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Volumn 9, Issue , 2016, Pages 5010-5116

Immune checkpoint inhibitors: The new frontier in non-small-cell lung cancer treatment

Author keywords

Checkpoint inhibitors; Immunotherapy; Nivolumab; Non small cell lung cancer; Pembrolizumab; Programmed death ligand 1; Programmed death 1

Indexed keywords

ANTINEOPLASTIC AGENT; ATEZOLIZUMAB; AVELUMAB; AZACITIDINE; BEVACIZUMAB; CARBOPLATIN; CERITINIB; CISPLATIN; CORTICOSTEROID; CRIZOTINIB; DOCETAXEL; DURVALUMAB; ENTINOSTAT; ERLOTINIB; GEFITINIB; GEMCITABINE; IPILIMUMAB; NIVOLUMAB; OSIMERTINIB; PACLITAXEL; PEMBROLIZUMAB; PEMETREXED; PLACEBO; TICILIMUMAB; URELUMAB; UTOMILUMAB;

EID: 84988810639     PISSN: None     EISSN: 11786930     Source Type: Journal    
DOI: 10.2147/OTT.S111209     Document Type: Review
Times cited : (27)

References (148)
  • 1
    • 84988827367 scopus 로고    scopus 로고
    • Lung and Bronchus Cancer [Webpage on the Internet]
    • Accessed August 10
    • SEER Stat Fact Sheets: Lung and Bronchus Cancer [Webpage on the Internet]. National Cancer Institute. Surveillance, Epidemiology and End Results Program. Available from: http://seer.cancer.gov/statfacts/ html/lungb.html. Accessed August 10, 2016.
    • (2016) National Cancer Institute. Surveillance, Epidemiology and End Results Program
  • 2
    • 0028926389 scopus 로고
    • Concomitant administration of interleukin-2 plus tumor necrosis factor in advanced non-small cell lung cancer
    • Schiller JH, Morgan-Ihrig C, Levitt ML. Concomitant administration of interleukin-2 plus tumor necrosis factor in advanced non-small cell lung cancer. Am J Clin Oncol. 1995;18:47-51.
    • (1995) Am J Clin Oncol , vol.18 , pp. 47-51
    • Schiller, J.H.1    Morgan-Ihrig, C.2    Levitt, M.L.3
  • 3
    • 0026653868 scopus 로고
    • Interleukin-2 and interferon-alpha in the treatment of patients with advanced non-small-cell lung cancer
    • Jansen RL, Slingerland R, Goey SH, Franks CR, Bolhuis RL, Stoter G. Interleukin-2 and interferon-alpha in the treatment of patients with advanced non-small-cell lung cancer. J Immunother. 1991;12:70-73.
    • (1991) J Immunother , vol.12 , pp. 70-73
    • Jansen, R.L.1    Slingerland, R.2    Goey, S.H.3    Franks, C.R.4    Bolhuis, R.L.5    Stoter, G.6
  • 4
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer. 2012;12:252-264.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 5
    • 33847190697 scopus 로고    scopus 로고
    • The toxins of William B. Coley and the treatment of bone and soft-tissue sarcomas
    • McCarthy EF. The toxins of William B. Coley and the treatment of bone and soft-tissue sarcomas. Iowa Orthop J. 2006;26:154-158.
    • (2006) Iowa Orthop J , vol.26 , pp. 154-158
    • McCarthy, E.F.1
  • 6
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science. 1996;271:1734-1736.
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 7
    • 33644525918 scopus 로고    scopus 로고
    • Murine B16 melanomas expressing high levels of the chemokine stromal-derived factor-1/CXCL12 induce tumor-specific T cell chemorepulsion and escape from immune control
    • Vianello F, Papeta N, Chen T, et al. Murine B16 melanomas expressing high levels of the chemokine stromal-derived factor-1/CXCL12 induce tumor-specific T cell chemorepulsion and escape from immune control. J Immunol. 2006;176:2902-2914.
    • (2006) J Immunol , vol.176 , pp. 2902-2914
    • Vianello, F.1    Papeta, N.2    Chen, T.3
  • 8
    • 84885433913 scopus 로고    scopus 로고
    • Current status of interleukin-10 and regulatory T-cells in cancer
    • Dennis KL, Blatner NR, Gounari F, Khazaie K. Current status of interleukin-10 and regulatory T-cells in cancer. Curr Opin Oncol. 2013; 25:637-645.
    • (2013) Curr Opin Oncol , vol.25 , pp. 637-645
    • Dennis, K.L.1    Blatner, N.R.2    Gounari, F.3    Khazaie, K.4
  • 9
    • 84880924265 scopus 로고    scopus 로고
    • The immune microenvironment of human tumors: General significance and clinical impact
    • Fridman WH, Dieu-Nosjean MC, Pages F, et al. The immune microenvironment of human tumors: general significance and clinical impact. Cancer Microenviron. 2013;6:117-122.
    • (2013) Cancer Microenviron , vol.6 , pp. 117-122
    • Fridman, W.H.1    Dieu-Nosjean, M.C.2    Pages, F.3
  • 10
    • 84938702933 scopus 로고    scopus 로고
    • MHC-I modulation due to changes in tumor cell metabolism regulates tumor sensitivity to CTL and NK cells
    • Catalan E, Charni S, Jaime P, et al; MHC-I modulation due to changes in tumor cell metabolism regulates tumor sensitivity to CTL and NK cells. Oncoimmunology. 2015;4:e985924.
    • (2015) Oncoimmunology , vol.4
    • Catalan, E.1    Charni, S.2    Jaime, P.3
  • 11
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: Integrating immunity’s roles in cancer suppression and promotion
    • Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science. 2011; 331:1565-1570.
    • (2011) Science , vol.331 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 12
    • 84867685827 scopus 로고    scopus 로고
    • Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation
    • Landsberg J, Kohlmeyer J, Renn M, et al. Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation. Nature. 2012;490:412-416.
    • (2012) Nature , vol.490 , pp. 412-416
    • Landsberg, J.1    Kohlmeyer, J.2    Renn, M.3
  • 13
    • 84920956732 scopus 로고    scopus 로고
    • PD-1 blockade induces responses by inhibiting adaptive immune resistance
    • Tumeh PC, Harview CL, Yearley JH, et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature. 2014;515: 568-571.
    • (2014) Nature , vol.515 , pp. 568-571
    • Tumeh, P.C.1    Harview, C.L.2    Yearley, J.H.3
  • 14
    • 0035846910 scopus 로고    scopus 로고
    • T cell receptor-MHC interactions up close
    • Hennecke J, Wiley DC. T cell receptor-MHC interactions up close. Cell. 2001;104:1-4.
