4-1BB signaling beyond T cells

Cellular and Molecular Immunology

Volumn 8, Issue 4, 2011, Pages 281-284

  Vinay, Dass S ^a   Kwon, Byoung S ^a,b  

^a TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b National Cancer Center   (South Korea)

Author keywords

4 1BB; APC; cytokines; natural killer cells; T cells

Indexed keywords

CD137 ANTIGEN; CD137 LIGAND; INTERLEUKIN 13; INTERLEUKIN 6; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

AUTOIMMUNE DISEASE; B LYMPHOCYTE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; HUMAN; IMMUNOREGULATION; MONOCYTE; NATURAL KILLER CELL; NEUTROPHIL; NONHUMAN; PHAGOCYTOSIS; PROTEIN CROSS LINKING; REVIEW; T LYMPHOCYTE; TUMOR GROWTH; VIRUS INFECTION;

ANIMALS; ANTIGENS, CD137; HUMANS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 79954593616     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2010.82     Document Type: Review

References (36)

1. Kwon BS, Weissman SM. cDNA sequences of two inducible T-cell genes. Proc Natl Acad Sci USA 1989; 86: 1963-1967. (Pubitemid 19087048)
2. Watts TH. The TNF/TNFR family members in costimulation of T cell responses. Annu Rev Immunol 2005; 23: 23-68. (Pubitemid 40563164)
3. Croft M. Costimulation of T cells by OX-40, 4-1BB, and CD27. Cytokine Growth Factor Rev 2003; 14: 265-273. (Pubitemid 36693146)
4. Wilcox RA, Chapoval AI, Gorski KS, Otsuji M, Shin T, Flies DB et al. Expression of functional CD137 receptor by dendritic cells. J Immunol 2002; 168: 4262-4267. (Pubitemid 34441322)
5. McHugh RS, Whitters MJ, Piccirillo CA, Young DA, Shevach EM, Collins M et al. CD41CD251 immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 2002; 16: 311-323. (Pubitemid 34211969)
6. Vinay DS, Kwon BS. Genes, transcripts, and proteins of CD137 receptor and ligand. In: Chen L, (ed.) CD137 Pathway: Immunology and Diseases. Springer: New York, 2006: 1-14.
7. Vinay DS, Cha K, Kwon BS. Dual immunoregulatory pathways of 4-1BB signaling. J Mol Med 2006; 84: 726-736. (Pubitemid 44328064)
8. Niu L, Strahotin S, Hewes B, Zhang B, Zhang Y, Archer D et al. Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice. J Immunol 2007; 178: 4194-4213. (Pubitemid 46492370)
9. Sun Y, Chen HM, Subudhi SK, Chen J, Koka R, Chen L et al. Costimulatory moleculetargeted antibody therapy of a spontaneous autoimmune disease. Nat Med 2002; 8: 1405-1413. (Pubitemid 36019426)
10. Vinay DS, Kim JD, Kwon BS. Amelioration of mercury-induced autoimmunity by 4- 1BB. J Immunol 2006; 177: 5708-5717.
11. Menoret A, Myers LM, Lee SJ, Mittler RS, Rossi RJ, Vella AT. TGFb protein processing and activity through TCR triggering of primary CD81 T regulatory cells. J Immunol 2006; 177: 6091-6097. (Pubitemid 44628824)
12. Myers L, CroftM, Kwon BS, Mittler RS, Vella AT. Peptide-specific CD8 T regulatory cells use IFN-c to elaborate TGF-b-based suppression. J Immunol 2005; 174: 7625-7632. (Pubitemid 40806267)
13. Choi BK, Asai T, Vinay DS, Kim YH, Kwon BS. 4-1BB-mediated amelioration of experimental autoimmune uveoretinitis is caused by indoleamine 2,3-dioxygenasedependent mechanisms. Cytokine 2006; 34: 233-242. (Pubitemid 44224104)
14. Seo SK, Choi JH, Kim YH, Kang WJ, Park YH, Suh JH et al. 4-1BB-mediated immunotherapy of rheumatoid arthritis. Nat Med 2004; 10: 1088-1094. (Pubitemid 39424870)
15. Futagawa T, Akiba H, Kodama T, Takeda K, Hosoda Y, Yagita H et al. Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells. Int Immunol 2002; 14: 275-286. (Pubitemid 34213639)
16. Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ et al. Immunobiology of dendritic cells. Annu Rev Immunol 2000; 18: 767-811. (Pubitemid 30365397)
17. Palucka K, Banchereau J. Dendritic cells: a link between innate and adaptive immunity. J Clin Immunol 1999; 19: 12-25. (Pubitemid 29113329)
18. Zhang B, Zhang Y, Niu L, Vella AT, Mittler RS. Dendritic cells and Stat3 are essential for CD137-induced CD8 T cell activation-induced cell death. J Immunol 2010; 184: 4770-4778.
19. Lee SW, Park Y, So T, Kwon BS, Cheroutre H, Mittler RS et al. Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells. Nat Immunol 2008; 9: 917-926.
20. Choi BK, Kim YH, Kwon PM, Lee SC, Kang SW, Kim MS et al. 4-1BB functions as a survival factor in dendritic cells. J Immunol 2009; 182: 4107-4115.
21. Auffray C, Sieweke MH, Geissmann F. Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu Rev Immunol 2009; 27: 669-692.
22. Schwarz H, Valbracht J, Tuckwell J, von Kempis J, Lotz M. ILA, the human 4-1BB homologues, is inducible in lymphoid and other cell lineages. Blood 1995; 85: 1043-1052.
23. Kienzle G, von Kempis J. CD137 (ILA/4-1BB), expressed by primary human monocytes, induces monocyte activation and apoptosis of B lymphocytes. Int Immunol 2000; 12: 73-82. (Pubitemid 30045414)
24. Benschop RJ, Cambier JC. B cell development: signal transduction by antigen receptors and their surrogates. Curr Opin Immunol 1999; 11: 143-151. (Pubitemid 29154898)
25. Williams MGH. B cells as effectors. Curr Opin Immunol 2003; 15: 354-361.
26. Bachmann MF, Zinkernagel RM. Neutralizing anti-viral responses. Annu Rev Immunol 1997; 15: 235-270.
27. Edwards JC, Cambridge G. B cell-targeting in rheumatoid arthritis and other autoimmune diseases. Nat Rev Immunol 2006; 6: 394-402.
28. Zhang X, Voskens CJ, Sallin M, Maniar A, Montes CL, Zhang Y et al. CD137 promotes proliferation and survival of human B cells. J Immunol 2010; 184: 787-795.
29. Matsukawa A, Yoshinaga M. Neutrophils as a source of cytokines in inflammation. Histol Histopathol 1999; 14: 511-516. (Pubitemid 29159020)
30. Bliss SK, Marshall AJ, Zhang Y, Denkers EY. Human polymorphonuclear leukocytes produce IL-12, TNF-a, and the chemokines macrophage-inflammatory protein-1a and -1b in response to Toxoplasma gondii antigens. J Immunol 1999; 162: 7369-7375. (Pubitemid 29277713)
31. Lee SC, Ju SA, Sung BH, Heo SK, Cho HR, Lee EA et al. Stimulation of the molecule 4- 1BB enhances host defense against Listeria monocytogenes infection in mice by inducing rapid infiltration and activation of neutrophils and monocytes. Infect Immun 2009; 179: 2168-2176.
32. Shea-Donohue T, Stiltz J, Zhao A, Notari L. Mast cells. Curr Gastroenterol Rep 2010; 12: 349-357.
33. Nishimoto H, Lee SW, Hong H, Potter KG, Yamamoto MM, Kinoshita T et al. Costimulation of mast cells by 4-1BB, a member of the tumor necrosis factor receptor superfamily, with the high-affinity IgE receptor. Blood 2005; 106: 4241-4248. (Pubitemid 41775932)
34. Trinchieri G. Biology of natural killer cells. Adv Immunol 1989; 47: 187-376. (Pubitemid 20010960)
35. Melero I, Johnston JV, Shufford WW, Mittler RS, Chen L. NK1.1 cells express 4-1BB (CDw137) costimulatory molecule and are required for tumor immunity elicited by anti-4-1BB monoclonal antibodies. Cell Immunol 1998; 190: 167-172. (Pubitemid 29011104)
36. Vinay DS, Choi BK, Bae JS, Kim WY, Gebhardt BM, Kwon BS. CD137-deficient mice have reduced NK/NKT cell numbers and function, are resistant to lipopolysaccharideinduced shock syndromes, and have lower IL-4 responses. J Immunol 2004; 173: 4218-4229. (Pubitemid 39280788)