Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 10, 2013, Pages 3841-3846

  Damo, Steven M ^a   Kehl Fie, Thomas E ^b   Sugitani, Norie ^a   Holt, Marilyn E ^a   Rathi, Subodh ^a   Murphy, Wesley J ^a   Zhang, Yaofang ^b   Betz, Christine ^c   Hench, Laura ^a   Fritz, Günter ^c   Skaar, Eric P ^b   Chazin, Walter J ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Antibiotic resistance; Bacterial pathogenesis; Isothermal titration calorimetry; Protein crystal structure; Staphylococcus aureus

Indexed keywords

CALGRANULIN; HETERODIMER; HISTIDINE; MANGANESE; PROTEIN S 100;

AMINO ACID SEQUENCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BINDING AFFINITY; BINDING SITE; BIOPHYSICS; CONTROLLED STUDY; INHIBITION KINETICS; INNATE IMMUNITY; ISOTHERMAL TITRATION CALORIMETRY; MICROBIOLOGY; MUTAGENESIS; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; STAPHYLOCOCCUS AUREUS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SUBSTITUTION; BINDING SITES; CALGRANULIN A; CALGRANULIN B; CRYSTALLOGRAPHY, X-RAY; HISTIDINE; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, INNATE; LEUKOCYTE L1 ANTIGEN COMPLEX; MANGANESE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN MULTIMERIZATION; RECOMBINANT PROTEINS; STAPHYLOCOCCUS AUREUS; ZINC;

EID: 84874640244     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1220341110     Document Type: Article

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