    • (2001) Cell , vol.104 , pp. 1-4
    • Hennecke, J.1    Wiley, D.C.2
  • 17
    • 0027392843 scopus 로고
    • Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells
    • Townsend SE, Allison JP. Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells. Science. 1993;259: 368-370.
    • (1993) Science , vol.259 , pp. 368-370
    • Townsend, S.E.1    Allison, J.P.2
  • 18
    • 84859720182 scopus 로고    scopus 로고
    • Positive and negative regulation of cellular immune responses in physiologic conditions and diseases
    • Vigano S, Perreau M, Pantaleo G, Harari A. Positive and negative regulation of cellular immune responses in physiologic conditions and diseases. Clin Dev Immunol. 2012;2012:485781.
    • (2012) Clin Dev Immunol , vol.2012
    • Vigano, S.1    Perreau, M.2    Pantaleo, G.3    Harari, A.4
  • 19
    • 79956077563 scopus 로고    scopus 로고
    • T cell exhaustion
    • Wherry EJ. T cell exhaustion. Nat Immunol. 2011;12:492-499.
    • (2011) Nat Immunol , vol.12 , pp. 492-499
    • Wherry, E.J.1
  • 20
    • 13444270323 scopus 로고    scopus 로고
    • Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity
    • Hirano F, Kaneko K, Tamura H, et al. Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Res. 2005;65:1089-1096.
    • (2005) Cancer Res , vol.65 , pp. 1089-1096
    • Hirano, F.1    Kaneko, K.2    Tamura, H.3
  • 21
    • 0030300139 scopus 로고    scopus 로고
    • The role of CTLA-4 in the regulation and initiation of T-cell responses
    • Chambers CA, Krummel MF, Boitel B, et al. The role of CTLA-4 in the regulation and initiation of T-cell responses. Immunol Rev. 1996; 153:27-46.
    • (1996) Immunol Rev , vol.153 , pp. 27-46
    • Chambers, C.A.1    Krummel, M.F.2    Boitel, B.3
  • 22
    • 0029960141 scopus 로고    scopus 로고
    • Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo
    • Krummel MF, Sullivan TJ, Allison JP. Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo. Int Immunol. 1996;8:519-523.
    • (1996) Int Immunol , vol.8 , pp. 519-523
    • Krummel, M.F.1    Sullivan, T.J.2    Allison, J.P.3
  • 24
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
    • Dong H, Strome SE, Salomao DR, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med. 2002;8:793-800.
    • (2002) Nat Med , vol.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3
  • 26
    • 84963621254 scopus 로고    scopus 로고
    • Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy
    • Topalian SL, Taube JM, Anders RA, Pardoll DM. Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy. Nat Rev Cancer. 2016;16:275-287.
    • (2016) Nat Rev Cancer , vol.16 , pp. 275-287
    • Topalian, S.L.1    Taube, J.M.2    Anders, R.A.3    Pardoll, D.M.4
  • 27
    • 84890020587 scopus 로고    scopus 로고
    • Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors
    • Akbay EA, Koyama S, Carretero J, et al. Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors. Cancer Discov. 2013;3:1355-1363.
    • (2013) Cancer Discov , vol.3 , pp. 1355-1363
    • Akbay, E.A.1    Koyama, S.2    Carretero, J.3
  • 28
    • 80052493233 scopus 로고    scopus 로고
    • Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido
    • Balachandran VP, Cavnar MJ, Zeng S, et al. Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido. Nat Med. 2011;17:1094-1100.
    • (2011) Nat Med , vol.17 , pp. 1094-1100
    • Balachandran, V.P.1    Cavnar, M.J.2    Zeng, S.3
  • 29
    • 84936953099 scopus 로고    scopus 로고
    • Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity
    • Spranger S, Bao R, Gajewski TF. Melanoma-intrinsic beta-catenin signalling prevents anti-tumour immunity. Nature. 2015;523:231-235.
    • (2015) Nature , vol.523 , pp. 231-235
    • Spranger, S.1    Bao, R.2    Gajewski, T.F.3
  • 30
    • 84920031180 scopus 로고    scopus 로고
    • In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates
    • Wang C, Thudium KB, Han M, et al. In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates. Cancer Immunol Res. 2014;2:846-856.
    • (2014) Cancer Immunol Res , vol.2 , pp. 846-856
    • Wang, C.1    Thudium, K.B.2    Han, M.3
  • 31
    • 34848900497 scopus 로고    scopus 로고
    • Programmed death-1 blockade enhances expansion and functional capacity of human melanoma antigen-specific CTLs
    • Wong RM, Scotland RR, Lau RL, et al. Programmed death-1 blockade enhances expansion and functional capacity of human melanoma antigen-specific CTLs. Int Immunol. 2007;19:1223-1234.
    • (2007) Int Immunol , vol.19 , pp. 1223-1234
    • Wong, R.M.1    Scotland, R.R.2    Lau, R.L.3
  • 32
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (Anti-PD-1) in melanoma
    • Hamid O, Robert C, Daud A, et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med. 2013;369: 134-144.
    • (2013) N Engl J Med , vol.369 , pp. 134-144
    • Hamid, O.1    Robert, C.2    Daud, A.3
  • 33
    • 84936749833 scopus 로고    scopus 로고
    • Overall survival and long-term safety of nivolumab (Anti-programmed death 1 antibody, BMS-936558, ONO-4538) in patients with previously treated advanced non-small-cell lung cancer
    • Gettinger SN, Horn L, Gandhi L, et al. Overall survival and long-term safety of nivolumab (anti-programmed death 1 antibody, BMS-936558, ONO-4538) in patients with previously treated advanced non-small-cell lung cancer. J Clin Oncol. 2015;33:2004-2012.
    • (2015) J Clin Oncol , vol.33 , pp. 2004-2012
    • Gettinger, S.N.1    Horn, L.2    Gandhi, L.3
  • 34
    • 84924901863 scopus 로고    scopus 로고
    • Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): A phase 2, single-arm trial
    • Rizvi NA, Mazieres J, Planchard D, et al. Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial. Lancet Oncol. 2015;16:257-265.
    • (2015) Lancet Oncol , vol.16 , pp. 257-265
    • Rizvi, N.A.1    Mazieres, J.2    Planchard, D.3
  • 35
    • 84936791837 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
    • Brahmer J, Reckamp KL, Baas P, et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl J Med. 2015;373:123-135.
    • (2015) N Engl J Med , vol.373 , pp. 123-135
    • Brahmer, J.1    Reckamp, K.L.2    Baas, P.3
  • 36
    • 84944937210 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
    • Borghaei H, Paz-Ares L, Horn L, et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med. 2015;373:1627-1639.
