메뉴 건너뛰기




Volumn 77, Issue 2, 2012, Pages 306-311

Increase of regulatory T cells in metastatic stage and CTLA-4 over expression in lymphocytes of patients with non-small cell lung cancer (NSCLC)

Author keywords

CTLA 4; FoxP3; Lung cancer; Non small cell lung cancer; Regulatory T cells; Tumor immunology

Indexed keywords

CD4 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3;

EID: 84863783251     PISSN: 01695002     EISSN: 18728332     Source Type: Journal    
DOI: 10.1016/j.lungcan.2012.04.011     Document Type: Article
Times cited : (144)

References (43)
  • 1
    • 0035806290 scopus 로고    scopus 로고
    • Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood
    • Jonuleit H., Schmitt E., Stassen M., Tuettenberg A., Knop J., Enk A.H. Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J Exp Med 2001, 193:1285-1294.
    • (2001) J Exp Med , vol.193 , pp. 1285-1294
    • Jonuleit, H.1    Schmitt, E.2    Stassen, M.3    Tuettenberg, A.4    Knop, J.5    Enk, A.H.6
  • 2
    • 0034716925 scopus 로고    scopus 로고
    • Regulatory T cells: key controllers of immunologic self-tolerance
    • Sakaguchi S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell 2000, 101:455-458.
    • (2000) Cell , vol.101 , pp. 455-458
    • Sakaguchi, S.1
  • 3
    • 16844365788 scopus 로고    scopus 로고
    • Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
    • Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 2005, 6:345-352.
    • (2005) Nat Immunol , vol.6 , pp. 345-352
    • Sakaguchi, S.1
  • 4
    • 0032193228 scopus 로고    scopus 로고
    • Expression and function of CTLA-4 in Th1 and Th2 cells
    • Alegre M.L., Shiels H., Thompson C.B., Gajewski T.F. Expression and function of CTLA-4 in Th1 and Th2 cells. J Immunol 1998, 161:3347-3356.
    • (1998) J Immunol , vol.161 , pp. 3347-3356
    • Alegre, M.L.1    Shiels, H.2    Thompson, C.B.3    Gajewski, T.F.4
  • 6
    • 0036721629 scopus 로고    scopus 로고
    • Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma
    • Liyanage U.K., Moore T.T., Joo H.G., Tanaka Y., Herrmann V., Doherty G., et al. Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma. J Immunol 2002, 169:2756-2761.
    • (2002) J Immunol , vol.169 , pp. 2756-2761
    • Liyanage, U.K.1    Moore, T.T.2    Joo, H.G.3    Tanaka, Y.4    Herrmann, V.5    Doherty, G.6
  • 7
    • 16844378685 scopus 로고    scopus 로고
    • Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma
    • Ormandy L.A., Hillemann T., Wedemeyer H., Manns M.P., Greten T.F., Korangy F. Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma. Cancer Res 2005, 65:2457-2464.
    • (2005) Cancer Res , vol.65 , pp. 2457-2464
    • Ormandy, L.A.1    Hillemann, T.2    Wedemeyer, H.3    Manns, M.P.4    Greten, T.F.5    Korangy, F.6
  • 8
    • 39749142196 scopus 로고    scopus 로고
    • Enhanced functionality of CD4+CD25(high)FoxP3+ regulatory T cells in the peripheral blood of patients with prostate cancer
    • Yokokawa J., Cereda V., Remondo C., Gulley J.L., Arlen P.M., Schlom J., et al. Enhanced functionality of CD4+CD25(high)FoxP3+ regulatory T cells in the peripheral blood of patients with prostate cancer. Clin Cancer Res 2008, 14:1032-1040.
    • (2008) Clin Cancer Res , vol.14 , pp. 1032-1040
    • Yokokawa, J.1    Cereda, V.2    Remondo, C.3    Gulley, J.L.4    Arlen, P.M.5    Schlom, J.6
  • 9
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel T.J., Coukos G., Zou L., Alvarez X., Cheng P., Mottram P., et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004, 10:942-949.
