ, Ashton JF, Cox MB, Stojanovska L (2008) Beneficial effects of Lepidium meyenii (maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content. Menopause15:1157-1162.
6. Campbell JK, Stroud CK, Nakamura NT, Lila MA, Erdman JW Jr (2006) Serum testosterone is reduced following short-term phytofluene, lycopene, or tomato powder consumption in F344 rats. J Nutr136:2813-2819.
7. Chiao JW, Wu H, Ramaswamy G, Conaway CC, Chung FL, Wang L, Liu D (2004) Ingestion of an isothiocyanates metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrest. Carcinogenesis25:1403-1408.
8. Chung F, Rubio J, Gonzales C, Gasco M, Gonzales GF (2005) Dose-response effects of Lepidium meyenii (maca) aqueous extract on testicular function and weight of different organs in adult rats. J Ethnopharmacol98:143-147.
9. Costello LC, Franklin RB (2006) The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots. Mol Cancer5:17.
10. Costello LC, Guan Z, Kukoui B, Feng P, Franklin RB (2004) Terminal oxidation and the effects of zinc in prostate and liver mitochondria. Mitochondrion4:331-338.
11. Duncan JR (1984) Aspartate transcarbamylase from regenerating rat liver - a zinc activated enzymes. Nutr Res4:93-98.
12. Ganapathy S, Chen Q, Singh KP, Shankar S, Srivastava RK (2010) Resveratrol enhances antitumor activity of TRAIL in prostate cancer xenografts through activation of FOXO transcription factor. PLoS ONE5:e15627.
13. Gao W, Kearbey JD, Nair VA, Chung K, Parlow AF, Miller DD, Dalton JT (2004) Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5α-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia. Endocrinology145:5420-5428.
14. Gasco M, Villegas L, Yucra S, Rubio J, Gonzales GF (2007) Effect dose-response of red maca on benign prostate hyperplasia in male rats. Phytomedicine14:460-464.
15. Gonzales GF (2006a) Biological effects of Lepidum meyenii, maca, a plant from the highlands of Peru. In: Recent Progress in Medicinal Plants. Natural Products, Vol. 15. Singh VK, Bhardwaj R, Govil JN, Sharma RK (eds). Studium Press LLC, USA, pp 217-242.
16. Gonzales GF (2006b) MACA, de la tradición a la ciencia. Universidad Peruana Cayetano Heredia, Lima-Perú, pp 46-67.
17. Gonzales C (2007) Efecto dosis respuesta del extracto hidroalcohólico de maca roja (Lepidium meyenii) sobre la próstata en ratas tratadas con andrógenos y estrógenos exógenos. Msc thesis, Faculty of Science and Phylosophy, Universidad Peruana Cayetano Heredia, Peru.
18. Gonzales C, Rubio J, Gasco M, Nieto J, Yucra S, Gonzales GF (2006) Effect of short-term and long-term treatments with three ecotypes of Lepidium meyenii (MACA) on spermatogenesis in rats. J Ethnopharmacol103:448-454.
19. Gonzales GF, Vasquez V, Rodriguez D, Maldonado C, Mormontoy J, Portella J, Pajuelo M, Villegas L, Gasco M (2007) Effect of two different extracts of red maca in male rats with testosterone-induced prostatic hyperplasia. Asian J Androl9:245-251.
20. Gonzales GF, Gasco M, Malheiros-Pereira A, Gonzales-Castañeda C (2008) Antagonistic effect of Lepidium meyenii (red maca) on prostatic hyperplasia in adult mice. Andrologia40:179-185.
21. Gonzales GF, Miranda S, Nieto J, Fernández G, Yucra S, Rubio J, Yi P, Gasco M (2005) Red Maca (Lepidium meyenii) reduced prostate size in rats. Reprod Biol Endocrinol3:5.
22. Habib FK, Mason MK, Smith PH, Stitch SR (1979) Cancer of the prostate: early diagnosis by zinc and hormone analysis?Br J Cancer39:700-704.
23. Hiipakka RA, Zhang HZ, Dai W, Dai Q, Liao S (2002) Structure-activity relationships for inhibition of human 5 alpha-reductases by polyphenols. Biochem Pharmacol63:1165-1176.
24. Hwang ES, Lee HJ. (2010) Effects of phenylethyl isothiocyanate and its metabolite on cell-cycle arrest and apoptosis in LNCaP human prostate cancer cells. Int J Food Sci Nutr61:324-336.
25. Keum YS, Jeong WS, Kong AN (2005) Chemopreventive functions of isothiocyanates. Drug News Perspect18:445-451.
26. Kristal AR, Lampe JW (2002) Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer42:1-9.
27. Le HT, Schaldach CM, Firestone GL, Bjeldanes LF (2003) Plant derived 3, 3'-diindolylmethane is a strong androgen antagonist in human prostate cancer cells. J Biol Chem278:21136-21145.
28. Lund TD, Munson DJ, Adlercreutz H, Handa RJ, Lephart ED (2004) Androgen receptor expression in the rat prostate is down-regulated by dietary phytoestrogens. Reprod Biol Endocrinol2:5.