    • (2015) N Engl J Med , vol.373 , pp. 1627-1639
    • Borghaei, H.1    Paz-Ares, L.2    Horn, L.3
  • 37
    • 84964898394 scopus 로고    scopus 로고
    • Pointed progress in second-line advanced non-small-cell lung cancer: The rapidly evolving field of checkpoint inhibition
    • Melosky B, Chu Q, Juergens R, Leighl N, McLeod D, Hirsh V. Pointed progress in second-line advanced non-small-cell lung cancer: the rapidly evolving field of checkpoint inhibition. J Clin Oncol. 2016;34: 1676-1688.
    • (2016) J Clin Oncol , vol.34 , pp. 1676-1688
    • Melosky, B.1    Chu, Q.2    Juergens, R.3    Leighl, N.4    McLeod, D.5    Hirsh, V.6
  • 38
    • 84929481480 scopus 로고    scopus 로고
    • Pembrolizumab for the treatment of non-small-cell lung cancer
    • Garon EB, Rizvi NA, Hui R, et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med. 2015;372:2018-2028.
    • (2015) N Engl J Med , vol.372 , pp. 2018-2028
    • Garon, E.B.1    Rizvi, N.A.2    Hui, R.3
  • 39
    • 84950117835 scopus 로고    scopus 로고
    • Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): A randomised controlled trial
    • Herbst RS, Baas P, Kim DW, et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet. 2016;387:1540-1550.
    • (2016) Lancet , vol.387 , pp. 1540-1550
    • Herbst, R.S.1    Baas, P.2    Kim, D.W.3
  • 40
    • 84942138571 scopus 로고    scopus 로고
    • Activity and safety of pembrolizumab in patients with metastatic non-small cell lung cancer with untreated brain metastases
    • abstr 8035
    • Goldberg S, Gettinger S, Mahajan A, et al. Activity and safety of pembrolizumab in patients with metastatic non-small cell lung cancer with untreated brain metastases. J Clin Oncol. 2015;33 (Suppl; abstr 8035).
    • (2015) J Clin Oncol , vol.33
    • Goldberg, S.1    Gettinger, S.2    Mahajan, A.3
  • 41
    • 84962038946 scopus 로고    scopus 로고
    • Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): A multicentre, open-label, phase 2 randomised controlled trial
    • Fehrenbacher L, Spira A, Ballinger M, et al. Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial. Lancet. 2016;387:1837-1846.
    • (2016) Lancet , vol.387 , pp. 1837-1846
    • Fehrenbacher, L.1    Spira, A.2    Ballinger, M.3
  • 42
    • 84944734156 scopus 로고    scopus 로고
    • Safety and clinical activity of MEDI4736, an anti-programmed cell death-ligand 1 (PD-L1) antibody, in patients with non-small cell lung cancer (NSCLC)
    • abstr 8032
    • Rizvi NA, Brahmer JR, Ou S-HI, et al. Safety and clinical activity of MEDI4736, an anti-programmed cell death-ligand 1 (PD-L1) antibody, in patients with non-small cell lung cancer (NSCLC). J Clin Oncol. 2015;33(Suppl; abstr 8032).
    • (2015) J Clin Oncol , vol.33
    • Rizvi, N.A.1    Brahmer, J.R.2    Ou, S.-H.3
  • 43
    • 84944751040 scopus 로고    scopus 로고
    • Avelumab (MSB0010718C), an anti-PD-L1 antibody, in advanced NSCLC patients: A phase 1b, open-label expansion trial in patients progressing after platinum-based chemotherapy
    • abstr 8034
    • Gulley JL, Spigel D, Kelly K, et al. Avelumab (MSB0010718C), an anti-PD-L1 antibody, in advanced NSCLC patients: A phase 1b, open-label expansion trial in patients progressing after platinum-based chemotherapy. J Clin Oncol. 2015;33:(Suppl; abstr 8034).
    • (2015) J Clin Oncol , vol.33
    • Gulley, J.L.1    Spigel, D.2    Kelly, K.3
  • 44
    • 84926416165 scopus 로고    scopus 로고
    • Optimal management of immune-related toxicities associated with checkpoint inhibitors in lung cancer
    • Howell M, Lee R, Bowyer S, et al. Optimal management of immune-related toxicities associated with checkpoint inhibitors in lung cancer. Lung Cancer. 2015;88:117-123.
    • (2015) Lung Cancer , vol.88 , pp. 117-123
    • Howell, M.1    Lee, R.2    Bowyer, S.3
  • 47
    • 76749084659 scopus 로고    scopus 로고
    • Randomized phase II clinical trial comparing tremelimumab (CP-675,206) with best supportive care (BSC) following first-line platinum-based therapy in patients (pts) with advanced non-small cell lung cancer (NSCLC)
    • abstr 8071
    • Zatloukal P, Heo D, Park K, et al. Randomized phase II clinical trial comparing tremelimumab (CP-675,206) with best supportive care (BSC) following first-line platinum-based therapy in patients (pts) with advanced non-small cell lung cancer (NSCLC). J Clin Oncol. 2009;27:15s(Suppl; abstr 8071).
    • (2009) J Clin Oncol , vol.27 , Issue.15s
    • Zatloukal, P.1    Heo, D.2    Park, K.3
  • 48
    • 84863911486 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: Results from a randomized, double-blind, multicenter phase II study
    • Lynch TJ, Bondarenko I, Luft A, et al. Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study. J Clin Oncol. 2012;30:2046-2054.
    • (2012) J Clin Oncol , vol.30 , pp. 2046-2054
    • Lynch, T.J.1    Bondarenko, I.2    Luft, A.3
  • 50
    • 74249120625 scopus 로고    scopus 로고
    • Pre-treatment with chemotherapy can enhance the antigenicity and immunogenicity of tumours by promoting adaptive immune responses
    • Liu WM, Fowler DW, Smith P, Dalgleish AG. Pre-treatment with chemotherapy can enhance the antigenicity and immunogenicity of tumours by promoting adaptive immune responses. Br J Cancer. 2010;102: 115-123.
    • (2010) Br J Cancer , vol.102 , pp. 115-123
    • Liu, W.M.1    Fowler, D.W.2    Smith, P.3    Dalgleish, A.G.4
  • 51
    • 33847368549 scopus 로고    scopus 로고
    • Metronomic cyclophosph-amide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients
    • Ghiringhelli F, Menard C, Puig PE, et al. Metronomic cyclophosph-amide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients. Cancer Immunol Immunother. 2007;56:641-648.
