The Hexahistidine Motif of Host-Defense Protein Human Calprotectin Contributes to Zinc Withholding and Its Functional Versatility

Journal of the American Chemical Society

Volumn 138, Issue 37, 2016, Pages 12243-12251

  Nakashige, Toshiki G ^a   Stephan, Jules R ^a   Cunden, Lisa S ^a   Brophy, Megan Brunjes ^a   Wommack, Andrew J ^a   Keegan, Brenna C ^b   Shearer, Jason M ^b   Nolan, Elizabeth M ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF NEVADA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING SITES; COORDINATION REACTIONS; DIMERS; IMMUNE SYSTEM; IRON COMPOUNDS; MANGANESE COMPOUNDS; METAL IONS; NICKEL COMPOUNDS; NUTRIENTS; PATHOGENS; X RAY ABSORPTION SPECTROSCOPY; ZINC COMPOUNDS;

ANTIMICROBIAL FUNCTIONS; C-TERMINAL TAIL; DIVALENTS; FIRST ROW TRANSITION METALS; HOST DEFENSE; INNATE IMMUNE RESPONSE; METAL-BINDING SITES; MICROBIAL PATHOGENS; TRANSITION METAL IONS; TRANSITION-METAL BINDING;

PROTEINS;

CALGRANULIN; CALGRANULIN A; FERROUS ION; HEXAHISTIDINE; PROTEINASE K; ZINC; HIS-HIS-HIS-HIS-HIS-HIS; HISTIDINE; OLIGOPEPTIDE; PROTEIN BINDING;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; CANDIDA ALBICANS; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; GEOMETRY; HOST RESISTANCE; INNATE IMMUNITY; ISOTHERMAL TITRATION CALORIMETRY; LACTOBACILLUS PLANTARUM; MICROBIAL GROWTH; NONHUMAN; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN MOTIF; X RAY ABSORPTION SPECTROSCOPY; CHEMISTRY; HUMAN; MOLECULAR MODEL; PROTEIN CONFORMATION;

HISTIDINE; HUMANS; LACTOBACILLUS PLANTARUM; LEUKOCYTE L1 ANTIGEN COMPLEX; MODELS, MOLECULAR; OLIGOPEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; ZINC;

EID: 84988655762     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.6b06845     Document Type: Article

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