    • (2004) Nat Med , vol.10 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3    Alvarez, X.4    Cheng, P.5    Mottram, P.6
  • 10
    • 0035874949 scopus 로고    scopus 로고
    • Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer
    • Woo E.Y., Chu C.S., Goletz T.J., Schlienger K., Yeh H., Coukos G., et al. Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer. Cancer Res 2001, 61:4766-4772.
    • (2001) Cancer Res , vol.61 , pp. 4766-4772
    • Woo, E.Y.1    Chu, C.S.2    Goletz, T.J.3    Schlienger, K.4    Yeh, H.5    Coukos, G.6
  • 11
    • 0041386189 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells in patients with gastrointestinal malignancies: possible involvement of regulatory T cells in disease progression
    • Sasada T., Kimura M., Yoshida Y., Kanai M., Takabayashi A. CD4+CD25+ regulatory T cells in patients with gastrointestinal malignancies: possible involvement of regulatory T cells in disease progression. Cancer 2003, 98:1089-1099.
    • (2003) Cancer , vol.98 , pp. 1089-1099
    • Sasada, T.1    Kimura, M.2    Yoshida, Y.3    Kanai, M.4    Takabayashi, A.5
  • 12
    • 0141891466 scopus 로고    scopus 로고
    • Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers
    • Ichihara F., Kono K., Takahashi A., Kawaida H., Sugai H., Fujii H. Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers. Clin Cancer Res 2003, 9:4404-4408.
    • (2003) Clin Cancer Res , vol.9 , pp. 4404-4408
    • Ichihara, F.1    Kono, K.2    Takahashi, A.3    Kawaida, H.4    Sugai, H.5    Fujii, H.6
  • 13
    • 16244409219 scopus 로고    scopus 로고
    • Characteristics of CD4+CD25+ regulatory T cells in the peripheral circulation of patients with head and neck cancer
    • Schaefer C., Kim G.G., Albers A., Hoermann K., Myers E.N., Whiteside T.L. Characteristics of CD4+CD25+ regulatory T cells in the peripheral circulation of patients with head and neck cancer. Br J Cancer 2005, 92:913-920.
    • (2005) Br J Cancer , vol.92 , pp. 913-920
    • Schaefer, C.1    Kim, G.G.2    Albers, A.3    Hoermann, K.4    Myers, E.N.5    Whiteside, T.L.6
  • 14
    • 0037217371 scopus 로고    scopus 로고
    • CD4+CD25+ suppressor lymphocytes in the circulation of patients immunized against melanoma antigens
    • Javia L.R., Rosenberg S.A. CD4+CD25+ suppressor lymphocytes in the circulation of patients immunized against melanoma antigens. J Immunother 2003, 26:85-93.
    • (2003) J Immunother , vol.26 , pp. 85-93
    • Javia, L.R.1    Rosenberg, S.A.2
  • 15
    • 3142737258 scopus 로고    scopus 로고
    • Foxp3 expressing CD4+CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells
    • Viguier M., Lemaitre F., Verola O., Cho M.S., Gorochov G., Dubertret L., et al. Foxp3 expressing CD4+CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells. J Immunol 2004, 173:1444-1453.
    • (2004) J Immunol , vol.173 , pp. 1444-1453
    • Viguier, M.1    Lemaitre, F.2    Verola, O.3    Cho, M.S.4    Gorochov, G.5    Dubertret, L.6
  • 16
    • 33646422454 scopus 로고    scopus 로고
    • Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma
    • Yang Z.Z., Novak A.J., Stenson M.J., Witzig T.E., Ansell S.M. Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma. Blood 2006, 107:3639-3646.
    • (2006) Blood , vol.107 , pp. 3639-3646
    • Yang, Z.Z.1    Novak, A.J.2    Stenson, M.J.3    Witzig, T.E.4    Ansell, S.M.5
  • 17
    • 27144559654 scopus 로고    scopus 로고
    • Increased expression of CD152 (CTLA-4) by normal T lymphocytes in untreated patients with B-cell chronic lymphocytic leukemia
    • Motta M., Rassenti L., Shelvin B.J., Lerner S., Kipps T.J., Keating M.J., et al. Increased expression of CD152 (CTLA-4) by normal T lymphocytes in untreated patients with B-cell chronic lymphocytic leukemia. Leukemia 2005, 19:1788-1793.