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 641-648
    • Ghiringhelli, F.1    Menard, C.2    Puig, P.E.3
  • 52
    • 84941874961 scopus 로고    scopus 로고
    • Immune modulation in advanced radiotherapies: Targeting out-of-field effects
    • Hanna GG, Coyle VM, Prise KM. Immune modulation in advanced radiotherapies: targeting out-of-field effects. Cancer Lett. 2015;368: 246-251.
    • (2015) Cancer Lett , vol.368 , pp. 246-251
    • Hanna, G.G.1    Coyle, V.M.2    Prise, K.M.3
  • 53
    • 84908269560 scopus 로고    scopus 로고
    • Nivolumab (Anti-PD-1; BMS-936558, ONO-4538) in combination with platinum-based doublet chemotherapy (PT-DC) in advanced non-small cell lung cancer (NSCLC)
    • abstr 8113
    • Antonia S, Brahmer JR, Gettinger S, et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with platinum-based doublet chemotherapy (PT-DC) in advanced non-small cell lung cancer (NSCLC). J Clin Oncol. 2014;32:5s(Suppl; abstr 8113).
    • (2014) J Clin Oncol , vol.32 , Issue.5s
    • Antonia, S.1    Brahmer, J.R.2    Gettinger, S.3
  • 54
    • 84944739668 scopus 로고    scopus 로고
    • Safety and efficacy of MPDL3280A (Anti-PDL1) in combination with platinum-based doublet chemotherapy in patients with advanced non-small cell lung cancer (NSCLC)
    • abstr 8030
    • Liu SV, Powderly JD, Camidge R, et al. Safety and efficacy of MPDL3280A (anti-PDL1) in combination with platinum-based doublet chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). J Clin Oncol. 2015;33(Suppl; abstr 8030).
    • (2015) J Clin Oncol , vol.33
    • Liu, S.V.1    Powderly, J.D.2    Camidge, R.3
  • 55
    • 84886583217 scopus 로고    scopus 로고
    • Activity of anti-PD-1 in murine tumor models: Role of “host” PD-L1 and synergistic effect of anti-PD-1 and anti-CTLA-4
    • Korman A, Chen B, Wang C, Wu L, Cardarelli P, Selby M. Activity of anti-PD-1 in murine tumor models: role of “host” PD-L1 and synergistic effect of anti-PD-1 and anti-CTLA-4. J Immunol. 2007;178:S82.
    • (2007) J Immunol , vol.178
    • Korman, A.1    Chen, B.2    Wang, C.3    Wu, L.4    Cardarelli, P.5    Selby, M.6
  • 56
    • 77749279776 scopus 로고    scopus 로고
    • PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
    • Curran MA, Montalvo W, Yagita H, Allison JP. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc Natl Acad Sci U S A. 2010;107:4275-4280.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 4275-4280
    • Curran, M.A.1    Montalvo, W.2    Yagita, H.3    Allison, J.P.4
  • 57
    • 84873129546 scopus 로고    scopus 로고
    • CTLA-4 blockade in tumor models: An overview of preclinical and translational research
    • Grosso JF, Jure-Kunkel MN. CTLA-4 blockade in tumor models: an overview of preclinical and translational research. Cancer Immun. 2013;13:5.
    • (2013) Cancer Immun , vol.13 , pp. 5
    • Grosso, J.F.1    Jure-Kunkel, M.N.2
  • 58
    • 84942430653 scopus 로고    scopus 로고
    • Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
    • Larkin J, Hodi FS, Wolchok JD. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med. 2015;373: 1270-1271.
    • (2015) N Engl J Med , vol.373 , pp. 1270-1271
    • Larkin, J.1    Hodi, F.S.2    Wolchok, J.D.3
  • 59
    • 84984681480 scopus 로고    scopus 로고
    • CheckMate 012: Safety and efficacy of first-line (1L) nivolumab (nivo; N) and ipilimumab (ipi; I) in advanced (adv) NSCLC
    • abstr 3001
    • Hellmann MD, Gettinger SN, Goldman JW, et al. CheckMate 012: Safety and efficacy of first-line (1L) nivolumab (nivo; N) and ipilimumab (ipi; I) in advanced (adv) NSCLC. J Clin Oncol. 2016;34:suppl; abstr 3001.
    • (2016) J Clin Oncol , vol.34
    • Hellmann, M.D.1    Gettinger, S.N.2    Goldman, J.W.3
  • 61
    • 84942138310 scopus 로고    scopus 로고
    • Phase 1 study of pembrolizumab (Pembro; MK-3475) plus ipilimumab (IPI) as second-line therapy for advanced non-small cell lung cancer (NSCLC): KEYNOTE-021 cohort D
    • abstr 8011
    • Patnaik A, Sociniski M, Gubens M, et al; Phase 1 study of pembrolizumab (pembro; MK-3475) plus ipilimumab (IPI) as second-line therapy for advanced non-small cell lung cancer (NSCLC): KEYNOTE-021 cohort D. J Clin Oncol. 2015;33(Suppl; abstr 8011).
    • (2015) J Clin Oncol , vol.33
    • Patnaik, A.1    Sociniski, M.2    Gubens, M.3
  • 62
    • 84960498096 scopus 로고    scopus 로고
    • Safety and antitumour activity of durvalumab plus tremelimumab in non-small cell lung cancer: A multicentre, phase 1b study
    • Antonia S, Goldberg SB, Balmanoukian A, et al. Safety and antitumour activity of durvalumab plus tremelimumab in non-small cell lung cancer: a multicentre, phase 1b study. Lancet Oncol. 2016;17:299-308.
    • (2016) Lancet Oncol , vol.17 , pp. 299-308
    • Antonia, S.1    Goldberg, S.B.2    Balmanoukian, A.3
  • 63
    • 64649084383 scopus 로고    scopus 로고
    • Radiation-induced bystander signalling in cancer therapy
    • Prise KM, O’Sullivan JM. Radiation-induced bystander signalling in cancer therapy. Nat Rev Cancer. 2009;9:351-360.
    • (2009) Nat Rev Cancer , vol.9 , pp. 351-360
    • Prise, K.M.1    O’Sullivan, J.M.2
  • 64
    • 67649359533 scopus 로고    scopus 로고
    • Systemic effects of local radiotherapy
    • Formenti SC, Demaria S. Systemic effects of local radiotherapy. Lancet Oncol. 2009;10:718-726.
    • (2009) Lancet Oncol , vol.10 , pp. 718-726
    • Formenti, S.C.1    Demaria, S.2
  • 65
    • 85003053854 scopus 로고    scopus 로고
    • An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer
    • Golden EB, Demaria S, Schiff PB, et al. An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer. Cancer Immunol Res. 2013;1:365-372.
