Metal chelation and inhibition of bacterial growth in tissue abscesses

Science

Volumn 319, Issue 5865, 2008, Pages 962-965

  Corbin, Brian D ^a   Seeley, Erin H ^a   Raab, Andrea ^d   Feldmann, Joerg ^d   Miller, Michael R ^a   Torres, Victor J ^a   Anderson, Kelsi L ^b   Dattilo, Brian M ^a   Dunman, Paul M ^b   Gerads, Russell ^e   Caprioli, Richard M ^a   Nacken, Wolfgang ^c   Chazin, Walter J ^a   Skaar, Eric P ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d UNIVERSITY OF ABERDEEN   (United Kingdom)

^e Applied Speciation and Consulting   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALGRANULIN; MANGANESE; TRANSCRIPTOME; ZINC;

BACTERIUM; CHELATION; GROWTH RESPONSE; IDENTIFICATION METHOD; IMMUNE SYSTEM; INHIBITION; METAL; PROTEIN; RODENT;

ABSCESS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; CHELATION THERAPY; CONTROLLED STUDY; HOST PATHOGEN INTERACTION; INNATE IMMUNITY; MICROBIAL GROWTH; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION;

ABSCESS; ANIMALS; CALCIUM; CHELATING AGENTS; DIMERIZATION; GENE EXPRESSION PROFILING; KIDNEY DISEASES; LEUKOCYTE L1 ANTIGEN COMPLEX; LIVER ABSCESS; MANGANESE; MASS SPECTROMETRY; MICE; NEUTROPHILS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; ZINC;

BACTERIA (MICROORGANISMS); MUS; STAPHYLOCOCCUS AUREUS;

EID: 39349117867     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1152449     Document Type: Article

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13. We thank members of the Skaar laboratory and F. DeLeo, D. Russell, and H. Seifert for critical reading of this manuscript; the Vanderbilt Pathology Core, Tissue Acquisition Core, O. Aranmolate, L. Zimmerman, M. Reyzer, and S. Joyce for technical assistance; and H. Gresham for providing the monoclonal antibody RB6-8C5. This research was supported by the Searle Scholars Program, NIH RO1 GM62112 (to W.J.C.), Engineering and Physical Sciences Research Council GR/S98689/01 (to J.F. and A.R.), NIH 5R01 GM58008-09 and U.S. Department of Defense W81XWH-05-1-0179 (to R.M.C.), and the Vanderbilt-Ingram Cancer Center Core Support Grant NIH P50 CA068485. E.P.S. holds an Investigator in Pathogenesis of Infectious Disease Award from the Burroughs Wellcome Fund. B.D.C., B.M.D., and V.J.T. were supported by NIH training grants T32 HL069765, T32 GM08320, and F32 AI071487, respectively. Minimum Information About a Microarray Experiment-compliant microarray data have been submitted to the Gene Expression Omnibus database under the provisional submission number GSE9828.