    • (2005) Leukemia , vol.19 , pp. 1788-1793
    • Motta, M.1    Rassenti, L.2    Shelvin, B.J.3    Lerner, S.4    Kipps, T.J.5    Keating, M.J.6
  • 18
    • 24744432528 scopus 로고    scopus 로고
    • Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine
    • Beyer M., Kochanek M., Darabi K., Popov A., Jensen M., Endl E., et al. Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine. Blood 2005, 106:2018-2025.
    • (2005) Blood , vol.106 , pp. 2018-2025
    • Beyer, M.1    Kochanek, M.2    Darabi, K.3    Popov, A.4    Jensen, M.5    Endl, E.6
  • 19
    • 28044434385 scopus 로고    scopus 로고
    • Increased population of CD4(+)CD25(high), regulatory T cells with their higher apoptotic and proliferating status in peripheral blood of acute myeloid leukemia patients
    • Wang X., Zheng J., Liu J., Yao J., He Y., Li X., et al. Increased population of CD4(+)CD25(high), regulatory T cells with their higher apoptotic and proliferating status in peripheral blood of acute myeloid leukemia patients. Eur J Haematol 2005, 75:468-476.
    • (2005) Eur J Haematol , vol.75 , pp. 468-476
    • Wang, X.1    Zheng, J.2    Liu, J.3    Yao, J.4    He, Y.5    Li, X.6
  • 20
    • 1442283424 scopus 로고    scopus 로고
    • Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma
    • Marshall N.A., Christie L.E., Munro L.R., Culligan D.J., Johnston P.W., Barker R.N., et al. Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma. Blood 2004, 103:1755-1762.
    • (2004) Blood , vol.103 , pp. 1755-1762
    • Marshall, N.A.1    Christie, L.E.2    Munro, L.R.3    Culligan, D.J.4    Johnston, P.W.5    Barker, R.N.6
  • 21
    • 0037364804 scopus 로고    scopus 로고
    • Natural versus adaptive regulatory T cells
    • Bluestone J.A., Abbas A.K. Natural versus adaptive regulatory T cells. Nat Rev Immunol 2003, 3:253-257.
    • (2003) Nat Rev Immunol , vol.3 , pp. 253-257
    • Bluestone, J.A.1    Abbas, A.K.2
  • 22
    • 0037364976 scopus 로고    scopus 로고
    • Regulatory T cells in transplantation tolerance
    • Wood K.J., Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Rev Immunol 2003, 3:199-210.
    • (2003) Nat Rev Immunol , vol.3 , pp. 199-210
    • Wood, K.J.1    Sakaguchi, S.2
  • 23
    • 0035806289 scopus 로고    scopus 로고
    • Certified professionals: CD4(+)CD25(+) suppressor T cells
    • Shevach E.M. Certified professionals: CD4(+)CD25(+) suppressor T cells. J Exp Med 2001, 193:F41-F46.
    • (2001) J Exp Med , vol.193
    • Shevach, E.M.1
  • 24
  • 25
    • 27744477593 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells in the peripheral blood of patients with breast cancer and non-small cell lung cancer
    • Okita R., Saeki T., Takashima S., Yamaguchi Y., Toge T. CD4+CD25+ regulatory T cells in the peripheral blood of patients with breast cancer and non-small cell lung cancer. Oncol Rep 2005, 14:1269-1273.
    • (2005) Oncol Rep , vol.14 , pp. 1269-1273
    • Okita, R.1    Saeki, T.2    Takashima, S.3    Yamaguchi, Y.4    Toge, T.5
  • 26
    • 33744457276 scopus 로고    scopus 로고
    • CD4(+)CD25high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers
    • Kono K., Kawaida H., Takahashi A., Sugai H., Mimura K., Miyagawa N., et al. CD4(+)CD25high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers. Cancer Immunol Immunother 2006, 55:1064-1071.