    • (2013) Cancer Immunol Res , vol.1 , pp. 365-372
    • Golden, E.B.1    Demaria, S.2    Schiff, P.B.3
  • 66
    • 84857815877 scopus 로고    scopus 로고
    • Immunologic correlates of the abscopal effect in a patient with melanoma
    • Postow MA, Callahan MK, Barker CA, et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med. 2012; 366:925-931.
    • (2012) N Engl J Med , vol.366 , pp. 925-931
    • Postow, M.A.1    Callahan, M.K.2    Barker, C.A.3
  • 67
    • 84893876109 scopus 로고    scopus 로고
    • Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice
    • Deng L, Liang H, Burnette B, et al. Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. J Clin Invest. 2014;124:687-695.
    • (2014) J Clin Invest , vol.124 , pp. 687-695
    • Deng, L.1    Liang, H.2    Burnette, B.3
  • 68
    • 84919494209 scopus 로고    scopus 로고
    • Current clinical trials testing combinations of immunotherapy and radiation
    • Crittenden M, Kohrt H, Levy R, et al. Current clinical trials testing combinations of immunotherapy and radiation. Semin Radiat Oncol. 2015;25:54-64.
    • (2015) Semin Radiat Oncol , vol.25 , pp. 54-64
    • Crittenden, M.1    Kohrt, H.2    Levy, R.3
  • 72
    • 84858760109 scopus 로고    scopus 로고
    • Combining immunotherapy and targeted therapies in cancer treatment
    • Vanneman M, Dranoff G. Combining immunotherapy and targeted therapies in cancer treatment. Nat Rev Cancer. 2012;12:237-251.
    • (2012) Nat Rev Cancer , vol.12 , pp. 237-251
    • Vanneman, M.1    Dranoff, G.2
  • 73
    • 84874872137 scopus 로고    scopus 로고
    • BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma
    • Frederick DT, Piris A, Cogdill AP, et al. BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma. Clin Cancer Res. 2013;19:1225-1231.
    • (2013) Clin Cancer Res , vol.19 , pp. 1225-1231
    • Frederick, D.T.1    Piris, A.2    Cogdill, A.P.3
  • 74
    • 84923072443 scopus 로고    scopus 로고
    • Association of PD-L1 overexpres-sion with activating EGFR mutations in surgically resected nonsmall-cell lung cancer
    • Azuma K, Ota K, Kawahara A, et al. Association of PD-L1 overexpres-sion with activating EGFR mutations in surgically resected nonsmall-cell lung cancer. Ann Oncol. 2014;25:1935-1940.
    • (2014) Ann Oncol , vol.25 , pp. 1935-1940
    • Azuma, K.1    Ota, K.2    Kawahara, A.3
  • 75
    • 84942849158 scopus 로고    scopus 로고
    • Induction of PD-L1 expression by the EML4-ALK oncoprotein and downstream signaling pathways in non-small cell lung cancer
    • Ota K, Azuma K, Kawahara A, et al. Induction of PD-L1 expression by the EML4-ALK oncoprotein and downstream signaling pathways in non-small cell lung cancer. Clin Cancer Res. 2015;21: 4014-4021.
    • (2015) Clin Cancer Res , vol.21 , pp. 4014-4021
    • Ota, K.1    Azuma, K.2    Kawahara, A.3
  • 76
    • 84920655625 scopus 로고    scopus 로고
    • PD-1 and PD-L1 expression in molecularly selected non-small-cell lung cancer patients
    • D’Incecco A, Andreozzi M, Ludovini V, et al. PD-1 and PD-L1 expression in molecularly selected non-small-cell lung cancer patients. Br J Cancer. 2015;112:95-102.
    • (2015) Br J Cancer , vol.112 , pp. 95-102
    • D’Incecco, A.1    Reozzi, M.2    Ludovini, V.3
  • 77
    • 84907651085 scopus 로고    scopus 로고
    • Safety and response with nivolumab (Anti-PD-1; BMS-936558, ONO-4538) plus erlotinib in patients (pts) with epidermal growth factor receptor mutant (EGFR MT) advanced NSCLC
    • abstr 8022
    • Rizvi NA, Chow LQM, Borghaei H, et al. Safety and response with nivolumab (anti-PD-1; BMS-936558, ONO-4538) plus erlotinib in patients (pts) with epidermal growth factor receptor mutant (EGFR MT) advanced NSCLC. J Clin Oncol. 2014;32:5s(Suppl; abstr 8022).
    • (2014) J Clin Oncol , vol.32 , Issue.5s
    • Rizvi, N.A.1    Chow, L.2    Borghaei, H.3
  • 78
    • 84946912433 scopus 로고    scopus 로고
    • Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy
    • Peng D, Kryczek I, Nagarsheth N, et al. Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy. Nature. 2015;527:249-253.
    • (2015) Nature , vol.527 , pp. 249-253
    • Peng, D.1    Kryczek, I.2    Nagarsheth, N.3
  • 79
    • 84890130945 scopus 로고    scopus 로고
    • Alterations of immune response of non-small cell lung cancer with azacytidine
    • Wrangle J, Wang W, Koch A, et al. Alterations of immune response of non-small cell lung cancer with azacytidine. Oncotarget. 2013;4: 2067-2079.
    • (2013) Oncotarget , vol.4 , pp. 2067-2079
    • Wrangle, J.1    Wang, W.2    Koch, A.3
  • 80
    • 84959019222 scopus 로고    scopus 로고
    • Epigenetic modulators and the new immunotherapies
    • Dear AE. Epigenetic modulators and the new immunotherapies. N Engl J Med. 2016;374:684-686.
    • (2016) N Engl J Med , vol.374 , pp. 684-686
    • Dear, A.E.1
  • 81
    • 84655163371 scopus 로고    scopus 로고
    • Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer
    • Juergens RA, Wrangle J, Vendetti FP, et al. Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer. Cancer Discov. 2011;1:598-607.
    • (2011) Cancer Discov , vol.1 , pp. 598-607
    • Juergens, R.A.1    Wrangle, J.2    Vendetti, F.P.3
  • 86
    • 84933678156 scopus 로고    scopus 로고
    • Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): A randomised, double-blind, phase 3 trial
    • Eggermont AM, Chiarion-Sileni V, Grob JJ, et al. Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): a randomised, double-blind, phase 3 trial. Lancet Oncol. 2015;16:522-530.
    • (2015) Lancet Oncol , vol.16 , pp. 522-530
    • Eggermont, A.M.1    Chiarion-Sileni, V.2    Grob, J.J.3
  • 88
    • 80054072961 scopus 로고    scopus 로고
    • Sequential vs. Concurrent chemoradiation for stage III non-small cell lung cancer: Randomized phase III trial RTOG 9410
    • Curran WJ Jr, Paulus R, Langer CJ, et al. Sequential vs. concurrent chemoradiation for stage III non-small cell lung cancer: randomized phase III trial RTOG 9410. J Natl Cancer Inst. 2011;103:1452-1460.