29. Martinez Caballero S, Carricajo Fernández C, Pérez-Fernandez R (2004) Effect of an integral suspension of Lepidium latifolium on prostate hyperplasia in rats. Fitoterapia75:187-191.
30. Miyoshi N, Uchida K, Osawa T, Nakamura Y (2004) Benzyl isothiocyanate modifies expression of the G2/M arrest-related genes. Biofactors21:23-26.
31. Nachshon-Kedmi M, Yannai S, Haj A, Fares FA (2003) Indole-3-carbinol and 303-diindolylmethane induce apoptosis in human prostate cancer cells. Food Chem Toxicol41:745-752.
32. Nachshon-Kedmi M, Yannai S, Fares FA (2004) Induction of apoptosis in human prostate cancer cell line, PC3, by 3030-diindolylmethane through the mitochondrial pathway. Br J Cancer91:1358-1363.
33. National Research Council (1996) Guide of the Care and Use of Laboratory Animals. National Academy Press, Washington, DC, p 125.
34. Nishino T, Wedel T, Schmitt O, Bühlmeyer K, Schönfelder M, Hirtreiter C, Schulz T, Kühnel W, Michna H (2004) Androgen-dependent morphology of prostates and seminal vesicles in the Hershberger assay: evaluation of immunohistochemical and morphometric parameters. Ann Anat186:247-253.
35. Petraki C, Sfikas C (2007) Histopathological changes induced by therapies in the benign prostate and prostate adenocarcinoma. Histol Histopathol22:107-118.
36. Ray A (2005) Cancer preventive role of selected dietary factors. Indian J Cancer42:15-24.
37. Siddiqui IA, Asim M, Hafeez BB, Adhami VM, Tarapore RS, Mukhtar H (2010) Green tea polyphenol EGCG blunts androgen receptor function in prostate cancer. FASEB J25:1198-1207.
38. Sing KK, Desouki MM, Franklin RB, Costello LC (2006) Mitochondrial aconitase and citrate metabolism in malignant and nonmalignant human prostate tissues. Mol Cancer5:14.
39. Steinbrecher A, Nimptsch K, Hüsing A, Rohrmann S, Linseisen J (2009) Dietary glucosinolate intake and risk of prostate cancer in the EPIC-Heidelberg cohort study. Int J Cancer125:2179-2186.
40. Talalay P, Fahey JW (2001) Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. J Nutr131:3027S-3033S.
41. Talpur N, Echard B, Bagchi D, Bagchi M, Preuss HG (2003) Comparison of Saw Palmetto (extract and whole berry) and Cernitin on prostate growth in rats. Mol Cell Biochem250:21-26.
42. Tello J, Hermann M, Calderon A (1992) La Maca (Lepidium meyenii Walp.) cultivo alimenticio potencial para las zonas altoandinas. Boletín de Lima14:59-66.
43. Tempany CM, Parting AW, Zerhouni EA, Zinreich SJ, Walsh PC (1993) The influence of Finasteride on the volume of the peripheral and periurethral zones of the prostate in men with benign prostatic hyperplasia. Prostate22:39-42.
44. Traish AM, Hassani J, Guay AT, Zitzmann M, Hansen ML (2011) Adverse side effects of 5α-reductase inhibitors therapy: persistent diminished libido and erectile dysfunction and depression in a subset of patients. J Sex Med8:872-884.
45. Valerio LG, Gonzales GF (2005) Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and maca (Lepidium meyenii). A critical synopsis. Toxicol Rev24:11-35.
46. Vallee BL (1988) Zinc: biochemistry, physiology, toxicology and clinical pathology. Biofactors1:31-36.
47. Wong YC, Wang YZ, Lee JS, Tam NN, Lee D (2000) Changes in serum and tissue zinc levels in sex hormone-induced prostatic carcinogenesis in the noble rat. Tumour Biol21:328-336.
48. Yllescas M (1994) Estudio químico y Fisicoquímico de tres ecotipos de Lepidium meyenii procedentes de Carhuamayo. Facultad de Farmacia y Bioquímica, Universidad Nacional Mayor de San Marcos, Lima-Peru.
49. Yucra S, Rubio J, Gasco M, Gonzales C, Steenland K, Gonzales GF (2006) Semen quality and reproductive sex hormone levels in Peruvian pesticide sprayers. Int J Occup Environ Health12:355-361.
50. Yucra S, Gasco M, Rubio J, Gonzales GF (2008) Semen quality in Peruvian pesticide applicators: association between urinary organophosphate metabolites and semen parameters. Environ Health7:59.
51. Zeliadt SB, Etzioni RD, Penson DF, Thompson IM, Ramsey SD (2005) Lifetime implications and cost-effectiveness of using Finasteride to prevent prostate cancer. Am J Med118:850-857.
52. Zlotta AR, Teillac P, Raynaud JP, Schulman CC (2005) Evaluation of male sexual function in patients with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) treated with a phytotherapeutic agent (Permixon), Tamsulosin or Finasteride. Eur Urol48:269-276.