    • (2006) Cancer Immunol Immunother , vol.55 , pp. 1064-1071
    • Kono, K.1    Kawaida, H.2    Takahashi, A.3    Sugai, H.4    Mimura, K.5    Miyagawa, N.6
  • 27
    • 77957607351 scopus 로고    scopus 로고
    • Increased prevalence of regulatory T cells in the tumor microenvironment and its correlation with TNM stage of hepatocellular carcinoma
    • Shen X., Li N., Li H., Zhang T., Wang F., Li Q. Increased prevalence of regulatory T cells in the tumor microenvironment and its correlation with TNM stage of hepatocellular carcinoma. J Cancer Res Clin Oncol 2010.
    • (2010) J Cancer Res Clin Oncol
    • Shen, X.1    Li, N.2    Li, H.3    Zhang, T.4    Wang, F.5    Li, Q.6
  • 28
    • 0030917081 scopus 로고    scopus 로고
    • Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2
    • Shiratori T., Miyatake S., Ohno H., Nakaseko C., Isono K., Bonifacino J.S., et al. Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2. Immunity 1997, 6:583-589.
    • (1997) Immunity , vol.6 , pp. 583-589
    • Shiratori, T.1    Miyatake, S.2    Ohno, H.3    Nakaseko, C.4    Isono, K.5    Bonifacino, J.S.6
  • 29
    • 0029120245 scopus 로고
    • CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
    • Krummel M.F., Allison J.P. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med 1995, 182:459-465.
    • (1995) J Exp Med , vol.182 , pp. 459-465
    • Krummel, M.F.1    Allison, J.P.2
  • 30
    • 77956637830 scopus 로고    scopus 로고
    • Circulating soluble CTLA4 (sCTLA4) is elevated in patients with breast cancer
    • Erfani N., Razmkhah M., Ghaderi A. Circulating soluble CTLA4 (sCTLA4) is elevated in patients with breast cancer. Cancer Invest 2010, 28:828-832.
    • (2010) Cancer Invest , vol.28 , pp. 828-832
    • Erfani, N.1    Razmkhah, M.2    Ghaderi, A.3
  • 31
    • 3042785065 scopus 로고    scopus 로고
    • Expression of CTLA-4 (CD152) in peripheral blood T cells of children with influenza virus infection including encephalopathy in comparison with respiratory syncytial virus infection
    • Ayukawa H., Matsubara T., Kaneko M., Hasegawa M., Ichiyama T., Furukawa S. Expression of CTLA-4 (CD152) in peripheral blood T cells of children with influenza virus infection including encephalopathy in comparison with respiratory syncytial virus infection. Clin Exp Immunol 2004, 137:151-155.
    • (2004) Clin Exp Immunol , vol.137 , pp. 151-155
    • Ayukawa, H.1    Matsubara, T.2    Kaneko, M.3    Hasegawa, M.4    Ichiyama, T.5    Furukawa, S.6
  • 32
    • 0031058008 scopus 로고    scopus 로고
    • Human ex vivo carcinoma cells produce transforming growth factor beta and thereby can inhibit lymphocyte functions in vitro
    • Vanky F., Nagy N., Hising C., Sjovall K., Larson B., Klein E. Human ex vivo carcinoma cells produce transforming growth factor beta and thereby can inhibit lymphocyte functions in vitro. Cancer Immunol Immunother 1997, 43:317-323.
    • (1997) Cancer Immunol Immunother , vol.43 , pp. 317-323
    • Vanky, F.1    Nagy, N.2    Hising, C.3    Sjovall, K.4    Larson, B.5    Klein, E.6
  • 34
    • 0028473701 scopus 로고
    • Molecular biology of pancreatic cancer: overexpression of fibroblast growth factors
    • Friess H., Korc M., Buchler M.W. Molecular biology of pancreatic cancer: overexpression of fibroblast growth factors. Chirurg 1994, 65:604-610.