    • (2011) J Natl Cancer Inst , vol.103 , pp. 1452-1460
    • Curran, W.J.1    Paulus, R.2    Langer, C.J.3
  • 89
    • 57449090435 scopus 로고    scopus 로고
    • Phase III study of cisplatin, etoposide, and concurrent chest radiation with or without consolidation docetaxel in patients with inoperable stage III non-small-cell lung cancer: The Hoosier Oncology Group and U.S. Oncology
    • Hanna N, Neubauer M, Yiannoutsos C, et al. Phase III study of cisplatin, etoposide, and concurrent chest radiation with or without consolidation docetaxel in patients with inoperable stage III non-small-cell lung cancer: the Hoosier Oncology Group and U.S. Oncology. J Clin Oncol. 2008;26:5755-5760.
    • (2008) J Clin Oncol , vol.26 , pp. 5755-5760
    • Hanna, N.1    Neubauer, M.2    Yiannoutsos, C.3
  • 90
    • 84940484434 scopus 로고    scopus 로고
    • Multinational randomized phase III trial with or without consolidation chemotherapy using docetaxel and cisplatin after concurrent chemoradiation in inoperable stage III non-small-cell lung cancer: KCSG-LU05-04
    • Ahn JS, Ahn YC, Kim JH, et al. Multinational randomized phase III trial with or without consolidation chemotherapy using docetaxel and cisplatin after concurrent chemoradiation in inoperable stage III non-small-cell lung cancer: KCSG-LU05-04. J Clin Oncol. 2015;33: 2660-2666.
    • (2015) J Clin Oncol , vol.33 , pp. 2660-2666
    • Ahn, J.S.1    Ahn, Y.C.2    Kim, J.H.3
  • 92
    • 67449155868 scopus 로고    scopus 로고
    • Functionally distinct LAG-3 and PD-1 subsets on activated and chronically stimulated CD8 T cells
    • Grosso JF, Goldberg MV, Getnet D, et al. Functionally distinct LAG-3 and PD-1 subsets on activated and chronically stimulated CD8 T cells. J Immunol. 2009;182:6659-6669.
    • (2009) J Immunol , vol.182 , pp. 6659-6669
    • Grosso, J.F.1    Goldberg, M.V.2    Getnet, D.3
  • 93
    • 22544445249 scopus 로고    scopus 로고
    • Expression of lymphocyte activation gene 3 (LAG-3) on B cells is induced by T cells
    • Kisielow M, Kisielow J, Capoferri-Sollami G, Karjalainen K. Expression of lymphocyte activation gene 3 (LAG-3) on B cells is induced by T cells. Eur J Immunol. 2005;35:2081-2088.
    • (2005) Eur J Immunol , vol.35 , pp. 2081-2088
    • Kisielow, M.1    Kisielow, J.2    Capoferri-Sollami, G.3    Karjalainen, K.4
  • 94
    • 84863115998 scopus 로고    scopus 로고
    • Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape
    • Woo SR, Turnis ME, Goldberg MV, et al. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res. 2012;72:917-927.
    • (2012) Cancer Res , vol.72 , pp. 917-927
    • Woo, S.R.1    Turnis, M.E.2    Goldberg, M.V.3
  • 96
    • 84934287610 scopus 로고    scopus 로고
    • Therapeutic potential and challenges of natural killer cells in treatment of solid tumors
    • Gras Navarro A, Bjorklund AT, Chekenya M. Therapeutic potential and challenges of natural killer cells in treatment of solid tumors. Front Immunol. 2015;6:202.
    • (2015) Front Immunol , vol.6 , pp. 202
    • Gras Navarro, A.1    Bjorklund, A.T.2    Chekenya, M.3
  • 97
    • 84894030202 scopus 로고    scopus 로고
    • Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies
    • Kohrt HE, Thielens A, Marabelle A, et al. Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies. Blood. 2014;123: 678-686.
    • (2014) Blood , vol.123 , pp. 678-686
    • Kohrt, H.E.1    Thielens, A.2    Marabelle, A.3
  • 98
    • 69249108787 scopus 로고    scopus 로고
    • Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells
    • Romagne F, Andre P, Spee P, et al. Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells. Blood. 2009;114: 2667-2677.
    • (2009) Blood , vol.114 , pp. 2667-2677
    • Romagne, F.1    Re, P.2    Spee, P.3
  • 101
    • 0242539820 scopus 로고    scopus 로고
    • Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance
    • Sabatos CA, Chakravarti S, Cha E, et al. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol. 2003;4:1102-1110.
    • (2003) Nat Immunol , vol.4 , pp. 1102-1110
    • Sabatos, C.A.1    Chakravarti, S.2    Cha, E.3
  • 102
    • 79956103042 scopus 로고    scopus 로고
    • Anti-TIM3 antibody promotes T cell IFN-gamma-mediated antitumor immunity and suppresses established tumors
    • Ngiow SF, von Scheidt B, Akiba H, Yagita H, Teng MW, Smyth MJ. Anti-TIM3 antibody promotes T cell IFN-gamma-mediated antitumor immunity and suppresses established tumors. Cancer Res. 2011;71: 3540-3551.
    • (2011) Cancer Res , vol.71 , pp. 3540-3551
    • Ngiow, S.F.1    Von Scheidt, B.2    Akiba, H.3    Yagita, H.4    Teng, M.W.5    Smyth, M.J.6
  • 103
    • 84958555198 scopus 로고    scopus 로고
    • Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints
    • Koyama S, Akbay EA, Li YY, et al. Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints. Nat Commun. 2016;7:10501.
    • (2016) Nat Commun , vol.7 , pp. 10501
    • Koyama, S.1    Akbay, E.A.2    Li, Y.Y.3
  • 104
    • 79954593616 scopus 로고    scopus 로고
    • Kwon BS. 4-1BB signaling beyond T cells
    • Vinay DS, Kwon BS. 4-1BB signaling beyond T cells. Cell Mol Immunol. 2011;8:281-284
    • (2011) Cell Mol Immunol , vol.8 , pp. 281-284
    • Vinay, D.S.1
  • 105
    • 79953041310 scopus 로고    scopus 로고
    • Costimulation through the CD137/4-1BB pathway protects human melanoma tumor-infiltrating lymphocytes from activation-induced cell death and enhances antitumor effector function
    • Hernandez-Chacon JA, Li Y, Wu RC, et al. Costimulation through the CD137/4-1BB pathway protects human melanoma tumor-infiltrating lymphocytes from activation-induced cell death and enhances antitumor effector function. J Immunother. 2011;34:236-250.
