53BP1 ablation rescues genomic instability in mice expressing ‘RING-less’ BRCA1

EMBO Reports

Volumn 17, Issue 11, 2016, Pages 1532-1541

  Li, Minxing ^a   Cole, Francesca ^b,c   Patel, Dharm S ^a   Misenko, Sarah M ^a   Her, Joonyoung ^a   Malhowski, Amy ^d   Alhamza, Ali ^a   Zheng, Haiyan ^a   Baer, Richard ^e   Ludwig, Thomas ^f   Jasin, Maria ^b   Nussenzweig, André ^d   Serrano, Lourdes ^g   Bunting, Samuel F ^a  

^a RUTGERS UNIVERSITY   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e NewYork Presbyterian Hospital   (United States)

^f OHIO STATE UNIVERSITY   (United States)

^g Life Sciences Building Rutgers University   (United States)

Author keywords

cancer; DNA repair; genomic integrity; mouse models; RAD51

Indexed keywords

53BP1 PROTEIN; BRCA1 ASSOCIATED RING DOMAIN PROTEIN 1; BRCA1 PROTEIN; CISPLATIN; DEMECOLCINE; HISTONE H2AX; HYDROXYUREA; OLAPARIB; PROTEIN; PROTEIN P53; RAD51 PROTEIN; TUBULIN; UNCLASSIFIED DRUG; BARD1 PROTEIN, MOUSE; BRCA1 PROTEIN, MOUSE; CARRIER PROTEIN; DNA BINDING PROTEIN; NUCLEAR PROTEIN; RAD51AP1 PROTEIN, MOUSE; SIGNAL PEPTIDE; TRP53BP1 PROTEIN, MOUSE; TUMOR SUPPRESSOR P53 BINDING PROTEIN 1; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; DNA DAMAGE; DNA DAMAGE RESPONSE; DOUBLE STRANDED DNA BREAK; EXON; GENE DELETION; GENE EXPRESSION; GENOMIC INSTABILITY; IONIZING RADIATION; M PHASE CELL CYCLE CHECKPOINT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPERMATOCYTE; ANIMAL; CHEMISTRY; DEFICIENCY; DNA REPAIR; FEMALE; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE;

ANIMALS; BASE SEQUENCE; CARRIER PROTEINS; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; EXONS; FEMALE; GENOMIC INSTABILITY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; NUCLEAR PROTEINS; SEQUENCE DELETION; TUMOR SUPPRESSOR P53-BINDING PROTEIN 1; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES;

EID: 84988883794     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.15252/embr.201642497     Document Type: Article

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