    • (1994) Chirurg , vol.65 , pp. 604-610
    • Friess, H.1    Korc, M.2    Buchler, M.W.3
  • 35
    • 4344696770 scopus 로고    scopus 로고
    • Acquisition of anergic and suppressive activities in transforming growth factor-beta-costimulated CD4+CD25- T cells
    • Park H.B., Paik D.J., Jang E., Hong S., Youn J. Acquisition of anergic and suppressive activities in transforming growth factor-beta-costimulated CD4+CD25- T cells. Int Immunol 2004, 16:1203-1213.
    • (2004) Int Immunol , vol.16 , pp. 1203-1213
    • Park, H.B.1    Paik, D.J.2    Jang, E.3    Hong, S.4    Youn, J.5
  • 36
    • 2142645808 scopus 로고    scopus 로고
    • Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7
    • Fantini M.C., Becker C., Monteleone G., Pallone F., Galle P.R., Neurath M.F. Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. J Immunol 2004, 172:5149-5153.
    • (2004) J Immunol , vol.172 , pp. 5149-5153
    • Fantini, M.C.1    Becker, C.2    Monteleone, G.3    Pallone, F.4    Galle, P.R.5    Neurath, M.F.6
  • 37
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen W., Jin W., Hardegen N., Lei K.J., Li L., Marinos N., et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003, 198:1875-1886.
    • (2003) J Exp Med , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.J.4    Li, L.5    Marinos, N.6
  • 38
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach D.R., Krummel M.F., Allison J.P. Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996, 271:1734-1736.
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 39
    • 4344714990 scopus 로고    scopus 로고
    • Role of dendritic cell phenotype, determinant spreading, and negative costimulatory blockade in dendritic cell-based melanoma immunotherapy
    • Ribas A., Glaspy J.A., Lee Y., Dissette V.B., Seja E., Vu H.T., et al. Role of dendritic cell phenotype, determinant spreading, and negative costimulatory blockade in dendritic cell-based melanoma immunotherapy. J Immunother 2004, 27:354-367.
    • (2004) J Immunother , vol.27 , pp. 354-367
    • Ribas, A.1    Glaspy, J.A.2    Lee, Y.3    Dissette, V.B.4    Seja, E.5    Vu, H.T.6
  • 40
    • 0034194329 scopus 로고    scopus 로고
    • Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade
    • Hurwitz A.A., Foster B.A., Kwon E.D., Truong T., Choi E.M., Greenberg N.M., et al. Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade. Cancer Res 2000, 60:2444-2448.
    • (2000) Cancer Res , vol.60 , pp. 2444-2448
    • Hurwitz, A.A.1    Foster, B.A.2    Kwon, E.D.3    Truong, T.4    Choi, E.M.5    Greenberg, N.M.6
  • 41
    • 0035903324 scopus 로고    scopus 로고
    • Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses
    • Sutmuller R.P., van Duivenvoorde L.M., van Elsas A., Schumacher T.N., Wildenberg M.E., Allison J.P., et al. Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J Exp Med 2001, 194:823-832.
    • (2001) J Exp Med , vol.194 , pp. 823-832
    • Sutmuller, R.P.1    van Duivenvoorde, L.M.2    van Elsas, A.3    Schumacher, T.N.4    Wildenberg, M.E.5    Allison, J.P.6
  • 42
    • 36849035139 scopus 로고    scopus 로고
    • Targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4): a novel strategy for the treatment of melanoma and other malignancies
    • O'Day S.J., Hamid O., Urba W.J. Targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4): a novel strategy for the treatment of melanoma and other malignancies. Cancer 2007, 110:2614-2627.
    • (2007) Cancer , vol.110 , pp. 2614-2627
    • O'Day, S.J.1    Hamid, O.2    Urba, W.J.3
  • 43
    • 79251487819 scopus 로고    scopus 로고
    • Targeting Foxp3+ regulatory T cells-related immunosuppression for cancer immunotherapy
    • Feng L.L., Wang X. Targeting Foxp3+ regulatory T cells-related immunosuppression for cancer immunotherapy. Chin Med J (Engl) 2010, 123:3334-3342.
    • (2010) Chin Med J (Engl) , vol.123 , pp. 3334-3342
    • Feng, L.L.1    Wang, X.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.