    • (2011) J Immunother , vol.34 , pp. 236-250
    • Hernandez-Chacon, J.A.1    Li, Y.2    Wu, R.C.3
  • 106
    • 0031007143 scopus 로고    scopus 로고
    • Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
    • Melero I, Shuford WW, Newby SA, et al. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med. 1997;3:682-685.
    • (1997) Nat Med , vol.3 , pp. 682-685
    • Melero, I.1    Shuford, W.W.2    Newby, S.A.3
  • 108
    • 44349150012 scopus 로고    scopus 로고
    • Inhibitory B7-family molecules in the tumour microenvironment
    • Zou W, Chen L. Inhibitory B7-family molecules in the tumour microenvironment. Nat Rev Immunol. 2008;8:467-477.
    • (2008) Nat Rev Immunol , vol.8 , pp. 467-477
    • Zou, W.1    Chen, L.2
  • 109
    • 84856356091 scopus 로고    scopus 로고
    • Induced expression of B7-H4 on the surface of lung cancer cell by the tumor-associated macrophages: A potential mechanism of immune escape
    • Chen C, Qu QX, Shen Y, et al. Induced expression of B7-H4 on the surface of lung cancer cell by the tumor-associated macrophages: a potential mechanism of immune escape. Cancer Lett. 2012;317:99-105.
    • (2012) Cancer Lett , vol.317 , pp. 99-105
    • Chen, C.1    Qu, Q.X.2    Shen, Y.3
  • 110
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol. 2009;9:162-174.
    • (2009) Nat Rev Immunol , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 111
    • 84901059693 scopus 로고    scopus 로고
    • Control of the adaptive immune response by tumor vasculature
    • Mauge L, Terme M, Tartour E, Helley D. Control of the adaptive immune response by tumor vasculature. Front Oncol. 2014;4:61.
    • (2014) Front Oncol , vol.4 , pp. 61
    • Mauge, L.1    Terme, M.2    Tartour, E.3    Helley, D.4
  • 112
    • 38049000452 scopus 로고    scopus 로고
    • Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy
    • Buckanovich RJ, Facciabene A, Kim S, et al. Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy. Nat Med. 2008;14:28-36.
    • (2008) Nat Med , vol.14 , pp. 28-36
    • Buckanovich, R.J.1    Facciabene, A.2    Kim, S.3
  • 113
    • 0242559053 scopus 로고    scopus 로고
    • Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis
    • Rodig N, Ryan T, Allen JA, et al. Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis. Eur J Immunol. 2003;33:3117-126.
    • (2003) Eur J Immunol , vol.33 , pp. 3117-3126
    • Rodig, N.1    Ryan, T.2    Allen, J.A.3
  • 114
    • 84997724674 scopus 로고    scopus 로고
    • Targeting the indoleamine 2,3-dioxygenase pathway in cancer
    • Moon YW, Hajjar J, Hwu P, Naing A. Targeting the indoleamine 2,3-dioxygenase pathway in cancer. J Immunother Cancer. 2015;3:51.
    • (2015) J Immunother Cancer , vol.3 , pp. 51
    • Moon, Y.W.1    Hajjar, J.2    Hwu, P.3    Naing, A.4
  • 115
    • 0036569127 scopus 로고    scopus 로고
    • Cutting edge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation
    • Woo EY, Yeh H, Chu CS, et al. Cutting edge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation. J Immunol. 2002;168:4272-4276.
    • (2002) J Immunol , vol.168 , pp. 4272-4276
    • Woo, E.Y.1    Yeh, H.2    Chu, C.S.3
  • 116
    • 84863783251 scopus 로고    scopus 로고
    • Increase of regulatory T cells in metastatic stage and CTLA-4 over expression in lymphocytes of patients with non-small cell lung cancer (NSCLC)
    • Erfani N, Mehrabadi SM, Ghayumi MA, et al. Increase of regulatory T cells in metastatic stage and CTLA-4 over expression in lymphocytes of patients with non-small cell lung cancer (NSCLC). Lung Cancer. 2012;77:306-311.
    • (2012) Lung Cancer , vol.77 , pp. 306-311
    • Erfani, N.1    Mehrabadi, S.M.2    Ghayumi, M.A.3
  • 117
    • 84881458660 scopus 로고    scopus 로고
    • Tumor-infiltrating regulatory T cells inhibit endogenous cytotoxic T cell responses to lung adenocarcinoma
    • Ganesan AP, Johansson M, Ruffell B, et al. Tumor-infiltrating regulatory T cells inhibit endogenous cytotoxic T cell responses to lung adenocarcinoma. J Immunol. 2013;191:2009-2017.
    • (2013) J Immunol , vol.191 , pp. 2009-2017
    • Ganesan, A.P.1    Johansson, M.2    Ruffell, B.3
  • 118
    • 33845590308 scopus 로고    scopus 로고
    • Tumor infiltrating Foxp3+ regulatory T-cells are associated with recurrence in pathologic stage I NSCLC patients
    • Petersen RP, Campa MJ, Sperlazza J, et al. Tumor infiltrating Foxp3+ regulatory T-cells are associated with recurrence in pathologic stage I NSCLC patients. Cancer. 2006;107:2866-2872.
    • (2006) Cancer , vol.107 , pp. 2866-2872
    • Petersen, R.P.1    Campa, M.J.2    Sperlazza, J.3
  • 119
    • 84867583274 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes predict response to chemotherapy in patients with advance non-small cell lung cancer
    • Liu H, Zhang T, Ye J, et al. Tumor-infiltrating lymphocytes predict response to chemotherapy in patients with advance non-small cell lung cancer. Cancer Immunol Immunother. 2012;61:1849-1856.
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 1849-1856
    • Liu, H.1    Zhang, T.2    Ye, J.3
  • 120
    • 84901594397 scopus 로고    scopus 로고
    • Neoadjuvant chemo-immunotherapy modifies CD4(+)CD25(+) regulatory T cells (Treg) in non-small cell lung cancer (NSCLC) patients
    • Pircher A, Gamerith G, Amann A, et al. Neoadjuvant chemo-immunotherapy modifies CD4(+)CD25(+) regulatory T cells (Treg) in non-small cell lung cancer (NSCLC) patients. Lung Cancer. 2014;85: 81-87.
    • (2014) Lung Cancer , vol.85 , pp. 81-87
    • Pircher, A.1    Gamerith, G.2    Amann, A.3
  • 121
    • 84926409739 scopus 로고    scopus 로고
    • Increase in activated Treg in TIL in lung cancer and in vitro depletion of Treg by ADCC using an antihu-man CCR4 mAb (KM2760)
    • Kurose K, Ohue Y, Sato E, et al. Increase in activated Treg in TIL in lung cancer and in vitro depletion of Treg by ADCC using an antihu-man CCR4 mAb (KM2760). J Thorac Oncol. 2015;10:74-83.
    • (2015) J Thorac Oncol , vol.10 , pp. 74-83
    • Kurose, K.1    Ohue, Y.2    Sato, E.3
  • 122
    • 84970011410 scopus 로고    scopus 로고
    • Changes in PD-L1 expression in non-small cell lung cancer by immunohistochemical analysis
    • abstr
    • Omori S, Kenmotsu H, Abe M, et al. Changes in PD-L1 expression in non-small cell lung cancer by immunohistochemical analysis. J Clin Oncol. 2015;33(Suppl; abstr e22118).
    • (2015) J Clin Oncol , vol.33
    • Omori, S.1    Kenmotsu, H.2    Abe, M.3
  • 123
    • 84929251102 scopus 로고    scopus 로고
    • Nivolumab: Targeting PD-1 to bolster antitumor immunity
    • Brahmer JR, Hammers H, Lipson EJ. Nivolumab: targeting PD-1 to bolster antitumor immunity. Future Oncol. 2015;11:1307-1326.
    • (2015) Future Oncol , vol.11 , pp. 1307-1326
    • Brahmer, J.R.1    Hammers, H.2    Lipson, E.J.3
  • 124
    • 84959127317 scopus 로고    scopus 로고
    • Intratumor heterogeneity (ITH) of lung adenocarcinomas defined by multiregion whole exome sequencing (WES)
    • abstr 11032
    • Zhang J, Fujimoto J, Zhang J, et al. Intratumor heterogeneity (ITH) of lung adenocarcinomas defined by multiregion whole exome sequencing (WES). J Clin Oncol. 2014;32:5s(Suppl; abstr 11032).
    • (2014) J Clin Oncol , vol.32 , Issue.5s
    • Zhang, J.1    Fujimoto, J.2    Zhang, J.3
  • 125
    • 84934436823 scopus 로고    scopus 로고
    • Circulating PD-L1 in NSCLC patients and the correlation between the level of PD-L1 expression and the clinical characteristics
    • Zhang J, Gao J, Li Y, et al. Circulating PD-L1 in NSCLC patients and the correlation between the level of PD-L1 expression and the clinical characteristics. Thorac Cancer. 2015;6:534-538.
    • (2015) Thorac Cancer , vol.6 , pp. 534-538
    • Zhang, J.1    Gao, J.2    Li, Y.3
  • 126
    • 84937108473 scopus 로고    scopus 로고
    • Smoking history and response to nivolumab in patients with advanced NSCLCs
    • Hellmann M, Creelan BC, Woo K, et al. Smoking history and response to nivolumab in patients with advanced NSCLCs. Ann Oncol. 2014;25(Suppl 4):429.
    • (2014) Ann Oncol , vol.25 , pp. 429
    • Hellmann, M.1    Creelan, B.C.2    Woo, K.3
  • 127
    • 84928761118 scopus 로고    scopus 로고
    • Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
    • Rizvi NA, Hellmann MD, Snyder A, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science. 2015;348:124-128.
    • (2015) Science , vol.348 , pp. 124-128
    • Rizvi, N.A.1    Hellmann, M.D.2    Snyder, A.3
  • 128
    • 84867696992 scopus 로고    scopus 로고
    • When progressive disease does not mean treatment failure: Reconsidering the criteria for progression
    • Oxnard GR, Morris MJ, Hodi FS, et al. When progressive disease does not mean treatment failure: reconsidering the criteria for progression. J Natl Cancer Inst. 2012;104:1534-1541.
    • (2012) J Natl Cancer Inst , vol.104 , pp. 1534-1541
    • Oxnard, G.R.1    Morris, M.J.2    Hodi, F.S.3
  • 129
    • 38649094865 scopus 로고    scopus 로고
    • The heterogeneity of the kinetics of response to ipilimumab in metastatic melanoma: Patient cases
    • Saenger YM, Wolchok JD. The heterogeneity of the kinetics of response to ipilimumab in metastatic melanoma: patient cases. Cancer Immun. 2008;8:1.
    • (2008) Cancer Immun , vol.8 , pp. 1
    • Saenger, Y.M.1    Wolchok, J.D.2
  • 130
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366: 2443-2454.
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 131
    • 73149092567 scopus 로고    scopus 로고
    • Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
    • Wolchok JD, Hoos A, O’Day S, et al. Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin Cancer Res. 2009;15:7412-7420.
    • (2009) Clin Cancer Res , vol.15 , pp. 7412-7420
    • Wolchok, J.D.1    Hoos, A.2    O’Day, S.3
  • 133
    • 84988879648 scopus 로고    scopus 로고
    • Characterization of patients treated with a programmed cell death protein 1 inhibitor (Anti-PD-1) past RECIST progression from a metastatic non-small cell lung cancer (mNSCLC) trial
    • abstr 3000
    • Kazandjian DG, Blumenthal GM, Khozin S, et al. Characterization of patients treated with a programmed cell death protein 1 inhibitor (anti-PD-1) past RECIST progression from a metastatic non-small cell lung cancer (mNSCLC) trial. Clin Oncol. 2016;34(Suppl; abstr 3000).
    • (2016) Clin Oncol , vol.34
    • Kazandjian, D.G.1    Blumenthal, G.M.2    Khozin, S.3
  • 135
    • 84959133719 scopus 로고    scopus 로고
    • Combination cancer immunotherapies tailored to the tumour microenvironment
    • Smyth MJ, Ngiow SF, Ribas A, Teng MW. Combination cancer immunotherapies tailored to the tumour microenvironment. Nat Rev Clin Oncol. 2016;13:143-158.
    • (2016) Nat Rev Clin Oncol , vol.13 , pp. 143-158
    • Smyth, M.J.1    Ngiow, S.F.2    Ribas, A.3    Teng, M.W.4
  • 136
    • 84907651086 scopus 로고    scopus 로고
    • First-line nivolumab (Anti-PD-1; BMS-936558, ONO-4538) monotherapy in advanced NSCLC: Safety, efficacy, and correlation of outcomes with PD-L1 status
    • abstr 8024
    • Gettinger SN, Sheperd FA, Antonia S, et al. First-line nivolumab (anti-PD-1; BMS-936558, ONO-4538) monotherapy in advanced NSCLC: safety, efficacy, and correlation of outcomes with PD-L1 status. J Clin Oncol. 2014;32:5s(Suppl; abstr 8024).
    • (2014) J Clin Oncol , vol.32 , Issue.5s
    • Gettinger, S.N.1    Sheperd, F.A.2    Antonia, S.3


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